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Select item 96063811.

GABBR1 monoallelic de novo variants linked to neurodevelopmental delay and epilepsy

Maria Lucia Cediel, Michal Stawarski, Xavier Blanc, Lenka Nosková, Martin Magner, Konrad Platzer, Janina Gburek-Augustat, Dustin Baldridge, John N. Constantino, Emmanuelle Ranza, Bernhard Bettler, Stylianos E. Antonarakis

Am J Hum Genet. 2022 Oct 6; 109(10): 1885–1893. Published online 2022 Sep 13. doi: 10.1016/j.ajhg.2022.08.010

PMCID:: PMC9606381

Abstract Article PDF–881K

Select item 93295762.

Phosphonate-Modified Cellulose Nanocrystals Potentiate the Th1 Polarising Capacity of Monocyte-Derived Dendritic Cells via GABA-B Receptor

Marina Bekić, Miloš Vasiljević, Dušica Stojanović, Vanja Kokol, Dušan Mihajlović, Dragana Vučević, Petar Uskoković, Miodrag Čolić, Sergej Tomić

Int J Nanomedicine. 2022; 17: 3191–3216. Published online 2022 Jul 23. doi: 10.2147/IJN.S362038

PMCID:: PMC9329576

Abstract Article PDF–14M

Select item 81650303.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80208354.

Structural basis of the activation of a metabotropic GABA receptor

Hamidreza Shaye, Andrii Ishchenko, Jordy Homing Lam, Gye Won Han, Li Xue, Philippe Rondard, Jean-Philippe Pin, Vsevolod Katritch, Cornelius Gati, Vadim Cherezov

Nature. Author manuscript; available in PMC 2021 Apr 5.

Published in final edited form as: Nature. 2020 Aug; 584(7820): 298–303. Published online 2020 Jun 17. doi: 10.1038/s41586-020-2408-4

PMCID:: PMC8020835

Abstract Article PDF–2.7M

Select item 78858255.

The neurotransmitter receptor Gabbr1 regulates proliferation and function of hematopoietic stem and progenitor cells

Lijian Shao, Adedamola Elujoba-Bridenstine, Katherine E. Zink, Laura M. Sanchez, Brian J. Cox, Karen E. Pollok, Anthony L. Sinn, Barbara J. Bailey, Emily C. Sims, Scott H. Cooper, Hal E. Broxmeyer, Kostandin V. Pajcini, Owen J. Tamplin

Blood. 2021 Feb 11; 137(6): 775–787. Prepublished online 2020 Sep 3. doi: 10.1182/blood.2019004415

PMCID:: PMC7885825

Abstract Article

Select item 77252816.

Structure of human GABA_B receptor in an inactive state

Jinseo Park, Ziao Fu, Aurel Frangaj, Jonathan Liu, Lidia Mosyak, Tong Shen, Vesna N. Slavkovich, Kimberly M. Ray, Jaume Taura, Baohua Cao, Yong Geng, Hao Zuo, Yongjun Kou, Robert Grassucci, Shaoxia Chen, Zheng Liu, Xin Lin, Justin P. Williams, William J. Rice, Edward T. Eng, Rick K. Huang, Rajesh K. Soni, Brian Kloss, Zhiheng Yu, Jonathan A. Javitch, Wayne A. Hendrickson, Paul A. Slesinger, Matthias Quick, Joseph Graziano, Hongtao Yu, Oliver Fiehn, Oliver B. Clarke, Joachim Frank, Qing R. Fan

Nature. Author manuscript; available in PMC 2020 Dec 24.

Published in final edited form as: Nature. 2020 Aug; 584(7820): 304–309. Published online 2020 Jun 24. doi: 10.1038/s41586-020-2452-0

Correction in:: Nature. 2020 Jul; 583(7818): E29.

PMCID:: PMC7725281

Abstract Article PDF–5.3M

Select item 74293647.

Structures of metabotropic GABA_B receptor

Makaía M. Papasergi-Scott, Michael J. Robertson, Alpay B. Seven, Ouliana Panova, Jesper M. Mathiesen, Georgios Skiniotis

Nature. Author manuscript; available in PMC 2020 Dec 24.

Published in final edited form as: Nature. 2020 Aug; 584(7820): 310–314. Published online 2020 Jun 24. doi: 10.1038/s41586-020-2469-4

PMCID:: PMC7429364

Abstract Article PDF–6.1M

Select item 64867838.

Structural basis for auxiliary subunit KCTD16 regulation of the GABA_B receptor

Hao Zuo, Ian Glaaser, Yulin Zhao, Igor Kurinov, Lidia Mosyak, Haonan Wang, Jonathan Liu, Jinseo Park, Aurel Frangaj, Emmanuel Sturchler, Ming Zhou, Patricia McDonald, Yong Geng, Paul A. Slesinger, Qing R. Fan

Proc Natl Acad Sci U S A. 2019 Apr 23; 116(17): 8370–8379. Published online 2019 Apr 10. doi: 10.1073/pnas.1903024116

PMCID:: PMC6486783

Abstract Article PDF–2.6M

Select item 56274829.

Newborn genome-wide DNA methylation in association with pregnancy anxiety reveals a potential role for GABBR1

Elise Beau Vangeel, Ehsan Pishva, Titia Hompes, Daniel van den Hove, Diether Lambrechts, Karel Allegaert, Kathleen Freson, Benedetta Izzi, Stephan Claes

Clin Epigenetics. 2017; 9: 107. Published online 2017 Oct 3. doi: 10.1186/s13148-017-0408-5

PMCID:: PMC5627482

Abstract Article PDF–943K

Select item 558850710.

