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Select item 100911081.

N6‐methyladenosine‐modified DBT alleviates lipid accumulation and inhibits tumor progression in clear cell renal cell carcinoma through the ANXA2/YAP axis‐regulated Hippo pathway

Daojia Miao, Qi Wang, Jian Shi, Qingyang Lv, Diaoyi Tan, Chuanyi Zhao, Zhiyong Xiong, Xiaoping Zhang

Cancer Commun (Lond) 2023 Apr; 43(4): 480–502. Published online 2023 Mar 1. doi: 10.1002/cac2.12413

PMCID:: PMC10091108

Abstract Article PDF–5.5M

Select item 100471542.

Inhibition of Sphingosine Kinase 2 Results in PARK2-Mediated Mitophagy and Induces Apoptosis in Multiple Myeloma

Jian Wu, Shengjun Fan, Daniel Feinberg, Xiaobei Wang, Shaima Jabbar, Yubin Kang

Curr Oncol. 2023 Mar; 30(3): 3047–3063. Published online 2023 Mar 4. doi: 10.3390/curroncol30030231

PMCID:: PMC10047154

Abstract Article PDF–5.1M

Select item 99891533.

Sphingosine kinase 2 regulates insulin receptor trafficking in hepatocytes

Gulibositan Aji, Sheng Jiang, Halmurat Obulkasim, Zhiqiang Lu, Wei Wang, Pu Xia

Exp Biol Med (Maywood) 2023 Jan; 248(1): 44–51. Published online 2022 Nov 20. doi: 10.1177/15353702221131886

PMCID:: PMC9989153

Abstract Article PDF–1.7M

Select item 95685634.

Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation

Sang-A Park, Yun-Ji Lim, Wai Lim Ku, Dunfang Zhang, Kairong Cui, Liu-Ya Tang, Cheryl Chia, Peter Zanvit, Zuojia Chen, Wenwen Jin, Dandan Wang, Junji Xu, Ousheng Liu, Fu Wang, Alexander Cain, Nancy Guo, Hiroko Nakatsukasa, Chuan Wu, Ying E. Zhang, Keji Zhao, WanJun Chen

Nat Commun. 2022; 13: 6069. Published online 2022 Oct 14. doi: 10.1038/s41467-022-33733-8

PMCID:: PMC9568563

Abstract Article PDF–1.8M

Select item 94510605.

Enzymatic independent role of sphingosine kinase 2 in regulating the expression of type I interferon during influenza A virus infection

Mengqiong Xu, Sisi Xia, Mei Wang, Xiaolian Liu, Xin Li, Weijie Chen, Yaohao Wang, Hongjian Li, Chuan Xia, Jun Chen, Jianguo Wu

PLoS Pathog. 2022 Sep; 18(9): e1010794. Published online 2022 Sep 7. doi: 10.1371/journal.ppat.1010794

PMCID:: PMC9451060

Abstract Article PDF–3.6M

Select item 93947716.

Loss of sphingosine kinase 2 protects against cisplatin-induced kidney injury

Dengpiao Xie, Gaizun Hu, Chaoling Chen, Fereshteh Ahmadinejad, Weili Wang, Pin-Lan Li, David A. Gewirtz, Ningjun Li

Am J Physiol Renal Physiol. 2022 Sep 1; 323(3): F322–F334. Published online 2022 Jul 13. doi: 10.1152/ajprenal.00229.2021

PMCID:: PMC9394771

Abstract Article

Select item 92626147.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 85131258.

Vitamin D Binding Protein and Risk of Renal Cell Carcinoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO)

Tyler B. Kratzer, Stephanie J. Weinstein, Demetrius Albanes, Alison M. Mondul

Int J Cancer. Author manuscript; available in PMC 2021 Oct 13.

Published in final edited form as: Int J Cancer. 2020 Aug 1; 147(3): 669–674. Published online 2019 Nov 19. doi: 10.1002/ijc.32758

PMCID:: PMC8513125

Abstract Article PDF–93K

Select item 82926299.

Ubiquitination Destabilizes Protein Sphingosine Kinase 2 to Regulate Glioma Malignancy

Hongliang Wang, Bing Zhao, Erbao Bian, Gang Zong, Jie He, Yuyang Wang, Chunchun Ma, Jinghai Wan

Front Cell Neurosci. 2021; 15: 660354. Published online 2021 Jul 7. doi: 10.3389/fncel.2021.660354

PMCID:: PMC8292629

Abstract Article PDF–5.2M

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 800904811.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 784473012.

