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Select item 108698001.

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation

Christopher B. Nelson, Samuel Rogers, Kaushik Roychoudhury, Yaw Sing Tan, Caroline J. Atkinson, Alexander P. Sobinoff, Christopher G. Tomlinson, Anton Hsu, Robert Lu, Eloise Dray, Michelle Haber, Jamie I. Fletcher, Anthony J. Cesare, Rashmi S. Hegde, Hilda A. Pickett

Nat Commun. 2024; 15: 1385. Published online 2024 Feb 15. doi: 10.1038/s41467-024-45683-4

PMCID:: PMC10869800

Abstract Article PDF–9.3M

Select item 106855632.

SIX1 amplification modulates stemness and tumorigenesis in breast cancer

Liantao Guo, Faminzi Li, Hanqing Liu, Deguang Kong, Chuang Chen, Shengrong Sun

J Transl Med. 2023; 21: 866. Published online 2023 Nov 29. doi: 10.1186/s12967-023-04679-2

PMCID:: PMC10685563

Abstract Article PDF–5.8M

Select item 106680323.

Altered binding affinity of SIX1-Q177R correlates with enhanced WNT5A and WNT pathway effector expression in Wilms tumor

Matthew J. Stevenson, Sabrina K. Phanor, Urvi Patel, Stephen S. Gisselbrecht, Martha L. Bulyk, Lori L. O'Brien

Dis Model Mech. 2023 Nov 1; 16(11): dmm050208. Published online 2023 Nov 17. doi: 10.1242/dmm.050208

PMCID:: PMC10668032

Abstract Article

Select item 103619704.

Phenotypic and molecular basis of SIX1 variants linked to non-syndromic deafness and atypical branchio-otic syndrome in South Korea

Somin Lee, Yejin Yun, Ju Hyuen Cha, Jin Hee Han, Dae Hee Lee, Jae-Jin Song, Moo Kyun Park, Jun Ho Lee, Seung Ha Oh, Byung Yoon Choi, Sang-Yeon Lee

Sci Rep. 2023; 13: 11776. Published online 2023 Jul 21. doi: 10.1038/s41598-023-38909-w

PMCID:: PMC10361970

Abstract Article PDF–2.6M

Select item 102366085.

LRRC75A‐AS1 delivered by M2 macrophage exosomes promotes cervical cancer progression via enhancing SIX1 expression

Hong‐Ying Sui, Xiu‐Ying Cui, Cai‐Xia Shi, Zhi‐Peng Yan, Hu‐Cheng Li, Fang Wang

Cancer Sci. 2023 Jun; 114(6): 2634–2649. Published online 2023 Mar 27. doi: 10.1111/cas.15780

PMCID:: PMC10236608

Abstract Article PDF–31M

Select item 100225906.

The SIX1/LDHA Axis Promotes Lactate Accumulation and Leads to NK Cell Dysfunction in Pancreatic Cancer

Wanli Ge, Lingdong Meng, Shouji Cao, Chaoqun Hou, Xiaole Zhu, Dongya Huang, Qiang Li, Yunpeng Peng, Kuirong Jiang

J Immunol Res. 2023; 2023: 6891636. Published online 2023 Mar 8. doi: 10.1155/2023/6891636

PMCID:: PMC10022590

Abstract Article PDF–3.3M

Select item 98034597.

Lack of association between SIX1/SIX6 locus polymorphisms and pseudoexfoliation syndrome in a population from the Republic of Korea

Young Chun Lee, Mee Yon Lee, Hye-Young Shin

Medicine (Baltimore) 2022 Dec 30; 101(52): e31542. Published online 2022 Dec 30. doi: 10.1097/MD.0000000000031542

PMCID:: PMC9803459

Abstract Article PDF–421K

Select item 91197368.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 89500839.

Generation of a new six1-null line in Xenopus tropicalis for study of development and congenital disease

Kelsey Coppenrath, Andre L.P. Tavares, Nikko-Ideen Shaidani, Marcin Wlizla, Sally A. Moody, Marko Horb

Genesis. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Genesis. 2021 Dec; 59(12): e23453. Published online 2021 Oct 19. doi: 10.1002/dvg.23453

PMCID:: PMC8950083

Abstract Article PDF–583K

Select item 880676110.

Long non-coding RNA (LncRNA) CASC9/microRNA(miR)-590–3p/sine oculis homeobox 1 (SIX1)/NF-κB axis promotes proliferation and migration in breast cancer

Jingzhi Chang, Yuxia Zhang, Xin Ye, Hui Guo, Kun Lu, Qing Liu, Yli Guo

Bioengineered. 2021; 12(1): 8709–8723. Published online 2021 Oct 28. doi: 10.1080/21655979.2021.1977555

PMCID:: PMC8806761

Abstract Article PDF–4.4M

Select item 877079611.

