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Select item 95085581.

Carboxylesterase 2 induces mitochondrial dysfunction via disrupting lipid homeostasis in oral squamous cell carcinoma

Xijuan Chen, Qin Liu, Yingyao Chen, Lixuan Wang, Rongchun Yang, Weilin Zhang, Xue Pan, Siyuan Zhang, Chuwen Chen, Tong Wu, Juan Xia, Bin Cheng, Xiaobing Chen, Xianyue Ren

Mol Metab. 2022 Nov; 65: 101600. Published online 2022 Sep 14. doi: 10.1016/j.molmet.2022.101600

PMCID:: PMC9508558

Abstract Article PDF–6.6M

Select item 94509602.

The COVID-19 Oral Drug Molnupiravir Is a CES2 Substrate: Potential Drug-Drug Interactions and Impact of CES2 Genetic Polymorphism In Vitro

Yue Shen, William Eades, William Liu, Bingfang Yan

Drug Metab Dispos. 2022 Sep; 50(9): 1151–1160. Published online 2022 Sep. doi: 10.1124/dmd.122.000918

PMCID:: PMC9450960

Abstract Article PDF–1.2M

Select item 92792853.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 64163365.

Prognostic Impact of Carboxylesterase 2 in Cholangiocarcinoma

Benjamin Goeppert, Marcus Renner, Stephan Singer, Thomas Albrecht, Qiangnu Zhang, Arianeb Mehrabi, Anita Pathil, Christoph Springfeld, Bruno Köhler, Christian Rupp, Karl Heinz Weiss, Anja A. Kühl, Ruza Arsenic, Ulrich Frank Pape, Arndt Vogel, Peter Schirmacher, Stephanie Roessler, Nalân Utku

Sci Rep. 2019; 9: 4338. Published online 2019 Mar 13. doi: 10.1038/s41598-019-40487-9

PMCID:: PMC6416336

Abstract Article PDF–2.7M

Select item 61666826.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 58316797.

The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer

Momoko Ishimine, Hyeon-Cheol Lee, Hirofumi Nakaoka, Hajime Orita, Toshiyuki Kobayashi, Konomi Mizuguchi, Mikumi Endo, Ituro Inoue, Koichi Sato, Takehiko Yokomizo

Dis Markers. 2018; 2018: 5280736. Published online 2018 Jan 31. doi: 10.1155/2018/5280736

PMCID:: PMC5831679

Abstract Article PDF–1.0M

Select item 58261478.

Effect of Genetic Variation of NAT2 on Isoniazid and SLCO1B1 and CES2 on Rifampin Pharmacokinetics in Ghanaian Children with Tuberculosis

Albert Dompreh, Xiaoli Tang, Jianlin Zhou, Hongmei Yang, Ariel Topletz, Eugene Adu Ahwireng, Sampson Antwi, Antony Enimil, Taimour Langaee, Charles A. Peloquin, Michael H. Court, Awewura Kwara

Antimicrob Agents Chemother. 2018 Mar; 62(3): e02099-17. Prepublished online 2017 Dec 20. Published online 2018 Feb 23. doi: 10.1128/AAC.02099-17

PMCID:: PMC5826147

Abstract Article PDF–947K

Select item 57903859.

Expression of Topoisomerase 1 and carboxylesterase 2 correlates with irinotecan treatment response in metastatic colorectal cancer

Chen Shaojun, Hua Li, Huang Haixin, Li Guisheng

Cancer Biol Ther. 2018; 19(3): 153–159. Published online 2018 Jan 16. doi: 10.1080/15384047.2017.1414754

PMCID:: PMC5790385

Abstract Article PDF–773K

Select item 553161110.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 527680511.

Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance

Maxwell A. Ruby, Julie Massart, Devon M. Hunerdosse, Milena Schönke, Jorge C. Correia, Sharon M. Louie, Jorge L. Ruas, Erik Näslund, Daniel K. Nomura, Juleen R. Zierath

Cell Rep. 2017 Jan 17; 18(3): 636–646. Published online 2017 Jan 17. doi: 10.1016/j.celrep.2016.12.070

PMCID:: PMC5276805

Abstract Article

Select item 487486712.

Carboxylesterase 2 Prevents Liver Steatosis by Modulating Lipolysis, ER stress and Lipogenesis and Is Regulated by HNF4α

Yuanyuan Li, Munaf Zalzala, Kavita Jadhav, Yang Xu, Takhar Kasumov, Liya Yin, Yanqiao Zhang

Hepatology. Author manuscript; available in PMC 2017 Jun 1.

