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Items: 1 to 20 of 112

1.
Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma
Suzannah G. Miller, Maria Hoh, Christopher C. Ebmeier, Jian Wei Tay, Natalie G. Ahn
Mol Biol Cell. 2024 Mar 1; 35(3): ar31. Published online 2024 Jan 29. doi: 10.1091/mbc.E23-06-0255
PMCID:
PMC10916866
AbstractArticlePDF–4.7M
2.
Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation
Wenmin Xia, Preethi Veeragandham, Yu Cao, Yayun Xu, Torrey E. Rhyne, Jiaxin Qian, Chao-Wei Hung, Peng Zhao, Ying Jones, Hui Gao, Christopher Liddle, Ruth T. Yu, Michael Downes, Ronald M. Evans, Mikael Rydén, Martin Wabitsch, Zichen Wang, Hiroyuki Hakozaki, Johannes Schöneberg, Shannon M. Reilly, Jianfeng Huang, Alan R. Saltiel
Nat Metab. 2024; 6(2): 273–289. Published online 2024 Jan 29. doi: 10.1038/s42255-024-00978-0
PMCID:
PMC10896723
AbstractArticlePDF–18M
3.
The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
Xin Gu, Christopher Nardone, Nolan Kamitaki, Aoyue Mao, Stephen J. Elledge, Michael E. Greenberg
Science. Author manuscript; available in PMC 2023 Oct 31.
Published in final edited form as: Science. 2023 Aug 25; 381(6660): eadh5021. Published online 2023 Aug 25. doi: 10.1126/science.adh5021
PMCID:
PMC10617673
AbstractArticlePDF–3.6M
4.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
5.
Ral GTPase promotes metastasis of pancreatic ductal adenocarcinoma via elevation of TGF-β1 production
Mingxin Cao, Xinming Li, Duc-Anh Trinh, Shingo Yoshimachi, Kota Goto, Natsumi Sakata, Masaharu Ishida, Hideo Ohtsuka, Michiaki Unno, Yuxia Wang, Ryutaro Shirakawa, Hisanori Horiuchi
J Biol Chem. 2023 Jun; 299(6): 104754. Published online 2023 Apr 26. doi: 10.1016/j.jbc.2023.104754
PMCID:
PMC10220265
AbstractArticlePDF–4.2M
6.
Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma
Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li
Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x
PMCID:
PMC9950447
AbstractArticlePDF–8.4M
7.
Identification of RALA as a Therapeutic Target and Prognostic Predictor of Osteosarcoma
Gentao Fan, Yan Zhu, Hao Zhu, Lingfeng Yu, Zhen Wang, Chenjun Zhai, Guangxin Zhou, Jianning Zhao, Yicun Wang
Biomed Res Int. 2023; 2023: 1150768. Published online 2023 Feb 7. doi: 10.1155/2023/1150768
PMCID:
PMC9936457
AbstractArticlePDF–7.2M
8.
HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation
Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang
Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005
PMCID:
PMC9772558
AbstractArticlePDF–8.2M
9.
Dysregulation of RalA signaling through dual regulatory mechanisms exerts its oncogenic functions in hepatocellular carcinoma
Lu Tian, Luqing Zhao, Karen Man‐Fong Sze, Charles Shing Kam, Vanessa Sheung‐In Ming, Xia Wang, Vanilla Xin Zhang, Daniel Wai‐Hung Ho, Tan‐To Cheung, Lo‐Kong Chan, Irene Oi‐Lin Ng
Hepatology. 2022 Jul; 76(1): 48–65. Published online 2021 Dec 17. doi: 10.1002/hep.32236
PMCID:
PMC9299834
AbstractArticlePDF–12M
10.
LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression
Xuexue Xu, Pengsheng Ding, Lan Shi, Gang Wu, Xiaoling Ma
BMC Cancer. 2022; 22: 630. Published online 2022 Jun 8. doi: 10.1186/s12885-022-09680-4
PMCID:
PMC9175482
AbstractArticlePDF–15M
11.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
12.
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy
Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang
Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003
PMCID:
PMC8897022
AbstractArticlePDF–3.0M
13.
EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation
Liyuan Wang, Chan Chen, Zemin Song, Honghong Wang, Minghui Ye, Donghai Wang, Wenqian Kang, Hudan Liu, Guoliang Qing
Nat Commun. 2022; 13: 12. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27609-6
PMCID:
PMC8748958
AbstractArticlePDF–3.0M
14.
RalA, PLD and mTORC1 Are Required for Kinase-Independent Pathways in DGKβ-Induced Neurite Outgrowth
Takuya Kano, Ryosuke Tsumagari, Akio Nakashima, Ushio Kikkawa, Shuji Ueda, Minoru Yamanoue, Nobuyuki Takei, Yasuhito Shirai
Biomolecules. 2021 Dec; 11(12): 1814. Published online 2021 Dec 2. doi: 10.3390/biom11121814
PMCID:
PMC8699322
AbstractArticlePDF–1.3M
15.
SARS‐CoV‐2–host proteome interactions for antiviral drug discovery
Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo
Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396
PMCID:
PMC8552907
AbstractArticlePDF–3.9M
16.
Calmodulin extracts the Ras family protein RalA from lipid bilayers by engagement with two membrane-targeting motifs
Samuel G. Chamberlain, Andrea Gohlke, Arooj Shafiq, Iolo J. Squires, Darerca Owen, Helen R. Mott
Proc Natl Acad Sci U S A. 2021 Sep 7; 118(36): e2104219118. Published online 2021 Sep 3. doi: 10.1073/pnas.2104219118
PMCID:
PMC8433508
AbstractArticlePDF–2.9M
17.
Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry
Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang
Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118
PMCID:
PMC8364181
AbstractArticlePDF–3.0M
18.
Ral GTPase–activating protein regulates the malignancy of pancreatic ductal adenocarcinoma
Shingo Yoshimachi, Ryutaro Shirakawa, Mingxin Cao, Duc Anh Trinh, Pan Gao, Natsumi Sakata, Kento Miyazaki, Kota Goto, Takayuki Miura, Kyohei Ariake, Shimpei Maeda, Kunihiro Masuda, Masaharu Ishida, Hideo Ohtsuka, Michiaki Unno, Hisanori Horiuchi
Cancer Sci. 2021 Aug; 112(8): 3064–3073. Published online 2021 Jun 15. doi: 10.1111/cas.14970
PMCID:
PMC8353909
AbstractArticlePDF–2.3M
19.
RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal
Syed S. Hussain, Tuyet-Minh Tran, Timothy B. Ware, Melissa A. Luse, Christopher T. Prevost, Ashley N. Ferguson, Jennifer A. Kashatus, Ku-Lung Hsu, David F. Kashatus
Cell Rep. Author manuscript; available in PMC 2021 Aug 6.
Published in final edited form as: Cell Rep. 2021 Jul 27; 36(4): 109451. doi: 10.1016/j.celrep.2021.109451
PMCID:
PMC8344381
AbstractArticlePDF–3.3M
20.
RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis
Máté Nászai, Karen Bellec, Yachuan Yu, Alvaro Román-Fernández, Emma Sandilands, Joel Johansson, Andrew D Campbell, Jim C Norman, Owen J Sansom, David M Bryant, Julia B Cordero
eLife. 2021; 10: e63807. Published online 2021 Jun 7. doi: 10.7554/eLife.63807
PMCID:
PMC8216719
AbstractArticlePDF–7.7M

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