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Items: 1 to 20 of 117

1.
Dual Role of NMDAR Containing NR2A and NR2B Subunits in Alzheimer’s Disease
Iu Raïch, Jaume Lillo, Joan Biel Rebassa, Toni Capó, Arnau Cordomí, Irene Reyes-Resina, Mercè Pallàs, Gemma Navarro
Int J Mol Sci. 2024 May; 25(9): 4757. Published online 2024 Apr 26. doi: 10.3390/ijms25094757
PMCID:
PMC11084423
AbstractArticlePDF–4.8M
2.
De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor
Yuchen Xu, Rui Song, Riley E. Perszyk, Wenjuan Chen, Sukhan Kim, Kristen L. Park, James P. Allen, Kelsey A. Nocilla, Jing Zhang, Wenshu XiangWei, Anel Tankovic, Ellington D. McDaniels, Rehan Sheikh, Ruth K. Mizu, Manish M. Karamchandani, Chun Hu, Hirofumi Kusumoto, Joseph Pecha, Gerarda Cappuccio, John Gaitanis, Jennifer Sullivan, Vandana Shashi, Slave Petrovski, Robin-Tobias Jauss, Hyun Kyung Lee, Xiuhua Bozarth, David R. Lynch, Ingo Helbig, Tyler Mark Pierson, Cornelius F. Boerkoel, Scott J. Myers, Johannes R. Lemke, Timothy A. Benke, Hongjie Yuan, Stephen F. Traynelis
Cell Mol Life Sci. 2024 Dec; 81(1): 153. Published online 2024 Mar 28. doi: 10.1007/s00018-023-05069-z
PMCID:
PMC10973091
AbstractArticlePDF–8.6M
3.
METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2
Weicheng Lu, Xiaohua Yang, Weiqiang Zhong, Guojun Chen, Xinqi Guo, Qingqing Ye, Yixin Xu, Zhenhua Qi, Yaqi Ye, Jingyun Zhang, Yuge Wang, Xintong Wang, Shu Wang, Qiyue Zhao, Weian Zeng, Junting Huang, Huijie Ma, Jingdun Xie
J Clin Invest. 2024 Mar 15; 134(6): e174847. Published online 2024 Feb 6. doi: 10.1172/JCI174847
PMCID:
PMC10940092
AbstractArticlePDF–13M
4.
Differential functional consequences of GRIN2A mutations associated with schizophrenia and neurodevelopmental disorders
Nate Shepard, David Baez-Nieto, Sumaiya Iqbal, Erkin Kurganov, Nikita Budnik, Arthur J. Campbell, Jen Q. Pan, Morgan Sheng, Zohreh Farsi
Sci Rep. 2024; 14: 2798. Published online 2024 Feb 2. doi: 10.1038/s41598-024-53102-3
PMCID:
PMC10837427
AbstractArticlePDF–4.3M
5.
Disease-associated nonsense and frame-shift variants resulting in the truncation of the GluN2A or GluN2B C-terminal domain decrease NMDAR surface expression and reduce potentiating effects of neurosteroids
Bohdan Kysilov, Viktor Kuchtiak, Barbora Hrcka Krausova, Ales Balik, Miloslav Korinek, Klevinda Fili, Mark Dobrovolski, Vera Abramova, Hana Chodounska, Eva Kudova, Paulina Bozikova, Jiri Cerny, Tereza Smejkalova, Ladislav Vyklicky
Cell Mol Life Sci. 2024 Dec; 81(1): 36. Published online 2024 Jan 12. doi: 10.1007/s00018-023-05062-6
PMCID:
PMC10786987
AbstractArticlePDF–4.8M
6.
GRIN2A (NR2A): a gene contributing to glutamatergic involvement in schizophrenia
Paul J. Harrison, David M. Bannerman
Mol Psychiatry. 2023; 28(9): 3568–3572. Published online 2023 Sep 22. doi: 10.1038/s41380-023-02265-y
PMCID:
PMC10730418
AbstractArticlePDF–541K
7.
Functional effects of disease-associated variants reveal that the S1–M1 linker of the NMDA receptor critically controls channel opening
Lingling Xie, Miranda J. McDaniel, Riley E. Perszyk, Sukhan Kim, Gerarda Cappuccio, Kevin A. Shapiro, Beatriz Muñoz-Cabello, Pedro A. Sanchez-Lara, Katheryn Grand, Jing Zhang, Kelsey A. Nocilla, Rehan Sheikh, Lluis Armengol, Roberta Romano, Tyler Mark Pierson, Hongjie Yuan, Scott J. Myers, Stephen F. Traynelis
Cell Mol Life Sci. 2023 Apr; 80(4): 110. Published online 2023 Mar 31. doi: 10.1007/s00018-023-04705-y
PMCID:
PMC10641759
AbstractArticlePDF–5.3M
8.
NMDA receptor genetics: The power of paralog homology and protein dynamics in defining dominant genetic variants.
Jacob G Charron, Angel Hernandez, Stephanie M Bilinovich, Daniel L Vogt, Laura A Bedinger, Laurie H Seaver, Michael Williams, Seth Devries, Daniel B Campbell, Caleb P Bupp, Jeremy W Prokop
Am J Med Genet A. Author manuscript; available in PMC 2023 Sep 1.
Published in final edited form as: Am J Med Genet A. 2022 Feb; 188(2): 556–568. Published online 2021 Nov 2. doi: 10.1002/ajmg.a.62554
PMCID:
PMC10472328
AbstractArticlePDF–2.0M
9.
