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Select item 111363251.

Lipid sensing and lipid sensors: Bile acids and their signaling pathways: eclectic regulators of diverse cellular functions

E. Scotti, F. Gilardi, C. Godio, E. Gers, J. Krneta, N. Mitro, E. De Fabiani, D. Caruso, M. Crestani

Cell Mol Life Sci. 2007 Oct; 64(19-20): 2477. Published online 2007 Sep 17. doi: 10.1007/s00018-007-7280-y

PMCID:: PMC11136325

Abstract PDF–850K

Select item 111136432.

Farnesoid X receptor alpha: a molecular link between bile acids and steroid signaling?

Marine Baptissart, Aurelie Vega, Emmanuelle Martinot, Silvère Baron, Jean-Marc A. Lobaccaro, David H. Volle

Cell Mol Life Sci. 2013 Dec; 70(23): 4511–4526. Published online 2013 Jun 20. doi: 10.1007/s00018-013-1387-0

PMCID:: PMC11113643

Abstract Article PDF–551K

Select item 110275193.

NR1H4 disease: rapidly progressing neonatal intrahepatic cholestasis and early death

Zhong-Die Li, Yu-Chuan Li, Jing-Zhao, Jian-She Wang, Xin-Bao Xie

Orphanet J Rare Dis. 2024; 19: 171. Published online 2024 Apr 19. doi: 10.1186/s13023-024-03166-1

PMCID:: PMC11027519

Abstract Article PDF–1.1M

Select item 106161974.

Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis

Juliane Tschuck, Lea Theilacker, Ina Rothenaigner, Stefanie A. I. Weiß, Banu Akdogan, Van Thanh Lam, Constanze Müller, Roman Graf, Stefanie Brandner, Christian Pütz, Tamara Rieder, Philippe Schmitt-Kopplin, Michelle Vincendeau, Hans Zischka, Kenji Schorpp, Kamyar Hadian

Nat Commun. 2023; 14: 6908. Published online 2023 Oct 30. doi: 10.1038/s41467-023-42702-8

PMCID:: PMC10616197

Abstract Article PDF–2.3M

Select item 102782995.

Regulon analysis identifies protective FXR and CREB5 in proximal tubules in early diabetic kidney disease

Wanting Shi, Weibo Le, Qiaoli Tang, Shaolin Shi, Jingsong Shi

BMC Nephrol. 2023; 24: 180. Published online 2023 Jun 19. doi: 10.1186/s12882-023-03239-6

PMCID:: PMC10278299

Abstract Article PDF–4.4M

Select item 99816146.

The role of the farnesoid X receptor in kidney health and disease: a potential therapeutic target in kidney diseases

Dong-Hyun Kim, Jung Sun Park, Hoon-In Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim

Exp Mol Med. 2023 Feb; 55(2): 304–312. Published online 2023 Feb 3. doi: 10.1038/s12276-023-00932-2

PMCID:: PMC9981614

Abstract Article PDF–871K

Select item 97018967.

CEBPB regulates the bile acid receptor FXR to accelerate colon cancer progression by modulating aerobic glycolysis

Zhengrong Wang, Jinghuan Pang, Lingyan Wang, Qinhui Dong, Dan Jin

J Clin Lab Anal. 2022 Nov; 36(11): e24703. Published online 2022 Sep 21. doi: 10.1002/jcla.24703

PMCID:: PMC9701896

Abstract Article PDF–7.0M

Select item 96959478.

The Farnesoid X Receptor as a Master Regulator of Hepatotoxicity

Magdalena Rausch, Sophia L. Samodelov, Michele Visentin, Gerd A. Kullak-Ublick

Int J Mol Sci. 2022 Nov; 23(22): 13967. Published online 2022 Nov 12. doi: 10.3390/ijms232213967

PMCID:: PMC9695947

Abstract Article PDF–1.4M

Select item 96299259.

Transcription Factor FXR Activates DHRS9 to Inhibit the Cell Oxidative Phosphorylation and Suppress Colon Cancer Progression

Jinlai Zhao, Yigang Wang, Yang Wang, Jianchao Gao, Haichao Yang, Xiaotang Wu, Hua Li

Anal Cell Pathol (Amst) 2022; 2022: 8275574. Published online 2022 Oct 26. doi: 10.1155/2022/8275574

PMCID:: PMC9629925

Abstract Article PDF–2.5M

Select item 945430310.

Reduced peroxisome proliferator-activated receptor-α and bile acid nuclear receptor NR1H4/FXR may affect the hepatic immune microenvironment of biliary atresia

Yingxuan Ma, Li Lu, Kezhe Tan, Zhi Li, Ting Guo, Yibo Wu, Wei Wu, Lulu Zheng, Feilong Fan, Jiayu Mo, Zhenhua Gong

Front Immunol. 2022; 13: 875593. Published online 2022 Aug 25. doi: 10.3389/fimmu.2022.875593

PMCID:: PMC9454303

Abstract Article PDF–14M

Select item 924113411.

Farnesoid X receptor protects against cisplatin-induced acute kidney injury by regulating the transcription of ferroptosis-related genes

Dong-Hyun Kim, Hoon-In Choi, Jung Sun Park, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim

Redox Biol. 2022 Aug; 54: 102382. Published online 2022 Jun 23. doi: 10.1016/j.redox.2022.102382

PMCID:: PMC9241134

Abstract Article PDF–20M

Select item 917431212.

