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Items: 1 to 20 of 27

1.
UBXN2A suppresses the Rictor-mTORC2 signaling pathway, an established tumorigenic pathway in human colorectal cancer
Sanam Sane, Rekha Srinivasan, Rashaun A. Potts, Morgan Eikanger, Diana Zagirova, Jessica Freeling, Casey A. Reihe, Ryan M. Antony, Brij K Gupta, Douglas Lynch, Jonathan Bleeker, Hassan Turaihi, Angela Pillatzki, Wei Zhou, Xu Luo, Michael Linnebacher, Diing Agany, Etienne Gnimpieba Zohim, Lisa E. Humphrey, Adrian R. Black, Khosrow Rezvani
Oncogene. Author manuscript; available in PMC 2023 Jun 22.
Published in final edited form as: Oncogene. 2023 May; 42(21): 1763–1776. Published online 2023 Apr 10. doi: 10.1038/s41388-023-02686-7
PMCID:
PMC10287065
AbstractArticlePDF–3.4M
2.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
3.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
4.
UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP
Yanfen Teng, Khosrow Rezvani, Mariella De Biasi
Biochem Pharmacol. Author manuscript; available in PMC 2021 Jan 4.
Published in final edited form as: Biochem Pharmacol. 2015 Oct 15; 97(4): 518–530. Published online 2015 Aug 8. doi: 10.1016/j.bcp.2015.08.084
PMCID:
PMC7780642
AbstractArticlePDF–1.5M
5.
RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation
Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen
Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117
PMCID:
PMC7322067
AbstractArticlePDF–2.7M
6.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
7.
UBXN2A enhances CHIP‐mediated proteasomal degradation of oncoprotein mortalin‐2 in cancer cells
Sanam Sane, Andre Hafner, Rekha Srinivasan, Daniall Masood, John l. Slunecka, Collin J. Noldner, Alex D. Hanson, Taylor Kruisselbrink, Xuejun Wang, Yiyang Wang, Jun Yin, Khosrow Rezvani
Mol Oncol. 2018 Oct; 12(10): 1753–1777. Published online 2018 Sep 3. doi: 10.1002/1878-0261.12372
PMCID:
PMC6166003
AbstractArticlePDF–1.7M
8.
LuTHy: a double‐readout bioluminescence‐based two‐hybrid technology for quantitative mapping of protein–protein interactions in mammalian cells
Philipp Trepte, Sabrina Kruse, Simona Kostova, Sheila Hoffmann, Alexander Buntru, Anne Tempelmeier, Christopher Secker, Lisa Diez, Aline Schulz, Konrad Klockmeier, Martina Zenkner, Sabrina Golusik, Kirstin Rau, Sigrid Schnoegl, Craig C Garner, Erich E Wanker
Mol Syst Biol. 2018 Jul; 14(7): e8071. Published online 2018 Jul 11. doi: 10.15252/msb.20178071
PMCID:
PMC6039870
AbstractArticlePDF–2.1M
9.
AP-SWATH Reveals Direct Involvement of VCP/p97 in Integrated Stress Response Signaling Through Facilitating CReP/PPP1R15B Degradation
Julia Hülsmann, Bojana Kravic, Matthias Weith, Matthias Gstaiger, Ruedi Aebersold, Ben C. Collins, Hemmo Meyer
Mol Cell Proteomics. 2018 Jul; 17(7): 1295–1307. Published online 2018 Mar 29. doi: 10.1074/mcp.RA117.000471
PMCID:
PMC6030730
AbstractArticlePDF–3.8M
10.
Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches
Nathan Zuzow, Arit Ghosh, Marilyn Leonard, Jeffrey Liao, Bing Yang, Eric J. Bennett
Mol Biol Cell. 2018 May 15; 29(10): 1258–1269. doi: 10.1091/mbc.E17-12-0714
PMCID:
PMC5935074
AbstractArticlePDF–5.9M
11.
Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients
Pallav Bhatnagar, Shirley Purvis, Emily Barron-Casella, Michael R DeBaun, James F Casella, Dan E Arking, Jeffrey R Keefer
J Hum Genet. Author manuscript; available in PMC 2018 Feb 23.
