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Select item 112359981.

Association of the neonatal Fc receptor promoter variable number of tandem repeat polymorphism with immunoglobulin response in patients with chronic inflammatory demyelinating polyneuropathy

Anna Lena Fisse, Emelie Schäfer, Alina Hieke, Maximilian Schröder, Rafael Klimas, Jil Brünger, Sophie Huckemann, Thomas Grüter, Melissa Sgodzai, Christiane Schneider‐Gold, Ralf Gold, Huu Phuc Nguyen, Kalliopi Pitarokoili, Jeremias Motte, Larissa Arning

Eur J Neurol. 2024 Apr; 31(4): e16205. Published online 2024 Jan 11. doi: 10.1111/ene.16205

PMCID:: PMC11235998

Abstract Article PDF–470K

Select item 110979122.

Albumin influences leucocyte FcRn expression in the early days of kidney transplantation

Pierre Boulard, Nicolas Azzopardi, Romain Levard, Jean-Marie Cornec, Juliette Lamamy, Bérénice Prieur, Marie-Véronique Demattei, Hervé Watier, Philippe Gatault, Valérie Gouilleux-Gruart

Clin Exp Immunol. 2024 Jun; 216(3): 307–317. Published online 2024 Feb 12. doi: 10.1093/cei/uxae011

PMCID:: PMC11097912

Abstract Article PDF–2.3M

Select item 98917663.

The therapeutic age of the neonatal Fc receptor

Michal Pyzik, Lisa K. Kozicky, Amit K. Gandhi, Richard S. Blumberg

Nat Rev Immunol. 2023 Feb 1 : 1–18. doi: 10.1038/s41577-022-00821-1 [Epub ahead of print]

PMCID:: PMC9891766

Abstract Article PDF–4.9M

Select item 94265094.

Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18

Xiangpeng Chen, Xiao Qu, Congcong Liu, Yong Zhang, Guigen Zhang, Pu Han, Yali Duan, Qi Li, Liang Wang, Wenjing Ruan, Peiyi Wang, Wensheng Wei, George F. Gao, Xin Zhao, Zhengde Xie

mBio. 2022 Jul-Aug; 13(4): e01166-22. Published online 2022 Jul 5. doi: 10.1128/mbio.01166-22

PMCID:: PMC9426509

Abstract Article PDF–3.5M

Select item 89142805.

An Expanded Genome-Wide Association Study of Fructosamine Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the Effector Transcript

Fernando Riveros-Mckay, David Roberts, Emanuele Di Angelantonio, Bing Yu, Nicole Soranzo, John Danesh, Elizabeth Selvin, Adam S. Butterworth, Inês Barroso

Diabetes. 2022 Feb; 71(2): 359–364. Published online 2021 Nov 9. doi: 10.2337/db21-0320

PMCID:: PMC8914280

Abstract Article PDF–1.1M

Select item 87419206.

Human IgE does not bind to human FcRn

Maximilian Brinkhaus, Elvera J. van der Kooi, Arthur E. H. Bentlage, Pleuni Ooijevaar-de Heer, Ninotska I. L. Derksen, Theo Rispens, Gestur Vidarsson

Sci Rep. 2022; 12: 62. Published online 2022 Jan 7. doi: 10.1038/s41598-021-03852-1

PMCID:: PMC8741920

Abstract Article PDF–2.1M

Select item 87144787.

新生儿 Fc受体基础研究和临床应用进展

Mangsha HU, Shuli WEI, Wuyuan ZHOU, Pingli WANG

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2021 Aug; 50(4): 537–544. Chinese. doi: 10.3724/zdxbyxb-2021-0252

PMCID:: PMC8714478

Abstract Article PDF–2.7M

Select item 83529648.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 757723410.

Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice

Benjamin E. Low, Gregory J. Christianson, Emily Lowell, Wenning Qin, Michael V. Wiles

MAbs. 2020 Jan-Dec; 12(1): 1829334. Published online 2020 Oct 7. doi: 10.1080/19420862.2020.1829334

PMCID:: PMC7577234

Abstract Article PDF–2.3M

Select item 753738711.

FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex–driven autoimmunity

Jonathan J. Hubbard, Michal Pyzik, Timo Rath, Lisa K. Kozicky, Kine M.K. Sand, Amit K. Gandhi, Algirdas Grevys, Stian Foss, Susan C. Menzies, Jonathan N. Glickman, Edda Fiebiger, Derry C. Roopenian, Inger Sandlie, Jan Terje Andersen, Laura M. Sly, Kristi Baker, Richard S. Blumberg

J Exp Med. 2020 Oct 5; 217(10): e20200359. Published online 2020 Jul 13. doi: 10.1084/jem.20200359

PMCID:: PMC7537387

Abstract Article PDF–3.4M

Select item 729362212.

FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodies

Sara Borghi, Stylianos Bournazos, Natalie K. Thulin, Chao Li, Anna Gajewski, Robert W. Sherwood, Sheng Zhang, Eva Harris, Prasanna Jagannathan, Lai-Xi Wang, Jeffrey V. Ravetch, Taia T. Wang

Proc Natl Acad Sci U S A. 2020 Jun 9; 117(23): 12943–12951. Published online 2020 May 27. doi: 10.1073/pnas.2004325117

PMCID:: PMC7293622

Abstract Article PDF–1.2M

Select item 716998313.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 683185114.

Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis

Mohamed Taha Moutaoufik, Ramy Malty, Shahreen Amin, Qingzhou Zhang, Sadhna Phanse, Alla Gagarinova, Mara Zilocchi, Larissa Hoell, Zoran Minic, Maria Gagarinova, Hiroyuki Aoki, Jocelyn Stockwell, Matthew Jessulat, Florian Goebels, Kirsten Broderick, Nichollas E. Scott, James Vlasblom, Gabriel Musso, Bhanu Prasad, Eleonora Lamantea, Barbara Garavaglia, Alex Rajput, Kei Murayama, Yasushi Okazaki, Leonard J. Foster, Gary D. Bader, Francisco S. Cayabyab, Mohan Babu

iScience. 2019 Sep 27; 19: 1114–1132. Published online 2019 Sep 4. doi: 10.1016/j.isci.2019.08.057

PMCID:: PMC6831851

Abstract Article PDF–9.8M

Select item 661745915.

Human cytomegalovirus evades antibody-mediated immunity through endoplasmic reticulum-associated degradation of the FcRn receptor

Xiaoyang Liu, Senthilkumar Palaniyandi, Iowis Zhu, Jin Tang, Weizhong Li, Xiaoling Wu, Susan Park Ochsner, C. David Pauza, Jeffrey I. Cohen, Xiaoping Zhu

Nat Commun. 2019; 10: 3020. Published online 2019 Jul 9. doi: 10.1038/s41467-019-10865-y

PMCID:: PMC6617459

Abstract Article PDF–4.4M

Select item 657283616.

Contribution of DNA methylation to the expression of FCGRT in human liver and myocardium

R. B. Cejas, D. C. Ferguson, A. Quiñones-Lombraña, J. E. Bard, J. G. Blanco

Sci Rep. 2019; 9: 8674. Published online 2019 Jun 17. doi: 10.1038/s41598-019-45203-1

PMCID:: PMC6572836

Abstract Article PDF–2.8M

Select item 651759117.

Reduced FcRn-mediated transcytosis of IgG2 due to a missing Glycine in its lower hinge

Nigel M. Stapleton, Maximilian Brinkhaus, Kathryn L. Armour, Arthur E. H. Bentlage, Steven W. de Taeye, A. Robin Temming, Juk Yee Mok, Giso Brasser, Marielle Maas, Wim J. E. van Esch, Mike R. Clark, Lorna M. Williamson, C. Ellen van der Schoot, Gestur Vidarsson

Sci Rep. 2019; 9: 7363. Published online 2019 May 14. doi: 10.1038/s41598-019-40731-2

PMCID:: PMC6517591

Abstract Article PDF–1.5M

Select item 647057018.

FcRn-Dependent Transcytosis of Monoclonal Antibody in Human Nasal Epithelial Cells In Vitro: A Prerequisite for a New Delivery Route for Therapy?

Emilie Bequignon, Christine Dhommée, Christelle Angely, Lucie Thomas, Mathieu Bottier, Estelle Escudier, Daniel Isabey, André Coste, Bruno Louis, Jean-François Papon, Valérie Gouilleux-Gruart

Int J Mol Sci. 2019 Mar; 20(6): 1379. Published online 2019 Mar 19. doi: 10.3390/ijms20061379

PMCID:: PMC6470570

Abstract Article PDF–5.0M

Select item 639758619.

The neonatal Fc receptor is a pan-echovirus receptor

Stefanie Morosky, Alexandra I. Wells, Kathryn Lemon, Azia S. Evans, Sandra Schamus, Christopher J. Bakkenist, Carolyn B. Coyne

Proc Natl Acad Sci U S A. 2019 Feb 26; 116(9): 3758–3763. Published online 2019 Feb 11. doi: 10.1073/pnas.1817341116

PMCID:: PMC6397586

Abstract Article PDF–1.3M

Select item 631626220.

FcRn Expression in Wildtype Mice, Transgenic Mice, and in Human Tissues

Tommy Li, Joseph P. Balthasar

Biomolecules. 2018 Dec; 8(4): 115. Published online 2018 Oct 15. doi: 10.3390/biom8040115

PMCID:: PMC6316262

Abstract Article PDF–1.9M

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