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Select item 108753611.

κ-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-κB pathway: KOR regulates OA synovitis via NF-κB

Yi Shi, Huaqiang Tao, Xueyan Li, Liyuan Zhang, Chunhui Li, Wen Sun, Miao Chu, Kai Chen, Pengfei Zhu, Qiang Wang, Chengyong Gu, Liangliang Wang, Xing Yang, Yuefeng Hao

Acta Biochim Biophys Sin (Shanghai) 2024 Jan 25; 56(1): 82–95. Published online 2023 Nov 28. doi: 10.3724/abbs.2023223

PMCID:: PMC10875361

Abstract Article PDF–4.1M

Select item 97196472.

The dynorphin/kappa opioid receptor mediates adverse immunological and behavioral outcomes induced by repetitive blast trauma

Suhjung Janet Lee, Aric F. Logsdon, Mayumi Yagi, Britahny M. Baskin, Elaine. R. Peskind, Murray M. Raskind, David G. Cook, Abigail. G. Schindler

J Neuroinflammation. 2022; 19: 288. Published online 2022 Dec 3. doi: 10.1186/s12974-022-02643-3

PMCID:: PMC9719647

Abstract Article PDF–3.5M

Select item 86747013.

Opioids in cancer: The κ-opioid receptor

Qier Zhou, Zhiwei Zhang, Songkai Long, Wanjun Li, Baiyun Wang, Na Liang

Mol Med Rep. 2022 Feb; 25(2): 44. Published online 2021 Dec 8. doi: 10.3892/mmr.2021.12560

PMCID:: PMC8674701

Abstract Article PDF–903K

Select item 86275094.

Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography

Kelly Smart, Ashley Yttredahl, Maria A. Oquendo, J. John Mann, Ansel T. Hillmer, Richard E. Carson, Jeffrey M. Miller

Transl Psychiatry. 2021; 11: 602. Published online 2021 Nov 27. doi: 10.1038/s41398-021-01729-5

PMCID:: PMC8627509

Abstract Article PDF–1.5M

Select item 85340295.

Oxytocin Is a Positive Allosteric Modulator of κ-Opioid Receptors but Not δ-Opioid Receptors in the G Protein Signaling Pathway

Kanako Miyano, Yuki Yoshida, Shigeto Hirayama, Hideki Takahashi, Haruka Ono, Yoshiyuki Meguro, Sei Manabe, Akane Komatsu, Miki Nonaka, Takaaki Mizuguchi, Hideaki Fujii, Yoshikazu Higami, Minoru Narita, Yasuhito Uezono

Cells. 2021 Oct; 10(10): 2651. Published online 2021 Oct 4. doi: 10.3390/cells10102651

PMCID:: PMC8534029

Abstract Article PDF–2.5M

Select item 72600866.

OPRM1, OPRK1 and COMT Genetic Polymorphisms Associated with Opioid Effects on Experimental Pain: A Randomized, Double-Blind, Placebo-Controlled Study

Kwo Wei David Ho, Margaret R. Wallace, Roland Staud, Roger B. Fillingim

Pharmacogenomics J. Author manuscript; available in PMC 2021 Jun 1.

Published in final edited form as: Pharmacogenomics J. 2020 Jun; 20(3): 471–481. Published online 2019 Dec 6. doi: 10.1038/s41397-019-0131-z

PMCID:: PMC7260086

Abstract Article PDF–1.0M

Select item 71699837.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 68513178.

Reactive oxygen species (ROS) generation is stimulated by κ opioid receptor activation through phosphorylated c-Jun N-terminal kinase and inhibited by p38 mitogen-activated protein kinase (MAPK) activation

Selena S. Schattauer, Andrea Bedini, Floyd Summers, Aiden Reilly-Treat, Mackenzie M. Andrews, Benjamin B. Land, Charles Chavkin

J Biol Chem. 2019 Nov 8; 294(45): 16884–16896. Published online 2019 Oct 1. doi: 10.1074/jbc.RA119.009592

PMCID:: PMC6851317

Abstract Article PDF–3.1M

Select item 67851449.

Social status and demographic effects of the kappa opioid receptor: a PET imaging study with a novel agonist radiotracer in healthy volunteers

David Matuskey, Mark Dias, Mika Naganawa, Brian Pittman, Shannan Henry, Songye Li, Hong Gao, Jim Ropchan, Nabeel Nabulsi, Richard E. Carson, Yiyun Huang

Neuropsychopharmacology. 2019 Sep; 44(10): 1714–1719. Published online 2019 Mar 30. doi: 10.1038/s41386-019-0379-7

PMCID:: PMC6785144

Abstract Article PDF–531K

Select item 678500410.

Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study

Diana Martinez, Mark Slifstein, David Matuskey, Nabeel Nabulsi, Ming-Qiang Zheng, Shu-fei Lin, Jim Ropchan, Nina Urban, Alexander Grassetti, Dinnisa Chang, Michael Salling, Richard Foltin, Richard E. Carson, Yiyun Huang

Neuropsychopharmacology. 2019 Sep; 44(10): 1720–1727. Published online 2019 Apr 26. doi: 10.1038/s41386-019-0398-4

PMCID:: PMC6785004

Abstract Article PDF–997K

Select item 662222411.

Dynorphins Regulate Fear Memory: from Mice to Men

Andras Bilkei-Gorzo, Susanne Erk, Britta Schürmann, Daniela Mauer, Kerstin Michel, Henning Boecker, Lukas Scheef, Henrik Walter, Andreas Zimmer

J Neurosci. 2012 Jul 4; 32(27): 9335–9343. doi: 10.1523/JNEUROSCI.1034-12.2012

PMCID:: PMC6622224

Abstract Article PDF–944K

Select item 622453312.

PET imaging reveals lower kappa opioid receptor availability in alcoholics but no effect of age

Aishwarya Vijay, Dana Cavallo, Alissa Goldberg, Bart de Laat, Nabeel Nabulsi, Yiyun Huang, Suchitra Krishnan-Sarin, Evan D. Morris

Neuropsychopharmacology. 2018 Dec; 43(13): 2539–2547. Published online 2018 Sep 6. doi: 10.1038/s41386-018-0199-1

PMCID:: PMC6224533

Abstract Article PDF–1.3M

Select item 614101913.

Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction

Vadim Yuferov, David Fussell, K. Steven LaForge, David A. Nielsen, Derek Gordon, Ann Ho, Suzanne M. Leal, Jurg Ott, Mary Jeanne Kreek

Pharmacogenetics. Author manuscript; available in PMC 2018 Sep 17.

Published in final edited form as: Pharmacogenetics. 2004 Dec; 14(12): 793–804. doi: 10.1097/00008571-200412000-00002

PMCID:: PMC6141019

Abstract Article PDF–813K

Select item 606116114.

Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics

Igor Bazov, Daniil Sarkisyan, Olga Kononenko, Hiroyuki Watanabe, Tatiana Yakovleva, Anita C. Hansson, Wolfgang H. Sommer, Rainer Spanagel, Georgy Bakalkin

Mol Neurobiol. 2018; 55(8): 7049–7061. Published online 2018 Jan 30. doi: 10.1007/s12035-017-0844-4