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Select item 105658761.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 102667942.

Poly(ADP-ribose) polymerase 9 mediates early protection against Mycobacterium tuberculosis infection by regulating type I IFN production

Shyamala Thirunavukkarasu, Mushtaq Ahmed, Bruce A. Rosa, Mark Boothby, Sung Hoon Cho, Javier Rangel-Moreno, Stanley K. Mbandi, Valérie Schreiber, Ananya Gupta, Joaquin Zuniga, Makedonka Mitreva, Deepak Kaushal, Thomas J. Scriba, Shabaana A. Khader

J Clin Invest. 2023 Jun 15; 133(12): e158630. Published online 2023 Jun 15. doi: 10.1172/JCI158630

PMCID:: PMC10266794

Abstract Article PDF–6.5M

Select item 102374223.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101516154.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 100695845.

ANXA1-derived peptide for targeting PD-L1 degradation inhibits tumor immune evasion in multiple cancers

Zheng-Zheng Yu, Yun-Ya Liu, Wei Zhu, Ding Xiao, Wei Huang, Shan-Shan Lu, Hong Yi, Ting Zeng, Xue-Ping Feng, Li Yuan, Jie-Ya Qiu, Di Wu, Qi Wen, Jian-Hua Zhou, Wei Zhuang, Zhi-Qiang Xiao

J Immunother Cancer. 2023; 11(3): e006345. Published online 2023 Mar 31. doi: 10.1136/jitc-2022-006345

PMCID:: PMC10069584

Abstract Article PDF–11M

Select item 100058986.

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA

Ellis G. Jaffray, Michael H. Tatham, Barbara Mojsa, Magda Liczmanska, Alejandro Rojas-Fernandez, Yili Yin, Graeme Ball, Ronald T. Hay

J Cell Biol. 2023 Apr 3; 222(4): e202201027. Published online 2023 Feb 28. doi: 10.1083/jcb.202201027

PMCID:: PMC10005898

Abstract Article PDF–6.7M

Select item 91052357.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 83327388.

The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling

Lilian Cristina Russo, Rebeka Tomasin, Isaac Araújo Matos, Antonio Carlos Manucci, Sven T. Sowa, Katie Dale, Keith W. Caldecott, Lari Lehtiö, Deborah Schechtman, Flavia C. Meotti, Alexandre Bruni-Cardoso, Nicolas Carlos Hoch

J Biol Chem. 2021 Sep; 297(3): 101041. Published online 2021 Aug 4. doi: 10.1016/j.jbc.2021.101041

PMCID:: PMC8332738

Abstract Article PDF–3.4M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 811356910.

Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells

Junji Xing, Ao Zhang, Yong Du, Mingli Fang, Laurie J. Minze, Yong-Jun Liu, Xian Chang Li, Zhiqiang Zhang

Nat Commun. 2021; 12: 2681. Published online 2021 May 11. doi: 10.1038/s41467-021-23003-4

PMCID:: PMC8113569

Abstract Article PDF–3.0M

Select item 811349011.

Androgen signaling uses a writer and a reader of ADP-ribosylation to regulate protein complex assembly

Chun-Song Yang, Kasey Jividen, Teddy Kamata, Natalia Dworak, Luke Oostdyk, Bartlomiej Remlein, Yasin Pourfarjam, In-Kwon Kim, Kang-Ping Du, Tarek Abbas, Nicholas E. Sherman, David Wotton, Bryce M. Paschal

Nat Commun. 2021; 12: 2705. Published online 2021 May 11. doi: 10.1038/s41467-021-23055-6

PMCID:: PMC8113490

Abstract Article PDF–2.0M

Select item 756660012.

Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins

Kathrin Nowak, Florian Rosenthal, Tobias Karlberg, Mareike Bütepage, Ann-Gerd Thorsell, Birgit Dreier, Jonas Grossmann, Jens Sobek, Ralph Imhof, Bernhard Lüscher, Herwig Schüler, Andreas Plückthun, Deena M. Leslie Pedrioli, Michael O. Hottiger

Nat Commun. 2020; 11: 5199. Published online 2020 Oct 15. doi: 10.1038/s41467-020-18981-w

PMCID:: PMC7566600

Abstract Article PDF–4.3M

Select item 750093813.

