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Select item 81650301.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 73964232.

Dipeptidyl peptidase like 6 promoter methylation is a potential prognostic biomarker for pancreatic ductal adenocarcinoma

Xin Zhao, Di Cao, Zhangyong Ren, Zhe Liu, Shaocheng Lv, Jiqiao Zhu, Lixin Li, Ren Lang, Qiang He

Biosci Rep. 2020 Jul 31; 40(7): BSR20200214. Published online 2020 Jul 30. doi: 10.1042/BSR20200214

PMCID:: PMC7396423

Abstract Article PDF–1.2M

Select item 65316103.

Loss of DPP6 in neurodegenerative dementia: a genetic player in the dysfunction of neuronal excitability

Rita Cacace, Bavo Heeman, Sara Van Mossevelde, Arne De Roeck, Julie Hoogmartens, Peter De Rijk, Helena Gossye, Kristof De Vos, Wouter De Coster, Mojca Strazisar, Greet De Baets, Joost Schymkowitz, Frederic Rousseau, Nathalie Geerts, Tim De Pooter, Karin Peeters, Anne Sieben, Jean-Jacques Martin, Sebastiaan Engelborghs, Eric Salmon, Patrick Santens, Rik Vandenberghe, Patrick Cras, Peter P. De Deyn, John C. van Swieten, Cornelia M. van Duijn, Julie van der Zee, Kristel Sleegers, Christine Van Broeckhoven, the BELNEU Consortium

Acta Neuropathol. 2019; 137(6): 901–918. Published online 2019 Mar 14. doi: 10.1007/s00401-019-01976-3

PMCID:: PMC6531610

Abstract Article PDF–3.2M

Select item 58333024.

Implication of LRRC4C and DPP6 in neurodevelopmental disorders

Gilles Maussion, Cristiana Cruceanu, Jill A. Rosenfeld, Scott C. Bell, Fabrice Jollant, Jin Szatkiewicz, Ryan L. Collins, Carrie Hanscom, Ilaria Kolobova, Nicolas Menjot de Champfleur, Ian Blumenthal, Colby Chiang, Vanessa Ota, Christina Hultman, Colm O’Dushlaine, Steve McCarroll, Martin Alda, Sebastien Jacquemont, Zehra Ordulu, Christian R. Marshall, Melissa T. Carter, Lisa G. Shaffer, Pamela Sklar, Santhosh Girirajan, Cynthia C. Morton, James F. Gusella, Gustavo Turecki, D. J. Stavropoulos, Patrick F. Sullivan, Stephen W. Scherer, Michael E. Talkowski, Carl Ernst

Am J Med Genet A. Author manuscript; available in PMC 2018 Mar 2.

Published in final edited form as: Am J Med Genet A. 2017 Feb; 173(2): 395–406. Published online 2016 Oct 19. doi: 10.1002/ajmg.a.38021

PMCID:: PMC5833302

Abstract Article PDF–734K

Select item 55316115.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 54952256.

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114

PMCID:: PMC5495225

Abstract Article PDF–1.3M

Select item 46172117.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 44657858.

Unique Cardiac Purkinje Fiber Transient Outward Current β-Subunit Composition: A Potential Molecular Link to Idiopathic Ventricular Fibrillation

Ling Xiao, Tamara T. Koopmann, Balázs Ördög, Pieter G. Postema, Arie O. Verkerk, Vivek Iyer, Kevin J. Sampson, Gerard J.J. Boink, Maya A. Mamarbachi, Andras Varro, Luc Jordaens, Jan Res, Robert S. Kass, Arthur A. Wilde, C.R. Bezzina, Stanley Nattel

Circ Res. Author manuscript; available in PMC 2015 Jun 14.

Published in final edited form as: Circ Res. 2013 May 10; 112(10): 1310–1322. Published online 2013 Mar 26. doi: 10.1161/CIRCRESAHA.112.300227

PMCID:: PMC4465785

Abstract Article PDF–4.9M

Select item 42316919.

DPP6 Domains Responsible for Its Localization and Function

Lin Lin, Laura K. Long, Michael M. Hatch, Dax A. Hoffman

J Biol Chem. 2014 Nov 14; 289(46): 32153–32165. Published online 2014 Sep 4. doi: 10.1074/jbc.M114.578070

PMCID:: PMC4231691

Abstract Article PDF–3.3M

Select item 399051010.