Published in final edited form as: J Hum Genet. 2011 Apr; 56(4): 316–323. Published online 2011 Feb 17. doi: 10.1038/jhg.2011.12
PMCID:
PMC5825003
AbstractArticlePDF–1.5M
12.
RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination
Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello, Gracjan Michlewski
BMC Biol. 2017; 15: 105. Published online 2017 Nov 8. doi: 10.1186/s12915-017-0444-9
PMCID:
PMC5678581
AbstractArticlePDF–3.2M
13.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
14.
FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis
Feng Xie, Ke Jin, Li Shao, Yao Fan, Yifei Tu, Yihao Li, Bin Yang, Hans van Dam, Peter ten Dijke, Honglei Weng, Steven Dooley, Shuai Wang, Junling Jia, Jin Jin, Fangfang Zhou, Long Zhang
Nat Commun. 2017; 8: 15021. Published online 2017 Apr 26. doi: 10.1038/ncomms15021
PMCID:
PMC5414047
AbstractArticlePDF–4.4M
15.
Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers
Anup Arumughan, Yvette Roske, Carolin Barth, Laura Lleras Forero, Kenny Bravo-Rodriguez, Alexandra Redel, Simona Kostova, Erik McShane, Robert Opitz, Katja Faelber, Kirstin Rau, Thorsten Mielke, Oliver Daumke, Matthias Selbach, Elsa Sanchez-Garcia, Oliver Rocks, Daniela Panáková, Udo Heinemann, Erich E. Wanker
Nat Commun. 2016; 7: 13047. Published online 2016 Oct 20. doi: 10.1038/ncomms13047
PMCID:
PMC5080433
AbstractArticlePDF–3.2M
16.
Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy
Sanam Sane, Ammara Abdullah, Morgan E. Nelson, Hongmin Wang, Subhash C. Chauhan, Samuel S. Newton, Khosrow Rezvani
Cell Stress Chaperones. 2016 Mar; 21(2): 313–326. Published online 2015 Dec 4. doi: 10.1007/s12192-015-0661-5
PMCID:
PMC4786526
AbstractArticlePDF–1.5M
17.
A plant alkaloid, veratridine, potentiates cancer chemosensitivity by UBXN2A-dependent inhibition of an oncoprotein, mortalin-2
Ammara Abdullah, Sanam Sane, Kate A. Branick, Jessica L. Freeling, Hongmin Wang, Dong Zhang, Khosrow Rezvani
Oncotarget. 2015 Sep 15; 6(27): 23561–23581. Published online 2015 Jul 11. doi: 10.18632/oncotarget.4452
PMCID:
PMC4695137
AbstractArticlePDF–6.5M
18.
The BioPlex Network: A Systematic Exploration of the Human Interactome
Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2016 Jul 16.
Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043
PMCID:
PMC4617211
AbstractArticlePDF–2.2M
19.
Systematic VCP-UBXD Adaptor Network Proteomics Identifies a Role for UBXN10 in Regulating Ciliogenesis
Malavika Raman, Mikhail Sergeev, Maija Garnaas, John R. Lydeard, Edward L. Huttlin, Wolfram Goessling, Jagesh V. Shah, J. Wade Harper
Nat Cell Biol. Author manuscript; available in PMC 2016 Apr 1.
Published in final edited form as: Nat Cell Biol. 2015 Oct; 17(10): 1356–1369. Published online 2015 Sep 21. doi: 10.1038/ncb3238
Correction in:
Nat Cell Biol. 2016 Mar; 18(3): 347.
PMCID:
PMC4610257
AbstractArticlePDF–4.5M
20.
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells
S Sane, A Abdullah, D A Boudreau, R K Autenried, B K Gupta, X Wang, H Wang, E H Schlenker, D Zhang, C Telleria, L Huang, S C Chauhan, K Rezvani
Cell Death Dis. 2014 Mar; 5(3): e1118. Published online 2014 Mar 13. doi: 10.1038/cddis.2014.100
PMCID:
PMC3973214
AbstractArticlePDF–1.9M

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