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Select item 87602781.

Structure and function of a family of tick-derived complement inhibitors targeting properdin

Katharina Braunger, Jiyoon Ahn, Matthijs M. Jore, Steven Johnson, Terence T. L. Tang, Dennis V. Pedersen, Gregers R. Andersen, Susan M. Lea

Nat Commun. 2022; 13: 317. Published online 2022 Jan 14. doi: 10.1038/s41467-021-27920-2

PMCID:: PMC8760278

Abstract Article PDF–2.4M

Select item 81650302.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79095143.

Properdin Is a Modulator of Tumour Immunity in a Syngeneic Mouse Melanoma Model

Izzat A. M. Al-Rayahi, Lee R. Machado, Cordula M. Stover

Medicina (Kaunas) 2021 Feb; 57(2): 85. Published online 2021 Jan 21. doi: 10.3390/medicina57020085

PMCID:: PMC7909514

Abstract Article PDF–816K

Select item 76833874.

The Role of Properdin in Killing of Non-Pathogenic Leptospira biflexa

Adriana Patricia Granados Martinez, Patrícia Antonia Estima Abreu, Silvio de Arruda Vasconcellos, Paulo Lee Ho, Viviana P. Ferreira, Gurpanna Saggu, Angela Silva Barbosa, Lourdes Isaac

Front Immunol. 2020; 11: 572562. Published online 2020 Nov 10. doi: 10.3389/fimmu.2020.572562

PMCID:: PMC7683387

Abstract Article PDF–822K

Select item 75112335.

Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement

Jie Zhang, Lihong Song, Dennis V Pedersen, Anna Li, John D Lambris, Gregers Rom Andersen, Tom Eirik Mollnes, Ying Jie Ma, Peter Garred

eLife. 2020; 9: e60908. Published online 2020 Sep 10. doi: 10.7554/eLife.60908

PMCID:: PMC7511233

Abstract Article PDF–2.5M

Select item 73874116.

Properdin Is a Key Player in Lysis of Red Blood Cells and Complement Activation on Endothelial Cells in Hemolytic Anemias Caused by Complement Dysregulation

Jin Y. Chen, Neeti S. Galwankar, Heather N. Emch, Smrithi S. Menon, Claudio Cortes, Joshua M. Thurman, Samuel A. Merrill, Robert A. Brodsky, Viviana P. Ferreira

Front Immunol. 2020; 11: 1460. Published online 2020 Jul 22. doi: 10.3389/fimmu.2020.01460

PMCID:: PMC7387411

Abstract Article PDF–2.3M

Select item 73220677.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 71699838.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 67415009.

Myeloperoxidase Directs Properdin-Mediated Complement Activation

Joseph O'Flynn, Karen O. Dixon, Maria C. Faber Krol, Mohamed R. Daha, Cees van Kooten

J Innate Immun. 2014 Jun; 6(4): 417–425. Published online 2013 Dec 20. doi: 10.1159/000356980

PMCID:: PMC6741500

Abstract Article PDF–187K

Select item 583915810.

Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells

Giorgio Giurato, Giovanni Nassa, Annamaria Salvati, Elena Alexandrova, Francesca Rizzo, Tuula A. Nyman, Alessandro Weisz, Roberta Tarallo

Sci Data. 2018; 5: 180031. Published online 2018 Mar 6. doi: 10.1038/sdata.2018.31

PMCID:: PMC5839158

Abstract Article PDF–1.9M

Select item 553161111.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 541942212.

Complement factor P is a ligand for the natural killer cell–activating receptor NKp46

Emilie Narni-Mancinelli, Laurent Gauthier, Myriam Baratin, Sophie Guia, Aurore Fenis, Ala-Eddine Deghmane, Benjamin Rossi, Patrick Fourquet, Bertrand Escalière, Yann M. Kerdiles, Sophie Ugolini, Muhamed-Kheir Taha, Eric Vivier

Sci Immunol. Author manuscript; available in PMC 2017 May 5.

Published in final edited form as: Sci Immunol. 2017 Apr 28; 2(10): eaam9628. Published online 2017 Apr 28. doi: 10.1126/sciimmunol.aam9628

PMCID:: PMC5419422

Abstract Article PDF–2.1M

Select item 539113813.

Functional and structural insight into properdin control of complement alternative pathway amplification

Dennis V Pedersen, Lubka Roumenina, Rasmus K Jensen, Trine AF Gadeberg, Chiara Marinozzi, Capucine Picard, Tania Rybkine, Steffen Thiel, Uffe BS Sørensen, Cordula Stover, Veronique Fremeaux‐Bacchi, Gregers R Andersen

EMBO J. 2017 Apr 13; 36(8): 1084–1099. Published online 2017 Mar 6. doi: 10.15252/embj.201696173

PMCID:: PMC5391138

Abstract Article PDF–4.4M

Select item 536336214.

