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Select item 111481841.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 111094832.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 111056303.

The deubiquitinase OTUD5 regulates Ku80 stability and non-homologous end joining

Fangzhou Li, Qianqian Sun, Kun Liu, Haichao Han, Ning Lin, Zhongyi Cheng, Yueming Cai, Feng Tian, Zebin Mao, Tanjun Tong, Wenhui Zhao

Cell Mol Life Sci. 2019 Oct; 76(19): 3861–3873. Published online 2019 Apr 12. doi: 10.1007/s00018-019-03094-5

PMCID:: PMC11105630

Abstract Article PDF–2.0M

Select item 110410144.

OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1

Yingnan Yang, Siying Jia, Ning Zhu, Xuelian Xiao, Ying Ma, Kangsheng Tu, Yong Guo, Qiuran Xu

Biol Direct. 2024; 19: 31. Published online 2024 Apr 24. doi: 10.1186/s13062-024-00475-0

PMCID:: PMC11041014

Abstract Article PDF–8.9M

Select item 108275175.

Hepatocyte Deubiquitinating Enzyme OTUD5 Deficiency Is a Key Aggravator for Metabolic Dysfunction-Associated Steatohepatitis by Disturbing Mitochondrial Homeostasis

Jingjing Dai, Liren Zhang, Ruizhi Zhang, Jing Ge, Feifan Yao, Suiqing Zhou, Jiali Xu, Kai Yu, Jing Xu, Longfeng Jiang, Ke Jin, Xinzheng Dai, Jun Li, Qing Li

Cell Mol Gastroenterol Hepatol. 2024; 17(3): 399–421. Published online 2023 Nov 29. doi: 10.1016/j.jcmgh.2023.11.014

PMCID:: PMC10827517

Abstract Article PDF–11M

Select item 107280816.

Autophagy of OTUD5 destabilizes GPX4 to confer ferroptosis-dependent kidney injury

Li-Kai Chu, Xu Cao, Lin Wan, Qiang Diao, Yu Zhu, Yu Kan, Li-Li Ye, Yi-Ming Mao, Xing-Qiang Dong, Qian-Wei Xiong, Ming-Cui Fu, Ting Zhang, Hui-Ting Zhou, Shi-Zhong Cai, Zhou-Rui Ma, Ssu-Wei Hsu, Reen Wu, Ching-Hsien Chen, Xiang-Ming Yan, Jun Liu

Nat Commun. 2023; 14: 8393. Published online 2023 Dec 18. doi: 10.1038/s41467-023-44228-5

PMCID:: PMC10728081

Abstract Article PDF–9.6M

Select item 101365337.

The Regulation and Double-Edged Roles of the Deubiquitinase OTUD5

Lin Fu, Kun Lu, Qian Jiao, Xi Chen, Fengju Jia

Cells. 2023 Apr; 12(8): 1161. Published online 2023 Apr 14. doi: 10.3390/cells12081161

PMCID:: PMC10136533

Abstract Article PDF–2.5M

Select item 95893058.

Mechanism of OTUD5 in non-small cell lung cancer cell proliferation, invasion, and migration

Xuebing Li, Baohua Lu, Lina Zhang, Jing Yang, Yurong Cheng, Dong Yan

Bosn J Basic Med Sci. 2022 Dec; 22(6): 901–911. Published online 2022 Jun 27. doi: 10.17305/bjbms.2022.7206

PMCID:: PMC9589305

Abstract Article PDF–4.1M

Select item 94816029.

Electrostatic and steric effects underlie acetylation-induced changes in ubiquitin structure and function

Simon Maria Kienle, Tobias Schneider, Katrin Stuber, Christoph Globisch, Jasmin Jansen, Florian Stengel, Christine Peter, Andreas Marx, Michael Kovermann, Martin Scheffner

Nat Commun. 2022; 13: 5435. Published online 2022 Sep 16. doi: 10.1038/s41467-022-33087-1

PMCID:: PMC9481602

Abstract Article PDF–3.7M

Select item 946345210.

Deubiquitinase OTUD5 modulates mTORC1 signaling to promote bladder cancer progression

Tao Hou, Weichao Dan, Tianjie Liu, Bo Liu, Yi Wei, Chenyang Yue, Taotao Que, Bohan Ma, Yuzeshi Lei, Zixi Wang, Jin Zeng, Yizeng Fan, Lei Li

Cell Death Dis. 2022 Sep; 13(9): 778. Published online 2022 Sep 9. doi: 10.1038/s41419-022-05128-6

PMCID:: PMC9463452

Abstract Article PDF–5.7M

Select item 937779711.

Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression

Qiangqiang Liu, Qian Luo, Jianyu Feng, Yanping Zhao, Biao Ma, Hongcheng Cheng, Tian Zhao, Hong Lei, Chenglong Mu, Linbo Chen, Yuanyuan Meng, Jiaojiao Zhang, Yijia Long, Jingyi Su, Guo Chen, Yanjun Li, Gang Hu, Xudong Liao, Quan Chen, Yushan Zhu

eLife. 2022; 11: e81247. Published online 2022 Aug 1. doi: 10.7554/eLife.81247

PMCID:: PMC9377797

Abstract Article PDF–4.9M

Select item 902051712.

Structural and functional consequences of NEDD8 phosphorylation

Katrin Stuber, Tobias Schneider, Jill Werner, Michael Kovermann, Andreas Marx, Martin Scheffner

Nat Commun. 2021; 12: 5939. Published online 2021 Oct 12. doi: 10.1038/s41467-021-26189-9

PMCID:: PMC9020517

Abstract Article PDF–2.8M

Select item 851385313.

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation

Jordan M. Meyers, Muthukumar Ramanathan, Ronald L. Shanderson, Aimee Beck, Laura Donohue, Ian Ferguson, Margaret G. Guo, Deepti S. Rao, Weili Miao, David Reynolds, Xue Yang, Yang Zhao, Yen-Yu Yang, Catherine Blish, Yinsheng Wang, Paul A. Khavari

PLoS Pathog. 2021 Oct; 17(10): e1009412. Published online 2021 Oct 1. doi: 10.1371/journal.ppat.1009412

PMCID:: PMC8513853

Abstract Article PDF–4.1M

Select item 846297414.

Photocaged Cell-Permeable Ubiquitin Probe for Temporal Profiling of Deubiquitinating Enzymes

Weijun Gui, Siqi Shen, Zhihao Zhuang

J Am Chem Soc. Author manuscript; available in PMC 2021 Nov 18.

Published in final edited form as: J Am Chem Soc. 2020 Nov 18; 142(46): 19493–19501. Published online 2020 Nov 3. doi: 10.1021/jacs.9b12426

PMCID:: PMC8462974

Abstract Article PDF–975K

Select item 832234315.

OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING

Yunyun Guo, Fei Jiang, Lingli Kong, Haifeng Wu, Honghai Zhang, Xiaorong Chen, Jian Zhao, Baoshan Cai, Yanqi Li, Chunhong Ma, Fan Yi, Lei Zhang, Bingyu Liu, Yi Zheng, Lingqiang Zhang, Chengjiang Gao

Cell Mol Immunol. 2021 Aug; 18(8): 1945–1955. Published online 2020 Sep 2. doi: 10.1038/s41423-020-00531-5

PMCID:: PMC8322343

Abstract Article PDF–3.8M

Select item 828276416.

N6-methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation

Yuanming Cheng, Wei Xie, Brian F Pickering, Karen L Chu, Angela M Savino, Xuejing Yang, Hanzhi Luo, Diu TT Nguyen, Shanlan Mo, Ersilia Barin, Anthony Velleca, Thomas Rohwetter, Dinshaw J Patel, Samie R Jaffrey, Michael G Kharas

Cancer Cell. Author manuscript; available in PMC 2022 Jul 12.

Published in final edited form as: Cancer Cell. 2021 Jul 12; 39(7): 958–972.e8. Published online 2021 May 27. doi: 10.1016/j.ccell.2021.04.017

PMCID:: PMC8282764

Abstract Article PDF–3.4M

Select item 816503017.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 810809318.

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig, Jiri Lukas, Chunaram Choudhary

Cell. Author manuscript; available in PMC 2021 May 10.

Published in final edited form as: Cell. 2018 May 3; 173(4): 972–988.e23. Published online 2018 Apr 12. doi: 10.1016/j.cell.2018.03.050

PMCID:: PMC8108093

Abstract Article PDF–3.5M

Select item 793767419.

Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways

Jin Hwa Cho, Kidae Kim, Sung Ah Kim, Sungryul Park, Bi-Oh Park, Jong-Hwan Kim, Seon-Young Kim, Min Jee Kwon, Myeong Hoon Han, Sung Bae Lee, Byoung Chul Park, Sung Goo Park, Jeong-Hoon Kim, Sunhong Kim

Cell Death Differ. 2021 Mar; 28(3): 900–914. Published online 2020 Oct 27. doi: 10.1038/s41418-020-00649-z

PMCID:: PMC7937674

Abstract Article PDF–3.9M

Select item 791983620.

OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase

Hyo Jin Kim, Jongchan Kim

Int J Mol Sci. 2021 Feb; 22(4): 1936. Published online 2021 Feb 16. doi: 10.3390/ijms22041936

PMCID:: PMC7919836

Abstract Article PDF–5.0M

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