PMC Links for GEO Profiles (Select 20470289) - PMC

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Items: 20

Select item 83944121.

Identification and Characterization of Cannabidiol as an OX1R Antagonist by Computational and In Vitro Functional Validation

Rosa Maria Vitale, Fabio Arturo Iannotti, Aniello Schiano Moriello, Lea Tunisi, Fabiana Piscitelli, Ranjev Savopoulos, Luigia Cristino, Luciano De Petrocellis, Pietro Amodeo, Roy Gray, Vincenzo Di Marzo

Biomolecules. 2021 Aug; 11(8): 1134. Published online 2021 Aug 1. doi: 10.3390/biom11081134

PMCID:: PMC8394412

Abstract Article PDF–3.5M

Select item 63619312.

Orexin in the anxiety spectrum: association of a HCRTR1 polymorphism with panic disorder/agoraphobia, CBT treatment response and fear-related intermediate phenotypes

Michael G. Gottschalk, Jan Richter, Christiane Ziegler, Miriam A. Schiele, Julia Mann, Maximilian J. Geiger, Christoph Schartner, György A. Homola, Georg W. Alpers, Christian Büchel, Lydia Fehm, Thomas Fydrich, Alexander L. Gerlach, Andrew T. Gloster, Sylvia Helbig-Lang, Raffael Kalisch, Tilo Kircher, Thomas Lang, Tina B. Lonsdorf, Christiane A. Pané-Farré, Andreas Ströhle, Heike Weber, Peter Zwanzger, Volker Arolt, Marcel Romanos, Hans-Ulrich Wittchen, Alfons Hamm, Paul Pauli, Andreas Reif, Jürgen Deckert, Susanne Neufang, Michael Höfler, Katharina Domschke

Transl Psychiatry. 2019; 9: 75. Published online 2019 Feb 4. doi: 10.1038/s41398-019-0415-8

PMCID:: PMC6361931

Abstract Article PDF–1.0M

Select item 62331263.

Activation of orexin system facilitates anesthesia emergence and pain control

Wei Zhou, Kevin Cheung, Steven Kyu, Lynn Wang, Zhonghui Guan, Philip A. Kurien, Philip E. Bickler, Lily Y. Jan

Proc Natl Acad Sci U S A. 2018 Nov 6; 115(45): E10740–E10747. Published online 2018 Oct 22. doi: 10.1073/pnas.1808622115

PMCID:: PMC6233126

Abstract Article PDF–1.5M

Select item 55572924.

Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions

Kyuho Han, Edwin E. Jeng, Gaelen T. Hess, David W. Morgens, Amy Li, Michael C. Bassik

Nat Biotechnol. Author manuscript; available in PMC 2017 Sep 20.

Published in final edited form as: Nat Biotechnol. 2017 May; 35(5): 463–474. Published online 2017 Mar 20. doi: 10.1038/nbt.3834

PMCID:: PMC5557292

Abstract Article PDF–3.4M

Select item 55495595.

The orexin 1 receptor modulates kappa opioid receptor function via a JNK-dependent mechanism

James D Robinson, Patricia H McDonald

Cell Signal. Author manuscript; available in PMC 2017 Aug 9.

Published in final edited form as: Cell Signal. 2015 Jul; 27(7): 1449–1456. Published online 2015 Apr 6. doi: 10.1016/j.cellsig.2015.03.026

PMCID:: PMC5549559

Abstract Article PDF–783K

Select item 44694076.

Modeling of the OX₁R–orexin-A complex suggests two alternative binding modes

Lasse Karhu, Ainoleena Turku, Henri Xhaard

BMC Struct Biol. 2015; 15: 9. Published online 2015 May 9. doi: 10.1186/s12900-015-0036-2

PMCID:: PMC4469407

Abstract Article PDF–5.6M

Select item 42907197.

