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Select item 110727661.

Cell adhesion tunes inflammatory TPL2 kinase signal transduction

Maria Vougioukalaki, Konstantina Georgila, Emmanouil I. Athanasiadis, Aristides G. Eliopoulos

Cell Mol Life Sci. 2022 Mar; 79(3): 156. Published online 2022 Feb 26. doi: 10.1007/s00018-022-04130-7

PMCID:: PMC11072766

Abstract Article PDF–2.1M

Select item 105760822.

Overexpression of TPL2 may be a predictor of good prognosis in patients with breast invasive ductal carcinoma

Qin Yu, Dan Wan, Rong Fu, Feng Li, Yutao Zhang

Sci Rep. 2023; 13: 17346. Published online 2023 Oct 13. doi: 10.1038/s41598-023-44660-z

PMCID:: PMC10576082

Abstract Article PDF–6.3M

Select item 99163423.

Epigenetic Regulation of MAP3K8 in EBV-Associated Gastric Carcinoma

Gaurab Roy, Ting Yang, Shangxin Liu, Yi-Ling Luo, Yuantao Liu, Qian Zhong

Int J Mol Sci. 2023 Feb; 24(3): 1964. Published online 2023 Jan 19. doi: 10.3390/ijms24031964

PMCID:: PMC9916342

Abstract Article PDF–5.6M

Select item 93793984.

ALKBH5/MAP3K8 axis regulates PD-L1+ macrophage infiltration and promotes hepatocellular carcinoma progression

Yu You, Diguang Wen, Lu Zeng, Jiao Lu, Xiao Xiao, Yucheng Chen, Hua Song, Zuojin Liu

Int J Biol Sci. 2022; 18(13): 5001–5018. Published online 2022 Aug 1. doi: 10.7150/ijbs.70149

PMCID:: PMC9379398

Abstract Article PDF–3.5M

Select item 89472575.

Loss of Tpl2 activates compensatory signaling and resistance to EGFR/MET dual inhibition in v-RAS transduced keratinocytes

Mary B. Kelley, Taylor J. Geddes, Maria Ochiai, Noah M. Lampl, W. Wade Kothmann, Sara R. Fierstein, Victoria Kent, Kathleen DeCicco-Skinner

PLoS One. 2022; 17(3): e0266017. Published online 2022 Mar 24. doi: 10.1371/journal.pone.0266017

PMCID:: PMC8947257

Abstract Article PDF–2.7M

Select item 88288956.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 87005747.

Unravelling the Impact of the Genetic Variant rs1042058 within the TPL2 Risk Gene Locus on Molecular and Clinical Disease Course Patients with Inflammatory Bowel Disease

Yasser Morsy, Nathalie Brillant, Yannick Franc, Michael Scharl, Marcin Wawrzyniak, on behalf of the Swiss IBD Cohort Study Group

Cells. 2021 Dec; 10(12): 3589. Published online 2021 Dec 20. doi: 10.3390/cells10123589

PMCID:: PMC8700574

Abstract Article PDF–4.0M

Select item 78482328.

Upregulation of Mobility in Pancreatic Cancer Cells by Secreted S100A11 Through Activation of Surrounding Fibroblasts

Yosuke Mitsui, Nahoko Tomonobu, Masami Watanabe, Rie Kinoshita, I Wayan Sumardika, Chen Youyi, Hitoshi Murata, Ken-ichi Yamamoto, Takuya Sadahira, Acosta Gonzalez Herik Rodrigo, Hitoshi Takamatsu, Kota Araki, Akira Yamauchi, Masahiro Yamamura, Hideyo Fujiwara, Yusuke Inoue, Junichiro Futami, Ken Saito, Hidekazu Iioka, Eisaku Kondo, Masahiro Nishibori, Shinichi Toyooka, Yasuhiko Yamamoto, Yasutomo Nasu, Masakiyo Sakaguchi

Oncol Res. 2019; 27(8): 945–956. Published online 2019 Aug 8. doi: 10.3727/096504019X15555408784978

PMCID:: PMC7848232

Abstract Article PDF–5.1M

Select item 76803769.

Her2 promotes early dissemination of breast cancer by suppressing the p38 pathway through Skp2-mediated proteasomal degradation of Tpl2

Guanwen Wang, Juan Wang, Antao Chang, Dongmei Cheng, Shan Huang, Dan Wu, Sherona Sirkisoon, Shuang Yang, Hui-Kuan Lin, Hui-Wen Lo, Rong Xiang, Peiqing Sun

Oncogene. Author manuscript; available in PMC 2021 Mar 28.

Published in final edited form as: Oncogene. 2020 Nov; 39(47): 7034–7050. Published online 2020 Sep 28. doi: 10.1038/s41388-020-01481-y

Correction in:: Oncogene. 2021 Feb 10

PMCID:: PMC7680376

Abstract Article PDF–3.1M

Select item 745625410.

TPL2 enforces RAS-induced inflammatory signaling and is activated by point mutations

Paarth B. Dodhiawala, Namrata Khurana, Daoxiang Zhang, Yi Cheng, Lin Li, Qing Wei, Kuljeet Seehra, Hongmei Jiang, Patrick M. Grierson, Andrea Wang-Gillam, Kian-Huat Lim

J Clin Invest. 2020 Sep 1; 130(9): 4771–4790. Published online 2020 Aug 10. doi: 10.1172/JCI137660

PMCID:: PMC7456254

Abstract Article PDF–23M

Select item 700080211.

