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Items: 1 to 20 of 212

1.
ITCH is a putative target for a novel 20q11.22 amplification detected in anaplastic thyroid carcinoma cells by array‐based comparative genomic hybridization
Takaya Ishihara, Hitoshi Tsuda, Akiko Hotta, Ken‐ichi Kozaki, Akira Yoshida, Jaeduk Yoshimura Noh, Koichi Ito, Issei Imoto, Johji Inazawa
Cancer Sci. 2008 Oct; 99(10): 1940–1949. Published online 2008 Oct 17. doi: 10.1111/j.1349-7006.2008.00900.x
PMCID:
PMC11158512
AbstractArticlePDF–539K
2.
K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors
Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer
Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740
PMCID:
PMC11109483
AbstractArticlePDF–2.9M
3.
Myofibrillogenesis Regulator‐1 Regulates the Ubiquitin Lysosomal Pathway of Notch3 Intracellular Domain Through E3 Ubiquitin‐Protein Ligase Itchy Homolog in the Metastasis of Non‐Small Cell Lung Cancer
Wenxia Zhao, Yang Li, Hanzeng Cheng, Mengyan Wang, Zhishuo Zhang, Meilian Cai, Cong Zhao, Xiaoming Xi, Xiaojun Zhao, Wuli Zhao, Yajun Yang, Rongguang Shao
Adv Sci (Weinh) 2024 Apr; 11(15): 2306472. Published online 2024 Feb 11. doi: 10.1002/advs.202306472
PMCID:
PMC11022719
AbstractArticlePDF–6.1M
4.
The E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation
Max Zachrisson Totland, Lars Mørland Knudsen, Nikoline Lander Rasmussen, Yasufumi Omori, Vigdis Sørensen, Vilde C. Wivestad Elster, Jakob Mørkved Stenersen, Mathias Larsen, Caroline Lunder Jensen, Anna A. Zickfeldt Lade, Emilie Bruusgaard, Sebastian Basing, Kushtrim Kryeziu, Andreas Brech, Trond Aasen, Ragnhild A. Lothe, Edward Leithe
Cell Mol Life Sci. 2024 Dec; 81(1): 171. Published online 2024 Apr 10. doi: 10.1007/s00018-024-05165-8
PMCID:
PMC11006747
AbstractArticlePDF–10M
5.
Comparative interactome analysis of α-arrestin families in human and Drosophila
Kyung-Tae Lee, Inez KA Pranoto, Soon-Young Kim, Hee-Joo Choi, Ngoc Bao To, Hansong Chae, Jeong-Yeon Lee, Jung-Eun Kim, Young V Kwon, Jin-Wu Nam
eLife. 2024; 12: RP88328. Published online 2024 Jan 25. doi: 10.7554/eLife.88328
PMCID:
PMC10945707
AbstractArticlePDF–2.8M
6.
Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity
Yifan Wang, L. Robert Hollingsworth, Lamba Omar Sangaré, Tatiana C. Paredes-Santos, Shruthi Krishnamurthy, Bennett H. Penn, Hao Wu, Jeroen P. J. Saeij
mBio. 2024 Mar; 15(3): e03302-23. Published online 2024 Feb 20. doi: 10.1128/mbio.03302-23
PMCID:
PMC10936166
AbstractArticlePDF–2.2M
7.
The E3 ubiquitin ligase Itch regulates death receptor and cholesterol trafficking to affect TRAIL-mediated apoptosis
James Holloway, Aidan Seeley, Neville Cobbe, Richard C. Turkington, Daniel B. Longley, Emma Evergren
Cell Death Dis. 2024 Jan; 15(1): 40. Published online 2024 Jan 12. doi: 10.1038/s41419-023-06417-4
PMCID:
PMC10786908
AbstractArticlePDF–5.9M
8.
UBE4B interacts with the ITCH E3 ubiquitin ligase to induce Ku70 and c-FLIPL polyubiquitination and enhanced neuroblastoma apoptosis
Christophe Le Clorennec, Divya Subramonian, Yuchen Huo, Peter E. Zage
Cell Death Dis. 2023 Nov; 14(11): 739. Published online 2023 Nov 13. doi: 10.1038/s41419-023-06252-7
PMCID:
PMC10643674
AbstractArticlePDF–10M
9.
Large‐scale phosphomimetic screening identifies phospho‐modulated motif‐based protein interactions
Johanna Kliche, Dimitriya Hristoforova Garvanska, Leandro Simonetti, Dilip Badgujar, Doreen Dobritzsch, Jakob Nilsson, Norman E Davey, Ylva Ivarsson
Mol Syst Biol. 2023 Jul; 19(7): e11164. Published online 2023 May 23. doi: 10.15252/msb.202211164
PMCID:
PMC10333884
AbstractArticlePDF–5.0M
10.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
11.