Calcium affects OX₁ orexin (hypocretin) receptor responses by modifying both orexin binding and the signal transduction machinery

Jaana Putula, Tero Pihlajamaa, Jyrki P Kukkonen

Br J Pharmacol. 2014 Dec; 171(24): 5816–5828. Published online 2014 Nov 5. doi: 10.1111/bph.12883

PMCID:: PMC4290719

Abstract Article PDF–933K

Select item 33402428.

Intramolecular Fluorescence Resonance Energy Transfer (FRET) Sensors of the Orexin OX₁ and OX₂ Receptors Identify Slow Kinetics of Agonist Activation

Tian-Rui Xu, Richard J. Ward, John D. Pediani, Graeme Milligan

J Biol Chem. 2012 Apr 27; 287(18): 14937–14949. Published online 2012 Mar 2. doi: 10.1074/jbc.M111.334300

PMCID:: PMC3340242

Abstract Article PDF–3.3M

Select item 31994899.

Heteromultimerization of Cannabinoid CB₁ Receptor and Orexin OX₁ Receptor Generates a Unique Complex in Which Both Protomers Are Regulated by Orexin A

Richard J. Ward, John D. Pediani, Graeme Milligan

J Biol Chem. 2011 Oct 28; 286(43): 37414–37428. Published online 2011 Sep 9. doi: 10.1074/jbc.M111.287649

PMCID:: PMC3199489

Abstract Article PDF–4.2M

Select item 319764310.

Dynein Light Chain Tctex-Type 1 Modulates Orexin Signaling through Its Interaction with Orexin 1 Receptor

David Duguay, Erika Bélanger-Nelson, Valérie Mongrain, Anna Beben, Armen Khatchadourian, Nicolas Cermakian

PLoS One. 2011; 6(10): e26430. Published online 2011 Oct 20. doi: 10.1371/journal.pone.0026430

PMCID:: PMC3197643

Abstract Article PDF–1.0M

Select item 317805911.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 308951412.

Temporal Profiling of Orexin Receptor-Arrestin-Ubiquitin Complexes Reveals Differences between Receptor Subtypes

Matthew B. Dalrymple, Werner C. Jaeger, Karin A. Eidne, Kevin D. G. Pfleger

J Biol Chem. 2011 May 13; 286(19): 16726–16733. Published online 2011 Mar 4. doi: 10.1074/jbc.M111.223537

PMCID:: PMC3089514

Abstract Article PDF–1.2M

Select item 307249913.

Evidence for an association between migraine and the hypocretin receptor 1 gene

Innocenzo Rainero, Elisa Rubino, Salvatore Gallone, Pierpaola Fenoglio, Luigi Rocco Picci, Laura Giobbe, Luca Ostacoli, Lorenzo Pinessi

J Headache Pain. 2011 Apr; 12(2): 193–199. Published online 2011 Feb 23. doi: 10.1007/s10194-011-0314-8

PMCID:: PMC3072499

Abstract Article PDF–192K

Select item 296315414.

Association Study of 182 Candidate Genes in Anorexia Nervosa

Andrea Poyastro Pinheiro, Cynthia M. Bulik, Laura M. Thornton, Patrick F. Sullivan, Tammy L. Root, Cinnamon S. Bloss, Wade H. Berrettini, Nicholas J. Schork, Walter H. Kaye, Andrew W. Bergen, Pierre Magistretti, Harry Brandt, Steve Crawford, Scott Crow, Manfred M. Fichter, David Goldman, Katherine A. Halmi, Craig Johnson, Allan S. Kaplan, Pamela K. Keel, Kelly L. Klump, Maria La Via, James E. Mitchell, Michael Strober, Alessandro Rotondo, Janet Treasure, D. Blake Woodside

Am J Med Genet B Neuropsychiatr Genet. Author manuscript; available in PMC 2010 Oct 25.

Published in final edited form as: Am J Med Genet B Neuropsychiatr Genet. 2010 Jul; 153B(5): 1070–1080. doi: 10.1002/ajmg.b.31082

PMCID:: PMC2963154

Abstract Article PDF–315K

Select item 282336615.

