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Select item 113015751.

Circadian regulation of MGMT expression and promoter methylation underlies daily rhythms in TMZ sensitivity in glioblastoma

Maria F. Gonzalez-Aponte, Anna R. Damato, Laura Lucía Trebucq, Tatiana Simon, Sandra P. Cárdenas-García, Kevin Cho, Gary J. Patti, Diego A. Golombek, Juan José Chiesa, Joshua B. Rubin, Erik D. Herzog

J Neurooncol. Author manuscript; available in PMC 2024 Aug 6.

Published in final edited form as: J Neurooncol. 2024 Feb; 166(3): 419–430. Published online 2024 Jan 26. doi: 10.1007/s11060-023-04535-9

PMCID:: PMC11301575

Abstract Article PDF–955K

Select item 111598402.

Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non‐small‐cell lung cancer

Min Kim, Hyo‐Gyoung Kang, Shin Yup Lee, Hyung Cheol Lee, Eung Bae Lee, Yi Young Choi, Won Kee Lee, Sukki Cho, Guang Jin, Hyo‐Sung Jheon, Ji Woong Son, Myung‐Hoon Lee, Deuk Kju Jung, Seung Ick Cha, Chang Ho Kim, Young Mo Kang, Sin Kam, Tae Hoon Jung, Sanghoon Jheon, Jae Yong Park

Cancer Sci. 2010 Nov; 101(11): 2436–2442. Published online 2010 Jul 31. doi: 10.1111/j.1349-7006.2010.01699.x

PMCID:: PMC11159840

Abstract Article PDF–209K

Select item 111583433.

MiR‐195, miR‐196b, miR‐181c, miR‐21 expression levels and O‐6‐methylguanine‐DNA methyltransferase methylation status are associated with clinical outcome in glioblastoma patients

Radek Lakomy, Jiri Sana, Simona Hankeova, Pavel Fadrus, Leos Kren, Eva Lzicarova, Marek Svoboda, Hana Dolezelova, Martin Smrcka, Rostislav Vyzula, Jaroslav Michalek, Marian Hajduch, Ondrej Slaby

Cancer Sci. 2011 Dec; 102(12): 2186–2190. Published online 2011 Oct 12. doi: 10.1111/j.1349-7006.2011.02092.x

PMCID:: PMC11158343

Abstract Article PDF–216K

Select item 109702674.

Constitutional BRCA1 and MGMT Methylation Are Significant Risk Factors for Triple-Negative Breast Cancer and High-Grade Serous Ovarian Cancer in Saudi Women

Nisreen Al-Moghrabi, Maram Al-Showimi, Amal Alqahtani, Osama Almalik, Hamed Alhusaini, Ghdah Almalki, Ajawhara Saad, Elaf Alsunayi

Int J Mol Sci. 2024 Mar; 25(6): 3108. Published online 2024 Mar 7. doi: 10.3390/ijms25063108

PMCID:: PMC10970267

Abstract Article PDF–1.0M

Select item 108481065.

Proteomic and metabolomic analyses illustrate the mechanisms of expression of the O⁶‐methylguanine‐DNA methyltransferase gene in glioblastoma

Xi Chen, Jinli Sun, Yukui Li, Weichao Jiang, Zhangyu Li, Jianyao Mao, Liwei Zhou, Sifang Chen, Guowei Tan

CNS Neurosci Ther. 2024 Feb; 30(2): e14415. Published online 2023 Aug 28. doi: 10.1111/cns.14415

PMCID:: PMC10848106

Abstract Article PDF–14M

Select item 108241256.

Glioblastoma with high O6-methyl-guanine DNA methyltransferase expression are more immunologically active than tumors with low MGMT expression

Yoshihiro Kushihara, Shota Tanaka, Yukari Kobayashi, Koji Nagaoka, Miyu Kikuchi, Takahide Nejo, Erika Yamazawa, Shohei Nambu, Kazuha Kugasawa, Hirokazu Takami, Shunsaku Takayanagi, Nobuhito Saito, Kazuhiro Kakimi

Front Immunol. 2024; 15: 1328375. Published online 2024 Jan 15. doi: 10.3389/fimmu.2024.1328375

PMCID:: PMC10824125

Abstract Article PDF–6.4M

Select item 108040267.

Preferential MGMT hypermethylation in SDH-deficient wild-type GIST

Olivier T Giger, Rogier ten Hoopen, David Shorthouse, Shukri Abdullahi, Venkata Ramesh Bulusu, Saili Jadhav, Eamonn R Maher, Ruth T Casey

J Clin Pathol. 2024 Jan; 77(1): 34–39. Published online 2022 Oct 5. doi: 10.1136/jcp-2022-208462

PMCID:: PMC10804026

Abstract Article PDF–458K

Select item 107972368.

