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Select item 97281431.

Comprehensive insights in GRK4 and hypertension: From mechanisms to potential therapeutics

Jian Yang, John E. Hall, Pedro A. Jose, Ken Chen, Chunyu Zeng

Pharmacol Ther. Author manuscript; available in PMC 2022 Dec 7.

Published in final edited form as: Pharmacol Ther. 2022 Nov; 239: 108194. Published online 2022 Apr 27. doi: 10.1016/j.pharmthera.2022.108194

PMCID:: PMC9728143

Abstract Article PDF–591K

Select item 94616642.

PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer

Liliang Shen, Junfeng Zhang, Zongtai Zheng, Fuhan Yang, Shenghua Liu, Yuan Wu, Yifan Chen, Tianyuan Xu, Shiyu Mao, Yang Yan, Wei Li, Wentao Zhang, Xudong Yao

Int J Biol Sci. 2022; 18(14): 5459–5474. Published online 2022 Aug 29. doi: 10.7150/ijbs.74546

PMCID:: PMC9461664

Abstract Article PDF–3.5M

Select item 85651803.

Genetic variants of GRK4 influence circadian rhythm of blood pressure and response to candesartan in hypertensive patients

Nian Cao, Hui Tang, Miao Tian, Xue Gong, Zaicheng Xu, Binqing Zhou, Cong Lan, Caiyu Chen, Shuang Qu, Shuo Zheng, Hongmei Ren, Chao Fan, Pedro A. Jose, Chunyu Zeng, Tianyang Xia

Clin Exp Hypertens. Author manuscript; available in PMC 2022 Apr 3.

Published in final edited form as: Clin Exp Hypertens. 2021 Oct 3; 43(7): 597–603. Published online 2021 Apr 25. doi: 10.1080/10641963.2021.1919357

PMCID:: PMC8565180

Abstract Article PDF–858K

Select item 83016214.

Targeted capture sequencing identifies genetic variations of GRK4 and RDH8 in Han Chinese with essential hypertension in Xinjiang

Wenxi Jiang, Xizi Wang, Ronghui Li, Panpan Wang, Guangle Shan, Xiaodong Jia, Mingliang Gu

PLoS One. 2021; 16(7): e0255311. Published online 2021 Jul 23. doi: 10.1371/journal.pone.0255311

PMCID:: PMC8301621

Abstract Article PDF–1.3M

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80262796.

The role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction

Liangpeng Li, Wenbin Fu, Xue Gong, Zhi Chen, Luxun Tang, Dezhong Yang, Qiao Liao, Xuewei Xia, Hao Wu, Chao Liu, Miao Tian, Andi Zeng, Lin Zhou, Pedro A Jose, Ken Chen, Wei Eric Wang, Chunyu Zeng

Eur Heart J. 2021 Apr 7; 42(14): 1415–1430. Published online 2020 Dec 6. doi: 10.1093/eurheartj/ehaa878

PMCID:: PMC8026279

Abstract Article PDF–1.7M

Select item 79104207.

Renal Dopamine Receptors and Oxidative Stress: Role in Hypertension

Jian Yang, Van Anthony M. Villar, Pedro A. Jose, Chunyu Zeng

Antioxid Redox Signal. March 2021; 34(9): 716–735. Published online 2021 Feb 24. doi: 10.1089/ars.2020.8106

PMCID:: PMC7910420

Abstract Article PDF–619K

Select item 76060088.

BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A

Chun‐guo Mao, Sha‐sha Jiang, Cheng Shen, Tan Long, Hua Jin, Qun‐You Tan, Bo Deng

Thorac Cancer. 2020 Nov; 11(11): 3326–3336. Published online 2020 Oct 1. doi: 10.1111/1759-7714.13676

PMCID:: PMC7606008

Abstract Article PDF–2.5M

Select item 74273279.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 704505810.

Novel candidate genes putatively involved in stress fracture predisposition detected by whole-exome sequencing

EITAN FRIEDMAN, DANIEL S. MORAN, DANNY BEN-AVRAHAM, RAN YANOVICH, GIL ATZMON

Genet Res (Camb) 2014; 96: e004. Published online 2014 May 28. doi: 10.1017/S001667231400007X

PMCID:: PMC7045058

Abstract Article PDF–424K

Select item 635050911.

G Protein-Coupled Receptor Kinase 4: Role in Hypertension

Jian Yang, Van Anthony M. Villar, John E. Jones, Pedro A. Jose, Chunyu Zeng

Hypertension. Author manuscript; available in PMC 2019 Jan 29.

Published in final edited form as: Hypertension. 2015 Jun; 65(6): 1148–1155. Published online 2015 Apr 13. doi: 10.1161/HYPERTENSIONAHA.115.05189

PMCID:: PMC6350509

Article PDF–511K

Select item 594435212.