MicroRNA-338-3p Suppresses Proliferation of Human Liver Cancer Cells by Targeting SphK2

Geqiong Xiao, Qiong Wang, Bo Li, Xiaohui Wu, Hui Liao, Yili Ren, Ning Ai

Oncol Res. 2018; 26(8): 1183–1189. Published online 2018 Sep 14. doi: 10.3727/096504018X15151495109394

PMCID:: PMC7844730

Abstract Article PDF–14M

Select item 743788613.

Expression of clock gene Dbp in omental and mesenteric adipose tissue in patients with type 2 diabetes

Kentaro Ushijima, Chisato Suzuki, Hiroko Kitamura, Ken Shimada, Hirotoshi Kawata, Akira Tanaka, Hisanaga Horie, Yoshinori Hosoya, Yasushi Imai, Chikamasa Yamashita, Akio Fujimura

BMJ Open Diabetes Res Care. 2020; 8(1): e001465. Published online 2020 Aug 18. doi: 10.1136/bmjdrc-2020-001465

PMCID:: PMC7437886

Abstract Article PDF–1.8M

Select item 741552214.

Sphingosine kinase-2 is overexpressed in large granular lymphocyte leukemia and promotes survival through Mcl-1

Francis R LeBlanc, Jennifer M Pearson, Su-Fern Tan, HeeJin Cheon, Jeffrey C. Xing, Wendy Dunton, David J Feith, Thomas P Loughran, Jr

Br J Haematol. Author manuscript; available in PMC 2021 Aug 1.

Published in final edited form as: Br J Haematol. 2020 Aug; 190(3): 405–417. Published online 2020 Mar 2. doi: 10.1111/bjh.16530

PMCID:: PMC7415522

Abstract Article PDF–1.5M

Select item 741133415.

Inhibition of sphingosine kinase 2 attenuates hypertrophic scar formation via upregulation of Smad7 in human hypertrophic scar fibroblasts

Jian Zeng, Bin Jiang, Xia Xiao, Rou Zhang

Mol Med Rep. 2020 Sep; 22(3): 2573–2582. Published online 2020 Jul 9. doi: 10.3892/mmr.2020.11313

PMCID:: PMC7411334

Abstract Article PDF–1.2M

Select item 732206716.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 694919217.

β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P₂ modulation

Gennaro Bruno, Francesca Cencetti, Alessandro Pini, Annalisa Tondo, Daniela Cuzzubbo, Filippo Fontani, Vanessa Strinna, Anna Maria Buccoliero, Gabriella Casazza, Chiara Donati, Luca Filippi, Paola Bruni, Claudio Favre, Maura Calvani

Oncogene. 2020; 39(2): 368–384. Published online 2019 Sep 2. doi: 10.1038/s41388-019-0993-1

PMCID:: PMC6949192

Abstract Article PDF–6.6M

Select item 693812918.

Metabolic Adaptation of Airway Smooth Muscle Cells to an SPHK2 Substrate Precedes Cytostasis

Pascale Blais-Lecours, Sofien Laouafa, Christian Arias-Reyes, Webster L. Santos, Vincent Joseph, Janette K. Burgess, Andrew J. Halayko, Jorge Soliz, David Marsolais

Am J Respir Cell Mol Biol. 2020 Jan; 62(1): 35–42. doi: 10.1165/rcmb.2018-0397OC

PMCID:: PMC6938129

Abstract Article PDF–895K

Select item 668242619.

The Role of Sphingosine Kinase 2 in Alcoholic Liver Disease

Eric K. Kwong, Runping Liu, Derrick Zhao, Xiaojiaoyang Li, Weiwei Zhu, Xuan Wang, Emily C. Gurley, Guanhua Lai, Jimin Liu, Phillip B. Hylemon, Huiping Zhou

Dig Liver Dis. Author manuscript; available in PMC 2020 Aug 1.

Published in final edited form as: Dig Liver Dis. 2019 Aug; 51(8): 1154–1163. Published online 2019 Apr 16. doi: 10.1016/j.dld.2019.03.020

PMCID:: PMC6682426

Abstract Article PDF–1.4M

Select item 640456820.

Sphingosine kinase 2 promotes lipotoxicity in pancreatic β-cells and the progression of diabetes

Ziyu Song, Wei Wang, Ning Li, Sishan Yan, Kuan Rong, Tian Lan, Pu Xia

FASEB J. 2019 Mar; 33(3): 3636–3646. Published online 2018 Nov 19. doi: 10.1096/fj.201801496R

PMCID:: PMC6404568

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