Phenotype–genotype correlation in patients with typical and atypical branchio-oto-renal syndrome

Masatsugu Masuda, Ayako Kanno, Kiyomitsu Nara, Hideki Mutai, Naoya Morisada, Kazumoto Iijima, Noriko Morimoto, Atsuko Nakano, Tomoko Sugiuchi, Yasuhide Okamoto, Sawako Masuda, Sayaka Katsunuma, Kaoru Ogawa, Tatsuo Matsunaga

Sci Rep. 2022; 12: 969. Published online 2022 Jan 19. doi: 10.1038/s41598-022-04885-w

PMCID:: PMC8770796

Abstract Article PDF–1.5M

Select item 863317312.

Homeoprotein SIX1 compromises antitumor immunity through TGF-β-mediated regulation of collagens

Wancheng Liu, Meiling Gao, Lili Li, Yu Chen, Huimin Fan, Qiaomei Cai, Yueyue Shi, Chaohu Pan, Junxiao Liu, Lucy S. Cheng, Heng Yang, Genhong Cheng

Cell Mol Immunol. 2021 Dec; 18(12): 2660–2672. Published online 2021 Nov 15. doi: 10.1038/s41423-021-00800-x

PMCID:: PMC8633173

Abstract Article PDF–4.1M

Select item 850998013.

Two naturally derived small molecules disrupt the sineoculis homeobox homolog 1–eyes absent homolog 1 (SIX1–EYA1) interaction to inhibit colorectal cancer cell growth

Jing Wu, Bin Huang, Hong-Bo He, Wen-Zhu Lu, Wei-Guo Wang, Hong Liu

Chin Med J (Engl) 2021 Oct 5; 134(19): 2340–2352. Published online 2021 Sep 23. doi: 10.1097/CM9.0000000000001736

PMCID:: PMC8509980

Abstract Article PDF–1.9M

Select item 827318814.

Unexpected role of SIX1 variants in craniosynostosis: expanding the phenotype of SIX1-related disorders

Eduardo Calpena, Maud Wurmser, Simon J McGowan, Rodrigo Atique, Débora R Bertola, Michael L Cunningham, Jonas A Gustafson, David Johnson, Jenny E V Morton, Maria Rita Passos-Bueno, Andrew T Timberlake, Richard P Lifton, Steven A Wall, Stephen R F Twigg, Pascal Maire, Andrew O M Wilkie

J Med Genet. 2022 Feb; 59(2): 165–169. Published online 2021 Jan 12. doi: 10.1136/jmedgenet-2020-107459

PMCID:: PMC8273188

Abstract Article PDF–3.0M

Select item 816503015.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 803497116.

Silencing SIX1 by miR-7160 inhibits non-small cell lung cancer cell growth

Hua-Si Zhao, Xiao-Min Tao, Qun Wang, Yuan-Yuan Fang, Hong-Yu Zhang, Hua-Qi Wang, Guo-Jun Zhang

Aging (Albany NY) 2021 Mar 31; 13(6): 8055–8067. Published online 2021 Mar 3. doi: 10.18632/aging.202398

PMCID:: PMC8034971

Abstract Article PDF–1.9M

Select item 800904817.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 794529518.

Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4α and SIX1/4

Soledad A. Camolotto, Veronika K. Belova, Luke Torre-Healy, Jeffery M. Vahrenkamp, Kristofer C. Berrett, Hannah Conway, Jill Shea, Chris Stubben, Richard Moffitt, Jason Gertz, Eric L. Snyder

Gut. Author manuscript; available in PMC 2021 May 1.

Published in final edited form as: Gut. 2021 May; 70(5): 900–914. Published online 2020 Aug 21. doi: 10.1136/gutjnl-2020-321316

PMCID:: PMC7945295

Abstract Article PDF–3.1M

Select item 786757319.

VEGF-C Mediates Tumor Growth and Metastasis Through Promoting EMT- Epithelial Breast Cancer cell Crosstalk

Deguang Kong, Hengbo Zhou, Deepika Neelakantan, Connor J. Hughes, Jessica Y. Hsu, Ramakrishnan Rajaram Srinivasan, Michael T. Lewis, Heide L. Ford

Oncogene. Author manuscript; available in PMC 2021 Jun 9.

Published in final edited form as: Oncogene. 2021 Feb; 40(5): 964–979. Published online 2020 Dec 9. doi: 10.1038/s41388-020-01539-x

PMCID:: PMC7867573

Abstract Article PDF–2.7M

Select item 783506120.

SPOCK1/SIX1axis promotes breast cancer progression by activating AKT/mTOR signaling

Ming Xu, Xianglan Zhang, Songnan Zhang, Junjie Piao, Yang Yang, Xinyue Wang, Zhenhua Lin

Aging (Albany NY) 2021 Jan 15; 13(1): 1032–1050. Published online 2020 Dec 3. doi: 10.18632/aging.202231

PMCID:: PMC7835061

Abstract Article PDF–3.7M

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