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Items: 1 to 20 of 816

1.
ATM inhibition exploits checkpoint defects and ATM-dependent double strand break repair in TP53-mutant glioblastoma
Daniel J. Laverty, Shiv K. Gupta, Gary A. Bradshaw, Alexander S. Hunter, Brett L. Carlson, Nery Matias Calmo, Jiajia Chen, Shulan Tian, Jann N. Sarkaria, Zachary D. Nagel
Nat Commun. 2024; 15: 5294. Published online 2024 Jun 21. doi: 10.1038/s41467-024-49316-8
PMCID:
PMC11192742
AbstractArticlePDF–2.8M
2.
Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non‐small‐cell lung cancer
Min Kim, Hyo‐Gyoung Kang, Shin Yup Lee, Hyung Cheol Lee, Eung Bae Lee, Yi Young Choi, Won Kee Lee, Sukki Cho, Guang Jin, Hyo‐Sung Jheon, Ji Woong Son, Myung‐Hoon Lee, Deuk Kju Jung, Seung Ick Cha, Chang Ho Kim, Young Mo Kang, Sin Kam, Tae Hoon Jung, Sanghoon Jheon, Jae Yong Park
Cancer Sci. 2010 Nov; 101(11): 2436–2442. Published online 2010 Jul 31. doi: 10.1111/j.1349-7006.2010.01699.x
PMCID:
PMC11159840
AbstractArticlePDF–209K
3.
The ataxia-telangiectasia mutated gene product regulates the cellular acid-labile sulfide fraction
Mohammad Z. Islam, Xinggui Shen, Sibile Pardue, Christopher G. Kevil, Rodney E. Shackelford
DNA Repair (Amst) Author manuscript; available in PMC 2024 May 24.
Published in final edited form as: DNA Repair (Amst). 2022 Aug; 116: 103344. Published online 2022 May 14. doi: 10.1016/j.dnarep.2022.103344
PMCID:
PMC11118069
AbstractArticlePDF–1.0M
4.
SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner
Anke Geng, Jiahui Sun, Huanyin Tang, Yang Yu, Xiyue Wang, Jingyuan Zhang, Xiaona Wang, Xiaoxiang Sun, Xiaofang Zhou, Neng Gao, Rong Tan, Zhu Xu, Ying Jiang, Zhiyong Mao
Nucleic Acids Res. 2024 May 22; 52(9): 5107–5120. Published online 2024 Mar 30. doi: 10.1093/nar/gkae190
PMCID:
PMC11109957
AbstractArticlePDF–2.3M
5.
Clinicopathologic, Genomic, and Immunophenotypic Landscape of ATM Mutations in Non–Small Cell Lung Cancer
Biagio Ricciuti, Arielle Elkrief, Joao Alessi, Xinan Wang, Yvonne Li, Hersh Gupta, Daniel M. Muldoon, Arrien A. Bertram, Federica Pecci, Giuseppe Lamberti, Alessandro Di Federico, Adriana Barrichello, Victor R. Vaz, Malini Gandhi, Elinton Lee, Geoffrey I. Shapiro, Hyesun Park, Mizuki Nishino, James Lindsay, Kristen D. Felt, Bijaya Sharma, Andrew D. Cherniack, Scott Rodig, Daniel R. Gomez, Narek Shaverdian, Mehrdad Rakaee, Chaitanya Bandlamudi, Marc Ladanyi, Pasi A. Janne, Adam J. Schoenfeld, Lynette M. Sholl, Mark M. Awad, Michael L. Cheng
Clin Cancer Res. Author manuscript; available in PMC 2024 Apr 20.
Published in final edited form as: Clin Cancer Res. 2023 Jul 5; 29(13): 2540–2550. doi: 10.1158/1078-0432.CCR-22-3413
PMCID:
PMC11031845
AbstractArticlePDF–1.3M
6.
Disproportionate Expression of ATM in Cerebellar Cortex During Human Neurodevelopment
Simon Deacon, William Dalleywater, Charles Peat, Simon M. L. Paine, Rob A. Dineen
Cerebellum. 2024; 23(2): 502–511. Published online 2023 Apr 29. doi: 10.1007/s12311-023-01560-2
PMCID:
PMC10951037
AbstractArticlePDF–1.3M
7.
Comparative interactome analysis of α-arrestin families in human and Drosophila
Kyung-Tae Lee, Inez KA Pranoto, Soon-Young Kim, Hee-Joo Choi, Ngoc Bao To, Hansong Chae, Jeong-Yeon Lee, Jung-Eun Kim, Young V Kwon, Jin-Wu Nam
eLife. 2024; 12: RP88328. Published online 2024 Jan 25. doi: 10.7554/eLife.88328
PMCID:
PMC10945707
AbstractArticlePDF–2.8M
8.
ATM-deficiency-induced microglial activation promotes neurodegeneration in ataxia-telangiectasia
Jenny Lai, Didem Demirbas, Junho Kim, Ailsa M. Jeffries, Allie Tolles, Junseok Park, Thomas W. Chittenden, Patrick G. Buckley, Timothy W. Yu, Michael A. Lodato, Eunjung Alice Lee
Cell Rep. Author manuscript; available in PMC 2024 Mar 2.