Cognitive functioning is prognostic in patients with IDH1-wild type and MGMT-unmethylated high-grade gliomas

Uroš Smrdel, Andreja Cirila Škufca Smrdel, Anja Podlesek, Marija Skoblar Vidmar, Gregor Kos, Jana Markovic, Jana Jereb, Jana Knific, Tina Rus

Croat Med J. 2023 Dec; 64(6): 383–390. doi: 10.3325/cmj.2023.64.383

PMCID:: PMC10797236

Abstract Article PDF–373K

Select item 107794849.

Pyrosequencing Analysis of O-6-Methylguanine-DNA Methyltransferase Methylation at Different Cut-Offs of Positivity Associated with Treatment Response and Disease-Specific Survival in Isocitrate Dehydrogenase-Wildtype Grade 4 Glioblastoma

Fábio França Vieira e Silva, Marina Di Domenico, Vito Carlo Alberto Caponio, Mario Pérez-Sayáns, Gisela Cristina Vianna Camolesi, Laura Isabel Rojo-Álvarez, Andrea Ballini, Abel García-García, María Elena Padín-Iruegas, Jose Manuel Suaréz-Peñaranda

Int J Mol Sci. 2024 Jan; 25(1): 612. Published online 2024 Jan 3. doi: 10.3390/ijms25010612

PMCID:: PMC10779484

Abstract Article PDF–1.9M

Select item 1073165910.

Mass Spectrometric Analysis of the Active Site Tryptic Peptide of Recombinant O⁶-Methylguanine-DNA Methyltransferase Following Incubation with Human Colorectal DNA Reveals the Presence of an O⁶-Alkylguanine Adductome

Rasha Abdelhady, Pattama Senthong, Claire E. Eyers, Onrapak Reamtong, Elizabeth Cowley, Luca Cannizzaro, Joanna Stimpson, Kathleen Cain, Oliver J. Wilkinson, Nicholas H. Williams, Perdita E. Barran, Geoffrey P. Margison, David M. Williams, Andrew C. Povey

Chem Res Toxicol. 2023 Dec 18; 36(12): 1921–1929. Published online 2023 Nov 20. doi: 10.1021/acs.chemrestox.3c00207

PMCID:: PMC10731659

Abstract Article PDF–3.4M

Select item 1062384611.

Variant allelic frequencies of driver mutations can identify gliomas with potentially false-negative MGMT promoter methylation results

Matthew McCord, Pouya Jamshidi, Vineeth Thirunavu, Lucas Santana-Santos, Erica Vormittag-Nocito, David Dittman, Stephanie Parker, Joseph Baczkowski, Lawrence Jennings, Jordain Walshon, Kathleen McCortney, Kristyn Galbraith, Hui Zhang, Rimas V. Lukas, Roger Stupp, Karan Dixit, Priya Kumthekar, Amy B. Heimberger, Matija Snuderl, Craig Horbinski

Acta Neuropathol Commun. 2023; 11: 175. Published online 2023 Nov 2. doi: 10.1186/s40478-023-01680-0

PMCID:: PMC10623846

Abstract Article PDF–2.3M

Select item 1037905812.

ERCC1 and MGMT Methylation as a Predictive Marker of Relapse and FOLFOX Response in Colorectal Cancer Patients from South Tunisia

Dhouha Jamai, Raja Gargouri, Boulbaba Selmi, Abdelmajid Khabir

Genes (Basel) 2023 Jul; 14(7): 1467. Published online 2023 Jul 19. doi: 10.3390/genes14071467

PMCID:: PMC10379058

Abstract Article PDF–1.3M

Select item 1032276813.

Treatment benefit in patients aged 80 years or older with biopsy-proven and non-resected glioblastoma is dependent on MGMT promoter methylation status

Jonathan Weller, Sophie Katzendobler, Sebastian Niedermeyer, Patrick N. Harter, Jochen Herms, Christoph Trumm, Maximilian Niyazi, Niklas Thon, Joerg-Christian Tonn, Veit M. Stoecklein

J Neurooncol. 2023; 163(2): 407–415. Published online 2023 Jun 8. doi: 10.1007/s11060-023-04362-y

PMCID:: PMC10322768

Abstract Article PDF–1.3M

Select item 1029730914.

Association between MGMT Enhancer Methylation and MGMT Promoter Methylation, MGMT Protein Expression, and Overall Survival in Glioblastoma

Katja Zappe, Katharina Pühringer, Simon Pflug, Daniel Berger, Andreas Böhm, Sabine Spiegl-Kreinecker, Margit Cichna-Markl

Cells. 2023 Jun; 12(12): 1639. Published online 2023 Jun 15. doi: 10.3390/cells12121639

PMCID:: PMC10297309

Abstract Article PDF–8.0M

Select item 1019693215.

