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Select item 111094831.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 97246712.

Human ZBP1 induces cell death‐independent inflammatory signaling via RIPK3 and RIPK1

Ruoshi Peng, Chris Kedong Wang, Xuan Wang‐Kan, Manja Idorn, Majken Kjær, Felix Y Zhou, Berthe Katrine Fiil, Frederik Timmermann, Susana L Orozco, Julia McCarthy, Carol S Leung, Xin Lu, Katrin Bagola, Jan Rehwinkel, Andrew Oberst, Jonathan Maelfait, Søren R Paludan, Mads Gyrd‐Hansen

EMBO Rep. 2022 Dec; 23(12): e55839. Published online 2022 Oct 21. doi: 10.15252/embr.202255839

PMCID:: PMC9724671

Abstract Article PDF–1.8M

Select item 97045273.

Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC

Tom Snelling, Natalia Shpiro, Robert Gourlay, Frederic Lamoliatte, Philip Cohen

Biochem J. 2022 Oct 28; 479(20): 2195–2216. Published online 2022 Oct 21. doi: 10.1042/BCJ20220401

PMCID:: PMC9704527

Abstract Article PDF–7.7M

Select item 96369714.

HOIP modulates the stability of GPx4 by linear ubiquitination

Kangyun Dong, Ran Wei, Taijie Jin, Mengmeng Zhang, Jiali Shen, Huaijiang Xiang, Bing Shan, Junying Yuan, Ying Li

Proc Natl Acad Sci U S A. 2022 Nov 1; 119(44): e2214227119. Published online 2022 Oct 24. doi: 10.1073/pnas.2214227119

PMCID:: PMC9636971

Abstract Article PDF–2.3M

Select item 96333095.

SHARPIN promotes cell proliferation of cholangiocarcinoma and inhibits ferroptosis via p53/SLC7A11/GPX4 signaling

Chong Zeng, Jie Lin, Ketao Zhang, Huohui Ou, Ke Shen, Qingbo Liu, Zibo Wei, Xinhuai Dong, Xiaokang Zeng, Liming Zeng, Weidong Wang, Jie Yao

Cancer Sci. 2022 Nov; 113(11): 3766–3775. Published online 2022 Sep 8. doi: 10.1111/cas.15531

PMCID:: PMC9633309

Abstract Article PDF–17M

Select item 95333696.

Identification and molecular analysis of RNF31 Q622H germline polymorphism

Seshiru Nakazawa, Ryo Mamiya, Reika Kawabata-Iwakawa, Daisuke Oikawa, Kyoichi Kaira, Fuminori Tokunaga, Sumihito Nobusawa, Yusuke Sato, Atsushi Sasaki, Toshiki Yajima, Ken Shirabe

Oncol Lett. 2022 Nov; 24(5): 394. Published online 2022 Sep 21. doi: 10.3892/ol.2022.13514

PMCID:: PMC9533369

Abstract Article PDF–3.1M

Select item 93600007.

OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways

Daisuke Oikawa, Min Gi, Hidetaka Kosako, Kouhei Shimizu, Hirotaka Takahashi, Masayuki Shiota, Shuhei Hosomi, Keidai Komakura, Hideki Wanibuchi, Daisuke Tsuruta, Tatsuya Sawasaki, Fuminori Tokunaga

Cell Death Dis. 2022 Aug; 13(8): 694. Published online 2022 Aug 8. doi: 10.1038/s41419-022-05145-5

PMCID:: PMC9360000

Abstract Article PDF–6.1M

Select item 93485768.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 92450059.

RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells

Zhengkui Zhang, Xiangjun Kong, Maarten A. Ligtenberg, Susan E. van Hal-van Veen, Nils L. Visser, Beaunelle de Bruijn, Kelly Stecker, Pim W. van der Helm, Thomas Kuilman, Esmée P. Hoefsmit, David W. Vredevoogd, Georgi Apriamashvili, Beau Baars, Emile E. Voest, Sjoerd Klarenbeek, Maarten Altelaar, Daniel S. Peeper

Cell Rep Med. 2022 Jun 21; 3(6): 100655. Published online 2022 Jun 9. doi: 10.1016/j.xcrm.2022.100655

PMCID:: PMC9245005

Abstract Article PDF–3.2M

Select item 910630310.

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen

Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638

PMCID:: PMC9106303

Abstract Article PDF–918K

Select item 910523511.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 894808712.

A functional variant of SHARPIN confers increased risk of late-onset Alzheimer’s disease

Yuya Asanomi, Daichi Shigemizu, Shintaro Akiyama, Akinori Miyashita, Risa Mitsumori, Norikazu Hara, Takeshi Ikeuchi, Shumpei Niida, Kouichi Ozaki

J Hum Genet. 2022; 67(4): 203–208. Published online 2021 Nov 5. doi: 10.1038/s10038-021-00987-x

PMCID:: PMC8948087

Abstract Article PDF–878K

Select item 889976713.

