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Select item 107816801.

TRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma

Donghee Kang, Hyun Jung Hwang, Yurim Baek, Jee Young Sung, KyeongJin Kim, Heon Joo Park, Young-Gyu Ko, Yong-Nyun Kim, Jae-Seon Lee

Cell Death Dis. 2024 Jan; 15(1): 26. Published online 2024 Jan 10. doi: 10.1038/s41419-024-06427-w

PMCID:: PMC10781680

Abstract Article PDF–2.7M

Select item 96648182.

PHLPP isoforms differentially regulate Akt isoforms and AS160 affecting neuronal insulin signaling and insulin resistance via Scribble

Medha Sharma, Chinmoy Sankar Dey

Cell Commun Signal. 2022; 20: 179. Published online 2022 Nov 14. doi: 10.1186/s12964-022-00987-0

PMCID:: PMC9664818

Abstract Article PDF–3.9M

Select item 89904673.

Mutant p53 achieved Gain-of-Function by promoting tumor growth and immune escape through PHLPP2/AKT/PD-L1 pathway

Nannan Liu, Xinxiu Jiang, Leiming Guo, Chuchu Zhang, Meimei Jiang, Zhuoran Sun, Yizheng Zhang, Wunan Mi, Jiehan Li, Yang Fu, Feng Wang, Lingling Zhang, Yingjie Zhang

Int J Biol Sci. 2022; 18(6): 2419–2438. Published online 2022 Mar 14. doi: 10.7150/ijbs.67200

PMCID:: PMC8990467

Abstract Article PDF–4.2M

Select item 89692174.

MiR-509-3p is oncogenic, targets the tumor suppressor PHLPP2, and functions as a novel tumor adjacent normal tissue based prognostic biomarker in colorectal cancer

Deepak Narayanan Iyer, Dominic Chi-Chung Foo, Oswens Siu-Hung Lo, Timothy Ming-Hun Wan, Xue Li, Ryan Wai-Yan Sin, Roberta Wen-Chi Pang, Wai-Lun Law, Lui Ng

BMC Cancer. 2022; 22: 351. Published online 2022 Mar 31. doi: 10.1186/s12885-021-09075-x

PMCID:: PMC8969217

Abstract Article PDF–2.8M

Select item 89679065.

TRIM46 activates AKT/HK2 signaling by modifying PHLPP2 ubiquitylation to promote glycolysis and chemoresistance of lung cancer cells

Jicheng Tantai, Xufeng Pan, Yong Chen, Yuzhou Shen, Chunyu Ji

Cell Death Dis. 2022 Mar; 13(3): 285. Published online 2022 Mar 30. doi: 10.1038/s41419-022-04727-7

PMCID:: PMC8967906

Abstract Article PDF–4.6M

Select item 89311766.

Integrated Analysis of Ulcerative Colitis Revealed an Association between PHLPP2 and Immune Infiltration

Ting Li, Weidong Liu, Wenjia Hui, Tian Shi, Huan Liu, Yan Feng, Feng Gao

Dis Markers. 2022; 2022: 4983471. Published online 2022 Mar 16. doi: 10.1155/2022/4983471

PMCID:: PMC8931176

Abstract Article PDF–1.0M

Select item 85235187.

Downregulation of PHLPP induced by endoplasmic reticulum stress promotes eIF2α phosphorylation and chemoresistance in colon cancer

Bianqin Guo, Xiaopeng Xiong, Sumati Hasani, Yang-An Wen, Austin T. Li, Rebecca Martinez, Ashley T. Skaggs, Tianyan Gao

Cell Death Dis. 2021 Nov; 12(11): 960. Published online 2021 Oct 18. doi: 10.1038/s41419-021-04251-0

PMCID:: PMC8523518

Abstract Article PDF–2.5M

Select item 84904658.

Phosphatase PHLPP2 regulates the cellular response to metabolic stress through AMPK

Yan Yan, Karl N. Krecke, Aditi S. Bapat, Tingyuan Yang, Michael W. Lopresti, Douglas G. Mashek, Ameeta Kelekar

Cell Death Dis. 2021 Oct; 12(10): 904. Published online 2021 Oct 4. doi: 10.1038/s41419-021-04196-4

PMCID:: PMC8490465

Abstract Article PDF–1.7M

Select item 84210189.

Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes

Blaz Lupse, Karthika Annamalai, Hazem Ibrahim, Supreet Kaur, Shirin Geravandi, Bhavishya Sarma, Anasua Pal, Sushil Awal, Arundhati Joshi, Sahar Rafizadeh, Murali Krishna Madduri, Mona Khazaei, Huan Liu, Ting Yuan, Wei He, Kanaka Durga Devi Gorrepati, Zahra Azizi, Qi Qi, Keqiang Ye, Jose Oberholzer, Kathrin Maedler, Amin Ardestani

Cell Rep. Author manuscript; available in PMC 2021 Sep 6.

Published in final edited form as: Cell Rep. 2021 Aug 3; 36(5): 109490. doi: 10.1016/j.celrep.2021.109490

PMCID:: PMC8421018

Abstract Article PDF–3.1M

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 807872111.

