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Select item 111094831.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 102374222.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 102016043.

The deubiquitinase STAMBP modulates cytokine secretion through the NLRP3 inflammasome

Joseph S. Bednash, Finny Johns, Niharika Patel, Taylor R. Smail, James D. Londino, Rama K. Mallampalli

Cell Signal. Author manuscript; available in PMC 2023 May 22.

Published in final edited form as: Cell Signal. 2021 Mar; 79: 109859. Published online 2020 Nov 27. doi: 10.1016/j.cellsig.2020.109859

PMCID:: PMC10201604

Abstract Article PDF–1.2M

Select item 98832614.

Phosphorylation of OTUB1 at Tyr 26 stabilizes the mTORC1 component, Raptor

Seung Un Seo, Seon Min Woo, Min Wook Kim, Eun-Woo Lee, Kyoung-jin Min, Taeg Kyu Kwon

Cell Death Differ. 2023 Jan; 30(1): 82–93. Published online 2022 Aug 4. doi: 10.1038/s41418-022-01047-3

PMCID:: PMC9883261

Abstract Article PDF–4.6M

Select item 97231775.

The deubiquitinating enzyme STAMBP is a newly discovered driver of triple-negative breast cancer progression that maintains RAI14 protein stability

Qianqian Yang, Ding Yan, Chaoying Zou, Qian Xue, Shuhui Lin, Qingtian Huang, Xiaofen Li, Daolin Tang, Xin Chen, Jinbao Liu

Exp Mol Med. 2022 Nov; 54(11): 2047–2059. Published online 2022 Nov 25. doi: 10.1038/s12276-022-00890-1

PMCID:: PMC9723177

Abstract Article PDF–6.9M

Select item 93485766.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 92828577.

Adaptor linked K63 di-ubiquitin activates Nedd4/Rsp5 E3 ligase

Lu Zhu, Qing Zhang, Ciro D Cordeiro, Sudeep Banjade, Richa Sardana, Yuxin Mao, Scott D Emr

eLife. 2022; 11: e77424. Published online 2022 Jun 30. doi: 10.7554/eLife.77424

PMCID:: PMC9282857

Abstract Article PDF–4.6M

Select item 91063038.

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen

Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638

PMCID:: PMC9106303

Abstract Article PDF–918K

Select item 88970229.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 886983210.

Characterization of the pVHL Interactome in Human Testis Using High-Throughput Library Screening

Antonella Falconieri, Giovanni Minervini, Federica Quaglia, Geppo Sartori, Silvio C. E. Tosatto

Cancers (Basel) 2022 Feb; 14(4): 1009. Published online 2022 Feb 17. doi: 10.3390/cancers14041009

PMCID:: PMC8869832

Abstract Article PDF–1.1M

Select item 881694411.

Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes

Seongmin Yoon, Konstantin Bogdanov, David Wallach

Cell Death Differ. 2022 Feb; 29(2): 306–322. Published online 2022 Jan 9. doi: 10.1038/s41418-021-00924-7

PMCID:: PMC8816944

Abstract Article PDF–5.4M

Select item 855290712.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 851385313.

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation

Jordan M. Meyers, Muthukumar Ramanathan, Ronald L. Shanderson, Aimee Beck, Laura Donohue, Ian Ferguson, Margaret G. Guo, Deepti S. Rao, Weili Miao, David Reynolds, Xue Yang, Yang Zhao, Yen-Yu Yang, Catherine Blish, Yinsheng Wang, Paul A. Khavari

PLoS Pathog. 2021 Oct; 17(10): e1009412. Published online 2021 Oct 1. doi: 10.1371/journal.ppat.1009412

PMCID:: PMC8513853

Abstract Article PDF–4.1M

Select item 844926714.

Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1

Yusong Guo, Qi Liu, Evan Mallette, Cody Caba, Feng Hou, Julia Fux, Gabriel LaPlante, Aiping Dong, Qi Zhang, Hui Zheng, Yufeng Tong, Wei Zhang

J Biol Chem. 2021 Oct; 297(4): 101107. Published online 2021 Aug 21. doi: 10.1016/j.jbc.2021.101107

PMCID:: PMC8449267

Abstract Article PDF–2.4M

Select item 835296415.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 820504716.

High-throughput screening of functional deubiquitinating enzymes in autophagy

Shuo Tian, Shouheng Jin, Yaoxing Wu, Tao Liu, Man Luo, Jiayu Ou, Weihong Xie, Jun Cui

Autophagy. 2021; 17(6): 1367–1378. Published online 2020 May 26. doi: 10.1080/15548627.2020.1761652

PMCID:: PMC8205047

Abstract Article PDF–6.1M

Select item 819013017.

STAMBP promotes lung adenocarcinoma metastasis by regulating the EGFR/MAPK signaling pathway

Hui Xu, Xiaomei Yang, Xiaofeng Xuan, Di Wu, Jieru Zhang, Xinchun Xu, Yuanjie Zhao, Chunping Ma, Dawei Li

Neoplasia. 2021 Jun; 23(6): 607–623. Published online 2021 Jun 5. doi: 10.1016/j.neo.2021.05.011

PMCID:: PMC8190130

Abstract Article PDF–8.0M

Select item 816503018.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 795739819.

The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63‐branched ubiquitin chains

Lukas Pluska, Ernst Jarosch, Henrik Zauber, Andreas Kniss, Anita Waltho, Katrin Bagola, Maximilian von Delbrück, Frank Löhr, Brenda A Schulman, Matthias Selbach, Volker Dötsch, Thomas Sommer

EMBO J. 2021 Mar 15; 40(6): e106094. Published online 2021 Feb 12. doi: 10.15252/embj.2020106094