Compound heterozygous variants in OTULIN are associated with fulminant atypical late‐onset ORAS

Julia Zinngrebe, Barbara Moepps, Thomas Monecke, Peter Gierschik, Ferdinand Schlichtig, Thomas F E Barth, Gudrun Strauß, Elena Boldrin, Carsten Posovszky, Ansgar Schulz, Ortraud Beringer, Eva Rieser, Eva‐Maria Jacobsen, Myriam Ricarda Lorenz, Klaus Schwarz, Ulrich Pannicke, Henning Walczak, Dierk Niessing, Catharina Schuetz, Pamela Fischer‐Posovszky, Klaus‐Michael Debatin

EMBO Mol Med. 2022 Mar 7; 14(3): e14901. Published online 2022 Feb 16. doi: 10.15252/emmm.202114901

PMCID:: PMC8899767

Abstract Article PDF–2.5M

Select item 880381614.

A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells

Hongli Yin, Ozge Karayel, Ying-Yin Chao, Thomas Seeholzer, Isabel Hamp, Oliver Plettenburg, Torben Gehring, Christina Zielinski, Matthias Mann, Daniel Krappmann

Cell Mol Life Sci. 2022 Feb; 79(2): 112. Published online 2022 Jan 31. doi: 10.1007/s00018-022-04154-z

PMCID:: PMC8803816

Abstract Article PDF–9.2M

Select item 859588615.

A missense variant in SHARPIN mediates Alzheimer’s disease-specific brain damages

Jun Young Park, Dongsoo Lee, Jang Jae Lee, Jungsoo Gim, Tamil Iniyan Gunasekaran, Kyu Yeong Choi, Sarang Kang, Ah Ra Do, Jinyeon Jo, Juhong Park, Kyungtaek Park, Donghe Li, Sanghun Lee, Hoowon Kim, Immanuel Dhanasingh, Suparna Ghosh, Seula Keum, Jee Hye Choi, Gyun Jee Song, Lee Sael, Sangmyung Rhee, Simon Lovestone, Eunae Kim, Seung Hwan Moon, Byeong C. Kim, SangYun Kim, Andrew J. Saykin, Kwangsik Nho, Sung Haeng Lee, Lindsay A. Farrer, Gyungah R. Jun, Sungho Won, Kun Ho Lee, for the Alzheimer’s Disease Neuroimaging Initiative

Transl Psychiatry. 2021; 11: 590. Published online 2021 Nov 16. doi: 10.1038/s41398-021-01680-5

PMCID:: PMC8595886

Abstract Article PDF–1.8M

Select item 856100416.

The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains

Carlos Gomez-Diaz, Gustav Jonsson, Katrin Schodl, Luiza Deszcz, Annika Bestehorn, Kevin Eislmayr, Jorge Almagro, Anoop Kavirayani, Mayu Seida, Lilian M. Fennell, Astrid Hagelkruys, Pavel Kovarik, Josef M. Penninger, Fumiyo Ikeda

iScience. 2021 Nov 19; 24(11): 103241. Published online 2021 Oct 8. doi: 10.1016/j.isci.2021.103241

PMCID:: PMC8561004

Abstract Article PDF–4.4M

Select item 851150617.

Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains

Paul R. Elliott, Derek Leske, Jane Wagstaff, Lisa Schlicher, Georgina Berridge, Sarah Maslen, Frederik Timmermann, Biao Ma, Roman Fischer, Stefan M.V. Freund, David Komander, Mads Gyrd-Hansen

Cell Rep. 2021 Oct 5; 37(1): 109777. Published online 2021 Oct 5. doi: 10.1016/j.celrep.2021.109777

PMCID:: PMC8511506

Abstract Article PDF–5.4M

Select item 848618818.

SHARPIN regulates the development of clear cell renal cell carcinoma by promoting von Hippel‐Lindau protein ubiquitination and degradation

Rusha Yin, Shuai Liu

Cancer Sci. 2021 Oct; 112(10): 4100–4111. Published online 2021 Aug 22. doi: 10.1111/cas.15096

PMCID:: PMC8486188

Abstract Article PDF–1.8M

Select item 843802419.

Hypoxia regulates overall mRNA homeostasis by inducing Met¹-linked linear ubiquitination of AGO2 in cancer cells

Hailong Zhang, Xian Zhao, Yanmin Guo, Ran Chen, Jianfeng He, Lian Li, Zhe Qiang, Qianqian Yang, Xiaojia Liu, Caihu Huang, Runhui Lu, Jiayu Fang, Yingting Cao, Jiayi Huang, Yanli Wang, Jian Huang, Guo-Qiang Chen, Jinke Cheng, Jianxiu Yu

Nat Commun. 2021; 12: 5416. Published online 2021 Sep 13. doi: 10.1038/s41467-021-25739-5

PMCID:: PMC8438024

Abstract Article PDF–5.7M

Select item 816503020.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

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