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Items: 1 to 20 of 364

1.
Characterization of human NSCLC cell line with innate etoposide‐resistance mediated by cytoplasmic localization of topoisomerase II alpha
Bautista de Lucio, Victor Manuel, Raul Barrera‐Rodríguez
Cancer Sci. 2005 Nov; 96(11): 774–783. Published online 2005 Nov 4. doi: 10.1111/j.1349-7006.2005.00111.x
PMCID:
PMC11158927
AbstractArticlePDF–290K
2.
Expression and potential molecular mechanism of TOP2A in metastasis of non-small cell lung cancer
Jiatao Wu, Wenjuan Li, Xueying Zhang, Fan Shi, Qianhao Jia, Yufei Wang, Yuqi Shi, Shiwu Wu, Xiaojing Wang
Sci Rep. 2024; 14: 12228. Published online 2024 May 28. doi: 10.1038/s41598-024-63055-2
PMCID:
PMC11133405
AbstractArticlePDF–8.9M
3.
The correlation study between TOP2A gene expression in circulating tumor cells and chemotherapeutic drug resistance of patients with breast cancer
Jin-hui Ye, Jian Yu, Ming-ying Huang, Yue-mei Mo
Breast Cancer. 2024; 31(3): 417–425. Published online 2024 Apr 1. doi: 10.1007/s12282-024-01553-x
PMCID:
PMC11045578
AbstractArticlePDF–805K
4.
The Novel C-terminal Truncated 90-kDa Isoform of Topoisomerase IIα (TOP2α/90) Is a Determinant of Etoposide Resistance in K562 Leukemia Cells via Heterodimerization with the TOP2α/170 Isoform
Ragu Kanagasabai, Soumendrakrishna Karmahapatra, Corey A. Kientz, Yang Yu, Victor A. Hernandez, Evan E. Kania, Jack C. Yalowich, Terry S. Elton
Mol Pharmacol. 2018 May; 93(5): 515–525. Published online 2018 May. doi: 10.1124/mol.117.111567
PMCID:
PMC11033944
AbstractArticlePDF–949K
5.
TOP2A modulates signaling via the AKT/mTOR pathway to promote ovarian cancer cell proliferation
Kaiwen Zhang, Xingyu Zheng, Yiqing Sun, Xinyu Feng, Xirong Wu, Wenlu Liu, Chao Gao, Ye Yan, Wenyan Tian, Yingmei Wang
Cancer Biol Ther. 2024; 25(1): 2325126. Published online 2024 Mar 6. doi: 10.1080/15384047.2024.2325126
PMCID:
PMC10936659
AbstractArticlePDF–7.9M
6.
Interaction network of human early embryonic transcription factors
Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo
EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0
PMCID:
PMC10933267
AbstractArticlePDF–2.9M
7.
Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis
Bin Zhang, Jie Li, Yijun Wang, Xixi Liu, Xiao Yang, Zhiyun Liao, Suke Deng, Yue Deng, Zhiyuan Zhou, Yu Tian, Wenwen Wei, Jingshu Meng, Yan Hu, Chao Wan, Zhanjie Zhang, Fang Huang, Lu Wen, Bian Wu, Yajie Sun, Yan Li, Kunyu Yang
Cell Death Differ. 2024 Mar; 31(3): 309–321. Published online 2024 Jan 29. doi: 10.1038/s41418-024-01257-x
PMCID:
PMC10923876
AbstractArticlePDF–8.3M
8.
HPV16 E6 promoting cervical cancer progression through down‐regulation of miR‐320a to increase TOP2A expression
Jianing Zhang, Xiaohui Yu, Yi Guo, Daqing Wang
Cancer Med. 2024 Feb; 13(3): e6875. Published online 2024 Jan 11. doi: 10.1002/cam4.6875
PMCID:
PMC10905336
AbstractArticlePDF–43M
9.
Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7
Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord
Mol Oncol. 2024 Feb; 18(2): 369–385. Published online 2023 Oct 22. doi: 10.1002/1878-0261.13537
PMCID:
PMC10850818
AbstractArticlePDF–2.7M
10.
TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence
Jiang Ren, Shuai Wang, Zhi Zong, Ting Pan, Sijia Liu, Wei Mao, Huizhe Huang, Xiaohua Yan, Bing Yang, Xin He, Fangfang Zhou, Long Zhang
Nat Commun. 2024; 15: 244. Published online 2024 Jan 4. doi: 10.1038/s41467-023-44502-6
PMCID:
PMC10764958
AbstractArticlePDF–4.4M
11.
