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Select item 111094831.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 102374222.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 94917133.

FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ

Hua Jiang, Weixiang Bian, Yue Sui, Huanle Li, Han Zhao, Wenqi Wang, Xu Li

Sci Adv. 2022 Sep; 8(38): eabq4831. Published online 2022 Sep 21. doi: 10.1126/sciadv.abq4831

PMCID:: PMC9491713

Abstract Article PDF–12M

Select item 91197364.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 90233005.

Human TDP1, APE1 and TREX1 repair 3′-DNA–peptide/protein cross-links arising from abasic sites in vitro

Xiaoying Wei, Zhishuo Wang, Caroline Hinson, Kun Yang

Nucleic Acids Res. 2022 Apr 22; 50(7): 3638–3657. Published online 2022 Mar 29. doi: 10.1093/nar/gkac185

PMCID:: PMC9023300

Abstract Article PDF–4.6M

Select item 85529076.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 83189187.

Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus

Ishtiaque Rashid, Michal Hammel, Aleksandr Sverzhinsky, Miaw-Sheue Tsai, John M. Pascal, John A. Tainer, Alan E. Tomkinson

J Biol Chem. 2021 Aug; 297(2): 100921. Published online 2021 Jun 25. doi: 10.1016/j.jbc.2021.100921

PMCID:: PMC8318918

Abstract Article PDF–3.5M

Select item 83017768.

New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition

Nadezhda S. Dyrkheeva, Aleksandr S. Filimonov, Olga A. Luzina, Alexandra L. Zakharenko, Ekaterina S. Ilina, Anastasia A. Malakhova, Sergey P. Medvedev, Jóhannes Reynisson, Konstantin P. Volcho, Suren M. Zakian, Nariman F. Salakhutdinov, Olga I. Lavrik

Biomolecules. 2021 Jul; 11(7): 973. Published online 2021 Jul 1. doi: 10.3390/biom11070973

PMCID:: PMC8301776

Abstract Article PDF–3.1M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 805712610.

Probing the evolutionary conserved residues Y204, F259, S400 and W590 that shape the catalytic groove of human TDP1 for 3′- and 5′-phosphodiester-DNA bond cleavage

Evgeny Kiselev, Thomas S. Dexheimer, Christophe Marchand, Shar-yin Naomi Huang, Yves Pommier

DNA Repair (Amst) Author manuscript; available in PMC 2021 Apr 20.

Published in final edited form as: DNA Repair (Amst). 2018 Jun-Jul; 66-67: 64–71. Published online 2018 May 2. doi: 10.1016/j.dnarep.2018.05.001

PMCID:: PMC8057126

Abstract Article PDF–1.1M

Select item 683438911.

SCAN1-TDP1 trapping on mitochondrial DNA promotes mitochondrial dysfunction and mitophagy

Arijit Ghosh, Sangheeta Bhattacharjee, Srijita Paul Chowdhuri, Abhik Mallick, Ishita Rehman, Sudipta Basu, Benu Brata Das

Sci Adv. 2019 Nov; 5(11): eaax9778. Published online 2019 Nov 6. doi: 10.1126/sciadv.aax9778

PMCID:: PMC6834389

Abstract Article PDF–5.5M

Select item 682133412.

Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening

George T Lountos, Xue Zhi Zhao, Evgeny Kiselev, Joseph E Tropea, Danielle Needle, Yves Pommier, Terrence R Burke, Jr, David S Waugh

Nucleic Acids Res. 2019 Nov 4; 47(19): 10134–10150. Published online 2019 Jun 14. doi: 10.1093/nar/gkz515

PMCID:: PMC6821334

Abstract Article PDF–10M

Select item 680741813.

Association of Tyrosyl‐DNA Phosphodiesterase 1 Polymorphism With Tourette Syndrome in Taiwanese Patients

Bor‐Tsang Wu, Wei‐Yong Lin, I‐Ching Chou, Hsin‐Ping Liu, Cheng‐Chun Lee, Yuhsin Tsai, Wan‐Chen Wu, Fuu‐Jen Tsai

J Clin Lab Anal. 2013 Jul; 27(4): 323–327. Published online 2013 Jul 12. doi: 10.1002/jcla.21606

PMCID:: PMC6807418

Abstract Article PDF–81K

Select item 662823614.

Mammalian Tyrosyl-DNA Phosphodiesterases in the Context of Mitochondrial DNA Repair

Shar-yin Naomi Huang, Yves Pommier

Int J Mol Sci. 2019 Jun; 20(12): 3015. Published online 2019 Jun 20. doi: 10.3390/ijms20123015

PMCID:: PMC6628236

Abstract Article PDF–1.0M

Select item 616668215.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 615874816.

TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining

Ajinkya S Kawale, Konstantin Akopiants, Kristoffer Valerie, Brian Ruis, Eric A Hendrickson, Shar-yin N Huang, Yves Pommier, Lawrence F Povirk

Nucleic Acids Res. 2018 Sep 28; 46(17): 8926–8939. Published online 2018 Aug 3. doi: 10.1093/nar/gky694

PMCID:: PMC6158748

Abstract Article PDF–3.2M

Select item 607772217.

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy

Tengfei Xiao, Wei Li, Xiaoqing Wang, Han Xu, Jixin Yang, Qiu Wu, Ying Huang, Joseph Geradts, Peng Jiang, Teng Fei, David Chi, Chongzhi Zang, Qi Liao, Jonathan Rennhack, Eran Andrechek, Nanlin Li, Simone Detre, Mitchell Dowsett, Rinath M. Jeselsohn, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2018 Jul 31; 115(31): 7869–7878. Published online 2018 Jul 9. doi: 10.1073/pnas.1722617115