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Items: 1 to 20 of 41

1.
The Role of Neutral Sphingomyelinase-2 (NSM2) in the Control of Neutral Lipid Storage in T Cells
Rebekka Schempp, Janna Eilts, Marie Schöl, Maria Fernanda Grijalva Yépez, Agnes Fekete, Dominik Wigger, Fabian Schumacher, Burkhard Kleuser, Marco van Ham, Lothar Jänsch, Markus Sauer, Elita Avota
Int J Mol Sci. 2024 Mar; 25(6): 3247. Published online 2024 Mar 13. doi: 10.3390/ijms25063247
PMCID:
PMC10970209
AbstractArticlePDF–7.4M
2.
Regulated translocation of neutral sphingomyelinase-2 to the plasma membrane drives insulin resistance in steatotic hepatocytes
S. El-Amouri, A. Karakashian, E. Bieberich, M. Nikolova-Karakashian
J Lipid Res. 2023 Oct; 64(10): 100435. Published online 2023 Aug 26. doi: 10.1016/j.jlr.2023.100435
PMCID:
PMC10550728
AbstractArticlePDF–5.8M
3.
Inhibition of Neutral Sphingomyelinase 2 by Novel Small Molecule Inhibitors Results in Decreased Release of Extracellular Vesicles by Vascular Smooth Muscle Cells and Attenuated Calcification
Angelina Pavlic, Hessel Poelman, Grzegorz Wasilewski, Kanin Wichapong, Petra Lux, Cecile Maassen, Esther Lutgens, Leon J. Schurgers, Chris P. Reutelingsperger, Gerry A. F. Nicolaes
Int J Mol Sci. 2023 Feb; 24(3): 2027. Published online 2023 Jan 19. doi: 10.3390/ijms24032027
PMCID:
PMC9916533
AbstractArticlePDF–5.1M
4.
Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti–PD-1 Therapy Efficacy
Anne Montfort, Florie Bertrand, Julia Rochotte, Julia Gilhodes, Thomas Filleron, Jean Milhès, Carine Dufau, Caroline Imbert, Joëlle Riond, Marie Tosolini, Christopher J. Clarke, Florent Dufour, Andrei A. Constantinescu, Nilton De França Junior, Virginie Garcia, Michel Record, Pierre Cordelier, Pierre Brousset, Philippe Rochaix, Sandrine Silvente-Poirot, Nicole Therville, Nathalie Andrieu-Abadie, Thierry Levade, Yusuf A. Hannun, Hervé Benoist, Nicolas Meyer, Olivier Micheau, Céline Colacios, Bruno Ségui
Cancer Immunol Res. Author manuscript; available in PMC 2022 Nov 3.
Published in final edited form as: Cancer Immunol Res. 2021 May; 9(5): 568–582. Published online 2021 Mar 16. doi: 10.1158/2326-6066.CIR-20-0342
PMCID:
PMC9631340
AbstractArticlePDF–1.7M
5.
Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease
Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel
Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205
PMCID:
PMC9348576
AbstractArticlePDF–3.0M
6.
Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects
Liubov S. Kalinichenko, Christiane Mühle, Tianye Jia, Felix Anderheiden, Maria Datz, Anna-Lisa Eberle, Volker Eulenburg, Jonas Granzow, Martin Hofer, Julia Hohenschild, Sabine E. Huber, Stefanie Kämpf, Georgios Kogias, Laura Lacatusu, Charlotte Lugmair, Stephen Mbu Taku, Doris Meixner, Nina Tesch, Marc Praetner, Cosima Rhein, Christina Sauer, Jessica Scholz, Franziska Ulrich, Florian Valenta, Esther Weigand, Markus Werner, Nicole Tay, Conor J. Mc Veigh, Jana Haase, An-Li Wang, Laila Abdel-Hafiz, Joseph P. Huston, Irena Smaga, Malgorzata Frankowska, Malgorzata Filip, Anbarasu Lourdusamy, Philipp Kirchner, Arif B. Ekici, Lena M. Marx, Neeraja Puliparambil Suresh, Renato Frischknecht, Anna Fejtova, Essa M. Saied, Christoph Arenz, Aline Bozec, Isabel Wank, Silke Kreitz, Andreas Hess, Tobias Bäuerle, Maria Dolores Ledesma, Daniel N. Mitroi, André M. Miranda, Tiago G. Oliveira, Erich Gulbins, Bernd Lenz, Gunter Schumann, Johannes Kornhuber, Christian P. Müller
Mol Psychiatry. 2021; 26(12): 7403–7416. Published online 2021 Sep 28. doi: 10.1038/s41380-021-01304-w
PMCID:
PMC8872992
AbstractArticlePDF–3.0M
7.
Activation of neutral sphingomyelinase 2 through hyperglycemia contributes to endothelial apoptosis via vesicle-bound intercellular transfer of ceramides
Andreas Zietzer, Alina Lisann Jahnel, Marko Bulic, Katharina Gutbrod, Philip Düsing, Mohammed Rabiul Hosen, Peter Dörmann, Nikos Werner, Georg Nickenig, Felix Jansen
Cell Mol Life Sci. 2022 Jan; 79(1): 48. Published online 2021 Dec 24. doi: 10.1007/s00018-021-04049-5
PMCID:
PMC8739297
AbstractArticlePDF–11M
8.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
9.
Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis
Qing Wu, Lulu Sun, Xiaomin Hu, Xuemei Wang, Feng Xu, Bo Chen, Xianyi Liang, Jialin Xia, Pengcheng Wang, Daisuke Aibara, Shaofei Zhang, Guangyi Zeng, Chuyu Yun, Yu Yan, Yicheng Zhu, Michael Bustin, Shuyang Zhang, Frank J. Gonzalez, Changtao Jiang
J Clin Invest. 2021 May 3; 131(9): e142865. Published online 2021 May 3. doi: 10.1172/JCI142865
PMCID:
PMC8087211
AbstractArticlePDF–13M
10.
The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme
Prajna Shanbhogue, Reece M. Hoffmann, Michael V. Airola, Rohan Maini, David J. Hamelin, Miguel Garcia-Diaz, John E. Burke, Yusuf A. Hannun
J Biol Chem. 2019 May 3; 294(18): 7488–7502. Published online 2019 Mar 19. doi: 10.1074/jbc.RA118.007288
PMCID:
PMC6509483
AbstractArticlePDF–4.0M
11.
DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation
Camilo Rojas, Elena Barnaeva, Ajit G. Thomas, Xin Hu, Noel Southall, Juan Marugan, Amrita Datta Chaudhuri, Seung-Wan Yoo, Niyada Hin, Ondrej Stepanek, Ying Wu, Sarah C. Zimmermann, Alexandra G. Gadiano, Takashi Tsukamoto, Rana Rais, Norman Haughey, Marc Ferrer, Barbara S. Slusher
Sci Rep. 2018; 8: 17715. Published online 2018 Dec 7. doi: 10.1038/s41598-018-36144-2
PMCID:
PMC6286365
AbstractArticlePDF–1.7M
12.
The Neutral Sphingomyelinase 2 Is Required to Polarize and Sustain T Cell Receptor Signaling
Charlene Börtlein, Annette Draeger, Roman Schoenauer, Alexander Kuhlemann, Markus Sauer, Sibylle Schneider-Schaulies, Elita Avota
Front Immunol. 2018; 9: 815. Published online 2018 Apr 18. doi: 10.3389/fimmu.2018.00815
PMCID:
PMC5915489
AbstractArticlePDF–7.8M
13.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
14.
Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation
Michael V. Airola, Prajna Shanbhogue, Achraf A. Shamseddine, Kip E. Guja, Can E. Senkal, Rohan Maini, Nana Bartke, Bill X. Wu, Lina M. Obeid, Miguel Garcia-Diaz, Yusuf A. Hannun
Proc Natl Acad Sci U S A. 2017 Jul 11; 114(28): E5549–E5558. Published online 2017 Jun 26. doi: 10.1073/pnas.1705134114
PMCID:
PMC5514751
AbstractArticlePDF–2.1M
15.
Dysregulated Sphingolipid Metabolism in Endometriosis
Yie Hou Lee, Chin Wen Tan, Abhishek Venkatratnam, Chuen Seng Tan, Liang Cui, Seong Feei Loh, Linda Griffith, Steven R. Tannenbaum, Jerry Kok Yen Chan
J Clin Endocrinol Metab. 2014 Oct; 99(10): E1913–E1921. Published online 2014 Jun 24. doi: 10.1210/jc.2014-1340
PMCID:
PMC5393497
AbstractArticle
16.
ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation
Christopher J. Clarke, Achraf A. Shamseddine, Joseph J. Jacob, Gabrielle Khalife, Tara A. Burns, Yusuf A. Hannun
J Lipid Res. 2016 May; 57(5): 868–881. doi: 10.1194/jlr.M067447
PMCID:
PMC4847633
AbstractArticlePDF–1.4M
17.
Roles and regulation of Neutral Sphingomyelinase-2 in cellular and pathological processes
Achraf A. Shamseddine, Michael V. Airola, Yusuf A. Hannun
Adv Biol Regul. Author manuscript; available in PMC 2016 Jan 1.
Published in final edited form as: Adv Biol Regul. 2015 Jan; 57: 24–41. Published online 2014 Oct 27. doi: 10.1016/j.jbior.2014.10.002
PMCID:
PMC4684640
AbstractArticlePDF–1.0M
18.
P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest
A A Shamseddine, C J Clarke, B Carroll, M V Airola, S Mohammed, A Rella, L M Obeid, Y A Hannun
Cell Death Dis. 2015 Oct; 6(10): e1947. Published online 2015 Oct 29. doi: 10.1038/cddis.2015.268
PMCID:
PMC4632297
AbstractArticlePDF–1.7M
19.
nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis
Michal Levy, S. Sianna Castillo, Tzipora Goldkorn
Biochem Biophys Res Commun. Author manuscript; available in PMC 2015 Mar 23.
Published in final edited form as: Biochem Biophys Res Commun. 2006 Jun 9; 344(3): 900–905. Published online 2006 Apr 19. doi: 10.1016/j.bbrc.2006.04.013
PMCID:
PMC4370275
AbstractArticlePDF–753K
20.
Secretion of small/microRNAs including miR-638 into extracellular spaces by sphingomyelin phosphodiesterase 3
SHIORI KUBOTA, MITSURU CHIBA, MIKI WATANABE, MAKI SAKAMOTO, NARUMI WATANABE
Oncol Rep. 2015 Jan; 33(1): 67–73. Published online 2014 Nov 13. doi: 10.3892/or.2014.3605
PMCID:
PMC4254672
AbstractArticlePDF–682K

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