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Select item 112342091.

Deubiquitination of CIB1 by USP14 promotes lenvatinib resistance via the PAK1-ERK1/2 axis in hepatocellular carcinoma

Ming-Hao Xu, Yi-Min Zheng, Bu-Gang Liang, Wen-Xin Xu, Jun Cao, Pei Wang, Zi-Ying Dong, Chen-Hao Zhou, Hui-Chuan Sun, Ning Ren, Ai-Wu Ke, Ying-Hao Shen

Int J Biol Sci. 2024; 20(9): 3269–3284. Published online 2024 Jun 3. doi: 10.7150/ijbs.96031

PMCID:: PMC11234209

Abstract Article PDF–9.9M

Select item 112123602.

Deciphering the SOX4/MAPK1 regulatory axis: a phosphoproteomic insight into IQGAP1 phosphorylation and pancreatic Cancer progression

Chao Song, Ganggang Wang, Mengmeng Liu, Siyang Han, Meiyuan Dong, Maozhen Peng, Wenquan Wang, Yicun Wang, Yaolin Xu, Liang Liu

J Transl Med. 2024; 22: 602. Published online 2024 Jun 28. doi: 10.1186/s12967-024-05377-3

PMCID:: PMC11212360

Abstract Article PDF–4.4M

Select item 111584863.

MEK‐ERK is involved in SUMO‐1 foci formation on apoptosis

Ryoko Utsubo‐Kuniyoshi, Yasuhito Terui, Yuko Mishima, Akiko Rokudai, Yuji Mishima, Natsuhiko Sugimura, Kiyotsugu Kojima, Yoshiko Sonoda, Tadashi Kasahara, Kiyohiko Hatake

Cancer Sci. 2007 Apr; 98(4): 569–576. Published online 2007 Jan 31. doi: 10.1111/j.1349-7006.2007.00422.x

PMCID:: PMC11158486

Abstract Article PDF–1.2M

Select item 111580714.

Activation of ERK1/2 occurs independently of KRAS or BRAF status in endometrial cancer and is associated with favorable prognosis

Yasunari Mizumoto, Satoru Kyo, Noriko Mori, Junko Sakaguchi, Satoshi Ohno, Yoshiko Maida, Manabu Hashimoto, Masahiro Takakura, Masaki Inoue

Cancer Sci. 2007 May; 98(5): 652–658. Published online 2007 Mar 27. doi: 10.1111/j.1349-7006.2007.00445.x

PMCID:: PMC11158071

Abstract Article PDF–278K

Select item 111363975.

Impaired apoptosis in lymphoblasts from Alzheimer’s disease patients: Cross-talk of Ca²⁺/calmodulin and ERK1/2 signaling pathways

F. Bartolomé, N. de las Cuevas, Ú. Muñoz, F. Bermejo, Á. Martín-Requero

Cell Mol Life Sci. 2007 Jun; 64(11): 1437–1448. Published online 2007 May 14. doi: 10.1007/s00018-007-7081-3

PMCID:: PMC11136397

Abstract Article PDF–591K

Select item 111317606.

CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK

J. Huang, T. Shi, T. Ma, Y. Zhang, X. Ma, Y. Lu, Q. Song, W. Liu, D. Ma, X. Qiu

Cell Mol Life Sci. 2008 Jan; 65(2): 338–349. Published online 2007 Dec 18. doi: 10.1007/s00018-007-7448-5

PMCID:: PMC11131760

Abstract Article PDF–2.1M

Select item 111157707.

Endocytosis of hepatitis C virus non-enveloped capsid-like particles induces MAPK–ERK1/2 signaling events

Konstantina Katsarou, Alexandros Α. Lavdas, Panagiota Tsitoura, Elisavet Serti, Panagiotis Markoulatos, Penelope Mavromara, Urania Georgopoulou

Cell Mol Life Sci. 2010 Jul; 67(14): 2491–2506. Published online 2010 Apr 1. doi: 10.1007/s00018-010-0351-5

PMCID:: PMC11115770

Abstract Article PDF–938K

Select item 110341848.

Different regulation of PKC isoenzymes and MAPK by PSK and IL-2 in the proliferative and cytotoxic activities of the NKL human natural killer cell line

Angel García-Lora, Marisol Martinez, Susana Pedrinaci, Federico Garrido

Cancer Immunol Immunother. 2003 Jan; 52(1): 59–64. Published online 2002 Oct 17. doi: 10.1007/s00262-002-0336-9

PMCID:: PMC11034184

Abstract Article PDF–327K

Select item 110028939.

ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2

Yvonne Benatzy, Megan A. Palmer, Dieter Lütjohann, Rei-Ichi Ohno, Nadja Kampschulte, Nils Helge Schebb, Dominik C. Fuhrmann, Ryan G. Snodgrass, Bernhard Brüne

Redox Biol. 2024 Jun; 72: 103149. Published online 2024 Apr 3. doi: 10.1016/j.redox.2024.103149

PMCID:: PMC11002893

Abstract Article PDF–8.3M

Select item 1086758710.

LncNFYB promotes the proliferation of rheumatoid arthritis fibroblast-like synoviocytes via LncNFYB/ANXA2/ERK1/2 axis

Shibai Xiao, Qingqing Ouyang, Yi Feng, Xiaoxi Lu, Yipeng Han, Hao Ren, Qin Huang, Jinjun Zhao, Changhong Xiao, Min Yang

J Biol Chem. 2024 Feb; 300(2): 105591. Published online 2023 Dec 21. doi: 10.1016/j.jbc.2023.105591

PMCID:: PMC10867587

Abstract Article PDF–5.7M

Select item 1086645311.

