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Items: 1 to 20 of 97

1.
BTK and PLCG2 remain unmutated in one-third of patients with CLL relapsing on ibrutinib
Silvia Bonfiglio, Lesley-Ann Sutton, Viktor Ljungström, Antonella Capasso, Tatjana Pandzic, Simone Weström, Hassan Foroughi-Asl, Aron Skaftason, Anna Gellerbring, Anna Lyander, Francesca Gandini, Gianluca Gaidano, Livio Trentin, Lisa Bonello, Gianluigi Reda, Csaba Bödör, Niki Stavroyianni, Constantine S. Tam, Roberto Marasca, Francesco Forconi, Panayiotis Panayiotidis, Ingo Ringshausen, Ozren Jaksic, Anna Maria Frustaci, Sunil Iyengar, Marta Coscia, Stephen P. Mulligan, Loïc Ysebaert, Vladimir Strugov, Carolina Pavlovsky, Renata Walewska, Anders Österborg, Diego Cortese, Pamela Ranghetti, Panagiotis Baliakas, Kostas Stamatopoulos, Lydia Scarfò, Richard Rosenquist, Paolo Ghia
Blood Adv. 2023 Jun 27; 7(12): 2794–2806. Published online 2023 Jan 31. doi: 10.1182/bloodadvances.2022008821
PMCID:
PMC10279547
AbstractArticlePDF–430K
2.
Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell
Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low
Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120
PMCID:
PMC10151615
AbstractArticlePDF–2.9M
3.
Carriers of the p.P522R variant in PLCγ2 have a slightly more responsive immune system
Annieck M. Diks, Cristina Teodosio, Bas de Mooij, Rick J. Groenland, Brigitta A. E. Naber, Inge F. de Laat, Sandra A. Vloemans, Susan Rohde, Marien I. de Jonge, Linda Lorenz, Debbie Horsten, Jacques J. M. van Dongen, Magdalena A. Berkowska, Henne Holstege
Mol Neurodegener. 2023; 18: 25. Published online 2023 Apr 20. doi: 10.1186/s13024-023-00604-9
PMCID:
PMC10116473
AbstractArticlePDF–3.0M
4.
The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia
Sadek Amhaz, Batiste Boëda, Mouna Chouchène, Sabrina Colasse, Florent Dingli, Damarys Loew, Julien Henri, Céline Prunier, Laurence Levy
BMC Biol. 2023; 21: 73. Published online 2023 Apr 7. doi: 10.1186/s12915-023-01576-4
PMCID:
PMC10080908
AbstractArticlePDF–3.2M
5.
The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model
Christel Claes, Whitney E. England, Emma P. Danhash, Sepideh Kiani Shabestari, Amit Jairaman, Jean Paul Chadarevian, Jonathan Hasselmann, Andy P. Tsai, Morgan A. Coburn, Jessica Sanchez, Tau En Lim, Jorge L. S. Hidalgo, Christina Tu, Michael D. Cahalan, Bruce T. Lamb, Gary E. Landreth, Robert C. Spitale, Mathew Blurton‐Jones, Hayk Davtyan
Alzheimers Dement. 2022 Oct; 18(10): 1765–1778. Published online 2022 Feb 9. doi: 10.1002/alz.12577
PMCID:
PMC9360195
AbstractArticlePDF–4.7M
6.
HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis
Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai
Nat Commun. 2022; 13: 4355. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32034-4
PMCID:
PMC9338313
AbstractArticlePDF–2.8M
7.
Heterozygous expression of the Alzheimer’s disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses
Shiden Solomon, Nirmal Kumar Sampathkumar, Ivo Carre, Mrityunjoy Mondal, George Chennell, Anthony C. Vernon, Marc-David Ruepp, Jacqueline C Mitchell
Cell Mol Life Sci. 2022 Aug; 79(8): 453. Published online 2022 Jul 27. doi: 10.1007/s00018-022-04473-1
PMCID:
PMC9329165
AbstractArticlePDF–2.7M
8.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
9.
Physical and functional interactome atlas of human receptor tyrosine kinases
Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo
EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041
PMCID:
PMC9171411
AbstractArticlePDF–1.9M
10.
Mechanisms of Resistance to Noncovalent Bruton’s Tyrosine Kinase Inhibitors
Eric Wang, Xiaoli Mi, Meghan C. Thompson, Skye Montoya, Ryan Q. Notti, Jumana Afaghani, Benjamin H. Durham, Alex Penson, Matthew T. Witkowski, Sydney X. Lu, Jessie Bourcier, Simon J. Hogg, Caroline Erickson, Dan Cui, Hana Cho, Michael Singer, Tulasigeri M. Totiger, Sana Chaudhry, Mark Geyer, Alvaro Alencar, Adam J. Linley, M. Lia Palomba, Catherine C. Coombs, Jae H. Park, Andrew Zelenetz, Lindsey Roeker, Mary Rosendahl, Donald E. Tsai, Kevin Ebata, Barbara Brandhuber, David M. Hyman, Iannis Aifantis, Anthony Mato, Justin Taylor, Omar Abdel-Wahab
N Engl J Med. Author manuscript; available in PMC 2022 May 6.