A central role of IKK2 and TPL2 in JNK activation and viral B-cell transformation

Stefanie Voigt, Kai R. Sterz, Fabian Giehler, Anne-Wiebe Mohr, Joanna B. Wilson, Andreas Moosmann, Arnd Kieser

Nat Commun. 2020; 11: 685. Published online 2020 Feb 4. doi: 10.1038/s41467-020-14502-x

PMCID:: PMC7000802

Abstract Article PDF–2.4M

Select item 689109712.

Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability

Divya Achuthankutty, Roshan Singh Thakur, Peter Haahr, Saskia Hoffmann, Alexandros P. Drainas, Anna H. Bizard, Joachim Weischenfeldt, Ian D. Hickson, Niels Mailand

J Cell Biol. 2019 Dec 2; 218(12): 3943–3953. Published online 2019 Oct 15. doi: 10.1083/jcb.201905064

PMCID:: PMC6891097

Abstract Article PDF–2.7M

Select item 672652013.

Identification of targetable recurrent MAP3K8 rearrangements in melanomas lacking known driver mutations

Brian D. Lehmann, Timothy M. Shaver, Douglas B. Johnson, Zhu Li, Paula I. Gonzalez-Ericsson, Violeta Sánchez, Yu Shyr, Melinda E. Sanders, Jennifer A. Pietenpol

Mol Cancer Res. Author manuscript; available in PMC 2020 Mar 1.

Published in final edited form as: Mol Cancer Res. 2019 Sep; 17(9): 1842–1853. Published online 2019 Jun 11. doi: 10.1158/1541-7786.MCR-19-0257

PMCID:: PMC6726520

Abstract Article PDF–2.3M

Select item 662864614.

The combination of TPL2 knockdown and TNFα causes synthetic lethality via caspase-8 activation in human carcinoma cell lines

Oksana B. Serebrennikova, Maria D. Paraskevopoulou, Elia Aguado-Fraile, Vasiliki Taraslia, Wenying Ren, Geeta Thapa, Jatin Roper, Keyong Du, Carlo M. Croce, Philip N. Tsichlis

Proc Natl Acad Sci U S A. 2019 Jul 9; 116(28): 14039–14048. Published online 2019 Jun 25. doi: 10.1073/pnas.1901465116

PMCID:: PMC6628646

Abstract Article PDF–1.3M

Select item 629462515.

Hypoxia potentiates monocyte-derived dendritic cells for release of tumor necrosis factor α via MAP3K8

Laurent M. Paardekooper, Maura B. Bendix, Andrea Ottria, Lieke W. de Haer, Martin ter Beest, Timothy R.D.J. Radstake, Wioleta Marut, Geert van den Bogaart

Biosci Rep. 2018 Dec 21; 38(6): BSR20182019. Prepublished online 2018 Nov 21. Published online 2018 Dec 14. doi: 10.1042/BSR20182019

PMCID:: PMC6294625

Abstract Article PDF–1.3M

Select item 592836916.

Overexpression of Tpl2 is linked to imatinib resistance and activation of MEK‐ERK and NF‐κB pathways in a model of chronic myeloid leukemia

Anna Chorzalska, Nagib Ahsan, R. Shyama Prasad Rao, Karim Roder, Xiaoqing Yu, John Morgan, Alexander Tepper, Steven Hines, Peng Zhang, Diana O. Treaba, Ting C. Zhao, Adam J. Olszewski, John L. Reagan, Olin Liang, Philip A. Gruppuso, Patrycja M. Dubielecka

Mol Oncol. 2018 May; 12(5): 630–647. Published online 2018 Apr 6. doi: 10.1002/1878-0261.12186

PMCID:: PMC5928369

Abstract Article PDF–1.5M

Select item 567964117.

Regulation of NF-κB by the p105-ABIN2-TPL2 complex and RelAp43 during rabies virus infection

Benoit Besson, Florian Sonthonnax, Magalie Duchateau, Youcef Ben Khalifa, Florence Larrous, Hyeju Eun, Véronique Hourdel, Mariette Matondo, Julia Chamot-Rooke, Regis Grailhe, Hervé Bourhy

PLoS Pathog. 2017 Oct; 13(10): e1006697. Published online 2017 Oct 30. doi: 10.1371/journal.ppat.1006697

PMCID:: PMC5679641

Abstract Article PDF–8.5M

Select item 555729218.

Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions

Kyuho Han, Edwin E. Jeng, Gaelen T. Hess, David W. Morgens, Amy Li, Michael C. Bassik

Nat Biotechnol. Author manuscript; available in PMC 2017 Sep 20.

Published in final edited form as: Nat Biotechnol. 2017 May; 35(5): 463–474. Published online 2017 Mar 20. doi: 10.1038/nbt.3834

PMCID:: PMC5557292

Abstract Article PDF–3.4M

Select item 510683119.

miR-589-5p inhibits MAP3K8 and suppresses CD90⁺ cancer stem cells in hepatocellular carcinoma

Xi Zhang, Peng Jiang, Ling Shuai, Kai Chen, Zhonghu Li, Yujun Zhang, Yan Jiang, Xiaowu Li

J Exp Clin Cancer Res. 2016; 35: 176. Published online 2016 Nov 11. doi: 10.1186/s13046-016-0452-6

PMCID:: PMC5106831

Abstract Article PDF–2.6M

Select item 510634420.

A TPL2 (MAP3K8) disease-risk polymorphism increases TPL2 expression thereby leading to increased pattern recognition receptor-initiated caspase-1 and caspase-8 activation, signalling and cytokine secretion

Matija Hedl, Clara Abraham

Gut. Author manuscript; available in PMC 2017 Nov 1.

Published in final edited form as: Gut. 2016 Nov; 65(11): 1799–1811. Published online 2015 Jul 27. doi: 10.1136/gutjnl-2014-308922

PMCID:: PMC5106344

Abstract Article PDF–5.1M

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