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Select item 111315431.

Basal autophagy is involved in the degradation of the ERAD component EDEM1

V. Le Fourn, K. Gaplovska-Kysela, B. Guhl, R. Santimaria, C. Zuber, J. Roth

Cell Mol Life Sci. 2009 Apr; 66(8): 1434–1445. Published online 2009 Mar 7. doi: 10.1007/s00018-009-9038-1

PMCID:: PMC11131543

Abstract Article PDF–4.0M

Select item 99868172.

METTL3 protects METTL14 from STUB1‐mediated degradation to maintain m⁶A homeostasis

Zhan‐Cheng Zeng, Qi Pan, Yu‐Meng Sun, Heng‐Jing Huang, Xiao‐Tong Chen, Tian‐Qi Chen, Bo He, Hua Ye, Shun‐Xin Zhu, Ke‐Jia Pu, Ke Fang, Wei Huang, Yue‐Qin Chen, Wen‐Tao Wang

EMBO Rep. 2023 Mar; 24(3): e55762. Published online 2023 Jan 4. doi: 10.15252/embr.202255762

PMCID:: PMC9986817

Abstract Article PDF–3.5M

Select item 92316233.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 87451084.

EDEM1 Regulates Amyloid Precursor Protein (APP) Metabolism and Amyloid-β Production

Jowita Nowakowska-Gołacka, Justyna Czapiewska, Hanna Sominka, Natalia Sowa-Rogozińska, Monika Słomińska-Wojewódzka

Int J Mol Sci. 2022 Jan; 23(1): 117. Published online 2021 Dec 23. doi: 10.3390/ijms23010117

PMCID:: PMC8745108

Abstract Article PDF–3.6M

Select item 85706945.

Purified EDEM3 or EDEM1 alone produces determinant oligosaccharide structures from M8B in mammalian glycoprotein ERAD

Ginto George, Satoshi Ninagawa, Hirokazu Yagi, Jun-ichi Furukawa, Noritaka Hashii, Akiko Ishii-Watabe, Ying Deng, Kazutoshi Matsushita, Tokiro Ishikawa, Yugoviandi P Mamahit, Yuta Maki, Yasuhiro Kajihara, Koichi Kato, Tetsuya Okada, Kazutoshi Mori

eLife. 2021; 10: e70357. Published online 2021 Oct 26. doi: 10.7554/eLife.70357

PMCID:: PMC8570694

Abstract Article PDF–3.9M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79263077.

EDEM3 Domains Cooperate to Perform Its Overall Cell Functioning

Georgiana Manica, Simona Ghenea, Cristian V. A. Munteanu, Eliza C. Martin, Cristian Butnaru, Marius Surleac, Gabriela N. Chiritoiu, Petruta R. Alexandru, Andrei-Jose Petrescu, Stefana M. Petrescu

Int J Mol Sci. 2021 Feb; 22(4): 2172. Published online 2021 Feb 22. doi: 10.3390/ijms22042172

PMCID:: PMC7926307

Abstract Article PDF–4.2M

Select item 73924918.

TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination

Gangliang Wang, Shuai Chen, Ziang Xie, Shuying Shen, Wenbin Xu, Wenxiang Chen, Xiang Li, Yizheng Wu, Liangping Li, Bin Liu, Xianjun Ding, An Qin, Shunwu Fan

Ann Rheum Dis. 2020 Aug; 79(8): 1111–1120. Published online 2020 May 14. doi: 10.1136/annrheumdis-2019-216911

PMCID:: PMC7392491

Abstract Article PDF–14M

Select item 72790499.

EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired

Marioara Chiritoiu, Gabriela N. Chiritoiu, Cristian V. A. Munteanu, Florin Pastrama, N. Erwin Ivessa, Stefana M. Petrescu

Int J Mol Sci. 2020 May; 21(10): 3468. Published online 2020 May 14. doi: 10.3390/ijms21103468

PMCID:: PMC7279049

Abstract Article PDF–12M

Select item 613095610.

EDEM1's mannosidase-like domain binds ERAD client proteins in a redox-sensitive manner and possesses catalytic activity

Lydia Lamriben, Michela E. Oster, Taku Tamura, Weihua Tian, Zhang Yang, Henrik Clausen, Daniel N. Hebert

J Biol Chem. 2018 Sep 7; 293(36): 13932–13945. Published online 2018 Jul 18. doi: 10.1074/jbc.RA118.004183

PMCID:: PMC6130956

Abstract Article PDF–2.5M

Select item 566346511.

A Global Analysis of The Receptor Tyrosine Kinase – Protein Phosphatase Interactome

Zhong Yao, Katelyn Darowski, Nicole St-Denis, Victoria Wong, Fabian Offensperger, Annabel Villedieu, Shahreen Amin, Ramy Malty, Hiroyuki Aoki, Hongbo Guo, Yang Xu, Caterina Iorio, Max Kotlyar, Andrew Emili, Igor Jurisica, Benjamin G Neel, Mohan Babu, Anne-Claude Gingras, Igor Stagljar

Mol Cell. Author manuscript; available in PMC 2017 Oct 31.