Association between Single Nucleotide Polymorphisms in Gamma-Aminobutyric Acid B Receptor, Insulin Receptor Substrate-1, and Hypocretin Neuropeptide Precursor Genes and Susceptibility to Obstructive Sleep Apnea Hypopnea Syndrome in a Chinese Han Population

Zhijun Li, Tingyu Tang, Jianzong Du, Wenjuan Wu, Xiaoxi Zhou, Guangyue Qin

Med Princ Pract. 2016 Nov; 25(6): 517–524. Published online 2016 Aug 10. doi: 10.1159/000448997

PMCID:: PMC5588507

Abstract Article PDF–182K

Select item 539911111.

Deficits in the activity of presynaptic γ-aminobutyric acid type B receptors contribute to altered neuronal excitability in fragile X syndrome

Ji-Yong Kang, Jayashree Chadchankar, Thuy N. Vien, Michelle I. Mighdoll, Thomas M. Hyde, Robert J. Mather, Tarek Z. Deeb, Menelas N. Pangalos, Nicholas J. Brandon, John Dunlop, Stephen J. Moss

J Biol Chem. 2017 Apr 21; 292(16): 6621–6632. Published online 2017 Feb 17. doi: 10.1074/jbc.M116.772541

PMCID:: PMC5399111

Abstract Article PDF–1.9M

Select item 537173012.

Systematic protein–protein interaction mapping for clinically relevant human GPCRs

Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar

Mol Syst Biol. 2017 Mar; 13(3): 918. Published online 2017 Mar 15. doi: 10.15252/msb.20167430

PMCID:: PMC5371730

Abstract Article PDF–4.1M

Select item 484160713.

High-throughput analyses of hnRNP H1 dissects its multi-functional aspect

Philip J. Uren, Emad Bahrami-Samani, Patricia Rosa de Araujo, Christine Vogel, Mei Qiao, Suzanne C. Burns, Andrew D. Smith, Luiz O. F. Penalva

RNA Biol. 2016 Apr; 13(4): 400–411. Published online 2016 Jan 13. doi: 10.1080/15476286.2015.1138030

PMCID:: PMC4841607

Abstract Article PDF–1.6M

Select item 480729614.

Post-endocytotic Deubiquitination and Degradation of the Metabotropic γ-Aminobutyric Acid Receptor by the Ubiquitin-specific Protease 14

Nicolas Lahaie, Michaela Kralikova, Laurent Prézeau, Jaroslav Blahos, Michel Bouvier

J Biol Chem. 2016 Mar 25; 291(13): 7156–7170. Published online 2016 Jan 27. doi: 10.1074/jbc.M115.686907

PMCID:: PMC4807296

Abstract Article PDF–2.2M

Select item 470055815.

GABBR1 and SLC6A1, two genes involved in modulation of GABA synaptic transmission influence risk for alcoholism; results from three ethnically diverse populations

Mary-Anne Enoch, Colin A. Hodgkinson, Pei-Hong Shen, Elena Gorodetsky, Cheryl A. Marietta, Alex Roy, David Goldman

Alcohol Clin Exp Res. Author manuscript; available in PMC 2017 Jan 1.

Published in final edited form as: Alcohol Clin Exp Res. 2016 Jan; 40(1): 93–101. doi: 10.1111/acer.12929

PMCID:: PMC4700558

Abstract Article PDF–786K

Select item 438154616.

Cytoskeletal rearrangement and Src and PI-3K-dependent Akt activation

Michelle T. Barati, Janice Scherzer, Rui Wu, Madhavi J. Rane, Jon B. Klein

Cell Signal. Author manuscript; available in PMC 2016 Jun 1.

Published in final edited form as: Cell Signal. 2015 Jun; 27(6): 1178–1185. Published online 2015 Feb 26. doi: 10.1016/j.cellsig.2015.02.022

PMCID:: PMC4381546

Abstract Article PDF–976K

Select item 437601617.

A novel human receptor involved in bitter tastant detection identified using Dictyostelium discoideum

Steven Robery, Richard Tyson, Christopher Dinh, Adam Kuspa, Angelika A. Noegel, Till Bretschneider, Paul L. R. Andrews, Robin S. B. Williams

J Cell Sci. 2013 Dec 1; 126(23): 5465–5476. doi: 10.1242/jcs.136440

PMCID:: PMC4376016

Abstract Article

Select item 402489818.

Heterodimeric coiled-coil interactions of human GABA_B receptor

Svetlana Burmakina, Yong Geng, Yan Chen, Qing R. Fan

Proc Natl Acad Sci U S A. 2014 May 13; 111(19): 6958–6963. Published online 2014 Apr 28. doi: 10.1073/pnas.1400081111

PMCID:: PMC4024898

Abstract Article PDF–1.3M

Select item 399930119.

Altered Gamma-Aminobutyric Acid Type B Receptor Subunit 1 Splicing In Alcoholics

Changhoon Lee, R. Dayne Mayfield, R. Adron Harris

Biol Psychiatry. Author manuscript; available in PMC 2015 May 15.

Published in final edited form as: Biol Psychiatry. 2014 May 15; 75(10): 765–773. Published online 2013 Oct 24. doi: 10.1016/j.biopsych.2013.08.028

PMCID:: PMC3999301

Abstract Article PDF–658K

Select item 386506520.

Structural mechanism of ligand activation in human GABA_B receptor

Yong Geng, Martin Bush, Lidia Mosyak, Feng Wang, Qing R. Fan

Nature. Author manuscript; available in PMC 2014 Jun 12.

Published in final edited form as: Nature. 2013 Dec 12; 504(7479): 254–259. Published online 2013 Dec 4. doi: 10.1038/nature12725

PMCID:: PMC3865065

Abstract Article PDF–2.0M

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