PMC Links for GEO Profiles (Select 38062161) - PMC

Shizuka Suzuki, Kan Uchiyama, Yutaro Motoi, Yuuki Yoshii, Yukari Inoue, Takahiro Kubota, Shunichi Odahara, Yuichiro Ohtaki, Shinichiro Takami, Zensho Ito, Nobuhiro Sato, Toshifumi Ohkusa, Shigeo Koido, Masayuki Saruta

BMC Gastroenterol. 2023; 23: 239. Published online 2023 Jul 15. doi: 10.1186/s12876-023-02881-6

PMCID:: PMC10350251

Abstract Article PDF–1.2M

Select item 99744344.

The influence of NUDT15 variants on 6-mercaptopurine-induced neutropenia in Vietnamese pediatric acute lymphoblastic leukemia

Mai-Lan Nguyen, Anh Vu Hoang, Bich Tram Duong, Nguyen The Nguyen Phung

HGG Adv. 2023 Apr 13; 4(2): 100183. Published online 2023 Feb 10. doi: 10.1016/j.xhgg.2023.100183

PMCID:: PMC9974434

Abstract Article PDF–1.6M

Select item 97966995.

Nudix hydrolase 15 (NUDT15) loss‐of‐function variants in an Australian inflammatory bowel disease population

Sadia Afrin, Lisa A. Simms, Anton Lord, Graham L. Radford‐Smith

Intern Med J. 2022 Nov; 52(11): 1971–1977. Published online 2022 Jun 8. doi: 10.1111/imj.15746

PMCID:: PMC9796699

Abstract Article PDF–979K

Select item 95478626.

Low NUDT15 expression levels due to bi-allelic NUDT15 variants and 6-mercaptopurine intolerance

Masanori Yoshida, Scott A Brown, Takaya Moriyama, Rina Nishii, Shin-ichi Tsujimoto, Yuji Yamada, Kaoru Yoshida, Ryota Shirai, Tomoo Osumi, Tomoyuki Utano, Reiji Fukano, Ko Kudo, Kimiyoshi Sakaguchi, Yuki Arakawa, Katsuyoshi Koh, Masahiro Sekiguchi, Masahiro Sekimizu, Takako Miyamura, Hisashi Ishida, Takeshi Inukai, Daisuke Tomizawa, Nobutaka Kiyokawa, Motohiro Kato, Jun J Yang

Br J Haematol. Author manuscript; available in PMC 2023 Oct 1.

Published in final edited form as: Br J Haematol. 2022 Oct; 199(2): 270–276. Published online 2022 Jul 29. doi: 10.1111/bjh.18375

PMCID:: PMC9547862

Abstract Article PDF–390K

Select item 89733087.

Susceptibility to thiopurine toxicity by TPMT and NUDT15 variants in Colombian children with acute lymphoblastic leukemia

Oscar Correa-Jimenez, Juan José Yunis, Adriana Linares-Ballesteros, Isabel Sarmiento-Urbina

Colomb Med (Cali) 2021 Jul-Sep; 52(3): e2074569. Published online 2021 Sep 30. doi: 10.25100/cm.v52i3.4569

PMCID:: PMC8973308

Abstract Article PDF–1.0M

Select item 87635858.

TPMT、NUDT15基因多态性对成人急性淋巴细胞白血病患者6-巯基嘌呤耐受性的影响

郝其姗, 王哲, 房秋云, 弓晓媛, 刘凯奇, 李艳, 魏辉, 王迎, 李庆华, 王敏, 田征, 王建祥, 秘营昌

Zhonghua Xue Ye Xue Za Zhi. 2021 Nov; 42(11): 911–916. Chinese. doi: 10.3760/cma.j.issn.0253-2727.2021.11.005

PMCID:: PMC8763585

Abstract Article PDF–847K

Select item 86783059.

TPMT and NUDT15 Variants Predict Discontinuation of Azathioprine for Myelotoxicity in Patients with Inflammatory Disease: Real-World Clinical Results

Alyson L. Dickson, Laura L. Daniel, Jacy Zanussi, W. Dale Plummer, Wei-Qi Wei, Ge Liu, Tyler Reese, Prathima Anandi, Kelly A. Birdwell, Vivian Kawai, Nancy J. Cox, William D. Dupont, Adriana M. Hung, QiPing Feng, C. Michael Stein, Cecilia P. Chung

Clin Pharmacol Ther. Author manuscript; available in PMC 2023 Jan 1.

Published in final edited form as: Clin Pharmacol Ther. 2022 Jan; 111(1): 263–271. Published online 2021 Oct 12. doi: 10.1002/cpt.2428

PMCID:: PMC8678305

Abstract Article PDF–959K

Select item 858134010.

NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells

Shinpei Somazu, Yoichi Tanaka, Minori Tamai, Atsushi Watanabe, Keiko Kagami, Masako Abe, Daisuke Harama, Tamao Shinohara, Koshi Akahane, Kumiko Goi, Kanji Sugita, Takaya Moriyama, Jun Yang, Hiroaki Goto, Masayoshi Minegishi, Shotaro Iwamoto, Junko Takita, Takeshi Inukai

J Cell Mol Med. 2021 Nov; 25(22): 10521–10533. Published online 2021 Oct 12. doi: 10.1111/jcmm.16981

PMCID:: PMC8581340

Abstract Article PDF–1.5M

Select item 847498611.