IL-17 promotes IL-18 production via the MEK/ERK/miR-4492 axis in osteoarthritis synovial fibroblasts

Kun-Tsan Lee, Chih-Yang Lin, Shan-Chi Liu, Xiu-Yuan He, Chun-Hao Tsai, Chih-Yuan Ko, Yuan-Hsin Tsai, Chia-Chia Chao, Po-Chun Chen, Chih-Hsin Tang

Aging (Albany NY) 2024 Jan 31; 16(2): 1829–1844. Published online 2024 Jan 22. doi: 10.18632/aging.205462

PMCID:: PMC10866453

Abstract Article PDF–1.7M

Select item 1075809212.

MAPK1 Mediates MAM Disruption and Mitochondrial Dysfunction in Diabetic Kidney Disease via the PACS-2-Dependent Mechanism

Shanshan Liu, Shuai Han, Cuili Wang, Hongjun Chen, Qiannan Xu, Shi Feng, Yucheng Wang, Jihong Yao, Qin Zhou, Xuanli Tang, Li Lin, Lidan Hu, Alan J Davidson, Bing Yang, Cunqi Ye, Fan Yang, Jianhua Mao, Chao Tong, Jianghua Chen, Hong Jiang

Int J Biol Sci. 2024; 20(2): 569–584. Published online 2024 Jan 1. doi: 10.7150/ijbs.89291

PMCID:: PMC10758092

Abstract Article PDF–12M

Select item 1072810713.

LncRNA SNHG8 regulates the migration and angiogenesis of pHUVECs induced by high glucose via the TRPM7/ERK_1/2 signaling axis

Zongcheng Fan, Xin Chen, Laicheng Wang, Jianjian Yu, Shunpeng Zhang, Changsheng Xu, Jinxiu Lin, Yunchai Lin, Feng Peng

Sci Rep. 2023; 13: 22485. Published online 2023 Dec 18. doi: 10.1038/s41598-023-49779-7

PMCID:: PMC10728107

Abstract Article PDF–9.2M

Select item 1072184314.

ERK2-topoisomerase II regulatory axis is important for gene activation in immediate early genes

Heeyoun Bunch, Deukyeong Kim, Masahiro Naganuma, Reiko Nakagawa, Anh Cong, Jaehyeon Jeong, Haruhiko Ehara, Hongha Vu, Jeong Ho Chang, Matthew J. Schellenberg, Shun-ichi Sekine

Nat Commun. 2023; 14: 8341. Published online 2023 Dec 14. doi: 10.1038/s41467-023-44089-y

PMCID:: PMC10721843

Abstract Article PDF–2.7M

Select item 1061640915.

Phase plane dynamics of ERK phosphorylation

Stanislav Y. Shvartsman, Sarah McFann, Martin Wühr, Boris Y. Rubinstein

J Biol Chem. 2023 Nov; 299(11): 105234. Published online 2023 Sep 9. doi: 10.1016/j.jbc.2023.105234

PMCID:: PMC10616409

Abstract Article PDF–1.0M

Select item 1061235716.

The complex impact of cancer-related missense mutations on the stability and on the biophysical and biochemical properties of MAPK1 and MAPK3 somatic variants

Maria Petrosino, Leonore Novak, Alessandra Pasquo, Paola Turina, Emidio Capriotti, Velia Minicozzi, Valerio Consalvi, Roberta Chiaraluce

Hum Genomics. 2023; 17: 95. Published online 2023 Oct 27. doi: 10.1186/s40246-023-00544-x

PMCID:: PMC10612357

Abstract Article PDF–4.7M

Select item 1059472717.

Nuclear respiratory factor 1 drives hepatocellular carcinoma progression by activating LPCAT1-ERK1/2-CREB axis

Ran Liu, Chuanzheng Yin, Peng Zhao, Bing Guo, Wenbo Ke, Xichuan Zheng, Dawei Xie, Yaofeng Wang, Gengqiao Wang, Yinzhao Jia, Yang Gao, Wenjun Hu, Gang Logan Liu, Zifang Song

Biol Direct. 2023; 18: 67. Published online 2023 Oct 24. doi: 10.1186/s13062-023-00428-z

PMCID:: PMC10594727

Abstract Article PDF–15M

Select item 1056795118.

A dual role for ERK-1/2 in the regulation of plasmin activity and cell migration in metastatic NSCLC-H1299 cells

Sarah Zeitlmayr, Ditila Cami, Belinda Selmani, Thomas Gudermann, Andreas Breit

Arch Toxicol. 2023; 97(12): 3113–3128. Published online 2023 Sep 15. doi: 10.1007/s00204-023-03600-6

PMCID:: PMC10567951

Abstract Article PDF–1.4M

Select item 1056329319.

MAPK1 promotes the metastasis and invasion of gastric cancer as a bidirectional transcription factor

Yue Wang, Zheng Guo, Yueli Tian, Liang Cong, Yulu Zheng, Zhiyuan Wu, Guangle Shan, Yao Xia, Yahong Zhu, Xingang Li, Ying Song

BMC Cancer. 2023; 23: 959. Published online 2023 Oct 10. doi: 10.1186/s12885-023-11480-3

PMCID:: PMC10563293

Abstract Article PDF–2.7M

Select item 1055726220.

ERK mediates interferon gamma-induced melanoma cell death

Ameya Champhekar, Rachel Heymans, Justin Saco, Guillem Turon Font, Cynthia Gonzalez, Anne Gao, John Pham, June Lee, Ryan Maryoung, Egmidio Medina, Katie M. Campbell, Daniel Karin, David Austin, Robert Damioseaux, Antoni Ribas

Mol Cancer. 2023; 22: 165. Published online 2023 Oct 6. doi: 10.1186/s12943-023-01868-x