Cytoplasmic YAP1‐mediated ESCRT‐III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer
Yan Guo, Yuqing Cui, Yangyang Li, Xiaoying Jin, Dandan Wang, Mengxia Lei, Fengzhi Chen, Yali Liu, Jinwen Xu, Guanyu Yao, Guangchun Zeng, Xuesong Chen
Cancer Commun (Lond) 2023 May; 43(5): 582–612. Published online 2023 Apr 2. doi: 10.1002/cac2.12417
PMCID:
PMC10174091
AbstractArticlePDF–22M
12.
The ubiquitin ligase Itch skews light zone selection in germinal centers
Lindsay Renshaw, Peter Kim, Macaul Crici, Hossein Fazelinia, Lynn Spruce, Paula Oliver, Emily Moser
J Immunol. Author manuscript; available in PMC 2024 May 15.
Published in final edited form as: J Immunol. 2023 May 15; 210(10): 1473–1481. doi: 10.4049/jimmunol.2200824
PMCID:
PMC10159933
AbstractArticlePDF–1.8M
13.
Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs
Filip Mihalič, Leandro Simonetti, Girolamo Giudice, Marie Rubin Sander, Richard Lindqvist, Marie Berit Akpiroro Peters, Caroline Benz, Eszter Kassa, Dilip Badgujar, Raviteja Inturi, Muhammad Ali, Izabella Krystkowiak, Ahmed Sayadi, Eva Andersson, Hanna Aronsson, Ola Söderberg, Doreen Dobritzsch, Evangelia Petsalaki, Anna K. Överby, Per Jemth, Norman E. Davey, Ylva Ivarsson
Nat Commun. 2023; 14: 2409. Published online 2023 Apr 26. doi: 10.1038/s41467-023-38015-5
PMCID:
PMC10132805
AbstractArticlePDF–4.2M
14.
Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma
Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li
Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x
PMCID:
PMC9950447
AbstractArticlePDF–8.4M
15.
MTSS1 curtails lung adenocarcinoma immune evasion by promoting AIP4-mediated PD-L1 monoubiquitination and lysosomal degradation
Yuan Wang, Zhenchang Jia, Chenxi Liang, Yunfei He, Min Cong, Qiuyao Wu, Pu Tian, Dasa He, Xiang Miao, Beibei Sun, Yue Yin, Chao Peng, Feng Yao, Da Fu, Yajun Liang, Peiyuan Zhang, Hua Xiong, Guohong Hu
Cell Discov. 2023; 9: 20. Published online 2023 Feb 21. doi: 10.1038/s41421-022-00507-x
PMCID:
PMC9944270
AbstractArticlePDF–3.2M
16.
ROS inhibits RORα degradation by decreasing its arginine methylation in liver cancer
Hyuntae Im, Hee‐ji Baek, Eunbi Yang, Kyeongkyu Kim, Se Kyu Oh, Jung‐Shin Lee, Hyunkyung Kim, Ji Min Lee
Cancer Sci. 2023 Jan; 114(1): 187–200. Published online 2022 Oct 1. doi: 10.1111/cas.15595
PMCID:
PMC9807526
AbstractArticlePDF–7.6M
17.
A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor
Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth
Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.
Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841
PMCID:
PMC9769698
AbstractArticlePDF–2.7M
18.
Proteasomal down-regulation of the proapoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanoma
David Romano, Lucía García-Gutiérrez, Nourhan Aboud, David J Duffy, Keith T Flaherty, Dennie T Frederick, Walter Kolch, David Matallanas
Life Sci Alliance. 2022 Oct; 5(10): e202201445. Published online 2022 Aug 29. doi: 10.26508/lsa.202201445
PMCID:
PMC9434705
AbstractArticlePDF–2.0M
19.
Enhancing PD-L1 Degradation by ITCH during MAPK Inhibitor Therapy Suppresses Acquired Resistance
Zhentao Yang, Yan Wang, Sixue Liu, Weixian Deng, Shirley H. Lomeli, Gatien Moriceau, James Wohlschlegel, Marco Piva, Roger S. Lo
Cancer Discov. 2022 Aug 5; 12(8): 1942–1959. Published online 2022 May 31. doi: 10.1158/2159-8290.CD-21-1463
PMCID:
PMC9357203
AbstractArticlePDF–6.8M
20.
Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease
Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel
Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205
PMCID:
PMC9348576
AbstractArticlePDF–3.0M

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