Farnesoid X receptor functions in cervical cancer via the p14^ARF-mouse double minute 2-p53 pathway

Xiaohua Huang, Bin Wang, Huimin Shen, Danmei Huang, Ganggang Shi

Mol Biol Rep. 2022; 49(5): 3617–3625. Published online 2022 Mar 28. doi: 10.1007/s11033-022-07201-x

PMCID:: PMC9174312

Abstract Article PDF–2.1M

Select item 910387713.

Enhancement of Farnesoid X Receptor Inhibits Migration, Adhesion and Angiogenesis through Proteasome Degradation and VEGF Reduction in Bladder Cancers

Chien-Rui Lai, Hisao-Hsien Wang, Hsin-Han Chang, Yu-Ling Tsai, Wen-Chiuan Tsai, Chen-Ray Lee, Chih-Ying Changchien, Yu-Chen Cheng, Sheng-Tang Wu, Ying Chen

Int J Mol Sci. 2022 May; 23(9): 5259. Published online 2022 May 9. doi: 10.3390/ijms23095259

PMCID:: PMC9103877

Abstract Article PDF–5.2M

Select item 901703814.

Identification of two novel pathogenic variants of the NR1H4 gene in intrahepatic cholestasis of pregnancy patients

Hua Lai, Xianxian Liu, Siming Xin, Jiusheng Zheng, Huai Liu, Yu Ouyang, Huoxiu Yang, Yang Zeng, Yang Zou, Xiaoming Zeng

BMC Med Genomics. 2022; 15: 90. Published online 2022 Apr 18. doi: 10.1186/s12920-022-01240-w

PMCID:: PMC9017038

Abstract Article PDF–2.3M

Select item 889615715.

Farnesoid X Receptor Deficiency Induces Hepatic Lipid and Glucose Metabolism Disorder via Regulation of Pyruvate Dehydrogenase Kinase 4

Wenyi Deng, Wenjing Fan, Tingting Tang, Hengquan Wan, Simin Zhao, Yao Tan, Kwabena Agyare Oware, Jieqiong Tan, Jiequn Li, Shunlin Qu

Oxid Med Cell Longev. 2022; 2022: 3589525. Published online 2022 Feb 24. doi: 10.1155/2022/3589525

PMCID:: PMC8896157

Abstract Article PDF–6.0M

Select item 881803316.

Pleiotropic roles of FXR in liver and colorectal cancers

Xiongfei Huang, Mingjie Fan, Wendong Huang

Mol Cell Endocrinol. Author manuscript; available in PMC 2023 Mar 1.

Published in final edited form as: Mol Cell Endocrinol. 2022 Mar 1; 543: 111543. Published online 2022 Jan 4. doi: 10.1016/j.mce.2021.111543

PMCID:: PMC8818033

Abstract Article PDF–843K

Select item 851677517.

Bile acids increase intestinal marker expression via the FXR/SNAI2/miR-1 axis in the stomach

Na Wang, Siran Wu, Jing Zhao, Min Chen, Jiaoxia Zeng, Guofang Lu, Jiaojiao Wang, Jian Zhang, Junye Liu, Yongquan Shi

Cell Oncol (Dordr) 2021; 44(5): 1119–1131. Published online 2021 Sep 12. doi: 10.1007/s13402-021-00622-z

PMCID:: PMC8516775

Abstract Article PDF–3.8M

Select item 849219518.

Role of FXR in Bile Acid and Metabolic Homeostasis in NASH: Pathogenetic Concepts and Therapeutic Opportunities

Richard Radun, Michael Trauner

Semin Liver Dis. 2021 Nov; 41(4): 461–475. Published online 2021 Jul 21. doi: 10.1055/s-0041-1731707

PMCID:: PMC8492195

Abstract Article PDF–493K

Select item 844017619.

Bile acid-induced tissue factor activity in hepatocytes correlates with activation of farnesoid X receptor

Theresa Greimel, Jörg Jahnel, Sina Pohl, Tanja Strini, Martin Tischitz, Nathalie Meier-Allard, Sandra Holasek, Katharina Meinel, Victor Aguiriano-Moser, Joachim Zobel, Harald Haidl, Siegfried Gallistl, Katrin Panzitt, Martin Wagner, Axel Schlagenhauf

Lab Invest. 2021; 101(10): 1394–1402. Published online 2021 Jun 18. doi: 10.1038/s41374-021-00628-z

PMCID:: PMC8440176

Abstract Article PDF–1.0M

Select item 836452820.

Pathophysiology of reflux oesophagitis: role of Toll-like receptors 2 and 4 and Farnesoid X receptor

Minna Nortunen, Nina Väkiparta, Katja Porvari, Juha Saarnio, Tuomo J Karttunen, Heikki Huhta

Virchows Arch. 2021; 479(2): 285–293. Published online 2021 Mar 8. doi: 10.1007/s00428-021-03066-w

PMCID:: PMC8364528

Abstract Article PDF–829K

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PMC Links for GEO Profiles (Select 38060216) (150)
PMC
Protein Links for OMIM (Select 615128) (0)
Protein
Bacillus velezensis strain LZN01 chromosome, complete genome
Bacillus velezensis strain LZN01 chromosome, complete genome
gi|2085959643|ref|NZ_CP081488.1|

Nucleotide
b-keto acyl reductase family protein [Populus trichocarpa]
b-keto acyl reductase family protein [Populus trichocarpa]
gi|224100105|ref|XP_002311745.1||gn _WGS:AARH|POPTR_0008s182001p

Protein

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