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Items: 1 to 20 of 102

1.
The APC/C E3 ligase subunit ANAPC11 mediates FOXO3 protein degradation to promote cell proliferation and lymph node metastasis in urothelial bladder cancer
Dong Yan, Qingqing He, Lu Pei, Meihua Yang, Lifang Huang, Jianqiu Kong, Wang He, Hao Liu, Shizhong Xu, Haide Qin, Tianxin Lin, Jian Huang
Cell Death Dis. 2023 Aug; 14(8): 516. Published online 2023 Aug 12. doi: 10.1038/s41419-023-06000-x
PMCID:
PMC10423259
AbstractArticlePDF–9.6M
2.
SIRT1 ubiquitination is regulated by opposing activities of APC/C-Cdh1 and AROS during stress-induced premature senescence
Sang Hyup Lee, Ji-Hye Yang, Ui-Hyun Park, Hanbyeul Choi, Yoo Sung Kim, Bo-Eun Yoon, Hye-Jeong Han, Hyun-Taek Kim, Soo-Jong Um, Eun-Joo Kim
Exp Mol Med. 2023 Jun; 55(6): 1232–1246. Published online 2023 Jun 1. doi: 10.1038/s12276-023-01012-1
PMCID:
PMC10318011
AbstractArticlePDF–4.5M
3.
The adapter protein FADD provides an alternate pathway for entry into the cell cycle by regulating APC/C-Cdh1 E3 ubiquitin ligase activity
Sahezeel Awadia, Merna Sitto, Sundaresh Ram, Wenbin Ji, Yajing Liu, Raheema Damani, Dipankar Ray, Theodore S. Lawrence, Craig J. Galban, Steven D. Cappell, Alnawaz Rehemtulla
J Biol Chem. 2023 Jun; 299(6): 104786. Published online 2023 May 4. doi: 10.1016/j.jbc.2023.104786
PMCID:
PMC10248554
AbstractArticlePDF–6.8M
4.
Molecular mechanisms for activation of the 26S proteasome
Donghoon Lee, Yanan Zhu, Louis Colson, Xiaorong Wang, Siyi Chen, Emre Tkacik, Lan Huang, Qi Ouyang, Alfred L. Goldberg, Ying Lu
Version 1. bioRxiv. Preprint. 2023 May 10. doi: 10.1101/2023.05.09.540094
Published in:
Mol Cell. 2023 Aug 17; 83(16): 2959–2975.e7.
PMCID:
PMC10197607
AbstractArticle
5.
Proximity Labeling Reveals Spatial Regulation of the Anaphase-Promoting Complex/Cyclosome by a Microtubule Adaptor
Xiaofu Cao, Adnan Shami Shah, Ethan J. Sanford, Marcus B. Smolka, Jeremy M. Baskin
ACS Chem Biol. Author manuscript; available in PMC 2023 Sep 16.
Published in final edited form as: ACS Chem Biol. 2022 Sep 16; 17(9): 2605–2618. Published online 2022 Aug 11. doi: 10.1021/acschembio.2c00527
PMCID:
PMC9933862
AbstractArticlePDF–2.5M
6.
Role of phosphorylation of Cdc20 in the regulation of the action of APC/C in mitosis
Danielle Shevah-Sitry, Shirly Miniowitz-Shemtov, Adar Teichner, Sharon Kaisari, Avram Hershko
Proc Natl Acad Sci U S A. 2022 Aug 30; 119(35): e2210367119. Published online 2022 Aug 24. doi: 10.1073/pnas.2210367119
PMCID:
PMC9436321
AbstractArticlePDF–1.0M
7.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
8.
Examining the mechanistic relationship of APC/CCDH1 and its interphase inhibitor EMI1
Derek L. Bolhuis, Raquel C. Martinez‐Chacin, Kaeli A. Welsh, Tatyana Bodrug, Liying Cui, Michael J. Emanuele, Nicholas G. Brown
Protein Sci. 2022 Jun; 31(6): e4324. Published online 2022 May 17. doi: 10.1002/pro.4324
PMCID:
PMC9112349
AbstractArticlePDF–4.2M
9.
Functional conservation and divergence of the helix‐turn‐helix motif of E2 ubiquitin‐conjugating enzymes
Kaeli A Welsh, Derek L Bolhuis, Anneroos E Nederstigt, Joshua Boyer, Brenda R S Temple, Thomas Bonacci, Li Gu, Alban Ordureau, J Wade Harper, Joshua P Steimel, Qi Zhang, Michael J Emanuele, Joseph S Harrison, Nicholas G Brown
EMBO J. 2022 Feb 1; 41(3): e108823. Published online 2021 Dec 23. doi: 10.15252/embj.2021108823
PMCID:
PMC8804933
AbstractArticlePDF–3.8M
10.
APC7 Mediates Ubiquitin Signaling in Constitutive Heterochromatin in the Developing Mammalian Brain
Cole J. Ferguson, Olivia Urso, Tatyana Bodrug, Brandon M. Gassaway, Edmond R. Watson, Jesuraj R. Prabu, Pablo Lara-Gonzalez, Raquel C. Martinez-Chacin, Dennis Y. Wu, Karlla W. Brigatti, Erik G. Puffenberger, Cora M. Taylor, Barbara Haas-Givler, Robert N. Jinks, Kevin A. Strauss, Arshad Desai, Harrison W. Gabel, Steven P. Gygi, Brenda A. Schulman, Nicholas G. Brown, Azad Bonni
Mol Cell. Author manuscript; available in PMC 2023 Jan 6.