Association of TOP2A and ADH1B with lipid levels and prognosis in patients with lung adenocarcinoma and squamous cell carcinoma
Dongdong Yin, Yinci Zhang, Hui Li, Longqiang Cheng
Clin Respir J. 2023 Dec; 17(12): 1301–1315. Published online 2023 Nov 20. doi: 10.1111/crj.13717
PMCID:
PMC10730466
AbstractArticlePDF–3.8M
12.
ERK2-topoisomerase II regulatory axis is important for gene activation in immediate early genes
Heeyoun Bunch, Deukyeong Kim, Masahiro Naganuma, Reiko Nakagawa, Anh Cong, Jaehyeon Jeong, Haruhiko Ehara, Hongha Vu, Jeong Ho Chang, Matthew J. Schellenberg, Shun-ichi Sekine
Nat Commun. 2023; 14: 8341. Published online 2023 Dec 14. doi: 10.1038/s41467-023-44089-y
PMCID:
PMC10721843
AbstractArticlePDF–2.7M
13.
EZH2-H3K27me3-mediated silencing of mir-139-5p inhibits cellular senescence in hepatocellular carcinoma by activating TOP2A
Ke Wang, Xunliang Jiang, Yu Jiang, Jun Liu, Yongtao Du, Zecheng Zhang, Yunlong Li, Xinhui Zhao, Jipeng Li, Rui Zhang
J Exp Clin Cancer Res. 2023; 42: 320. Published online 2023 Nov 27. doi: 10.1186/s13046-023-02855-2
PMCID:
PMC10680220
AbstractArticlePDF–11M
14.
The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
Xin Gu, Christopher Nardone, Nolan Kamitaki, Aoyue Mao, Stephen J. Elledge, Michael E. Greenberg
Science. Author manuscript; available in PMC 2023 Oct 31.
Published in final edited form as: Science. 2023 Aug 25; 381(6660): eadh5021. Published online 2023 Aug 25. doi: 10.1126/science.adh5021
PMCID:
PMC10617673
AbstractArticlePDF–3.6M
15.
Role of TOP2A and CDC6 in liver cancer
Wei Jia, Xiang Liu, Zhilei Zhang
Medicine (Baltimore) 2023 Oct 20; 102(42): e35604. Published online 2023 Oct 20. doi: 10.1097/MD.0000000000035604
PMCID:
PMC10589547
AbstractArticlePDF–3.8M
16.
Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates
Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert
Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644
PMCID:
PMC10565876
AbstractArticlePDF–3.7M
17.
cDCBLD2 mediates sorafenib resistance in hepatocellular carcinoma by sponging miR-345-5p binding to the TOP2A coding sequence
YeLing Ruan, TianYi Chen, LongBo Zheng, JingWei Cai, Hu Zhao, YaLi Wang, LiYe Tao, JunJie Xu, Lin Ji, XiuJun Cai
Int J Biol Sci. 2023; 19(14): 4608–4626. Published online 2023 Aug 28. doi: 10.7150/ijbs.86227
PMCID:
PMC10535695
AbstractArticlePDF–10M
18.
The abscission checkpoint senses chromatin bridges through Top2α recruitment to DNA knots
Eleni Petsalaki, Sofia Balafouti, Athina A. Kyriazi, George Zachos
J Cell Biol. 2023 Nov 6; 222(11): e202303123. Published online 2023 Aug 28. doi: 10.1083/jcb.202303123
PMCID:
PMC10461104
AbstractArticlePDF–12M
19.
O‐GlcNAcylation promotes topoisomerase IIα catalytic activity in breast cancer chemoresistance
Yangzhi Liu, Kairan Yu, Keren Zhang, Mingshan Niu, Qiushi Chen, Yajie Liu, Lingyan Wang, Nana Zhang, Wenli Li, Xiaomin Zhong, Guohui Li, Sijin Wu, Jianing Zhang, Yubo Liu
EMBO Rep. 2023 Jul; 24(7): e56458. Published online 2023 May 30. doi: 10.15252/embr.202256458
PMCID:
PMC10328065
AbstractArticlePDF–13M
20.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M

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