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Select item 110070001.

Potent CTLs can be induced against tumor cells in an environment of lower levels of systemic MFG‐E8

Yu Mizote, Takako Inoue, Takashi Akazawa, Kei Kunimasa, Motohiro Tamiya, Yachiyo Kumamoto, Arisa Tsuda, Satomi Yoshida, Kumiko Tatsumi, Tomoya Ekawa, Keiichiro Honma, Kazumi Nishino, Hideaki Tahara

Cancer Sci. 2024 Apr; 115(4): 1114–1128. Published online 2024 Feb 8. doi: 10.1111/cas.16099

PMCID:: PMC11007000

Abstract Article PDF–8.3M

Select item 108509742.

PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the β5 integrin

Ritwik Datta, Dibyanti Mukherjee, Michael J. Podolsky, Christopher D. Yang, Diana L. Alba, Sukhmani Singh, Thomas D. Arnold, Suneil Koliwad, Carlos O. Lizama, Kamran Atabai

J Biol Chem. 2024 Feb; 300(2): 105631. Published online 2024 Jan 8. doi: 10.1016/j.jbc.2024.105631

PMCID:: PMC10850974

Abstract Article PDF–2.9M

Select item 107633693.

Lactadherin immunoblockade in small extracellular vesicles inhibits sEV-mediated increase of pro-metastatic capacities

Eduardo Durán-Jara, Matías del Campo, Valentina Gutiérrez, Ignacio Wichmann, César Trigo, Marcelo Ezquer, Lorena Lobos-González

Biol Res. 2024; 57: 1. Published online 2024 Jan 3. doi: 10.1186/s40659-023-00477-8

PMCID:: PMC10763369

Abstract Article PDF–5.7M

Select item 106276894.

Expression and clinical association of MFG-E8 and TAM receptors in diabetic patients with different stages of microvascular complication: An experimental study

Yin Xiong, Beibei Wang, Jinyu Jiao, Meina Tang, Ke Li, Rui Jiang, Wei Huang

Medicine (Baltimore) 2023 Nov 3; 102(44): e35788. Published online 2023 Nov 3. doi: 10.1097/MD.0000000000035788

PMCID:: PMC10627689

Abstract Article PDF–1.1M

Select item 106204125.

Transcriptomic analyses reveal proinflammatory activation of human brain microvascular endothelial cells by aging-associated peptide medin and reversal by nanoliposomes

Yining Zhang, Nina Karamanova, Kaleb T. Morrow, Jillian Madine, Seth Truran, Maria Lozoya, Volkmar Weissig, Ming Li, Mehdi Nikkhah, Jin G. Park, Raymond Q. Migrino

Sci Rep. 2023; 13: 18802. Published online 2023 Nov 1. doi: 10.1038/s41598-023-45959-7

PMCID:: PMC10620412

Abstract Article PDF–2.1M

Select item 105896446.

Targeting MFGE8 secreted by cancer-associated fibroblasts blocks angiogenesis and metastasis in esophageal squamous cell carcinoma

Beilei Liu, Baifeng Zhang, Jiali Qi, Hongyu Zhou, Licheng Tan, Jinlin Huang, Jiao Huang, Xiaona Fang, Lanqi Gong, Jie Luo, Shan Liu, Li Fu, Fei Ling, Stephianie Ma, Dora Lai-wan Kwong, Xin Wang, Xin-Yuan Guan

Proc Natl Acad Sci U S A. 2023 Oct 17; 120(42): e2307914120. Published online 2023 Oct 10. doi: 10.1073/pnas.2307914120

PMCID:: PMC10589644

Abstract Article PDF–6.8M

Select item 105186337.