Published in final edited form as: Cell Rep. 2024 Jan 23; 43(1): 113622. Published online 2023 Dec 29. doi: 10.1016/j.celrep.2023.113622
PMCID:
PMC10908398
AbstractArticlePDF–1.4M
9.
ATM-Mediated translocation of RanBPM regulates DNA damage response by stabilizing p21 in non-small cell lung cancer cells
Tanggang Deng, Lin Xie, Chen Xiaofang, Zhenbin Zhang, Yugang Xiao, Yuchong Peng, Linglong Yin, Yongming Fu, Xiong Li
Cell Oncol (Dordr) 2024; 47(1): 245–258. Published online 2023 Sep 7. doi: 10.1007/s13402-023-00866-x
PMCID:
PMC10899406
AbstractArticlePDF–8.3M
10.
The ATM Ser49Cys Variant Effects ATM Function as a Regulator of Oncogene-Induced Senescence
Caroline Atkinson, Aideen M. McInerney-Leo, Martina Proctor, Catherine Lanagan, Alexander J. Stevenson, Farhad Dehkhoda, Mary Caole, Ellie Maas, Stephen Ainger, Antonia L. Pritchard, Peter A. Johansson, Paul Leo, Nicholas K. Hayward, Richard A. Sturm, Emma L. Duncan, Brian Gabrielli
Int J Mol Sci. 2024 Feb; 25(3): 1664. Published online 2024 Jan 29. doi: 10.3390/ijms25031664
PMCID:
PMC10855307
AbstractArticlePDF–2.7M
11.
STAG2 Regulates Homologous Recombination Repair and Sensitivity to ATM Inhibition
Jie Zhou, Run‐Cong Nie, Zhang‐Ping He, Xiao‐Xia Cai, Jie‐Wei Chen, Wen‐ping Lin, Yi‐Xin Yin, Zhi‐Cheng Xiang, Tian‐Chen Zhu, Juan‐Juan Xie, You‐Cheng Zhang, Xin Wang, Peng Lin, Dan Xie, Alan D D'Andrea, Mu‐Yan Cai
Adv Sci (Weinh) 2023 Dec; 10(36): 2302494. Published online 2023 Nov 20. doi: 10.1002/advs.202302494
PMCID:
PMC10754142
AbstractArticlePDF–9.3M
12.
ATM Mutations Associate with Distinct Co-Mutational Patterns and Therapeutic Vulnerabilities in NSCLC
Natalie I. Vokes, Ana Galan Cobo, Margarita Fernandez-Chas, David Molkentine, Santiago Treviño, III, Vitaly Druker, Yu Qian, Sonia Patel, Stephanie Schmidt, Lingzhi Hong, Jeff Lewis, Waree Rinsurongkawong, Vadeerat Rinsurongkawong, J. Jack Lee, Marcelo V. Negrao, Don L. Gibbons, Ara Vaporciyan, Xiuning Le, Jia Wu, Jianjun Zhang, Una Rigney, Sonia Iyer, Emma Dean, John V. Heymach
Clin Cancer Res. 2023 Dec 1; 29(23): 4958–4972. Published online 2023 Sep 21. doi: 10.1158/1078-0432.CCR-23-1122
PMCID:
PMC10690143
AbstractArticlePDF–12M
13.
Identification and characterization of ATM founder mutation in BRCA-negative breast cancer patients of Arab ethnicity
Rong Bu, Abdul K. Siraj, Maha Al-Rasheed, Kaleem Iqbal, Saud Azam, Zeeshan Qadri, Wael Haqawi, Asma Tulbah, Fouad Al-Dayel, Osama Almalik, Khawla S. Al-Kuraya
Sci Rep. 2023; 13: 20924. Published online 2023 Nov 27. doi: 10.1038/s41598-023-48231-0
PMCID:
PMC10684510
AbstractArticlePDF–976K
14.
ATM, KAP1 and the Epstein–Barr virus polymerase processivity factor direct traffic at the intersection of transcription and replication
Huanzhou Xu, Ibukun A Akinyemi, John Haley, Michael T McIntosh, Sumita Bhaduri-McIntosh
Nucleic Acids Res. 2023 Nov 10; 51(20): 11104–11122. Published online 2023 Oct 19. doi: 10.1093/nar/gkad823
PMCID:
PMC10639065
AbstractArticlePDF–1.8M
15.
The epigenetic modifier HDAC2 and the checkpoint kinase ATM determine the responses of microsatellite instable colorectal cancer cells to 5-fluorouracil
Nicole Kiweler, Helena Schwarz, Alexandra Nguyen, Stephanie Matschos, Christina Mullins, Andrea Piée-Staffa, Christina Brachetti, Wynand P. Roos, Günter Schneider, Michael Linnebacher, Walburgis Brenner, Oliver H. Krämer
Cell Biol Toxicol. 2023; 39(5): 2401–2419. Published online 2022 May 24. doi: 10.1007/s10565-022-09731-3
PMCID:
PMC10547618
AbstractArticlePDF–1.9M
16.
