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Select item 111481841.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 102374222.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 102131173.

Rbpj deficiency disrupts vascular remodeling via abnormal Apelin and Cdc42 activity in brain arteriovenous malformation

Subhodip Adhicary, Kayleigh Fanelli, Sera Nakisli, Brittney Ward, Isaac Pearce, Corinne M. Nielsen

Stroke. Author manuscript; available in PMC 2024 Jun 1.

Published in final edited form as: Stroke. 2023 Jun; 54(6): 1593–1605. Published online 2023 Apr 13. doi: 10.1161/STROKEAHA.122.041853

PMCID:: PMC10213117

Abstract Article PDF–1.4M

Select item 98251714.

The structure, binding and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3

Daniel Hall, Benedetto Daniele Giaimo, Sung-Soo Park, Wiebke Hemmer, Tobias Friedrich, Francesca Ferrante, Marek Bartkuhn, Zhenyu Yuan, Franz Oswald, Tilman Borggrefe, Jean-François Rual, Rhett A Kovall

Nucleic Acids Res. 2022 Dec 9; 50(22): 13083–13099. Published online 2022 Dec 8. doi: 10.1093/nar/gkac1137

PMCID:: PMC9825171

Abstract Article PDF–7.6M

Select item 95403455.

The in vivo Interaction Landscape of Histones H3.1 and H3.3

Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins

Mol Cell Proteomics. 2022 Oct; 21(10): 100411. Published online 2022 Sep 9. doi: 10.1016/j.mcpro.2022.100411

PMCID:: PMC9540345

Abstract Article PDF–3.9M

Select item 94917136.

FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ

Hua Jiang, Weixiang Bian, Yue Sui, Huanle Li, Han Zhao, Wenqi Wang, Xu Li

Sci Adv. 2022 Sep; 8(38): eabq4831. Published online 2022 Sep 21. doi: 10.1126/sciadv.abq4831

PMCID:: PMC9491713

Abstract Article PDF–12M

Select item 94592527.

RITA1 drives the growth of bladder cancer cells by recruiting TRIM25 to facilitate the proteasomal degradation of RBPJ

Huancheng Tang, Xiangdong Li, Lijuan Jiang, Zefu Liu, Lei Chen, Jiawei Chen, Minhua Deng, Fangjian Zhou, Xianchong Zheng, Zhuowei Liu

Cancer Sci. 2022 Sep; 113(9): 3071–3084. Published online 2022 Jun 28. doi: 10.1111/cas.15459

PMCID:: PMC9459252

Abstract Article PDF–19M

Select item 92792858.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 92768119.

Hydroxylation of the NOTCH1 intracellular domain regulates Notch signaling dynamics

Francesca Ferrante, Benedetto Daniele Giaimo, Tobias Friedrich, Toshiya Sugino, Daniel Mertens, Sabrina Kugler, Bernd Martin Gahr, Steffen Just, Leiling Pan, Marek Bartkuhn, Michael Potente, Franz Oswald, Tilman Borggrefe

Cell Death Dis. 2022 Jul; 13(7): 600. Published online 2022 Jul 12. doi: 10.1038/s41419-022-05052-9

PMCID:: PMC9276811

Abstract Article PDF–1.8M

Select item 927448510.

Interaction between BEND5 and RBPJ suppresses breast cancer growth and metastasis via inhibiting Notch signaling

Yanzhu Shi, Deyu Zhang, Jingyi Chen, Qiwei Jiang, Songze Song, Yue Mi, Tao Wang, Qinong Ye

Int J Biol Sci. 2022; 18(10): 4233–4244. Published online 2022 Jun 27. doi: 10.7150/ijbs.70866

PMCID:: PMC9274485

Abstract Article PDF–2.6M

Select item 910523511.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 905883612.

The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside

Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang

J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009

PMCID:: PMC9058836

Abstract Article PDF–2.9M

Select item 892305713.

