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Items: 1 to 20 of 35

1.
Diminished arachidonate 5-lipoxygenase perturbs phase separation and transcriptional response of Runx2 to reverse pathological ventricular remodeling
Saiyang Xie, Mengya Chen, Wenxi Fang, Shiqiang Liu, Qingqing Wu, Chen Liu, Yun Xing, Wenke Shi, Man Xu, Min Zhang, Si Chen, Xiaofeng Zeng, Shasha Wang, Wei Deng, Qizhu Tang
eBioMedicine. 2022 Dec; 86: 104359. Published online 2022 Nov 14. doi: 10.1016/j.ebiom.2022.104359
PMCID:
PMC9672960
AbstractArticlePDF–7.2M
2.
Phenotypically-Silent Bone Morphogenetic Protein Receptor 2 (Bmpr2) Mutations Predispose Rats to Inflammation-Induced Pulmonary Arterial Hypertension by Enhancing The Risk for Neointimal Transformation
Wen Tian, Xinguo Jiang, Yon K. Sung, Eric Shuffle, Ting-Hsuan Wu, Peter N. Kao, Allen B. Tu, Peter Dorfmüller, Aiqin Cao, Lingli Wang, Gongyong Peng, Yesl Kim, Patrick Zhang, James Chappell, Shravani Pasupneti, Petra Dahms, Peter Maguire, Hassan Chaib, Roham Zamanian, Marc Peters-Golden, Michael P. Snyder, Norbert F. Voelkel, Marc Humbert, Marlene Rabinovitch, Mark R. Nicolls
Circulation. Author manuscript; available in PMC 2020 Oct 22.
Published in final edited form as: Circulation. 2019 Oct 22; 140(17): 1409–1425. Published online 2019 Aug 29. doi: 10.1161/CIRCULATIONAHA.119.040629
PMCID:
PMC6803052
AbstractArticlePDF–3.9M
3.
The organization of leukotriene biosynthesis on the nuclear envelope revealed by single molecule localization microscopy and computational analyses
Angela B. Schmider, Melissa Vaught, Nicholas C. Bauer, Hunter L. Elliott, Matthew D. Godin, Giorgianna E. Ellis, Peter A. Nigrovic, Roy J. Soberman
PLoS One. 2019; 14(2): e0211943. Published online 2019 Feb 8. doi: 10.1371/journal.pone.0211943
PMCID:
PMC6368329
AbstractArticlePDF–3.3M
4.
Trauma and Hemorrhagic Shock Activate Molecular Association of ALOX5 and ALOX5AP in Lung Tissue
Geoffrey R. Nunns, John R. Stringham, Fabia Gamboni, Ernest E. Moore, Miguel Fragoso, Gregory R. Stettler, Christopher C. Silliman, Anirban Banerjee
J Surg Res. Author manuscript; available in PMC 2019 Sep 1.
Published in final edited form as: J Surg Res. 2018 Sep; 229: 262–270. Published online 2018 May 5. doi: 10.1016/j.jss.2018.03.023
PMCID:
PMC6020847
AbstractArticlePDF–1.1M
5.
Novel mechanism of regulation of the 5-lipoxygenase/leukotriene B4 pathway by high-density lipoprotein in macrophages
Shigeyasu Tsuda, Masakazu Shinohara, Toshihiko Oshita, Manabu Nagao, Nobuaki Tanaka, Takeshige Mori, Tetsuya Hara, Yasuhiro Irino, Ryuji Toh, Tatsuro Ishida, Ken-ichi Hirata
Sci Rep. 2017; 7: 12989. Published online 2017 Oct 11. doi: 10.1038/s41598-017-13154-0
PMCID:
PMC5636875
AbstractArticlePDF–1.9M
6.
5-LO inhibition ameliorates palmitic acid-induced ER stress, oxidative stress and insulin resistance via AMPK activation in murine myotubes
Hyun Jeong Kwak, Hye-Eun Choi, Hyae Gyeong Cheon
Sci Rep. 2017; 7: 5025. Published online 2017 Jul 10. doi: 10.1038/s41598-017-05346-5
PMCID:
PMC5504062
AbstractArticlePDF–6.5M
7.
Epigenetic Histone Modifications Involved in Profibrotic Gene Regulation by 12/15-Lipoxygenase and Its Oxidized Lipid Products in Diabetic Nephropathy
Hang Yuan, Marpadga A. Reddy, Supriya Deshpande, Ye Jia, Jung Tak Park, Linda L. Lanting, Wen Jin, Mitsuo Kato, Zhong Gao Xu, Sadhan Das, Rama Natarajan
Antioxid Redox Signal. 2016 Mar 1; 24(7): 361–375. doi: 10.1089/ars.2015.6372
PMCID:
PMC4779982
AbstractArticlePDF–1.9M
8.
ATP Allosterically Activates the Human 5-Lipoxygenase Molecular Mechanism of Arachidonic Acid and 5(S)-Hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic Acid
Christopher J. Smyrniotis, Shannon R. Barbour, Zexin Xia, Mark S. Hixon, Theodore R. Holman
Biochemistry. 2014 Jul 15; 53(27): 4407–4419. Published online 2014 Jun 3. doi: 10.1021/bi401621d
PMCID:
PMC4215895
AbstractArticlePDF–886K
9.
Mesenteric lymph diversion abrogates 5-lipoxygenase activation in the kidney following trauma and hemorrhagic shock
John R. Stringham, Ernest E. Moore, Fabia Gamboni, Jeffrey N. Harr, Miguel Fragoso, Theresa L. Chin, Caitlin E. Carr, Christopher C. Silliman, Anirban Banerjee
J Trauma Acute Care Surg. Author manuscript; available in PMC 2014 Jul 10.