ATM inhibition enhances the efficacy of radiation across distinct molecular subgroups of pediatric high-grade glioma
Jia Xie, Teneema Kuriakose, Brandon Bianski, Nathaniel Twarog, Evan Savage, Ke Xu, Xiaoyan Zhu, Chen He, Baranda Hansen, Hong Wang, Anthony High, Yuxin Li, Jerold E Rehg, Heather S Tillman, Burgess B Freeman, III, Zoran Rankovic, Arzu Onar-Thomas, Yiping Fan, Gang Wu, Junmin Peng, Shondra Miller, Suzanne J Baker, Anang A Shelat, Christopher L Tinkle
Neuro Oncol. 2023 Oct; 25(10): 1828–1841. Published online 2023 Mar 27. doi: 10.1093/neuonc/noad064
PMCID:
PMC10547515
AbstractArticlePDF–33M
17.
Somatic loss of ATM is a late event in pancreatic tumorigenesis
Raymond M. Paranal, Zhengdong Jiang, Danielle Hutchings, Valentyna Kryklyva, Christian Gauthier, Kohei Fujikura, Neha Nanda, Bo Huang, Michael Skaro, Christopher L. Wolfgang, Jin He, David S. Klimstra, Randall E. Brand, Aatur D. Singhi, Angelo DeMarzo, Lei Zheng, Michael Goggins, Lodewijk A. A. Brosens, Ralph H. Hruban, Alison P. Klein, Tamara Lotan, Laura D. Wood, Nicholas J. Roberts
J Pathol. Author manuscript; available in PMC 2024 Aug 1.
Published in final edited form as: J Pathol. 2023 Aug; 260(4): 455–464. Published online 2023 Jun 22. doi: 10.1002/path.6136
PMCID:
PMC10524278
AbstractArticlePDF–841K
18.
Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk
Naomi Wilcox, Martine Dumont, Anna González-Neira, Sara Carvalho, Charles Joly Beauparlant, Marco Crotti, Craig Luccarini, Penny Soucy, Stéphane Dubois, Rocio Nuñez-Torres, Guillermo Pita, Eugene J. Gardner, Joe Dennis, M. Rosario Alonso, Nuria Álvarez, Caroline Baynes, Annie Claude Collin-Deschesnes, Sylvie Desjardins, Heiko Becher, Sabine Behrens, Manjeet K. Bolla, Jose E. Castelao, Jenny Chang-Claude, Sten Cornelissen, Thilo Dörk, Christoph Engel, Manuela Gago-Dominguez, Pascal Guénel, Andreas Hadjisavvas, Eric Hahnen, Mikael Hartman, Belén Herráez, SGBCC Investigators, Audrey Jung, Renske Keeman, Marion Kiechle, Jingmei Li, Maria A. Loizidou, Michael Lush, Kyriaki Michailidou, Mihalis I. Panayiotidis, Xueling Sim, Soo Hwang Teo, Jonathan P. Tyrer, Lizet E. van der Kolk, Cecilia Wahlström, Qin Wang, John R. B. Perry, Javier Benitez, Marjanka K. Schmidt, Rita K. Schmutzler, Paul D. P. Pharoah, Arnaud Droit, Alison M. Dunning, Anders Kvist, Peter Devilee, Douglas F. Easton, Jacques Simard
Nat Genet. 2023; 55(9): 1435–1439. Published online 2023 Aug 17. doi: 10.1038/s41588-023-01466-z
Correction in:
Nat Genet. 2023; 55(11): 2009.
PMCID:
PMC10484782
AbstractArticlePDF–3.5M
19.
ATAXIA TELANGIECTASIA MUTATED PROTECTS AGAINST LIPOPOLYSACCARIDE-INDUCED BLOOD-BRAIN BARRIER DISRUPTION BY REGULATING ATK/DRP1-MEDIATED MITOCHONDRIAL HOMEOSTASIS
Shiyuan Luo, Zhuochen Lyu, Lingling Ge, Yinjiao Li, Yuqi Liu, Yuan Yuan, Rui Zhao, Lei Huang, Jianyuan Zhao, Hongjun Huang, Yan Luo
Shock. 2023 Jul; 60(1): 100–109. Published online 2023 May 5. doi: 10.1097/SHK.0000000000002139
PMCID:
PMC10417231
AbstractArticlePDF–1.0M
20.
BRCA-deficient metastatic prostate cancer has an adverse prognosis and distinct genomic phenotype
Heidi Fettke, Chao Dai, Edmond M. Kwan, Tiantian Zheng, Pan Du, Nicole Ng, Patricia Bukczynska, Maria Docanto, Louise Kostos, Siavash Foroughi, Stephen Brown, Lisa-Jane K. Graham, Kate Mahon, Lisa G. Horvath, Shidong Jia, Manish Kohli, Arun A. Azad
eBioMedicine. 2023 Sep; 95: 104738. Published online 2023 Aug 5. doi: 10.1016/j.ebiom.2023.104738
PMCID:
PMC10412463
AbstractArticlePDF–1.8M

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