G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling

Pingping Xiao, Xishi Huang, Lanzhen Huang, Jing Yang, Ang Li, Ke Shen, Philip B. Wedegaertner, Xiaoshan Jiang

Exp Cell Res. Author manuscript; available in PMC 2018 Nov 15.

Published in final edited form as: Exp Cell Res. 2017 Nov 15; 360(2): 273–280. Published online 2017 Sep 11. doi: 10.1016/j.yexcr.2017.09.017

PMCID:: PMC5944352

Abstract Article PDF–945K

Select item 537636113.

INCREASED RENAL OXIDATIVE STRESS IN SALT-SENSITIVE HUMAN GRK4γ486V TRANSGENIC MICE

Zhenyu Diao, Laureano D. Asico, Van Anthony M. Villar, Xiaoxu Zheng, Santiago Cuevas, Ines Armando, Pedro A. Jose, Xiaoyan Wang

Free Radic Biol Med. Author manuscript; available in PMC 2018 May 1.

Published in final edited form as: Free Radic Biol Med. 2017 May; 106: 80–90. Published online 2017 Feb 9. doi: 10.1016/j.freeradbiomed.2017.02.021

PMCID:: PMC5376361

Abstract Article PDF–1.0M

Select item 496894914.

Gastro-renal axis

Pedro A. Jose, Robin A. Felder, Zhiwei Yang, Chunyu Zeng, Gilbert M. Eisner

Hypertension. Author manuscript; available in PMC 2017 Jun 1.

Published in final edited form as: Hypertension. 2016 Jun; 67(6): 1056–1063. Published online 2016 Apr 4. doi: 10.1161/HYPERTENSIONAHA.115.06424

PMCID:: PMC4968949

Article PDF–559K

Select item 478780615.

The FMRP/GRK4 mRNA interaction uncovers a new mode of binding of the Fragile X mental retardation protein in cerebellum

Thomas Maurin, Mireille Melko, Sabiha Abekhoukh, Olfa Khalfallah, Laetitia Davidovic, Marielle Jarjat, Simona D'Antoni, Maria Vincenza Catania, Hervé Moine, Elias Bechara, Barbara Bardoni

Nucleic Acids Res. 2015 Sep 30; 43(17): 8540–8550. Published online 2015 Aug 6. doi: 10.1093/nar/gkv801

PMCID:: PMC4787806

Abstract Article PDF–2.2M

Select item 471326216.

HUMAN GRK4γ^142V VARIANT PROMOTES AT₁R-MEDIATED HYPERTENSION VIA RENAL HDAC1 INHIBITION

Zheng Wang, Chunyu Zeng, Van Anthony M. Villar, Shi-You Chen, Prasad Konkalmatt, Xiaoyan Wang, Laureano D. Asico, John E. Jones, Yu Yang, Hironobu Sanada, Robin A. Felder, Gilbert M. Eisner, Matthew R. Weir, Ines Armando, Pedro A. Jose

Hypertension. Author manuscript; available in PMC 2017 Feb 1.

Published in final edited form as: Hypertension. 2016 Feb; 67(2): 325–334. Published online 2015 Dec 14. doi: 10.1161/HYPERTENSIONAHA.115.05962

PMCID:: PMC4713262

Abstract Article PDF–3.1M

Select item 469467317.

Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis

He Zhang, Zhao-qing Sun, Shuang-shuang Liu, Li-na Yang

Clin Interv Aging. 2016; 11: 17–27. Published online 2015 Dec 23. doi: 10.2147/CIA.S94510

PMCID:: PMC4694673

Abstract Article PDF–792K

Select item 455949018.

Common variants of the G protein-coupled receptor type 4 are associated with human essential hypertension and predict the blood pressure response to angiotensin receptor blockade

Hironobu Sanada, Minoru Yoneda, Junichi Yatabe, Scott M. Williams, Jacquelaine Bartlett, Marquitta J. White, Lindsay N. Gordon, Robin A Felder, Gilbert M. Eisner, Ines Armando, Pedro A. Jose

Pharmacogenomics J. Author manuscript; available in PMC 2017 Feb 1.

Published in final edited form as: Pharmacogenomics J. 2016 Feb; 16(1): 3–9. Published online 2015 Mar 3. doi: 10.1038/tpj.2015.6

PMCID:: PMC4559490

Abstract Article PDF–316K

Select item 453644219.

Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4

Samantha J. Allen, Gopal Parthasarathy, Paul L. Darke, Ronald E. Diehl, Rachael E. Ford, Dawn L. Hall, Scott A. Johnson, John C. Reid, Keith W. Rickert, Jennifer M. Shipman, Stephen M. Soisson, Paul Zuck, Sanjeev K. Munshi, Kevin J. Lumb

J Biol Chem. 2015 Aug 14; 290(33): 20360–20373. Published online 2015 Jul 1. doi: 10.1074/jbc.M115.648907