Published in final edited form as: Mol Cell. 2017 Jan 19; 65(2): 347–360. Published online 2017 Jan 5. doi: 10.1016/j.molcel.2016.12.004

PMCID:: PMC5663465

Abstract Article PDF–2.1M

Select item 554841312.

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling

Parveen Kumar, Prathyusha Munnangi, KVS Rammohan Chowdary, Varun J. Shah, Swapnil R. Shinde, Nanci R. Kolli, Rachita R. Halehalli, Hampapathalu A. Nagarajaram, Subbareddy Maddika

J Proteome Res. 2017 Aug 4; 16(8): 2789–2801. Published online 2017 Jul 4. doi: 10.1021/acs.jproteome.7b00065

PMCID:: PMC5548413

Abstract Article PDF–5.2M

Select item 553161113.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 461721114.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 439981715.

EDEM1 targets misfolded HLA-B27 dimers for endoplasmic reticulum associated degradation

David B. Guiliano, Helen Fussell, Izabela Lenart, Edward Tsao, Darren Nesbeth, Adam J. Fletcher, Elaine C. Campbell, Nasim Yousaf, Sarah Williams, Susana Santos, Amy Cameron, Greg J. Towers, Paul Kellam, Daniel N. Hebert, Keith Gould, Simon J. Powis, Antony N. Antoniou

Arthritis Rheumatol. Author manuscript; available in PMC 2015 Apr 16.

Published in final edited form as: Arthritis Rheumatol. 2014 Nov; 66(11): 2976–2988. doi: 10.1002/art.38809

PMCID:: PMC4399817

Abstract Article PDF–802K

Select item 412198016.

EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step

Satoshi Ninagawa, Tetsuya Okada, Yoshiki Sumitomo, Yukiko Kamiya, Koichi Kato, Satoshi Horimoto, Tokiro Ishikawa, Shunichi Takeda, Tetsushi Sakuma, Takashi Yamamoto, Kazutoshi Mori

J Cell Biol. 2014 Aug 4; 206(3): 347–356. doi: 10.1083/jcb.201404075

PMCID:: PMC4121980

Abstract Article PDF–2.6M

Select item 404959117.

EDEM2 and OS-9 Are Required for ER-Associated Degradation of Non-Glycosylated Sonic Hedgehog

Hsiang-Yun Tang, Chih-Hsiang Huang, Ya-Han Zhuang, John C. Christianson, Xin Chen

PLoS One. 2014; 9(6): e92164. Published online 2014 Jun 9. doi: 10.1371/journal.pone.0092164

PMCID:: PMC4049591

Abstract Article PDF–5.9M

Select item 392327618.

Identification of Genes Promoting Skin Youthfulness by Genome-Wide Association Study

Anne L.S. Chang, Gil Atzmon, Aviv Bergman, Samantha Brugmann, Scott X Atwood, Howard Y Chang, Nir Barzilai

J Invest Dermatol. 2014 Mar; 134(3): 651–657. Prepublished online 2013 Sep 13. Published online 2013 Oct 17. doi: 10.1038/jid.2013.381

PMCID:: PMC3923276

Abstract Article PDF–2.3M

Select item 355488919.

A Shared Endoplasmic Reticulum-associated Degradation Pathway Involving the EDEM1 Protein for Glycosylated and Nonglycosylated Proteins

Marina Shenkman, Bella Groisman, Efrat Ron, Edward Avezov, Linda M. Hendershot, Gerardo Z. Lederkremer

J Biol Chem. 2013 Jan 25; 288(4): 2167–2178. Published online 2012 Dec 11. doi: 10.1074/jbc.M112.438275

PMCID:: PMC3554889

Abstract Article PDF–4.9M

Select item 342034020.

MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity

Oliver Stehling, Ajay A. Vashisht, Judita Mascarenhas, Zophonias O. Jonsson, Tanu Sharma, Daili J.A. Netz, Antonio J. Pierik, James A. Wohlschlegel, Roland Lill

Science. Author manuscript; available in PMC 2013 Jan 13.

Published in final edited form as: Science. 2012 Jul 13; 337(6091): 195–199. Published online 2012 Jun 7. doi: 10.1126/science.1219723

PMCID:: PMC3420340

Abstract Article PDF–1.8M

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Influenza virus H5N1 infection of U251 astrocyte cell line: time course
Influenza virus H5N1 infection of U251 astrocyte cell line: time course
Accession: GDS6010

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Early onset colorectal cancer: normal-appearing colonic mucosa
Accession: GDS2609

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