Genome-Wide Diet-Gene Interaction Analyses for Risk of Colorectal Cancer

Jane C. Figueiredo, Li Hsu, Carolyn M. Hutter, Yi Lin, Peter T. Campbell, John A. Baron, Sonja I. Berndt, Shuo Jiao, Graham Casey, Barbara Fortini, Andrew T. Chan, Michelle Cotterchio, Mathieu Lemire, Steven Gallinger, Tabitha A. Harrison, Loic Le Marchand, Polly A. Newcomb, Martha L. Slattery, Bette J. Caan, Christopher S. Carlson, Brent W. Zanke, Stephanie A. Rosse, Hermann Brenner, Edward L. Giovannucci, Kana Wu, Jenny Chang-Claude, Stephen J. Chanock, Keith R. Curtis, David Duggan, Jian Gong, Robert W. Haile, Richard B. Hayes, Michael Hoffmeister, John L. Hopper, Mark A. Jenkins, Laurence N. Kolonel, Conghui Qu, Anja Rudolph, Robert E. Schoen, Fredrick R. Schumacher, Daniela Seminara, Deanna L. Stelling, Stephen N. Thibodeau, Mark Thornquist, Greg S. Warnick, Brian E. Henderson, Cornelia M. Ulrich, W. James Gauderman, John D. Potter, Emily White, Ulrike Peters, on behalf of CCFR, and GECCO

PLoS Genet. 2014 Apr; 10(4): e1004228. Published online 2014 Apr 17. doi: 10.1371/journal.pgen.1004228

PMCID:: PMC3990510

Abstract Article PDF–878K

Select item 398462811.

A Genome-Wide Association Study of Clinical Symptoms of Dissociation in a Trauma-Exposed Sample

Erika J. Wolf, Ann M. Rasmusson, Karen S. Mitchell, Mark W. Logue, Clinton T. Baldwin, Mark W. Miller

Depress Anxiety. Author manuscript; available in PMC 2015 Apr 1.

Published in final edited form as: Depress Anxiety. 2014 Apr; 31(4): 352–360. Published online 2014 Mar 27. doi: 10.1002/da.22260

PMCID:: PMC3984628

Abstract Article PDF–657K

Select item 387357712.

The Prion Protein Modulates A-type K⁺ Currents Mediated by Kv4.2 Complexes through Dipeptidyl Aminopeptidase-like Protein 6

Robert C. C. Mercer, Li Ma, Joel C. Watts, Robert Strome, Serene Wohlgemuth, Jing Yang, Neil R. Cashman, Michael B. Coulthart, Gerold Schmitt-Ulms, Jack H. Jhamandas, David Westaway

J Biol Chem. 2013 Dec 27; 288(52): 37241–37255. Published online 2013 Nov 13. doi: 10.1074/jbc.M113.488650

PMCID:: PMC3873577

Abstract Article PDF–2.4M

Select item 377561113.

DPP6 regulation of dendritic morphogenesis impacts hippocampal synaptic development

Lin Lin, Wei Sun, Ben Throesch, Faith Kung, Jameice T Decoster, Cory J Berner, Richard E. Cheney, Bernardo Rudy, Dax A Hoffman

Nat Commun. Author manuscript; available in PMC 2014 Feb 5.

Published in final edited form as: Nat Commun. 2013; 4: 2270. doi: 10.1038/ncomms3270

PMCID:: PMC3775611

Abstract Article PDF–2.5M

Select item 374394614.

Generalization of Variants Identified by Genome-wide Association Studies for Electrocardiographic Traits in African Americans

Janina M. Jeff, Marylyn D. Ritchie, Joshua C. Denny, Abel N. Kho, Andrea H. Ramirez, David Crosslin, Loren Armstrong, Melissa A. Basford, Wendy A. Wolf, Jennifer A. Pacheco, Rex L. Chisholm, Dan M. Roden, M. Geoffrey Hayes, Dana C. Crawford

Ann Hum Genet. Author manuscript; available in PMC 2014 Jul 30.