Association of MGMT Promoter Methylation With Survival in Low-grade and Anaplastic Gliomas After Alkylating Chemotherapy

Connor J. Kinslow, Ann Mercurio, Prashanth Kumar, Ali I. Rae, Markus D. Siegelin, Jack Grinband, Kekoa Taparra, Pavan S. Upadhyayula, Guy M. McKhann, Michael B. Sisti, Jeffrey N. Bruce, Peter D. Canoll, Fabio M. Iwamoto, Lisa A. Kachnic, James B. Yu, Simon K. Cheng, Tony J. C. Wang

JAMA Oncol. 2023 Jul; 9(7): 919–927. Published online 2023 May 18. doi: 10.1001/jamaoncol.2023.0990

Correction in:: JAMA Oncol. 2023 Jul; 9(7): 1009.

PMCID:: PMC10196932

Abstract Article

Select item 1017011716.

MGMT is frequently inactivated in pancreatic NET-G2 and is associated with the therapeutic activity of STZ-based regimens

Kohei Yagi, Hiroaki Ono, Atsushi Kudo, Yuko Kinowaki, Daisuke Asano, Shuichi Watanabe, Yoshiya Ishikawa, Hiroki Ueda, Keiichi Akahoshi, Shinji Tanaka, Minoru Tanabe

Sci Rep. 2023; 13: 7535. Published online 2023 May 9. doi: 10.1038/s41598-023-34666-y

PMCID:: PMC10170117

Abstract Article PDF–1.8M

Select item 1009452817.

Influence of MMR, MGMT Promotor Methylation and Protein Expression on Overall and Progression-Free Survival in Primary Glioblastoma Patients Treated with Temozolomide

Konstantin R. Brawanski, Susanne Sprung, Christian F. Freyschlag, Romana Hoeftberger, Thomas Ströbel, Johannes Haybaeck, Claudius Thomé, Claudia Manzl, Anna M. Birkl-Toeglhofer

Int J Mol Sci. 2023 Apr; 24(7): 6184. Published online 2023 Mar 24. doi: 10.3390/ijms24076184

PMCID:: PMC10094528

Abstract Article PDF–2.0M

Select item 988113618.

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain

Lisa Marie Weber, Yulin Jia, Bastian Stielow, Stephen S Gisselbrecht, Yinghua Cao, Yanpeng Ren, Iris Rohner, Jessica King, Elisabeth Rothman, Sabrina Fischer, Clara Simon, Ignasi Forné, Andrea Nist, Thorsten Stiewe, Martha L Bulyk, Zhanxin Wang, Robert Liefke

Nucleic Acids Res. 2023 Jan 25; 51(2): 574–594. Published online 2022 Dec 20. doi: 10.1093/nar/gkac1188

PMCID:: PMC9881136

Abstract Article PDF–4.4M

Select item 986352919.

ProNGF Expression and Targeting in Glioblastoma Multiforme

Mark Marsland, Amiee Dowdell, Sam Faulkner, Phillip Jobling, Robert A. Rush, Craig Gedye, James Lynam, Cassandra P. Griffin, Mark Baker, Joanne Marsland, Chen Chen Jiang, Hubert Hondermarck

Int J Mol Sci. 2023 Jan; 24(2): 1616. Published online 2023 Jan 13. doi: 10.3390/ijms24021616

PMCID:: PMC9863529

Abstract Article PDF–4.2M

Select item 965411420.

The Significance of MGMT Promoter Methylation Status in Diffuse Glioma

Nikola Jovanović, Milica Lazarević, Vladimir J. Cvetković, Vesna Nikolov, Jelena Kostić Perić, Milena Ugrin, Sonja Pavlović, Tatjana Mitrović

Int J Mol Sci. 2022 Nov; 23(21): 13034. Published online 2022 Oct 27. doi: 10.3390/ijms232113034

PMCID:: PMC9654114

Abstract Article PDF–2.8M

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PMC Links for GEO Profiles (Select 34497128) (287)
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Helicobacter sp. 13S00401-1 NODE_706_length_246_cov_587.479_ID_1411, whole genom...
Helicobacter sp. 13S00401-1 NODE_706_length_246_cov_587.479_ID_1411, whole genome shotgun sequence
gi|1238407498|ref|NZ_MLAR01000056.1 |WGS:NZ_MLAR01|NODE_706_length_246_cov_587.479_ID_1411

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