Oncogenic role of MIR516A in human bladder cancer was mediated by its attenuating PHLPP2 expression and BECN1-dependent autophagy

Honglei Jin, Jiugao Ma, Jiheng Xu, Hongyan Li, Yuanyuan Chang, Nan Zang, Zhongxian Tian, Xin Wang, Nannan Zhao, Lu Liu, Caiyi Chen, Qipeng Xie, Yongyong Lu, Zhouxi Fang, Xing Huang, Chuanshu Huang, Haishan Huang

Autophagy. 2021; 17(4): 840–854. Published online 2020 Mar 1. doi: 10.1080/15548627.2020.1733262

PMCID:: PMC8078721

Abstract Article PDF–4.0M

Select item 778207412.

SIK2 represses AKT/GSK3β/β‐catenin signaling and suppresses gastric cancer by inhibiting autophagic degradation of protein phosphatases

Xiao‐man Dai, Yan‐hui Zhang, Xiao‐han Lin, Xiao‐xing Huang, Yi Zhang, Chao‐rong Xue, Wan‐nan Chen, Jian‐xin Ye, Xin‐jian Lin, Xu Lin

Mol Oncol. 2021 Jan; 15(1): 228–245. Published online 2020 Nov 20. doi: 10.1002/1878-0261.12838

PMCID:: PMC7782074

Abstract Article PDF–5.2M

Select item 751204813.

HAND2-AS1 Works as a ceRNA of miR-3118 to Suppress Proliferation and Migration in Breast Cancer by Upregulating PHLPP2

Guolei Dong, Xiaorui Wang, Yan Jia, Yongsheng Jia, Weipeng Zhao, Jin Zhang, Zhongsheng Tong

Biomed Res Int. 2020; 2020: 8124570. Published online 2020 Sep 14. doi: 10.1155/2020/8124570

PMCID:: PMC7512048

Abstract Article PDF–3.7M

Select item 737786614.

PHLPP2 is regulated by competing endogenous RNA network in pathogenesis of colon cancer

Hong-Kun Wu, Chang Liu, Xin-Xing Li, Wei Ji, Chen-De Xin, Zhi-Qian Hu, Lin Zhou

Aging (Albany NY) 2020 Jul 15; 12(13): 12812–12840. Published online 2020 Jul 7. doi: 10.18632/aging.103246

PMCID:: PMC7377866

Abstract Article PDF–4.3M

Select item 682591615.

PHLPP2 as a novel metastatic and prognostic biomarker in non‐small cell lung cancer patients

Hongmei Wang, Ruixue Gu, Fanglin Tian, Yuechao Liu, Weina Fan, Guiqin Xue, Li Cai, Ying Xing

Thorac Cancer. 2019 Nov; 10(11): 2124–2132. Published online 2019 Sep 30. doi: 10.1111/1759-7714.13196

PMCID:: PMC6825916

Abstract Article PDF–3.3M

Select item 665359316.

Identification and development of long non‐coding RNA‐associated regulatory network in colorectal cancer

Hongda Pan, Jingxin Pan, Shibo Song, Lei Ji, Hong Lv, Zhangru Yang

J Cell Mol Med. 2019 Aug; 23(8): 5200–5210. Published online 2019 May 29. doi: 10.1111/jcmm.14395

PMCID:: PMC6653593

Abstract Article PDF–1.8M

Select item 620232817.

PHLPP2 stabilization by p27 mediates its inhibition of bladder cancer invasion by promoting autophagic degradation of MMP2 protein

Minggang Peng, Jingjing Wang, Dongyun Zhang, Honglei Jin, Jingxia Li, Xue-Ru Wu, Chuanshu Huang

Oncogene. 2018; 37(43): 5735–5748. Published online 2018 Jun 21. doi: 10.1038/s41388-018-0374-1

PMCID:: PMC6202328

Abstract Article PDF–2.8M

Select item 583958518.

Identification of proteins interacting with the mitochondrial small heat shock protein Hsp22 of Drosophila melanogaster: Implication in mitochondrial homeostasis

Afrooz Dabbaghizadeh, Geneviève Morrow, Yasmine Ould Amer, Etienne Hebert Chatelain, Nicolas Pichaud, Robert M. Tanguay

PLoS One. 2018; 13(3): e0193771. Published online 2018 Mar 6. doi: 10.1371/journal.pone.0193771

PMCID:: PMC5839585

Abstract Article PDF–15M

Select item 582692619.

VIRMA mediates preferential m⁶A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

Yanan Yue, Jun Liu, Xiaolong Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu

Cell Discov. 2018; 4: 10. Published online 2018 Feb 27. doi: 10.1038/s41421-018-0019-0

PMCID:: PMC5826926

Abstract Article PDF–2.3M

Select item 578357220.

PHLPPing through History: A Decade in the Life of PHLPP Phosphatases

Agnieszka T. Grzechnik, Alexandra C. Newton

Biochem Soc Trans. Author manuscript; available in PMC 2018 Jan 24.

Published in final edited form as: Biochem Soc Trans. 2016 Dec 15; 44(6): 1675–1682. doi: 10.1042/BST20160170

PMCID:: PMC5783572

Abstract Article PDF–503K

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PHB2 prohibitin 2 [Homo sapiens]
PHB2 prohibitin 2 [Homo sapiens]
Gene ID:11331

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Srd5a1 steroid 5 alpha-reductase 1 [Mus musculus]
Srd5a1 steroid 5 alpha-reductase 1 [Mus musculus]
Gene ID:78925

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