Transcription Factor Protein Interactomes Reveal Genetic Determinants in Heart Disease

Barbara Gonzalez-Teran, Maureen Pittman, Franco Felix, Reuben Thomas, Desmond Richmond-Buccola, Ruth Hüttenhain, Krishna Choudhary, Elisabetta Moroni, Mauro W. Costa, Yu Huang, Arun Padmanabhan, Michael Alexanian, Clara Youngna Lee, Bonnie E. J. Maven, Kaitlen Samse-Knapp, Sarah U. Morton, Michael McGregor, Casey A. Gifford, J. G. Seidman, Christine E. Seidman, Bruce D. Gelb, Giorgio Colombo, Bruce R. Conklin, Brian L. Black, Benoit G. Bruneau, Nevan J. Krogan, Katherine S. Pollard, Deepak Srivastava

Cell. Author manuscript; available in PMC 2023 Mar 3.

Published in final edited form as: Cell. 2022 Mar 3; 185(5): 794–814.e30. Published online 2022 Feb 18. doi: 10.1016/j.cell.2022.01.021

PMCID:: PMC8923057

Abstract Article PDF–2.5M

Select item 882889514.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 858131415.

Colon cancer cells secreted CXCL11 via RBP‐Jκ to facilitated tumour‐associated macrophage‐induced cancer metastasis

Mengjie Liu, Xiao Fu, Lili Jiang, Jiequn Ma, Xiaoqiang Zheng, Shuhong Wang, Hui Guo, Tao Tian, Kejun Nan, Wenjuan Wang

J Cell Mol Med. 2021 Nov; 25(22): 10575–10590. Published online 2021 Oct 16. doi: 10.1111/jcmm.16989

PMCID:: PMC8581314

Abstract Article PDF–4.8M

Select item 851385316.

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation

Jordan M. Meyers, Muthukumar Ramanathan, Ronald L. Shanderson, Aimee Beck, Laura Donohue, Ian Ferguson, Margaret G. Guo, Deepti S. Rao, Weili Miao, David Reynolds, Xue Yang, Yang Zhao, Yen-Yu Yang, Catherine Blish, Yinsheng Wang, Paul A. Khavari

PLoS Pathog. 2021 Oct; 17(10): e1009412. Published online 2021 Oct 1. doi: 10.1371/journal.ppat.1009412

PMCID:: PMC8513853

Abstract Article PDF–4.1M

Select item 816503017.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 805077518.

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner

Lauriane Vélot, Frédéric Lessard, Félix-Antoine Bérubé-Simard, Christophe Tav, Bertrand Neveu, Valentine Teyssier, Imène Boudaoud, Ugo Dionne, Noémie Lavoie, Steve Bilodeau, Frédéric Pouliot, Nicolas Bisson

Mol Cell Proteomics. 2021; 20: 100064. Published online 2021 Feb 26. doi: 10.1016/j.mcpro.2021.100064

PMCID:: PMC8050775

Abstract Article PDF–3.6M

Select item 786205919.

Merkel cell carcinoma-derived exosome-shuttle miR-375 induces fibroblast polarization by inhibition of RBPJ and p53

Kaiji Fan, Ivelina Spassova, Jan Gravemeyer, Cathrin Ritter, Kai Horny, Anja Lange, Thilo Gambichler, Niels Ødum, David Schrama, Dirk Schadendorf, Selma Ugurel, Jürgen C. Becker

Oncogene. 2021; 40(5): 980–996. Published online 2020 Dec 11. doi: 10.1038/s41388-020-01576-6

PMCID:: PMC7862059

Abstract Article PDF–6.2M

Select item 781184720.

Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ

Louise M. C. Webb, Sigrid Fra‐Bido, Silvia Innocentin, Louise S. Matheson, Noudjoud Attaf, Alexandre Bignon, Julien Novarino, Nicolas Fazilleau, Michelle A. Linterman

Aging Cell. 2021 Jan; 20(1): e13295. Published online 2021 Jan 2. doi: 10.1111/acel.13295

PMCID:: PMC7811847

Abstract Article PDF–2.1M

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Gamma secretase inhibitor MRK-003 effect on pancreatic ductal adenocarcinoma tum...
Gamma secretase inhibitor MRK-003 effect on pancreatic ductal adenocarcinoma tumor xenografts
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