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Items: 1 to 20 of 98

1.
Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by DNA minor groove anchor competition
Wataru Kobayashi, Anna H. Sappler, Daniel Bollschweiler, Maximilian Kümmecke, Jérôme Basquin, Eda Nur Arslantas, Siwat Ruangroengkulrith, Renate Hornberger, Karl Duderstadt, Kikuë Tachibana
Nat Struct Mol Biol. 2024; 31(5): 757–766. Published online 2024 Feb 26. doi: 10.1038/s41594-024-01239-0
PMCID:
PMC11102866
AbstractArticlePDF–16M
2.
Aberrant phosphorylation of human LRH1 at serine 510 is predictable of hepatocellular carcinoma recurrence
Atsushi Nishimagi, Makoto Kobayashi, Kotaro Sugimoto, Yasuhide Kofunato, Naoya Sato, Junichiro Haga, Teruhide Ishigame, Takashi Kimura, Akira Kenjo, Yasuyuki Kobayashi, Yuko Hashimoto, Shigeru Marubashi, Hideki Chiba
Clin Exp Med. 2023; 23(8): 4985–4995. Published online 2023 Jun 7. doi: 10.1007/s10238-023-01098-x
PMCID:
PMC10725388
AbstractArticlePDF–3.8M
3.
Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia
Rizaldy C. Zapata, Dinghong Zhang, Avraham Libster, Alessandra Porcu, Patricia Montilla-Perez, Aisha Nur, Baijie Xu, Zhi Zhang, Stephanie M. Correa, Chen Liu, Francesca Telese, Olivia Osborn
Mol Psychiatry. 2023; 28(5): 1857–1867. Published online 2023 Feb 10. doi: 10.1038/s41380-023-01981-9
PMCID:
PMC10412731
AbstractArticlePDF–1.6M
4.
LRH1 promotes pancreatic cancer metastasis
Qiushi Lin, Arihiro Aihara, Waihong Chung, Yu Li, Xuesong Chen, Zheping Huang, Shaofan Weng, Rolf I. Carlson, Christina Nadolny, Jack R. Wands, Xiaoqun Dong
Cancer Lett. Author manuscript; available in PMC 2023 Apr 3.
Published in final edited form as: Cancer Lett. 2014 Aug 1; 350(1-2): 15–24. Published online 2014 Apr 24. doi: 10.1016/j.canlet.2014.04.017
PMCID:
PMC10068836
AbstractArticlePDF–3.8M
5.
A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets
Yadi Zhou, Yuan Liu, Shagun Gupta, Mauricio I. Paramo, Yuan Hou, Chengsheng Mao, Yuan Luo, Julius Judd, Shayne Wierbowski, Marta Bertolotti, Mriganka Nerkar, Lara Jehi, Nir Drayman, Vlad Nicolaescu, Haley Gula, Savaş Tay, Glenn Randall, Peihui Wang, John T. Lis, Cédric Feschotte, Serpil C. Erzurum, Feixiong Cheng, Haiyuan Yu
Nat Biotechnol. Author manuscript; available in PMC 2023 Jan 20.
Published in final edited form as: Nat Biotechnol. 2023 Jan; 41(1): 128–139. Published online 2022 Oct 10. doi: 10.1038/s41587-022-01474-0
PMCID:
PMC9851973
AbstractArticlePDF–4.0M
6.
MicroRNA‐433‐3p enhances chemosensitivity of glioma to cisplatin by downregulating NR5A2
Jun Li, Jingshun Gu, Juntong Wang, Aiwu You, Yuyan Zhang, Guomin Rao, Shuang Li, Xuehua Ge, Kun Zhang, Dongchun Wang
Brain Behav. 2022 Dec; 12(12): e2632. Published online 2022 Oct 27. doi: 10.1002/brb3.2632
PMCID:
PMC9759127
AbstractArticlePDF–2.4M
7.
LRH‐1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance
Svenja Michalek, Thomas Goj, Anna Pia Plazzo, Blerim Marovca, Beat Bornhauser, Thomas Brunner
EMBO Rep. 2022 Sep; 23(9): e54195. Published online 2022 Jul 8. doi: 10.15252/embr.202154195
PMCID:
PMC9442305
AbstractArticlePDF–3.8M
8.
NF-κB Regulation of LRH-1 and ABCG5/8 Potentiates Phytosterol Role in the Pathogenesis of Parenteral Nutrition–Associated Cholestasis
Swati Ghosh, Michael W. Devereaux, Aimee L. Anderson, Sarah Gehrke, Julie A. Reisz, Angelo D’Alessandro, David J. Orlicky, Mark Lovell, Karim C. El Kasmi, Colin T. Shearn, Ronald J. Sokol
Hepatology. Author manuscript; available in PMC 2022 Dec 1.
Published in final edited form as: Hepatology. 2021 Dec; 74(6): 3284–3300. Published online 2021 Aug 27. doi: 10.1002/hep.32071
PMCID:
PMC8639620
AbstractArticlePDF–1.8M
9.
