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Select item 107213121.

GADD45A is a mediator of mitochondrial loss, atrophy, and weakness in skeletal muscle

George R. Marcotte, Matthew J. Miller, Hawley E. Kunz, Zachary C. Ryan, Matthew D. Strub, Patrick M. Vanderboom, Carrie J. Heppelmann, Sarah Chau, Zachary D. Von Ruff, Sean P. Kilroe, Andrew T. McKeen, Jason M. Dierdorff, Jennifer I. Stern, Karl A. Nath, Chad E. Grueter, Vitor A. Lira, Andrew R. Judge, Blake B. Rasmussen, K. Sreekumaran Nair, Ian R. Lanza, Scott M. Ebert, Christopher M. Adams

JCI Insight. 2023 Nov 22; 8(22): e171772. Published online 2023 Nov 22. doi: 10.1172/jci.insight.171772

PMCID:: PMC10721312

Article PDF–13M

Select item 106340812.

IRE1-mediated degradation of pre-miR-301a promotes apoptosis through upregulation of GADD45A

Magdalena Gebert, Sylwia Bartoszewska, Lukasz Opalinski, James F. Collawn, Rafał Bartoszewski

Cell Commun Signal. 2023; 21: 322. Published online 2023 Nov 9. doi: 10.1186/s12964-023-01349-0

PMCID:: PMC10634081

Article PDF–8.1M

Select item 103126743.

AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor

Philipp Trepte, Christopher Secker, Simona Kostova, Sibusiso B. Maseko, Soon Gang Choi, Jeremy Blavier, Igor Minia, Eduardo Silva Ramos, Patricia Cassonnet, Sabrina Golusik, Martina Zenkner, Stephanie Beetz, Mara J. Liebich, Nadine Scharek, Anja Schütz, Marcel Sperling, Michael Lisurek, Yang Wang, Kerstin Spirohn, Tong Hao, Michael A. Calderwood, David E. Hill, Markus Landthaler, Julien Olivet, Jean-Claude Twizere, Marc Vidal, Erich E. Wanker

Version 1. bioRxiv. Preprint. 2023 Jun 14. doi: 10.1101/2023.06.14.544560

Published in:: Mol Syst Biol. 2024 Apr; 20(4): 428–457.

PMCID:: PMC10312674

Article PDF–9.6M

Select item 101048154.

Polymorphisms within DIO2 and GADD45A genes increase the risk of liver disease progression in chronic hepatitis b carriers

Magda Rybicka, Eloi R. Verrier, Thomas F. Baumert, Krzysztof Piotr Bielawski

Sci Rep. 2023; 13: 6124. Published online 2023 Apr 14. doi: 10.1038/s41598-023-32753-8

PMCID:: PMC10104815

Article PDF–1.2M

Select item 98919745.

Growth arrest and DNA damage‐inducible alpha regulates muscle repair and fat infiltration through ATP synthase F1 subunit alpha

Wenjing You, Shiqi Liu, Jianfei Ji, Defeng Ling, Yuang Tu, Yanbing Zhou, Wentao Chen, Teresa G. Valencak, Yizhen Wang, Tizhong Shan

J Cachexia Sarcopenia Muscle. 2023 Feb; 14(1): 326–341. Published online 2022 Dec 13. doi: 10.1002/jcsm.13134

PMCID:: PMC9891974

Article PDF–6.0M

Select item 97388316.

MAGOH and MAGOHB Knockdown in Melanoma Cells Decreases Nonsense-Mediated Decay Activity and Promotes Apoptosis via Upregulation of GADD45A

Agnes Soederberg, Tina Meißgeier, Anja Katrin Bosserhoff, Lisa Linck-Paulus

Cells. 2022 Dec; 11(23): 3859. Published online 2022 Nov 30. doi: 10.3390/cells11233859

PMCID:: PMC9738831

Article PDF–3.1M

Select item 92626147.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Article PDF–3.6M

Select item 82855128.

Growth arrest and DNA damage-inducible proteins (GADD45) in psoriasis

Pedro Rodríguez-Jiménez, Lola Fernández-Messina, María C. Ovejero-Benito, Pablo Chicharro, Paula Vera-Tomé, Alicia Vara, Danay Cibrian, Pedro Martínez-Fleta, María Jiménez-Fernández, Inés Sánchez-García, Mar Llamas-Velasco, Francisco Abad-Santos, Francisco Sánchez-Madrid, Esteban Dauden, Hortensia de la Fuente

Sci Rep. 2021; 11: 14579. Published online 2021 Jul 16. doi: 10.1038/s41598-021-93780-x

PMCID:: PMC8285512

Article PDF–3.1M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Article PDF–2.2M

Select item 773761010.

Receptor‐mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy

Amelia E Ohnstad, Jose M Delgado, Brian J North, Isha Nasa, Arminja N Kettenbach, Sebastian W Schultz, Christopher J Shoemaker

EMBO J. 2020 Dec 15; 39(24): e104948. Published online 2020 Nov 23. doi: 10.15252/embj.2020104948

PMCID:: PMC7737610

Article PDF–3.7M

Select item 729621111.