Published in final edited form as: Hepatology. 2016 Jun; 63(6): 1860–1874. Published online 2016 Mar 15. doi: 10.1002/hep.28472

PMCID:: PMC4874867

Abstract Article PDF–1.8M

Select item 455419313.

Carboxylesterase 2 as a Determinant of Response to Irinotecan and Neoadjuvant FOLFIRINOX Therapy in Pancreatic Ductal Adenocarcinoma

Michela Capello, Minhee Lee, Hong Wang, Ingrid Babel, Matthew H. Katz, Jason B. Fleming, Anirban Maitra, Huamin Wang, Weihua Tian, Ayumu Taguchi, Samir M. Hanash

J Natl Cancer Inst. 2015 Aug; 107(8): djv132. Published online 2015 May 28. doi: 10.1093/jnci/djv132

PMCID:: PMC4554193

Abstract Article PDF–3.4M

Select item 449658514.

ONTOGENIC EXPRESSION OF HUMAN CARBOXYLESTERASE-2 AND CYTOCHROME P450 3A4 IN LIVER AND DUODENUM: POSTNATAL SURGE AND ORGAN-DEPENDENT REGULATION

Yi-Tzai Chen, Lynnie Trzoss, Dongfang Yang, Bingfang Yan

Toxicology. Author manuscript; available in PMC 2016 Apr 1.

Published in final edited form as: Toxicology. 2015 Apr 1; 330: 55–61. Published online 2015 Feb 24. doi: 10.1016/j.tox.2015.02.007

PMCID:: PMC4496585

Abstract Article PDF–522K

Select item 406549815.

Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: Role of carboxylesterase 1 and 2

Shuqi Xie, Abdolsamad Borazjani, M. Jason Hatfield, Carol C. Edwards, Philip M. Potter, Matthew K. Ross

Chem Res Toxicol. Author manuscript; available in PMC 2014 Jun 21.

Published in final edited form as: Chem Res Toxicol. 2010 Dec 20; 23(12): 1890–1904. doi: 10.1021/tx1002194

PMCID:: PMC4065498

Abstract Article PDF–2.0M

Select item 391254316.

Identification of Carboxylesterase-Dependent Dabigatran Etexilate Hydrolysis

S. Casey Laizure, Robert B. Parker, Vanessa L. Herring, Zhe-Yi Hu

Drug Metab Dispos. 2014 Feb; 42(2): 201–206. Published online 2014 Feb. doi: 10.1124/dmd.113.054353

PMCID:: PMC3912543

Abstract Article PDF–570K

Select item 356985817.

Examination of the carboxylesterase phenotype in human liver

Matthew K. Ross, Abdolsamad Borazjani, Ran Wang, J. Allen Crow, Shuqi Xie

Arch Biochem Biophys. Author manuscript; available in PMC 2013 Jun 1.

Published in final edited form as: Arch Biochem Biophys. 2012 Jun 1; 522(1): 44–56. Published online 2012 Apr 16. doi: 10.1016/j.abb.2012.04.010

PMCID:: PMC3569858

Abstract Article PDF–3.1M

Select item 317805918.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 312720619.

Roger S. Holmes, Matthew W. Wright, Stanley J. F. Laulederkind, Laura A. Cox, Masakiyo Hosokawa, Teruko Imai, Shun Ishibashi, Richard Lehner, Masao Miyazaki, Everett J. Perkins, Phillip M. Potter, Matthew R. Redinbo, Jacques Robert, Tetsuo Satoh, Tetsuro Yamashita, Bingfan Yan, Tsuyoshi Yokoi, Rudolf Zechner, Lois J. Maltais

Mamm Genome. Author manuscript; available in PMC 2011 Oct 8.

Published in final edited form as: Mamm Genome. 2010 Oct; 21(9-10): 427–441. Published online 2010 Oct 8. doi: 10.1007/s00335-010-9284-4

PMCID:: PMC3127206

Abstract Article PDF–1.0M

Select item 295863820.

Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin

MJ Hatfield, L Tsurkan, JL Hyatt, X Yu, CC Edwards, LD Hicks, RM Wadkins, PM Potter

Br J Pharmacol. 2010 Aug; 160(8): 1916–1928. doi: 10.1111/j.1476-5381.2010.00700.x

PMCID:: PMC2958638

Abstract Article PDF–1.0M

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PMC Links for GEO Profiles (Select 13272190) (38)
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CAG:110_56_8
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lipase 1 [Arabidopsis thaliana]
lipase 1 [Arabidopsis thaliana]
gi|330251283|gnl|JCVI|AT2G15230.1|g 06377.1|

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