Children with Early-Onset Psychosis Have Increased Burden of Rare GRIN2A Variants
Margaret A. Hojlo, Merhawi Ghebrelul, Casie A. Genetti, Richard Smith, Shira Rockowitz, Emma Deaso, Alan H. Beggs, Pankaj B. Agrawal, David C. Glahn, Joseph Gonzalez-Heydrich, Catherine A. Brownstein
Genes (Basel) 2023 Apr; 14(4): 779. Published online 2023 Mar 23. doi: 10.3390/genes14040779
PMCID:
PMC10138040
AbstractArticlePDF–279K
10.
Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs
Tsung-Han Chou, Hyunook Kang, Noriko Simorowski, Stephen F. Traynelis, Hiro Furukawa
Mol Cell. Author manuscript; available in PMC 2023 Dec 1.
Published in final edited form as: Mol Cell. 2022 Dec 1; 82(23): 4548–4563.e4. Published online 2022 Oct 28. doi: 10.1016/j.molcel.2022.10.008
PMCID:
PMC9722627
AbstractArticlePDF–3.3M
11.
SAPAP3 regulates epileptic seizures involving GluN2A in post-synaptic densities
Yanke Zhang, Junhong Wu, Yin Yan, Yixue Gu, Yuanlin Ma, Min Wang, Hui Zhang, Kaiyan Tao, Yang Lü, Weihua Yu, Wei Jing, Xuefeng Wang, Xin Tian
Cell Death Dis. 2022 May; 13(5): 437. Published online 2022 May 5. doi: 10.1038/s41419-022-04876-9
PMCID:
PMC9072407
AbstractArticlePDF–5.1M
12.
Common synaptic phenotypes arising from diverse mutations in the human NMDA receptor subunit GluN2A
Marwa Elmasri, Daniel William Hunter, Giles Winchester, Ella Emine Bates, Wajeeha Aziz, Does Moolenaar Van Der Does, Eirini Karachaliou, Kenji Sakimura, Andrew. Charles Penn
Commun Biol. 2022; 5: 174. Published online 2022 Feb 28. doi: 10.1038/s42003-022-03115-3
PMCID:
PMC8885697
AbstractArticlePDF–5.1M
13.
N-Methyl-d-aspartic Acid (NMDA) Receptor Is Involved in the Inhibitory Effect of Ketamine on Human Sperm Functions
Ying Chen, Wenqing Xu, Yuan Yuan, Houyang Chen, Shuangyan Zheng, Yuanqiao He, Tao Luo
Int J Mol Sci. 2021 Nov; 22(22): 12370. Published online 2021 Nov 16. doi: 10.3390/ijms222212370
PMCID:
PMC8622018
AbstractArticlePDF–2.7M
14.
Recurrent seizure‐related GRIN1 variant: Molecular mechanism and targeted therapy
Yuchen Xu, Rui Song, Wenjuan Chen, Katie Strong, Daniel Shrey, Satyanarayana Gedela, Stephen F. Traynelis, Guojun Zhang, Hongjie Yuan
Ann Clin Transl Neurol. 2021 Jul; 8(7): 1480–1494. Published online 2021 Jul 6. doi: 10.1002/acn3.51406
PMCID:
PMC8283169
AbstractArticlePDF–5.1M
15.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
16.
Conformational rearrangement of the NMDA receptor amino-terminal domain during activation and allosteric modulation
Vojtech Vyklicky, Cherise Stanley, Chris Habrian, Ehud Y. Isacoff
Nat Commun. 2021; 12: 2694. Published online 2021 May 11. doi: 10.1038/s41467-021-23024-z
PMCID:
PMC8113580
AbstractArticlePDF–1.2M
17.
Leptin modulates pancreatic β-cell membrane potential through Src kinase–mediated phosphorylation of NMDA receptors
Veronica A. Cochrane, Yi Wu, Zhongying Yang, Assmaa ElSheikh, Jeremy Dunford, Paul Kievit, Dale A. Fortin, Show-Ling Shyng
J Biol Chem. 2020 Dec 11; 295(50): 17281–17297. Published online 2020 Oct 9. doi: 10.1074/jbc.RA120.015489
PMCID:
PMC7863909
AbstractArticlePDF–2.2M
18.
Exploratory study of selected nucleotide variants in GRIN1, GRIN2A and GRIN2B encoding subunits of the NMDA receptor in a targeted group of schizophrenia patients with chronic cognitive impairment
Marek Krzystanek, Marek Asman, Joanna Witecka, Artur Pałasz, Ryszard Wiaderkiewicz
Pharmacol Rep. 2021; 73(1): 269–277. Published online 2020 Nov 25. doi: 10.1007/s43440-020-00192-1
PMCID:
PMC7862516
AbstractArticlePDF–2.0M
19.
Selected single-nucleotide variants in GRIN1, GRIN2A, and GRIN2B encoding subunits of the NMDA receptor are not biomarkers of schizophrenia resistant to clozapine: exploratory study
Marek Krzystanek, Marek Asman, Joanna Witecka, Artur Pałasz, Ryszard Wiaderkiewicz
Pharmacol Rep. 2021; 73(1): 309–315. Published online 2020 Oct 6. doi: 10.1007/s43440-020-00165-4
PMCID:
PMC7862503
AbstractArticlePDF–678K
20.
mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia
Hoau-Yan Wang, Mathew L. MacDonald, Karin E. Borgmann-Winter, Anamika Banerjee, Patrick Sleiman, Andrew Tom, Amber Khan, Kuo-Chieh Lee, Panos Roussos, Steven J. Siegel, Scott E Hemby, Warren B. Bilker, Raquel E. Gur, Chang-Gyu Hahn
Mol Psychiatry. Author manuscript; available in PMC 2020 Sep 18.
Published in final edited form as: Mol Psychiatry. 2020 Apr; 25(4): 750–760. Published online 2018 Sep 13. doi: 10.1038/s41380-018-0234-y
PMCID:
PMC7500805
AbstractArticlePDF–1.2M

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