DHX33 Recruits Gadd45a To Cause DNA Demethylation and Regulates a Subset of Gene Transcription

Weimin Feng, Shiyun Chen, Jiuling Wang, Xingshun Wang, Huaiyong Chen, Wen Ning, Yandong Zhang

Mol Cell Biol. 2020 Jul; 40(13): e00460-19. Prepublished online 2020 Apr 20. Published online 2020 Jun 15. doi: 10.1128/MCB.00460-19

PMCID:: PMC7296211

Article PDF–5.5M

Select item 716998312.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Article PDF–5.4M

Select item 714552613.

The mRNA repressor TRIM71 cooperates with Nonsense-Mediated Decay factors to destabilize the mRNA of CDKN1A/p21

Lucia A Torres-Fernández, Bettina Jux, Maximilian Bille, Yasmine Port, Karin Schneider, Matthias Geyer, Günter Mayer, Waldemar Kolanus

Nucleic Acids Res. 2019 Dec 16; 47(22): 11861–11879. Published online 2019 Nov 16. doi: 10.1093/nar/gkz1057

PMCID:: PMC7145526

Article PDF–7.0M

Select item 694079314.

ER Stress Induces Cell Cycle Arrest at the G2/M Phase Through eIF2α Phosphorylation and GADD45α

Duckgue Lee, Daniel Hokinson, Soyoung Park, Rosalie Elvira, Fedho Kusuma, Ji-Min Lee, Miyong Yun, Seok-Geun Lee, Jaeseok Han

Int J Mol Sci. 2019 Dec; 20(24): 6309. Published online 2019 Dec 13. doi: 10.3390/ijms20246309

PMCID:: PMC6940793

Article PDF–2.9M

Select item 689239315.

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets

Kristen Mengwasser, Richard Adeyemi, Yumei Leng, Mei Yuk Choi, Connor Clairmont, Alan D’Andrea, Stephen J. Elledge

Mol Cell. Author manuscript; available in PMC 2019 Dec 4.

Published in final edited form as: Mol Cell. 2019 Mar 7; 73(5): 885–899.e6. Published online 2019 Jan 24. doi: 10.1016/j.molcel.2018.12.008

PMCID:: PMC6892393

Article PDF–1.7M

Select item 642009816.

GADD45A binds R-loops and recruits TET1 to CpG island promoters

Khelifa Arab, Emil Karaulanov, Michael Musheev, Philipp Trnka, Andrea Schäfer, Ingrid Grummt, Christof Niehrs

Nat Genet. Author manuscript; available in PMC 2019 Jul 7.

Published in final edited form as: Nat Genet. 2019 Feb; 51(2): 217–223. Published online 2019 Jan 7. doi: 10.1038/s41588-018-0306-6

PMCID:: PMC6420098

Article PDF–1.7M

Select item 635565017.

Transcriptional repression of IKKβ by p53 in arsenite-induced GADD45α accumulation and apoptosis

Yongliang Hu, Rui Jin, Ming Gao, Huan Xu, Shuxian Zou, Xiaoguang Li, Chen Xing, Qiyu Wang, Hongli Wang, Jiannan Feng, Meiru Hu, Lun Song

Oncogene. 2019; 38(5): 731–746. Published online 2018 Sep 3. doi: 10.1038/s41388-018-0478-7

PMCID:: PMC6355650

Article PDF–5.3M

Select item 610715318.

Differential expression of vitamin D associated genes in the aorta of coronary artery disease patients with and without rheumatoid arthritis

Ingvild Oma, Ole Kristoffer Olstad, Jacqueline Kirsti Andersen, Torstein Lyberg, Øyvind Molberg, Ida Fostad, Morten Wang Fagerland, Sven Martin Almdahl, Stein Erik Rynning, Arne Yndestad, Pål Aukrust, Jon Elling Whist, Ivana Hollan

PLoS One. 2018; 13(8): e0202346. Published online 2018 Aug 23. doi: 10.1371/journal.pone.0202346

PMCID:: PMC6107153

Article PDF–1.0M

Select item 594329319.

GADD45α sensitizes cervical cancer cells to radiotherapy via increasing cytoplasmic APE1 level

Qing Li, Xi Wei, Zhi-Wei Zhou, Shu-Nan Wang, Hua Jin, Kui-Jun Chen, Jia Luo, Kenneth D. Westover, Jian-Min Wang, Dong Wang, Cheng-Xiong Xu, Jin-Lu Shan

Cell Death Dis. 2018 May; 9(5): 524. Published online 2018 May 9. doi: 10.1038/s41419-018-0452-x

PMCID:: PMC5943293

Article PDF–1.9M

Select item 584142620.

Down-regulation of GADD45A enhances chemosensitivity in melanoma

Jia Liu, Guoqiang Jiang, Ping Mao, Jing Zhang, Lin Zhang, Likun Liu, Jia Wang, Lawrence Owusu, Baoyin Ren, Yawei Tang, Weiling Li

Sci Rep. 2018; 8: 4111. Published online 2018 Mar 7. doi: 10.1038/s41598-018-22484-6

PMCID:: PMC5841426

Article PDF–2.8M

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