Published in final edited form as: N Engl J Med. 2022 Feb 24; 386(8): 735–743. doi: 10.1056/NEJMoa2114110
PMCID:
PMC9074143
AbstractArticlePDF–1014K
11.
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy
Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang
Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003
PMCID:
PMC8897022
AbstractArticlePDF–3.0M
12.
PLCG2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer’s disease
Andy P. Tsai, Chuanpeng Dong, Peter Bor-Chian Lin, Evan J. Messenger, Brad T. Casali, Miguel Moutinho, Yunlong Liu, Adrian L. Oblak, Bruce T. Lamb, Gary E. Landreth, Stephanie J. Bissel, Kwangsik Nho
Genome Med. 2022; 14: 17. Published online 2022 Feb 18. doi: 10.1186/s13073-022-01022-0
PMCID:
PMC8857783
AbstractArticlePDF–3.0M
13.
Low BACH2 Expression Predicts Adverse Outcome in Chronic Lymphocytic Leukaemia
Carmela Ciardullo, Katarzyna Szoltysek, Peixun Zhou, Monika Pietrowska, Lukasz Marczak, Elaine Willmore, Amir Enshaei, Anna Walaszczyk, Jia Yee Ho, Vikki Rand, Scott Marshall, Andrew G. Hall, Christine J. Harrison, Meera Soundararajan, Jeyanthy Eswaran
Cancers (Basel) 2022 Jan; 14(1): 23. Published online 2021 Dec 21. doi: 10.3390/cancers14010023
PMCID:
PMC8750551
AbstractArticlePDF–2.8M
14.
Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer
Joseph M Chan, Álvaro Quintanal-Villalonga, Vianne Ran Gao, Yubin Xie, Viola Allaj, Ojasvi Chaudhary, Ignas Masilionis, Jacklynn Egger, Andrew Chow, Thomas Walle, Marissa Mattar, Dig VK Yarlagadda, James L. Wang, Fathema Uddin, Michael Offin, Metamia Ciampricotti, Besnik Qeriqi, Amber Bahr, Elisa de Stanchina, Umesh K Bhanot, W Victoria Lai, Matthew J Bott, David R Jones, Arvin Ruiz, Marina K. Baine, Yanyun Li, Natasha Rekhtman, John T Poirier, Tal Nawy, Triparna Sen, Linas Mazutis, Travis Hollmann, Dana Pe’er, Charles M Rudin
Cancer Cell. Author manuscript; available in PMC 2022 Nov 8.
Published in final edited form as: Cancer Cell. 2021 Nov 8; 39(11): 1479–1496.e18. Published online 2021 Oct 14. doi: 10.1016/j.ccell.2021.09.008
PMCID:
PMC8628860
AbstractArticlePDF–5.3M
15.
Phospholipase Cγ2 regulates endocannabinoid and eicosanoid networks in innate immune cells
Hui Jing, Alex Reed, Olesya A. Ulanovskaya, Jan-Sebastian Grigoleit, Dylan M. Herbst, Cassandra L. Henry, Haoxin Li, Sabrina Barbas, Jason Germain, Kim Masuda, Benjamin F. Cravatt
Proc Natl Acad Sci U S A. 2021 Oct 12; 118(41): e2112971118. Published online 2021 Oct 4. doi: 10.1073/pnas.2112971118
PMCID:
PMC8522274
AbstractArticlePDF–2.3M
16.
PLCγ2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophages
Juliane Obst, Hazel L. Hall-Roberts, Thomas B. Smith, Mira Kreuzer, Lorenza Magno, Elena Di Daniel, John B. Davis, Emma Mead
Sci Rep. 2021; 11: 19842. Published online 2021 Oct 6. doi: 10.1038/s41598-021-96144-7
PMCID:
PMC8494732
AbstractArticlePDF–7.2M
17.
The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration
Jacob T. Jackson, Elisabeth Mulazzani, Stephen L. Nutt, Seth L. Masters
J Biol Chem. 2021 Aug; 297(2): 100905. Published online 2021 Jun 19. doi: 10.1016/j.jbc.2021.100905
PMCID:
PMC8318911
AbstractArticlePDF–1.5M
18.
Case Report: A Rare Case of Autoinflammatory Phospholipase Cγ2 (PLCγ2)-Associated Antibody Deficiency and Immune Dysregulation Complicated With Gangrenous Pyoderma and Literature Review
Na Wu, Bingqing Zhang, Tao Wang, Min Shen, Xuejun Zeng
Front Immunol. 2021; 12: 667430. Published online 2021 May 19. doi: 10.3389/fimmu.2021.667430
PMCID:
PMC8170136
AbstractArticlePDF–12M
19.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
20.
TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation
Lorenza Magno, Tom D. Bunney, Emma Mead, Fredrik Svensson, Magda N. Bictash
Mol Neurodegener. 2021; 16: 22. Published online 2021 Apr 6. doi: 10.1186/s13024-021-00436-5
PMCID:
PMC8022522
AbstractArticlePDF–1.4M

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