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Items: 1 to 20 of 74

1.
The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons
Linda Makhlouf, Joshua J. Peter, Helge M. Magnussen, Rohan Thakur, David Millrine, Thomas C. Minshull, Grace Harrison, Joby Varghese, Frederic Lamoliatte, Martina Foglizzo, Thomas Macartney, Antonio N. Calabrese, Elton Zeqiraj, Yogesh Kulathu
Nature. 2024; 627(8003): 437–444. Published online 2024 Feb 21. doi: 10.1038/s41586-024-07093-w
PMCID:
PMC10937380
AbstractArticlePDF–16M
2.
Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis
Robert S. Kiss, Jarred Chicoine, Youssef Khalil, Robert Sladek, He Chen, Alessandro Pisaturo, Cyril Martin, Jessica D. Dale, Tegan A. Brudenell, Archith Kamath, Jeffrey Kyei-Boahen, Anouar Hafiane, Girija Daliah, Célia Alecki, Tayah S. Hopes, Martin Heier, Irene A. Aligianis, Jean-Jacques Lebrun, Julie Aspden, Emanuele Paci, Anja Kerksiek, Dieter Lütjohann, Peter Clayton, Jimi C. Wills, Alex von Kriegsheim, Tommy Nilsson, Eamonn Sheridan, Mark T. Handley
J Biol Chem. 2023 Nov; 299(11): 105295. Published online 2023 Sep 28. doi: 10.1016/j.jbc.2023.105295
PMCID:
PMC10641524
AbstractArticlePDF–3.8M
3.
ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis
Alexandre Janer, Jordan L Morris, Michiel Krols, Hana Antonicka, Mari J Aaltonen, Zhen-Yuan Lin, Hanish Anand, Anne-Claude Gingras, Julien Prudent, Eric A Shoubridge
Life Sci Alliance. 2024 Jan; 7(1): e202302335. Published online 2023 Nov 6. doi: 10.26508/lsa.202302335
PMCID:
PMC10627786
AbstractArticlePDF–5.2M
4.
Mapping the MOB proteins’ proximity network reveals a unique interaction between human MOB3C and the RNase P complex
Islam E. Elkholi, Jonathan Boulais, Marie-Pier Thibault, Hong-Duc Phan, Amélie Robert, Lien B. Lai, Denis Faubert, Matthew J. Smith, Venkat Gopalan, Jean-Franҫois Côté
J Biol Chem. 2023 Sep; 299(9): 105123. Published online 2023 Aug 1. doi: 10.1016/j.jbc.2023.105123
PMCID:
PMC10480535
AbstractArticlePDF–2.4M
5.
Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control
Ryosuke Ishimura, Sota Ito, Gaoxin Mao, Satoko Komatsu-Hirota, Toshifumi Inada, Nobuo N. Noda, Masaaki Komatsu
Sci Adv. 2023 Aug; 9(33): eadh3635. Published online 2023 Aug 18. doi: 10.1126/sciadv.adh3635
PMCID:
PMC10438457
AbstractArticlePDF–2.0M
6.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
7.
Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell
Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low
Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120
PMCID:
PMC10151615
AbstractArticlePDF–2.9M
8.
RPL26/uL24 UFMylation is essential for ribosome-associated quality control at the endoplasmic reticulum
Francesco Scavone, Samantha C. Gumbin, Paul A. Da Rosa, Ron R. Kopito
Proc Natl Acad Sci U S A. 2023 Apr 18; 120(16): e2220340120. Published online 2023 Apr 10. doi: 10.1073/pnas.2220340120
PMCID:
PMC10120006
AbstractArticlePDF–1.5M
9.
Dysregulation of PD-L1 by UFMylation imparts tumor immune evasion and identified as a potential therapeutic target
Junzhi Zhou, Xiaohe Ma, Xingrui He, Beiying Chen, Jiao Yuan, Zhemin Jin, Lijing Li, Zhiguo Wang, Qian Xiao, Yafei Cai, Yongkang Zou
Proc Natl Acad Sci U S A. 2023 Mar 14; 120(11): e2215732120. Published online 2023 Mar 9. doi: 10.1073/pnas.2215732120
Correction in:
Proc Natl Acad Sci U S A. 2023 May 23; 120(21): e2306087120.
PMCID:
PMC10089188
AbstractArticlePDF–14M
10.
SAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum
Lihui Wang, Yue Xu, Sijung Yun, Quan Yuan, Prasanna Satpute-Krishnan, Yihong Ye
Cell Rep. Author manuscript; available in PMC 2023 Mar 13.
Published in final edited form as: Cell Rep. 2023 Jan 31; 42(1): 112028. Published online 2023 Jan 23. doi: 10.1016/j.celrep.2023.112028
PMCID:
PMC10010011
AbstractArticlePDF–2.9M
11.
METTL3 protects METTL14 from STUB1‐mediated degradation to maintain m6A homeostasis
Zhan‐Cheng Zeng, Qi Pan, Yu‐Meng Sun, Heng‐Jing Huang, Xiao‐Tong Chen, Tian‐Qi Chen, Bo He, Hua Ye, Shun‐Xin Zhu, Ke‐Jia Pu, Ke Fang, Wei Huang, Yue‐Qin Chen, Wen‐Tao Wang
EMBO Rep. 2023 Mar; 24(3): e55762. Published online 2023 Jan 4. doi: 10.15252/embr.202255762
PMCID:
PMC9986817
AbstractArticlePDF–3.5M
12.
CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment
Daphne J. Smits, Jordy Dekker, Rachel Schot, Brahim Tabarki, Amal Alhashem, Jeroen A. A. Demmers, Dick H. W. Dekkers, Antonio Romito, Peter J. van der Spek, Tjakko J. van Ham, Aida M. Bertoli-Avella, Grazia M. S. Mancini
Hum Genet. 2023; 142(3): 379–397. Published online 2022 Dec 20. doi: 10.1007/s00439-022-02511-3
PMCID:
PMC9950183
AbstractArticlePDF–2.4M
13.
A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets
Yadi Zhou, Yuan Liu, Shagun Gupta, Mauricio I. Paramo, Yuan Hou, Chengsheng Mao, Yuan Luo, Julius Judd, Shayne Wierbowski, Marta Bertolotti, Mriganka Nerkar, Lara Jehi, Nir Drayman, Vlad Nicolaescu, Haley Gula, Savaş Tay, Glenn Randall, Peihui Wang, John T. Lis, Cédric Feschotte, Serpil C. Erzurum, Feixiong Cheng, Haiyuan Yu
Nat Biotechnol. Author manuscript; available in PMC 2023 Jan 20.
Published in final edited form as: Nat Biotechnol. 2023 Jan; 41(1): 128–139. Published online 2022 Oct 10. doi: 10.1038/s41587-022-01474-0
PMCID:
PMC9851973
AbstractArticlePDF–4.0M
14.
The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3
Ryosuke Ishimura, Afnan H. El-Gowily, Daisuke Noshiro, Satoko Komatsu-Hirota, Yasuko Ono, Mayumi Shindo, Tomohisa Hatta, Manabu Abe, Takefumi Uemura, Hyeon-Cheol Lee-Okada, Tarek M. Mohamed, Takehiko Yokomizo, Takashi Ueno, Kenji Sakimura, Tohru Natsume, Hiroyuki Sorimachi, Toshifumi Inada, Satoshi Waguri, Nobuo N. Noda, Masaaki Komatsu
Nat Commun. 2022; 13: 7857. Published online 2022 Dec 21. doi: 10.1038/s41467-022-35501-0
PMCID:
PMC9772183
AbstractArticlePDF–4.1M
15.
A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor
Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth
Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.
Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841
PMCID:
PMC9769698
AbstractArticlePDF–2.7M
16.
A non‐canonical scaffold‐type E3 ligase complex mediates protein UFMylation
Joshua J Peter, Helge M Magnussen, Paul A DaRosa, David Millrine, Stephen P Matthews, Frederic Lamoliatte, Ramasubramanian Sundaramoorthy, Ron R Kopito, Yogesh Kulathu
EMBO J. 2022 Nov; 41(21): e111015. Published online 2022 Sep 19. doi: 10.15252/embj.2022111015
PMCID:
PMC9627666
AbstractArticlePDF–6.4M
17.
UFL1 alleviates ER stress and apoptosis stimulated by LPS via blocking the ferroptosis pathway in human granulosa-like cells
Jingyi Li, Xiangting Tang, Xueer Tu, Zhe Jin, Hao Dong, Qi Yang, Ting Yao, Zezheng Pan
Cell Stress Chaperones. 2022 Sep; 27(5): 485–497. Published online 2022 Jun 21. doi: 10.1007/s12192-022-01284-y
PMCID:
PMC9485362
AbstractArticlePDF–1.8M
18.
ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold
Wenjing Yang, Beili Wang, Qian Yu, Te Liu, Tong Li, Tongtong Tian, Anli Jin, Lin Ding, Wei Chen, Hao Wang, Jingrong Xian, Baishen Pan, Jian Zhou, Jia Fan, Xinrong Yang, Wei Guo
Theranostics. 2022; 12(14): 6189–6206. Published online 2022 Aug 21. doi: 10.7150/thno.72134
PMCID:
PMC9475462
AbstractArticlePDF–4.6M
19.
Signaling from the RNA sensor RIG-I is regulated by ufmylation
Daltry L. Snider, Moonhee Park, Kristen A. Murphy, Dia C. Beachboard, Stacy M. Horner
Proc Natl Acad Sci U S A. 2022 Apr 12; 119(15): e2119531119. Published online 2022 Apr 8. doi: 10.1073/pnas.2119531119
PMCID:
PMC9169834
AbstractArticlePDF–1.8M
20.
Ubiquitin-like modifier 1 ligating enzyme 1 relieves cisplatin-induced premature ovarian failure by reducing endoplasmic reticulum stress in granulosa cells
Xiangting Tang, Hao Dong, Zhi Fang, Jingyi Li, Qi Yang, Ting Yao, Zezheng Pan
Reprod Biol Endocrinol. 2022; 20: 84. Published online 2022 May 24. doi: 10.1186/s12958-022-00956-9
PMCID:
PMC9128268
AbstractArticlePDF–14M

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