Published in final edited form as: Mol Cell. 2022 Jan 6; 82(1): 90–105.e13. Published online 2021 Dec 22. doi: 10.1016/j.molcel.2021.11.031
PMCID:
PMC8741739
AbstractArticlePDF–4.4M
11.
CDC20 promotes bone formation via APC/C dependent ubiquitination and degradation of p65
Yangge Du, Min Zhang, Xuejiao Liu, Zheng Li, Menglong Hu, Yueming Tian, Longwei Lv, Xiao Zhang, Yunsong Liu, Ping Zhang, Yongsheng Zhou
EMBO Rep. 2021 Sep 6; 22(9): e52576. Published online 2021 Aug 12. doi: 10.15252/embr.202152576
PMCID:
PMC8419691
AbstractArticlePDF–4.8M
12.
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger
Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y
PMCID:
PMC8352964
AbstractArticlePDF–4.5M
13.
In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators
Jennifer L. Franks, Raquel C. Martinez-Chacin, Xianxi Wang, Rochelle L. Tiedemann, Thomas Bonacci, Rajarshi Choudhury, Derek L. Bolhuis, Taylor P. Enrico, Ryan D. Mouery, Jeffrey S. Damrauer, Feng Yan, Joseph S. Harrison, M. Ben Major, Katherine A. Hoadley, Aussie Suzuki, Scott B. Rothbart, Nicholas G. Brown, Michael J. Emanuele
PLoS Biol. 2020 Dec; 18(12): e3000975. Published online 2020 Dec 11. doi: 10.1371/journal.pbio.3000975
PMCID:
PMC7758050
AbstractArticlePDF–4.2M
14.
Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S
Anna KL Liess, Alena Kucerova, Kristian Schweimer, Dörte Schlesinger, Olexandr Dybkov, Henning Urlaub, Jörg Mansfeld, Sonja Lorenz
Sci Signal. Author manuscript; available in PMC 2022 Jul 20.
Published in final edited form as: Sci Signal. 2020 Oct 20; 13(654): eaba8208. Published online 2020 Oct 20. doi: 10.1126/scisignal.aba8208
PMCID:
PMC7613103
AbstractArticlePDF–2.5M
15.
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism
Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat
Nat Metab. Author manuscript; available in PMC 2020 Dec 1.
Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z
PMCID:
PMC7566881
AbstractArticlePDF–4.8M
16.
The Negative Cross-Talk between SAG/RBX2/ROC2 and APC/C E3 Ligases in Regulation of Cell Cycle Progression and Drug Resistance
Shizhen Zhang, Yanwen Shen, Hua Li, Chao Bi, Yilun Sun, Xiufang Xiong, Wenyi Wei, Yi Sun
Cell Rep. Author manuscript; available in PMC 2020 Sep 21.
Published in final edited form as: Cell Rep. 2020 Sep 8; 32(10): 108102. doi: 10.1016/j.celrep.2020.108102
PMCID:
PMC7505520
AbstractArticlePDF–2.4M
17.
APC/C-dependent control of gene expression and cell identity
Eugene Oh, Kevin G. Mark, Annamaria Mocciaro, Edmond R. Watson, J. Rajan Prabu, Denny D. Cha, Martin Kampmann, Nathan Gamarra, Coral Y. Zhou, Michael Rape
Nature. Author manuscript; available in PMC 2020 Aug 19.
Published in final edited form as: Nature. 2020 Mar; 579(7797): 136–140. Published online 2020 Feb 19. doi: 10.1038/s41586-020-2034-1
PMCID:
PMC7402266
AbstractArticlePDF–5.3M
18.
Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming
Raquel C. Martinez-Chacin, Tatyana Bodrug, Derek L. Bolhuis, Katarzyna M. Kedziora, Thomas Bonacci, Alban Ordureau, Morgan E. Gibbs, Florian Weissmann, Renping Qiao, Gavin D. Grant, Jeanette G. Cook, Jan-Michael Peters, J. Wade Harper, Michael J. Emanuele, Nicholas G. Brown
Nat Struct Mol Biol. Author manuscript; available in PMC 2020 Nov 11.
Published in final edited form as: Nat Struct Mol Biol. 2020 Jun; 27(6): 550–560. Published online 2020 May 11. doi: 10.1038/s41594-020-0424-6
PMCID:
PMC7293561
AbstractArticlePDF–1.9M
19.
Paradoxical mitotic exit induced by a small molecule inhibitor of APC/CCdc20
Katherine V. Richeson, Tatyana Bodrug, Katharine L. Sackton, Masaya Yamaguchi, Joao A. Paulo, Steven P. Gygi, Brenda A. Schulman, Nicholas G. Brown, Randall W. King
Nat Chem Biol. Author manuscript; available in PMC 2020 Sep 9.
Published in final edited form as: Nat Chem Biol. 2020 May; 16(5): 546–555. Published online 2020 Mar 9. doi: 10.1038/s41589-020-0495-z
PMCID:
PMC7289404
AbstractArticlePDF–1.9M
20.
A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase
Claudio Alfieri, Thomas Tischer, David Barford
EMBO Rep. 2020 Jun 4; 21(6): e49831. Published online 2020 Apr 19. doi: 10.15252/embr.201949831
PMCID:
PMC7271329
AbstractArticlePDF–3.2M

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