Published in final edited form as: J Trauma Acute Care Surg. 2014 May; 76(5): 1214–1221. doi: 10.1097/TA.0000000000000231
PMCID:
PMC4091733
AbstractArticlePDF–716K
10.
Functional characterization of genetic enzyme variations in human lipoxygenases
Thomas Horn, Kumar Reddy Kakularam, Monika Anton, Constanze Richter, Pallu Reddanna, Hartmut Kuhn
Redox Biol. 2013; 1(1): 566–577. Published online 2013 Nov 11. doi: 10.1016/j.redox.2013.11.001
PMCID:
PMC3840004
AbstractArticlePDF–4.2M
11.
5-Lipoxygenase Metabolite 4-HDHA Is a Mediator of the Antiangiogenic Effect of ω-3 Polyunsaturated Fatty Acids
Przemyslaw Sapieha, Andreas Stahl, Jing Chen, Molly R. Seaward, Keirnan L. Willett, Nathan M. Krah, Roberta J. Dennison, Kip M. Connor, Christopher M. Aderman, Elvira Liclican, Arianna Carughi, Dalia Perelman, Yoshihide Kanaoka, John Paul SanGiovanni, Karsten Gronert, Lois E. H. Smith
Sci Transl Med. Author manuscript; available in PMC 2013 Jul 15.
Published in final edited form as: Sci Transl Med. 2011 Feb 9; 3(69): 69ra12. doi: 10.1126/scitranslmed.3001571
PMCID:
PMC3711031
AbstractArticlePDF–3.5M
12.
Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach
DANIEL BÖHM, KSENIA KELLER, JULIA PIETER, NILS BOEHM, DOMINIK WOLTERS, WULF SIGGELKOW, ANTJE LEBRECHT, MARCUS SCHMIDT, HEINZ KÖLBL, NORBERT PFEIFFER, FRANZ-HERMANN GRUS
Oncol Rep. 2012 Aug; 28(2): 429–438. Published online 2012 Jun 1. doi: 10.3892/or.2012.1849
PMCID:
PMC3583517
AbstractArticlePDF–501K
13.
Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663
Nathaniel C. Gilbert, Zhe Rui, David B. Neau, Maria T. Waight, Sue G. Bartlett, William E. Boeglin, Alan R. Brash, Marcia E. Newcomer
FASEB J. 2012 Aug; 26(8): 3222–3229. doi: 10.1096/fj.12-205286
PMCID:
PMC3405276
AbstractArticle
14.
The structure of human 5-lipoxygenase
Nathaniel C. Gilbert, Sue G. Bartlett, Maria T. Waight, David B. Neau, William E. Boeglin, Alan R. Brash, Marcia E. Newcomer
Science. Author manuscript; available in PMC 2011 Dec 23.
Published in final edited form as: Science. 2011 Jan 14; 331(6014): 217–219. doi: 10.1126/science.1197203
PMCID:
PMC3245680
AbstractArticlePDF–1.3M
15.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
16.
Arachidonate 5-Lipoxygenase Establishes Adaptive Humoral Immunity by Controlling Primary B Cells and Their Cognate T-Cell Help
Tsutomu Nagashima, Shingo Ichimiya, Tomoki Kikuchi, Yoshiyuki Saito, Hiroshi Matsumiya, Shihoko Ara, Shigeru Koshiba, Jun Zhang, Chizuru Hatate, Akiko Tonooka, Terufumi Kubo, Rui Carrie Ye, Bungo Hirose, Hideaki Shirasaki, Takashi Izumi, Tsuyoshi Takami, Tetsuo Himi, Noriyuki Sato
Am J Pathol. 2011 Jan; 178(1): 222–232. doi: 10.1016/j.ajpath.2010.11.033
PMCID:
PMC3070564
AbstractArticlePDF–1.7M
17.
Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation
Sungwhan F. Oh, Padmini S. Pillai, Antonio Recchiuti, Rong Yang, Charles N. Serhan
J Clin Invest. 2011 Feb 1; 121(2): 569–581. Published online 2011 Jan 4. doi: 10.1172/JCI42545
PMCID:
PMC3026718
AbstractArticlePDF–1.5M
18.
Flavocoxid, a dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase, reduces pancreatic damage in an experimental model of acute pancreatitis
F Polito, A Bitto, N Irrera, F Squadrito, C Fazzari, L Minutoli, D Altavilla
Br J Pharmacol. 2010 Nov; 161(5): 1002–1011. doi: 10.1111/j.1476-5381.2010.00933.x
PMCID:
PMC2998682
AbstractArticlePDF–1.0M
19.
Human Dicer C-terminus functions as a 5-lipoxygenase binding domain
Vildan Dincbas-Renqvist, Geneviève Pépin, Marija Rakonjac, Isabelle Plante, Dominique L. Ouellet, Andreas Hermansson, Isabelle Goulet, Johanne Doucet, Bengt Samuelsson, Olof Rådmark, Patrick Provost
Biochim Biophys Acta. Author manuscript; available in PMC 2010 Jul 13.
Published in final edited form as: Biochim Biophys Acta. 2009 Feb; 1789(2): 99–108. Published online 2008 Oct 28. doi: 10.1016/j.bbagrm.2008.10.002
PMCID:
PMC2903566
AbstractArticlePDF–1.1M
20.
Intrapulmonary Administration of Leukotriene B4 Enhances Pulmonary Host Defense against Pneumococcal Pneumonia
Peter Mancuso, Casey Lewis, Carlos Henrique Serezani, Deepti Goel, Marc Peters-Golden
Infect Immun. 2010 May; 78(5): 2264–2271. Published online 2010 Mar 15. doi: 10.1128/IAI.01323-09
PMCID:
PMC2863513
AbstractArticlePDF–1.0M

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