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Select item 99663091.

Paracrine Effects of Renal Proximal Tubular Epithelial Cells on Podocyte Injury under Hypoxic Conditions Are Mediated by Arginase-II and TGF-β1

Yiqiong Ma, Duilio Michele Potenza, Guillaume Ajalbert, Andrea Brenna, Cui Zhu, Xiu-Fen Ming, Zhihong Yang

Int J Mol Sci. 2023 Feb; 24(4): 3587. Published online 2023 Feb 10. doi: 10.3390/ijms24043587

PMCID:: PMC9966309

Abstract Article PDF–3.1M

Select item 98284692.

Arginase 2 negatively regulates sorafenib-induced cell death by mediating ferroptosis in melanoma: The role of Arginase 2 in sorafenib-induced ferroptosis in melanoma

Yi Yu, Yuanyuan Ren, Caihua Wang, Zhuozhuo Li, Fanglin Niu, Zi Li, Qiang Ye, Jiangxia Wang, Yuan Yan, Ping Liu, Lu Qian, Yuyan Xiong

Acta Biochim Biophys Sin (Shanghai) 2022 Nov; 54(11): 1658–1670. Published online 2022 Nov 9. doi: 10.3724/abbs.2022166

PMCID:: PMC9828469

Abstract Article PDF–2.1M

Select item 98084623.

Characterisation of the immune microenvironment of primary breast cancer and brain metastasis reveals depleted T-cell response associated to ARG2 expression

A. Giannoudis, D. Varešlija, V. Sharma, R. Zakaria, A. Platt-Higgins, P.S. Rudland, M.D. Jenkinson, L.S. Young, C. Palmieri

ESMO Open. 2022 Dec; 7(6): 100636. Published online 2022 Nov 21. doi: 10.1016/j.esmoop.2022.100636

PMCID:: PMC9808462

Abstract Article PDF–678K

Select item 94961884.

Role of Arginase-II in Podocyte Injury under Hypoxic Conditions

Zhilong Ren, Duilio Michele Potenza, Yiqiong Ma, Guillaume Ajalbert, David Hoogewijs, Xiu-Fen Ming, Zhihong Yang

Biomolecules. 2022 Sep; 12(9): 1213. Published online 2022 Aug 31. doi: 10.3390/biom12091213

PMCID:: PMC9496188

Abstract Article PDF–5.6M

Select item 93485765.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 91751346.

Hypoxic pulmonary endothelial cells release epidermal growth factor leading to vascular smooth muscle cell arginase‐2 expression and proliferation

Bernadette Chen, Yi Jin, Caitlyn M. Pool, Yusen Liu, Leif D. Nelin

Physiol Rep. 2022 Jun; 10(11): e15342. Published online 2022 Jun 8. doi: 10.14814/phy2.15342

PMCID:: PMC9175134

Abstract Article PDF–1.2M

Select item 87608897.

OxLDL Triggers Retrograde Translocation of Arginase 2 in Aortic Endothelial Cells via ROCK and Mitochondrial Processing Peptidase

Deepesh Pandey, Anil Bhunia, Young Jun Oh, Fumin Chang, Yehudit Bergman, Jae Hyung Kim, Janna Serbo, Tatiana N. Boronina, Robert N. Cole, Jennifer Van Eyk, Alan T. Remaley, Dan E. Berkowitz, Lewis Romer

Circ Res. Author manuscript; available in PMC 2022 Jan 15.

Published in final edited form as: Circ Res. 2014 Aug 1; 115(4): 450–459. Published online 2014 Jun 5. doi: 10.1161/CIRCRESAHA.115.304262

PMCID:: PMC8760889

Abstract Article PDF–2.3M

Select item 86921358.

Identification and Validation of a Prognostic Model Based on Three MVI-Related Genes in Hepatocellular Carcinoma

Yongchang Tang, Lei Xu, Yupeng Ren, Yuxuan Li, Feng Yuan, Mingbo Cao, Yong Zhang, Meihai Deng, Zhicheng Yao

Int J Biol Sci. 2022; 18(1): 261–275. Published online 2022 Jan 1. doi: 10.7150/ijbs.66536

PMCID:: PMC8692135

Abstract Article PDF–2.9M

Select item 86259809.

Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes

Lorella Marselli, Emanuele Bosi, Carmela De Luca, Silvia Del Guerra, Marta Tesi, Mara Suleiman, Piero Marchetti

Int J Mol Sci. 2021 Nov; 22(22): 12099. Published online 2021 Nov 9. doi: 10.3390/ijms222212099

PMCID:: PMC8625980

Abstract Article PDF–4.7M

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 758155011.

Melanoma-associated fibroblasts impair CD8+ T cell function and modify expression of immune checkpoint regulators via increased arginase activity

Barbara Érsek, Pálma Silló, Ugur Cakir, Viktor Molnár, András Bencsik, Balázs Mayer, Eva Mezey, Sarolta Kárpáti, Zoltán Pós, Krisztián Németh

Cell Mol Life Sci. 2021 Jan; 78(2): 661–673. Published online 2020 Apr 23. doi: 10.1007/s00018-020-03517-8

PMCID:: PMC7581550

Abstract Article PDF–3.1M

Select item 754939812.

Atherosclerosis Linked to Aberrant Amino Acid Metabolism and Immunosuppressive Amino Acid Catabolizing Enzymes

Bozidarka L. Zaric, Jelena N. Radovanovic, Zoran Gluvic, Alan J. Stewart, Magbubah Essack, Olaa Motwalli, Takashi Gojobori, Esma R. Isenovic

Front Immunol. 2020; 11: 551758. Published online 2020 Sep 28. doi: 10.3389/fimmu.2020.551758

PMCID:: PMC7549398

Abstract Article PDF–2.3M

Select item 753156413.

Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action

Mark Austin, Daniel Burschowsky, Denice T.Y. Chan, Lesley Jenkinson, Stuart Haynes, Agata Diamandakis, Chitra Seewooruthun, Alexandra Addyman, Sebastian Fiedler, Stephanie Ryman, Jessica Whitehouse, Louise H. Slater, Andreas V. Hadjinicolaou, Uzi Gileadi, Ellen Gowans, Yoko Shibata, Michelle Barnard, Teresa Kaserer, Pooja Sharma, Nadia M. Luheshi, Robert W. Wilkinson, Tristan J. Vaughan, Sarah V. Holt, Vincenzo Cerundolo, Mark D. Carr, Maria A. T. Groves

MAbs. 2020 Jan-Dec; 12(1): 1801230. Published online 2020 Sep 3. doi: 10.1080/19420862.2020.1801230

PMCID:: PMC7531564

Abstract Article PDF–9.1M

Select item 743248514.

Arginase as a Potential Biomarker of Disease Progression: A Molecular Imaging Perspective

Gonçalo S. Clemente, Aren van Waarde, Inês F. Antunes, Alexander Dömling, Philip H. Elsinga

Int J Mol Sci. 2020 Aug; 21(15): 5291. Published online 2020 Jul 25. doi: 10.3390/ijms21155291

PMCID:: PMC7432485

Abstract Article PDF–3.7M

Select item 707265115.

p32-Dependent p38 MAPK Activation by Arginase II Downregulation Contributes to Endothelial Nitric Oxide Synthase Activation in HUVECs

Bon-Hyeock Koo, Moo-Ho Won, Young-Myeong Kim, Sungwoo Ryoo

Cells. 2020 Feb; 9(2): 392. Published online 2020 Feb 8. doi: 10.3390/cells9020392

PMCID:: PMC7072651

Abstract Article PDF–1.7M

Select item 697527516.

Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues

Margaret M. Lowe, Ian Boothby, Sean Clancy, Richard S. Ahn, Wilson Liao, David N. Nguyen, Kathrin Schumann, Alexander Marson, Kelly M. Mahuron, Gillian A. Kingsbury, Zheng Liu, Priscila Munoz Sandoval, Robert Sanchez Rodriguez, Mariela L. Pauli, Keyon Taravati, Sarah T. Arron, Isaac M. Neuhaus, Hobart W. Harris, Esther A. Kim, Uk Sok Shin, Matthew F. Krummel, Adil Daud, Tiffany C. Scharschmidt, Michael D. Rosenblum

JCI Insight. 2019 Dec 19; 4(24): e129756. Published online 2019 Dec 19. doi: 10.1172/jci.insight.129756

PMCID:: PMC6975275

Abstract Article PDF–5.0M

Select item 694204417.

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity

Jae Jin Kim, Seo Yun Lee, Fade Gong, Anna M. Battenhouse, Daniel R. Boutz, Aarti Bashyal, Samantha T. Refvik, Cheng-Ming Chiang, Blerta Xhemalce, Tanya T. Paull, Jennifer S. Brodbelt, Edward M. Marcotte, Kyle M. Miller

Genes Dev. 2019 Dec 1; 33(23-24): 1751–1774. doi: 10.1101/gad.331231.119

PMCID:: PMC6942044

Abstract Article PDF–10M

Select item 682159918.

Increased neonatal level of arginase 2 in cases of childhood acute lymphoblastic leukemia implicates immunosuppression in the etiology

Amalie B. Nielsen, Mi Zhou, Adam J. de Smith, Rong Wang, Lucie McCoy, Helen Hansen, Libby Morimoto, Kirsten Grønbæk, Christoffer Johansen, Scott C. Kogan, Catherine Metayer, Paige M. Bracci, Xiaomei Ma, Joseph L. Wiemels

Haematologica. 2019 Nov; 104(11): e514–e516. doi: 10.3324/haematol.2019.216465

PMCID:: PMC6821599

Article PDF–2.3M

Select item 673893319.

Hypoxia Triggers SENP1 Modulation of Kruppel-Like Factor 15 and Transcriptional Regulation of Arginase 2 in Pulmonary Endothelium

Deepesh Pandey, Yohei Nomura, Max C. Rossberg, Daijiro Hori, Anil Bhatta, Gizem Keceli, Thorsten Leucker, Lakshmi Santhanam, Larissa A. Shimoda, Dan Berkowitz, Lewis Romer

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2019 Sep 11.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2018 Apr; 38(4): 913–926. Published online 2018 Feb 22. doi: 10.1161/ATVBAHA.117.310660

PMCID:: PMC6738933

Abstract Article PDF–908K

Select item 662002820.

Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality

Jo Ishizawa, Sarah F. Zarabi, R. Eric Davis, Ondrej Halgas, Takenobu Nii, Yulia Jitkova, Ran Zhao, Jonathan St-Germain, Lauren E. Heese, Grace Egan, Vivian R. Ruvolo, Samir H. Barghout, Yuki Nishida, Rose Hurren, Wencai Ma, Marcela Gronda, Todd Link, Keith Wong, Mark Mabanglo, Kensuke Kojima, Gautam Borthakur, Neil MacLean, John Man Chun Ma, Andrew B. Leber, Mark D. Minden, Walid Houry, Hagop Kantarjian, Martin Stogniew, Brian Raught, Emil F. Pai, Aaron D. Schimmer, Michael Andreeff

Cancer Cell. Author manuscript; available in PMC 2020 May 13.

Published in final edited form as: Cancer Cell. 2019 May 13; 35(5): 721–737.e9. Published online 2019 May 2. doi: 10.1016/j.ccell.2019.03.014

PMCID:: PMC6620028

Abstract Article PDF–2.9M

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