Arachidonic acid release mediated by OX₁ orexin receptors

Pauli M Turunen, Marie E Ekholm, Pentti Somerharju, Jyrki P Kukkonen

Br J Pharmacol. 2010 Jan; 159(1): 212–221. Published online 2009 Dec 4. doi: 10.1111/j.1476-5381.2009.00535.x

PMCID:: PMC2823366

Abstract Article PDF–496K

Select item 254295816.

Hypocretin Receptor Expression in Canine and Murine Narcolepsy Models and in Hypocretin-Ligand Deficient Human Narcolepsy

Kazuo Mishima, Nobuhiro Fujiki, Yasushi Yoshida, Takeshi Sakurai, Makoto Honda, Emmanuel Mignot, Seiji Nishino

Sleep. 2008 Aug 1; 31(8): 1119–1126.

PMCID:: PMC2542958

Abstract Article PDF–605K

Select item 248824917.

Orexins Stimulate Steroidogenic Acute Regulatory Protein Expression through Multiple Signaling Pathways in Human Adrenal H295R Cells

Manjunath Ramanjaneya, Alex C. Conner, Jing Chen, Peter R. Stanfield, Harpal S. Randeva

Endocrinology. 2008 Aug; 149(8): 4106–4115. Published online 2008 May 1. doi: 10.1210/en.2007-1739

PMCID:: PMC2488249

Abstract Article

Select item 135612918.

Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes

Kouichi Kimura, Ai Wakamatsu, Yutaka Suzuki, Toshio Ota, Tetsuo Nishikawa, Riu Yamashita, Jun-ichi Yamamoto, Mitsuo Sekine, Katsuki Tsuritani, Hiroyuki Wakaguri, Shizuko Ishii, Tomoyasu Sugiyama, Kaoru Saito, Yuko Isono, Ryotaro Irie, Norihiro Kushida, Takahiro Yoneyama, Rie Otsuka, Katsuhiro Kanda, Takahide Yokoi, Hiroshi Kondo, Masako Wagatsuma, Katsuji Murakawa, Shinichi Ishida, Tadashi Ishibashi, Asako Takahashi-Fujii, Tomoo Tanase, Keiichi Nagai, Hisashi Kikuchi, Kenta Nakai, Takao Isogai, Sumio Sugano

Genome Res. 2006 Jan; 16(1): 55–65. doi: 10.1101/gr.4039406

PMCID:: PMC1356129

Abstract Article PDF–438K

Select item 13924119.

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

Mammalian Gene Collection (MGC) Program Team

Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26): 16899–16903. Published online 2002 Dec 11. doi: 10.1073/pnas.242603899

PMCID:: PMC139241

Abstract Article PDF–118K

Select item 1821320.

The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

L. de Lecea, T. S. Kilduff, C. Peyron, X.-B. Gao, P. E. Foye, P. E. Danielson, C. Fukuhara, E. L. F. Battenberg, V. T. Gautvik, F. S. Bartlett, II, W. N. Frankel, A. N. van den Pol, F. E. Bloom, K. M. Gautvik, J. G. Sutcliffe

Proc Natl Acad Sci U S A. 1998 Jan 6; 95(1): 322–327. doi: 10.1073/pnas.95.1.322

PMCID:: PMC18213

Abstract Article PDF–347K

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PMC Links for GEO Profiles (Select 20470289) (20)
PMC
219285[geneid] (1039)
ClinVar
LDHC lactate dehydrogenase C [Homo sapiens]
LDHC lactate dehydrogenase C [Homo sapiens]
Gene ID:3948

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Gene Links for GEO Profiles (Select 27116224) (1)
Gene
MRGPRX1 MAS related GPR family member X1 [Homo sapiens]
MRGPRX1 MAS related GPR family member X1 [Homo sapiens]
Gene ID:259249

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