Structural insights into ADP-ribosylation of ubiquitin by Deltex family E3 ubiquitin ligases

Chatrin Chatrin, Mads Gabrielsen, Lori Buetow, Mark A. Nakasone, Syed F. Ahmed, David Sumpton, Gary J. Sibbet, Brian O. Smith, Danny T. Huang

Sci Adv. 2020 Sep; 6(38): eabc0418. Published online 2020 Sep 18. doi: 10.1126/sciadv.abc0418

PMCID:: PMC7500938

Abstract Article PDF–3.4M

Select item 744247414.

DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination

Syed Feroj Ahmed, Lori Buetow, Mads Gabrielsen, Sergio Lilla, Chatrin Chatrin, Gary J. Sibbet, Sara Zanivan, Danny T. Huang

Sci Adv. 2020 Aug; 6(34): eabc0629. Published online 2020 Aug 21. doi: 10.1126/sciadv.abc0629

PMCID:: PMC7442474

Abstract Article PDF–2.4M

Select item 739233415.

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells

Seung W. Ryu, Rose Stewart, D. Chase Pectol, Nicolette A. Ender, Oshadi Wimalarathne, Ji-Hoon Lee, Carlos P. Zanini, Antony Harvey, Jon M. Huibregtse, Peter Mueller, Tanya T. Paull

PLoS Biol. 2020 Jul; 18(7): e3000606. Published online 2020 Jul 20. doi: 10.1371/journal.pbio.3000606

PMCID:: PMC7392334

Abstract Article PDF–2.7M

Select item 736675116.

Molecular and clinical characterization of PARP9 in gliomas: A potential immunotherapeutic target

Hao Xu, Songshan Chai, Yihao Wang, Jiajing Wang, Dongdong Xiao, Junjun Li, Nanxiang Xiong

CNS Neurosci Ther. 2020 Aug; 26(8): 804–814. Published online 2020 Apr 24. doi: 10.1111/cns.13380

PMCID:: PMC7366751

Abstract Article PDF–2.0M

Select item 645686817.

A Study into the ADP-Ribosylome of IFN-γ-Stimulated THP-1 Human Macrophage-like Cells Identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-Ribosylation

Hideyuki Higashi, Takashi Maejima, Lang Ho Lee, Yukiyoshi Yamazaki, Michael O. Hottiger, Sasha A. Singh, Masanori Aikawa

J Proteome Res. 2019 Apr 5; 18(4): 1607–1622. Published online 2019 Mar 8. doi: 10.1021/acs.jproteome.8b00895

PMCID:: PMC6456868

Abstract Article PDF–5.6M

Select item 631010218.

Interactome and proteome dynamics uncover immune modulatory associations of the pathogen sensing factor cGAS

Krystal K. Lum, Bokai Song, Joel D. Federspiel, Benjamin A. Diner, Timothy Howard, Ileana M. Cristea

Cell Syst. Author manuscript; available in PMC 2019 Dec 26.

Published in final edited form as: Cell Syst. 2018 Dec 26; 7(6): 627–642.e6. Published online 2018 Nov 21. doi: 10.1016/j.cels.2018.10.010

PMCID:: PMC6310102

Abstract Article PDF–3.5M

Select item 583915819.

Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells

Giorgio Giurato, Giovanni Nassa, Annamaria Salvati, Elena Alexandrova, Francesca Rizzo, Tuula A. Nyman, Alessandro Weisz, Roberta Tarallo

Sci Data. 2018; 5: 180031. Published online 2018 Mar 6. doi: 10.1038/sdata.2018.31

PMCID:: PMC5839158

Abstract Article PDF–1.9M

Select item 555693520.

Ubiquitin Modification by the E3 Ligase/ADP-ribosyltransferase Dtx3L/Parp9

Chun-Song Yang, Kasey Jividen, Adam Spencer, Natalia Dworak, Li Ni, Luke T. Oostdyk, Mandovi Chatterjee, Beata Kusmider, Brian Reon, Mahmut Parlak, Vera Gorbunova, Tarek Abbas, Erin Jeffery, Nicholas E. Sherman, Bryce M. Paschal

Mol Cell. Author manuscript; available in PMC 2018 May 18.

Published in final edited form as: Mol Cell. 2017 May 18; 66(4): 503–516.e5. doi: 10.1016/j.molcel.2017.04.028

PMCID:: PMC5556935

Abstract Article PDF–1.9M

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