Published in final edited form as: Ann Hum Genet. 2013 Jul; 77(4): 321–332. Published online 2013 Mar 28. doi: 10.1111/ahg.12023

PMCID:: PMC3743946

Abstract Article PDF–375K

Select item 373727015.

Functional Stoichiometry Underlying KChIP Regulation of Kv4.2 Functional Expression

Kumud Kunjilwar, Yan Qian, Paul J. Pfaffinger

J Neurochem. Author manuscript; available in PMC 2014 Aug 1.

Published in final edited form as: J Neurochem. 2013 Aug; 126(4): 462–472. Published online 2013 Jun 10. doi: 10.1111/jnc.12309

PMCID:: PMC3737270

Abstract Article PDF–2.0M

Select item 362190516.

A New TASK for Dipeptidyl Peptidase-like Protein 6

Brian M. Nadin, Paul J. Pfaffinger

PLoS One. 2013; 8(4): e60831. Published online 2013 Apr 9. doi: 10.1371/journal.pone.0060831

PMCID:: PMC3621905

Abstract Article PDF–2.5M

Select item 360728917.

A Novel N-terminal Motif of Dipeptidyl Peptidase-like Proteins Produces Rapid Inactivation of Kv4.2 Channels by a Pore-blocking Mechanism

Henry H. Jerng, Kevin Dougherty, Manuel Covarrubias, Paul J. Pfaffinger

Channels (Austin) Author manuscript; available in PMC 2013 Mar 25.

Published in final edited form as: Channels (Austin). 2009 Nov; 3(6): 448–461. Published online 2009 Nov 30. doi: 10.4161/chan.3.6.10216

PMCID:: PMC3607289

Abstract Article PDF–2.7M

Select item 356372218.

Encephalitis and antibodies to DPPX, a subunit of Kv4.2 potassium channels

Anna Boronat, Jeffrey M. Gelfand, Nuria Gresa-Arribas, Hyo-Young Jeong, Michael Walsh, Kirk Roberts, Eugenia Martinez-Hernandez, Myrna R. Rosenfeld, Rita Balice-Gordon, Francesc Graus, Bernardo Rudy, Josep Dalmau

Ann Neurol. Author manuscript; available in PMC 2014 Jan 1.

Published in final edited form as: Ann Neurol. 2013 Jan; 73(1): 120–128. Published online 2012 Dec 7. doi: 10.1002/ana.23756

PMCID:: PMC3563722

Abstract Article PDF–1.8M

Select item 356108419.

Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers

Gordan Lauc, Jennifer E. Huffman, Maja Pučić, Lina Zgaga, Barbara Adamczyk, Ana Mužinić, Mislav Novokmet, Ozren Polašek, Olga Gornik, Jasminka Krištić, Toma Keser, Veronique Vitart, Blanca Scheijen, Hae-Won Uh, Mariam Molokhia, Alan Leslie Patrick, Paul McKeigue, Ivana Kolčić, Ivan Krešimir Lukić, Olivia Swann, Frank N. van Leeuwen, L. Renee Ruhaak, Jeanine J. Houwing-Duistermaat, P. Eline Slagboom, Marian Beekman, Anton J. M. de Craen, André M. Deelder, Qiang Zeng, Wei Wang, Nicholas D. Hastie, Ulf Gyllensten, James F. Wilson, Manfred Wuhrer, Alan F. Wright, Pauline M. Rudd, Caroline Hayward, Yurii Aulchenko, Harry Campbell, Igor Rudan

PLoS Genet. 2013 Jan; 9(1): e1003225. Published online 2013 Jan 31. doi: 10.1371/journal.pgen.1003225

PMCID:: PMC3561084

Abstract Article PDF–1.0M

Select item 352727620.

A Synthetic Interaction Screen Identifies Factors Selectively Required for Proliferation and TERT Transcription in p53-Deficient Human Cancer Cells

Li Xie, Claude Gazin, Sung Mi Park, Lihua J. Zhu, Marie-anne Debily, Ellen L. W. Kittler, Maria L. Zapp, David Lapointe, Stephane Gobeil, Ching-Man Virbasius, Michael R. Green

PLoS Genet. 2012 Dec; 8(12): e1003151. Published online 2012 Dec 20. doi: 10.1371/journal.pgen.1003151