Nuclear receptor NR5A2 negatively regulates cell proliferation and tumor growth in nervous system malignancies
Dimitrios Gkikas, Dimitris Stellas, Alexia Polissidis, Theodora Manolakou, Maroula G. Kokotou, George Kokotos, Panagiotis K. Politis
Proc Natl Acad Sci U S A. 2021 Sep 28; 118(39): e2015243118. Published online 2021 Sep 24. doi: 10.1073/pnas.2015243118
PMCID:
PMC8488649
AbstractArticlePDF–2.6M
10.
Impact of cytosine methylation on DNA binding specificities of human transcription factors
Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale
Science. Author manuscript; available in PMC 2021 Mar 30.
Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239
PMCID:
PMC8009048
AbstractArticlePDF–2.6M
11.
MicroRNA-219-5p Represses the Proliferation, Migration, and Invasion of Gastric Cancer Cells by Targeting the LRH-1/Wnt/β-Catenin Signaling Pathway
Chunsheng Li, Jingrong Dong, Zhenqi Han, Kai Zhang
Oncol Res. 2017; 25(4): 617–627. Published online 2017 Apr 14. doi: 10.3727/096504016X14768374457986
PMCID:
PMC7841075
AbstractArticlePDF–4.6M
12.
Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist
Suzanne G. Mays, Józef Stec, Xu Liu, Emma H. D’Agostino, Richard J. Whitby, Eric A. Ortlund
Sci Rep. 2020; 10: 22279. Published online 2020 Dec 17. doi: 10.1038/s41598-020-79251-9
PMCID:
PMC7747700
AbstractArticlePDF–4.0M
13.
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism
Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat
Nat Metab. Author manuscript; available in PMC 2020 Dec 1.
Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z
PMCID:
PMC7566881
AbstractArticlePDF–4.8M
14.
Temporal activation of LRH‐1 and RAR‐γ in human pluripotent stem cells induces a functional naïve‐like state
Adeleh Taei, Tahereh Kiani, Zeinab Taghizadeh, Sharif Moradi, Azam Samadian, Sepideh Mollamohammadi, Ali Sharifi‐Zarchi, Stefan Guenther, Azimeh Akhlaghpour, Behrouz Asgari Abibeiglou, Mostafa Najar‐Asl, Razieh Karamzadeh, Keynoosh Khalooghi, Thomas Braun, Seyedeh‐Nafiseh Hassani, Hossein Baharvand
EMBO Rep. 2020 Oct 5; 21(10): e47533. Published online 2020 Aug 16. doi: 10.15252/embr.201847533
PMCID:
PMC7534641
AbstractArticlePDF–4.8M
15.
GATA6 enhances the stemness of human colon cancer cells by creating a metabolic symbiosis through upregulating LRH‐1 expression
Hung‐Tzu Lai, Chin‐Ting Chiang, Wen‐Ko Tseng, Ta‐Chung Chao, Yeu Su
Mol Oncol. 2020 Jun; 14(6): 1327–1347. Published online 2020 Feb 26. doi: 10.1002/1878-0261.12647
PMCID:
PMC7266275
AbstractArticlePDF–4.5M
16.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
17.
Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development
Pu Wang, Feng Yan, Zhijun Li, Yanbao Yu, Scott E. Parnell, Yue Xiong
J Clin Invest. 2019 Oct 1; 129(10): 4393–4407. Published online 2019 Sep 9. doi: 10.1172/JCI129107
PMCID:
PMC6763242
AbstractArticlePDF–12M
18.
The orphan nuclear receptor LRH-1/NR5a2 critically regulates T cell functions
Carina Seitz, Juan Huang, Anna-Lena Geiselhöringer, Pamela Galbani-Bianchi, Svenja Michalek, Truong San Phan, Cindy Reinhold, Lea Dietrich, Christian Schmidt, Nadia Corazza, M. Eugenia Delgado, Theresa Schnalzger, Kristina Schoonjans, Thomas Brunner
Sci Adv. 2019 Jul; 5(7): eaav9732. Published online 2019 Jul 17. doi: 10.1126/sciadv.aav9732
PMCID:
PMC6636985
AbstractArticlePDF–11M
19.
Polymorphisms in NR5A2, gene encoding Liver Receptor Homolog-1 are associated with Preterm Birth
Dinushan C Kaluarachchi, Allison M Momany, Tamara D Busch, Lucas G Gimenez, Cesar Saleme, Viviana Cosentino, Kaare Christensen, John M Dagle, Kelli K Ryckman, Jeffrey C Murray
Pediatr Res. Author manuscript; available in PMC 2019 Jun 27.
Published in final edited form as: Pediatr Res. 2016 May; 79(5): 776–780. Published online 2016 Jan 13. doi: 10.1038/pr.2016.7
PMCID:
PMC6596415
AbstractArticlePDF–70K
20.
Transcriptional Regulation of Ovarian Steroidogenic Genes: Recent Findings Obtained from Stem Cell-Derived Steroidogenic Cells
Takashi Yazawa, Yoshitaka Imamichi, Toshio Sekiguchi, Kaoru Miyamoto, Junsuke Uwada, Md. Rafiqul Islam Khan, Nobuo Suzuki, Akihiro Umezawa, Takanobu Taniguchi
Biomed Res Int. 2019; 2019: 8973076. Published online 2019 Apr 1. doi: 10.1155/2019/8973076
PMCID:
PMC6463655
AbstractArticlePDF–1.1M

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