Properdin and factor H production by human dendritic cells modulates their T‐cell stimulatory capacity and is regulated by IFN‐γ

Karen O. Dixon, Joseph O'Flynn, Ngaisah Klar‐Mohamad, Mohamed R. Daha, Cees van Kooten

Eur J Immunol. 2017 Mar; 47(3): 470–480. Published online 2017 Mar 13. doi: 10.1002/eji.201646703

PMCID:: PMC5363362

Abstract Article PDF–1.7M

Select item 527849315.

Properdin binding to complement activating surfaces depends on initial C3b deposition

Morten Harboe, Christina Johnson, Stig Nymo, Karin Ekholt, Camilla Schjalm, Julie K. Lindstad, Anne Pharo, Bernt Christian Hellerud, Kristina Nilsson Ekdahl, Tom Eirik Mollnes, Per H. Nilsson

Proc Natl Acad Sci U S A. 2017 Jan 24; 114(4): E534–E539. Published online 2017 Jan 9. doi: 10.1073/pnas.1612385114

PMCID:: PMC5278493

Abstract Article PDF–913K

Select item 523412016.

Sven Micklisch, Yuchen Lin, Saskia Jacob, Marcus Karlstetter, Katharina Dannhausen, Prasad Dasari, Monika von der Heide, Hans-Martin Dahse, Lisa Schmölz, Felix Grassmann, Medhanie Alene, Sascha Fauser, Harald Neumann, Stefan Lorkowski, Diana Pauly, Bernhard H. Weber, Antonia M. Joussen, Thomas Langmann, Peter F. Zipfel, Christine Skerka

J Neuroinflammation. 2017; 14: 4. Published online 2017 Jan 5. doi: 10.1186/s12974-016-0776-3

PMCID:: PMC5234120

Abstract Article PDF–2.9M

Select item 488877417.

Properdin-mediated C5a production enhances stable binding of platelets to granulocytes in human whole blood

Adam Z. Blatt, Gurpanna Saggu, Koustubh V. Kulkarni, Claudio Cortes, Joshua M. Thurman, Daniel Ricklin, John D. Lambris, Jesus G. Valenzuela, Viviana P. Ferreira

J Immunol. Author manuscript; available in PMC 2017 Jun 1.

Published in final edited form as: J Immunol. 2016 Jun 1; 196(11): 4671–4680. Published online 2016 Apr 25. doi: 10.4049/jimmunol.1600040

PMCID:: PMC4888774

Abstract Article PDF–929K

Select item 488219018.

Widespread expansion of protein interaction capabilities by alternative splicing

Xinping Yang, Jasmin Coulombe-Huntington, Shuli Kang, Gloria M. Sheynkman, Tong Hao, Aaron Richardson, Song Sun, Fan Yang, Yun A. Shen, Ryan R. Murray, Kerstin Spirohn, Bridget E. Begg, Miquel Duran-Frigola, Andrew MacWilliams, Samuel J. Pevzner, Quan Zhong, Shelly A. Wanamaker, Stanley Tam, Lila Ghamsari, Nidhi Sahni, Song Yi, Maria D. Rodriguez, Dawit Balcha, Guihong Tan, Michael Costanzo, Brenda Andrews, Charles Boone, Xianghong J. Zhou, Kourosh Salehi-Ashtiani, Benoit Charloteaux, Alyce A. Chen, Michael A. Calderwood, Patrick Aloy, Frederick P. Roth, David E. Hill, Lilia M. Iakoucheva, Yu Xia, Marc Vidal

Cell. Author manuscript; available in PMC 2017 Feb 11.

Published in final edited form as: Cell. 2016 Feb 11; 164(4): 805–817. doi: 10.1016/j.cell.2016.01.029

PMCID:: PMC4882190

Abstract Article PDF–1.9M

Select item 477810419.

Serum properdin consumption as a biomarker of C5 convertase dysregulation in C3 glomerulopathy

F. Corvillo, M. Bravo García‐Morato, P. Nozal, S. Garrido, A. Tortajada, S. Rodríguez de Córdoba, M. López‐Trascasa

Clin Exp Immunol. 2016 Apr; 184(1): 118–125. Published online 2016 Jan 22. doi: 10.1111/cei.12754

PMCID:: PMC4778104

Abstract Article PDF–271K

Select item 403742420.

Properdin has an ascendancy over factor H regulation in complement-mediated renal tubular damage

Seiji Nagamachi, Isao Ohsawa, Hiyori Suzuki, Nobuyuki Sato, Hiroyuki Inoshita, Atsuko Hisada, Daisuke Honda, Mamiko Shimamoto, Yoshio Shimizu, Satoshi Horikoshi, Yasuhiko Tomino

BMC Nephrol. 2014; 15: 82. Published online 2014 May 22. doi: 10.1186/1471-2369-15-82

PMCID:: PMC4037424

Abstract Article PDF–2.9M

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