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Select item 111094831.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 110593942.

Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2

Wei Dong, Qing Li, Xing Lu, Jianfeng Lan, Zhidong Qiu, Xuehong Wang, Junnan Wang, Xiaojiao Zheng, Sifan Chen, Chong Zhang, Junfei Jin

Exp Mol Med. 2024 Apr; 56(4): 946–958. Published online 2024 Apr 1. doi: 10.1038/s12276-024-01203-4

PMCID:: PMC11059394

Abstract Article PDF–7.4M

Select item 109805593.

Diminished Efficacy of Programmed Death-(Ligand)1 Inhibition in STK11- and KEAP1-Mutant Lung Adenocarcinoma Is Affected by KRAS Mutation Status

Biagio Ricciuti, Kathryn C. Arbour, Jessica J. Lin, Amir Vajdi, Natalie Vokes, Lingzhi Hong, Jianjun Zhang, Michael Y. Tolstorukov, Yvonne Y. Li, Liam F. Spurr, Andrew D. Cherniack, Gonzalo Recondo, Giuseppe Lamberti, Xinan Wang, Deepti Venkatraman, Joao V. Alessi, Victor R. Vaz, Hira Rizvi, Jacklynn Egger, Andrew J. Plodkowski, Sara Khosrowjerdi, Subba Digumarthy, Hyesun Park, Nuno Vaz, Mizuki Nishino, Lynette M. Sholl, David Barbie, Mehmet Altan, John V. Heymach, Ferdinandos Skoulidis, Justin F. Gainor, Matthew D. Hellmann, Mark M. Awad

J Thorac Oncol. Author manuscript; available in PMC 2024 Mar 29.

Published in final edited form as: J Thorac Oncol. 2022 Mar; 17(3): 399–410. Published online 2021 Nov 2. doi: 10.1016/j.jtho.2021.10.013

PMCID:: PMC10980559

Abstract Article PDF–1.5M

Select item 109452594.

GSTP alleviates acute lung injury by S-glutathionylation of KEAP1 and subsequent activation of NRF2 pathway

Xiaolin Sun, Chaorui Guo, Chunyan Huang, Ning Lv, Huili Chen, Haoyan Huang, Yulin Zhao, Shanliang Sun, Di Zhao, Jingwei Tian, Xijing Chen, Yongjie Zhang

Redox Biol. 2024 May; 71: 103116. Published online 2024 Mar 6. doi: 10.1016/j.redox.2024.103116

PMCID:: PMC10945259

Abstract Article PDF–16M

Select item 109168665.

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma

Suzannah G. Miller, Maria Hoh, Christopher C. Ebmeier, Jian Wei Tay, Natalie G. Ahn

Mol Biol Cell. 2024 Mar 1; 35(3): ar31. Published online 2024 Jan 29. doi: 10.1091/mbc.E23-06-0255

PMCID:: PMC10916866

Abstract Article PDF–4.7M

Select item 108803706.

A tumor suppressor protein encoded by circKEAP1 inhibits osteosarcoma cell stemness and metastasis by promoting vimentin proteasome degradation and activating anti-tumor immunity

Ying Zhang, Zhaoyong Liu, Zhigang Zhong, Yanchen Ji, Huancheng Guo, Weidong Wang, Chuangzhen Chen

J Exp Clin Cancer Res. 2024; 43: 52. Published online 2024 Feb 21. doi: 10.1186/s13046-024-02971-7

PMCID:: PMC10880370

Abstract Article PDF–19M

Select item 107644557.

Study of the effect of keap1 on oxidative stress in human umbilical cord mesenchymal stem cells

Hongrong Deng, Yunxia Chen, Huiwen Liu, Li Wang, Hao Xu, Bin Tan, Qin Yi, Rui Wang, Bolin He, Jie Tian, Jing Zhu

Mol Biol Rep. 2024; 51(1): 67. Published online 2024 Jan 3. doi: 10.1007/s11033-023-08997-y

PMCID:: PMC10764455

Abstract Article PDF–4.1M

Select item 107559708.

KEAP1 mutation in lung adenocarcinoma promotes immune evasion and immunotherapy resistance

Anastasia-Maria Zavitsanou, Ray Pillai, Yuan Hao, Warren L. Wu, Eric Bartnicki, Triantafyllia Karakousi, Sahith Rajalingam, Alberto Herrera, Angeliki Karatza, Ali Rashidfarrokhi, Sabrina Solis, Metamia Ciampricotti, Anna H. Yeaton, Ellie Ivanova, Corrin A. Wohlhieter, Terkild B. Buus, Makiko Hayashi, Burcu Karadal-Ferrena, Harvey I. Pass, John T. Poirier, Charles M. Rudin, Kwok-Kin Wong, Andre L. Moreira, Kamal M. Khanna, Aristotelis Tsirigos, Thales Papagiannakopoulos, Sergei B. Koralov

Cell Rep. Author manuscript; available in PMC 2023 Dec 29.

Published in final edited form as: Cell Rep. 2023 Nov 28; 42(11): 113295. Published online 2023 Oct 26. doi: 10.1016/j.celrep.2023.113295

PMCID:: PMC10755970

Abstract Article PDF–2.3M

Select item 106174669.

Oxidative stress sensor Keap1 recognizes HBx protein to activate the Nrf2/ARE signaling pathway, thereby inhibiting hepatitis B virus replication

Adi Ariffianto, Lin Deng, Takayuki Abe, Chieko Matsui, Masahiko Ito, Akihide Ryo, Hussein Hassan Aly, Koichi Watashi, Tetsuro Suzuki, Masashi Mizokami, Yoshiharu Matsuura, Ikuo Shoji

J Virol. 2023 Oct; 97(10): e01287-23. Published online 2023 Oct 6. doi: 10.1128/jvi.01287-23

PMCID:: PMC10617466

Abstract Article PDF–5.0M

Select item 1056587610.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 1056462211.

Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly

Roslin J. Adamson, N Connor Payne, Sergio G. Bartual, Ralph Mazitschek, Alex N. Bullock

Free Radic Biol Med. 2023 Aug 1; 204: 215–225. doi: 10.1016/j.freeradbiomed.2023.04.021

PMCID:: PMC10564622

Abstract Article PDF–5.7M

Select item 1046041312.

FSP1 confers ferroptosis resistance in KEAP1 mutant non-small cell lung carcinoma in NRF2-dependent and -independent manner

Jong Woo Kim, Min-Ju Kim, Tae-Hee Han, Ji-Yoon Lee, Sangok Kim, Hyerin Kim, Kyoung-Jin Oh, Won Kon Kim, Baek-Soo Han, Kwang-Hee Bae, Hyun Seung Ban, Soo Han Bae, Sang Chul Lee, Haeseung Lee, Eun-Woo Lee

Cell Death Dis. 2023 Aug; 14(8): 567. Published online 2023 Aug 26. doi: 10.1038/s41419-023-06070-x

PMCID:: PMC10460413

Abstract Article PDF–3.8M

Select item 1033388413.

Large‐scale phosphomimetic screening identifies phospho‐modulated motif‐based protein interactions

Johanna Kliche, Dimitriya Hristoforova Garvanska, Leandro Simonetti, Dilip Badgujar, Doreen Dobritzsch, Jakob Nilsson, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2023 Jul; 19(7): e11164. Published online 2023 May 23. doi: 10.15252/msb.202211164

PMCID:: PMC10333884

Abstract Article PDF–5.0M

Select item 1028148414.

TRIM13 inhibits cell proliferation and induces autophagy in lung adenocarcinoma by regulating KEAP1/NRF2 pathway

Bo Yu, Yu Zhou, Jinxi He

Cell Cycle. 2023; 22(12): 1496–1513. Published online 2023 May 28. doi: 10.1080/15384101.2023.2216504

PMCID:: PMC10281484

Abstract Article PDF–4.1M

Select item 1026713415.

SMURF1 attenuates endoplasmic reticulum stress by promoting the degradation of KEAP1 to activate NRF2 antioxidant pathway

Lei Dong, Mengchuan Xu, Yang Li, Wanting Xu, Chengwei Wu, Hanfei Zheng, Zhenyu Xiao, Guochen Sun, Lei Ding, Xiaobo Li, Wenming Li, Liying Zhou, Qin Xia

Cell Death Dis. 2023 Jun; 14(6): 361. Published online 2023 Jun 14. doi: 10.1038/s41419-023-05873-2

PMCID:: PMC10267134

Abstract Article PDF–4.4M

Select item 1023742216.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1019062117.

DDRGK1 Enhances Osteosarcoma Chemoresistance via Inhibiting KEAP1‐Mediated NRF2 Ubiquitination

Xin Wang, Tangjun Zhou, Xiao Yang, Xiankun Cao, Gu Jin, Pu Zhang, Jiadong Guo, Kewei Rong, Baixing Li, Yibin Hu, Kexin Liu, Peixiang Ma, An Qin, Jie Zhao

Adv Sci (Weinh) 2023 May; 10(14): 2204438. Published online 2023 Mar 25. doi: 10.1002/advs.202204438

PMCID:: PMC10190621

Abstract Article PDF–7.3M

Select item 1018928718.

The KEAP1-NRF2 pathway: Targets for therapy and role in cancer

Simone Adinolfi, Tommi Patinen, Ashik Jawahar Deen, Sini Pitkänen, Jouni Härkönen, Emilia Kansanen, Jenni Küblbeck, Anna-Liisa Levonen

Redox Biol. 2023 Jul; 63: 102726. Published online 2023 Apr 29. doi: 10.1016/j.redox.2023.102726

PMCID:: PMC10189287

Abstract Article PDF–3.7M

Select item 1010193319.

Optimization of the C2 substituents on the 1,4-bis(arylsulfonamido)naphthalene-N,N’-diacetic acid scaffold for better inhibition of Keap1-Nrf2 protein-protein interaction

Dhulfiqar Ali Abed, Ahmed R. Ali, Sumi Lee, Mai-Uyen Nguyen, Michael P. Verzi, Longqin Hu

Eur J Med Chem. Author manuscript; available in PMC 2024 Apr 5.

Published in final edited form as: Eur J Med Chem. 2023 Apr 5; 252: 115302. Published online 2023 Mar 22. doi: 10.1016/j.ejmech.2023.115302

PMCID:: PMC10101933

Abstract Article PDF–2.0M

Select item 1002399120.

miR-125b-5p in adipose derived stem cells exosome alleviates pulmonary microvascular endothelial cells ferroptosis via Keap1/Nrf2/GPX4 in sepsis lung injury

Kuo Shen, Xujie Wang, Yunwei Wang, Yanhui Jia, Yue Zhang, Kejia Wang, Liang Luo, Weixia Cai, Jin Li, Shaohui Li, Yuting Du, Lixia Zhang, Hao Zhang, Yuxi Chen, Chaolei Xu, Jinxin Zhang, Ruizhi Wang, Xuekang Yang, Yunchuan Wang, Dahai Hu

Redox Biol. 2023 Jun; 62: 102655. Published online 2023 Mar 9. doi: 10.1016/j.redox.2023.102655

PMCID:: PMC10023991

Abstract Article PDF–16M

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