A novel single-tube multiplex real-time PCR assay for genotyping of thiopurine intolerance-causing variant NUDT15 c.415C>T

Xiaoyun Lian, Yanwei Li, Lan Li, Kaicheng U, Wenxia Wang, Yinmin Shi, Jiying Ma, Huijuan Wang

Exp Biol Med (Maywood) 2021 Sep; 246(18): 1961–1967. Published online 2021 Jun 30. doi: 10.1177/15353702211026579

PMCID:: PMC8474986

Abstract Article PDF–572K

Select item 838341112.

TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in inflammatory bowel disease: a prospective study from India

Narinder Grover, Prateek Bhatia, Antriksh Kumar, Minu Singh, Deepesh Lad, Harshal S. Mandavdhare, Jayanta Samanta, Kaushal K. Prasad, Usha Dutta, Vishal Sharma

BMC Gastroenterol. 2021; 21: 327. Published online 2021 Aug 23. doi: 10.1186/s12876-021-01900-8

PMCID:: PMC8383411

Abstract Article PDF–985K

Select item 832153213.

Understanding the Origins of Loss of Protein Function by Analyzing the Effects of Thousands of Variants on Activity and Abundance

Matteo Cagiada, Kristoffer E Johansson, Audrone Valanciute, Sofie V Nielsen, Rasmus Hartmann-Petersen, Jun J Yang, Douglas M Fowler, Amelie Stein, Kresten Lindorff-Larsen

Mol Biol Evol. 2021 Aug; 38(8): 3235–3246. Published online 2021 Mar 29. doi: 10.1093/molbev/msab095

PMCID:: PMC8321532

Abstract Article PDF–1.0M

Select item 826374614.

NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir

Rina Nishii, Takanori Mizuno, Daniel Rehling, Colton Smith, Brandi L. Clark, Xujie Zhao, Scott A. Brown, Brandon Smart, Takaya Moriyama, Yuji Yamada, Tatsuo Ichinohe, Makoto Onizuka, Yoshiko Atsuta, Lei Yang, Wenjian Yang, Paul G. Thomas, Pål Stenmark, Motohiro Kato, Jun J. Yang

Nat Commun. 2021; 12: 4181. Published online 2021 Jul 7. doi: 10.1038/s41467-021-24509-7

PMCID:: PMC8263746

Abstract Article PDF–1.4M

Select item 816503015.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 804210816.

Association of genetic variants in TPMT, ITPA, and NUDT15 with azathioprine-induced myelosuppression in southwest china patients with autoimmune hepatitis

Qiang Miao, Lin Yan, Yanhong Zhou, Yi Li, Yuangao Zou, Lanlan Wang, Yangjuan Bai, Junlong Zhang

Sci Rep. 2021; 11: 7984. Published online 2021 Apr 12. doi: 10.1038/s41598-021-87095-0

PMCID:: PMC8042108

Abstract Article PDF–1.0M

Select item 782225817.

DNA-thioguanine nucleotide as a treatment marker in acute lymphoblastic leukemia patients with NUDT15 variant genotypes

Hee Young Ju, Ji Won Lee, Hee Won Cho, Ju Kyung Hyun, Youngeun Ma, Eun Sang Yi, Keon Hee Yoo, Ki Woong Sung, Rihwa Choi, Hong Hoe Koo, Soo-Youn Lee

PLoS One. 2021; 16(1): e0245667. Published online 2021 Jan 22. doi: 10.1371/journal.pone.0245667

PMCID:: PMC7822258

Abstract Article PDF–1.2M

Select item 746323718.

Determination of NUDT15 variants by targeted sequencing can identify compound heterozygosity in pediatric acute lymphoblastic leukemia patients

Chih-Hsiang Yu, Ya-Hsuan Chang, Der-Shiun Wang, Shiann-Tarng Jou, Chien-Yu Lin, Kai-Hsin Lin, Meng-Yao Lu, Lovely Raghav, Hsiu-Hao Chang, Kang-Hsi Wu, Shu-Wei Chou, Yu-Ling Ni, Dong-Tsamn Lin, Shu-Wha Lin, Hsuan-Yu Chen, Yung-Li Yang

Sci Rep. 2020; 10: 14400. Published online 2020 Sep 1. doi: 10.1038/s41598-020-71468-y

PMCID:: PMC7463237

Abstract Article PDF–1.5M

Select item 734901719.

Association of NUDT15 c.415C>T and FPGS 2572C>T Variants with the Risk of Early Hematologic Toxicity During 6-MP and Low-Dose Methotrexate-Based Maintenance Therapy in Indian Patients with Acute Lymphoblastic Leukemia

Sunitha Kodidela, Patchava Dorababu, Dimpal N. Thakkar, Biswajit Dubashi, Rajan Sundaram, Niveditha Muralidharan, Ravi Prasad Nidanapu, Anil Aribandi, Suresh Chandra Pradhan, Chakradhara Rao Satyanarayana Uppugunduri

Genes (Basel) 2020 Jun; 11(6): 594. Published online 2020 May 28. doi: 10.3390/genes11060594

PMCID:: PMC7349017

Abstract Article PDF–605K

Select item 717644820.

Association of thiopurine S-methyltransferase and NUDT15 polymorphisms with azathioprine-induced myelotoxicity in Chinese patients with rheumatological disease

Song-Sen Su, Yan-Fang Lin, Hong Zhou

Chin Med J (Engl) 2020 Apr 20; 133(8): 1002–1004. Published online 2020 Apr 20. doi: 10.1097/CM9.0000000000000756

PMCID:: PMC7176448

Article PDF–133K

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