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer’s disease via MFG-E8

Makis Tzioras, Michael J.D. Daniels, Caitlin Davies, Paul Baxter, Declan King, Sean McKay, Balazs Varga, Karla Popovic, Madison Hernandez, Anna J. Stevenson, Jack Barrington, Elizabeth Drinkwater, Julia Borella, Rebecca K. Holloway, Jane Tulloch, Jonathan Moss, Clare Latta, Jothy Kandasamy, Drahoslav Sokol, Colin Smith, Veronique E. Miron, Ragnhildur Thóra Káradóttir, Giles E. Hardingham, Christopher M. Henstridge, Paul M. Brennan, Barry W. McColl, Tara L. Spires-Jones

Cell Rep Med. 2023 Sep 19; 4(9): 101175. Published online 2023 Aug 30. doi: 10.1016/j.xcrm.2023.101175

PMCID:: PMC10518633

Abstract Article PDF–7.3M

Select item 105029388.

A rare missense variant in the milk fat globule-EGF factor 8 (MFGE8) increases T2DM susceptibility and cardiovascular disease risk with population-specific effects

Bishwa R. Sapkota, Dharambir K. Sanghera

Acta Diabetol. Author manuscript; available in PMC 2023 Sep 15.

Published in final edited form as: Acta Diabetol. 2020 Jun; 57(6): 733–741. Published online 2020 Feb 6. doi: 10.1007/s00592-019-01463-x

Correction in:: Acta Diabetol. 2022 Jun 1

PMCID:: PMC10502938

Abstract Article PDF–485K

Select item 102374229.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 999586710.

CircSMAD2 accelerates endometrial cancer cell proliferation and metastasis by regulating the miR-1277-5p/MFGE8 axis

Yan Wu, Fuhua Wang, Jing Shi, Xiangyun Guo, Feng Li

J Gynecol Oncol. 2023 Mar; 34(2): e19. Published online 2023 Jan 2. doi: 10.3802/jgo.2023.34.e19

PMCID:: PMC9995867

Abstract Article PDF–2.3M

Select item 981060211.

MFG-E8 stabilized by deubiquitinase USP14 suppresses cigarette smoke-induced ferroptosis in bronchial epithelial cells

Yanan Cui, Lijuan Luo, Zihang Zeng, Xiangming Liu, Tiao Li, Xue He, Yiming Ma, Weiwei Meng, Huihui Zeng, Yingjiao Long, Dandan Zong, Yan Chen

Cell Death Dis. 2023 Jan; 14(1): 2. Published online 2023 Jan 3. doi: 10.1038/s41419-022-05455-8

PMCID:: PMC9810602

Abstract Article PDF–7.2M

Select item 971949212.

MFG-E8 has guiding significance for the prognosis and treatment of sepsis

Wei Wu, Jing Wang, Jingdi Chen, Jiaming Lu, Yaojia Lao, Kai Huang, Jun Lin

Sci Rep. 2022; 12: 20916. Published online 2022 Dec 3. doi: 10.1038/s41598-022-25601-8

PMCID:: PMC9719492

Abstract Article PDF–1.2M

Select item 971211313.

Medin co-aggregates with vascular amyloid-β in Alzheimer’s disease

Jessica Wagner, Karoline Degenhardt, Marleen Veit, Nikolaos Louros, Katerina Konstantoulea, Angelos Skodras, Katleen Wild, Ping Liu, Ulrike Obermüller, Vikas Bansal, Anupriya Dalmia, Lisa M. Häsler, Marius Lambert, Matthias De Vleeschouwer, Hannah A. Davies, Jillian Madine, Deborah Kronenberg-Versteeg, Regina Feederle, Domenico Del Turco, K. Peter R. Nilsson, Tammaryn Lashley, Thomas Deller, Marla Gearing, Lary C. Walker, Peter Heutink, Frederic Rousseau, Joost Schymkowitz, Mathias Jucker, Jonas J. Neher

Nature. 2022; 612(7938): 123–131. Published online 2022 Nov 16. doi: 10.1038/s41586-022-05440-3

PMCID:: PMC9712113

Abstract Article PDF–26M

Select item 934857614.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 917141115.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 911973616.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983