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Select item 105305791.

GABBR2 as a Downstream Effector of the Androgen Receptor Induces Cisplatin Resistance in Bladder Cancer

Mohammad Amin Elahi Najafi, Masato Yasui, Yuki Teramoto, Tomoyuki Tatenuma, Guiyang Jiang, Hiroshi Miyamoto

Int J Mol Sci. 2023 Sep; 24(18): 13733. Published online 2023 Sep 6. doi: 10.3390/ijms241813733

PMCID:: PMC10530579

Abstract Article PDF–2.8M

Select item 101894952.

Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia

Yu-Han H. Hsu, Greta Pintacuda, Ruize Liu, Eugeniu Nacu, April Kim, Kalliopi Tsafou, Natalie Petrossian, William Crotty, Jung Min Suh, Jackson Riseman, Jacqueline M. Martin, Julia C. Biagini, Daya Mena, Joshua K.T. Ching, Edyta Malolepsza, Taibo Li, Tarjinder Singh, Tian Ge, Shawn B. Egri, Benjamin Tanenbaum, Caroline R. Stanclift, Annie M. Apffel, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Stanley Global Asia Initiatives, Steven A. Carr, Monica Schenone, Jake Jaffe, Nadine Fornelos, Hailiang Huang, Kevin C. Eggan, Kasper Lage

iScience. 2023 May 19; 26(5): 106701. Published online 2023 Apr 18. doi: 10.1016/j.isci.2023.106701

PMCID:: PMC10189495

Abstract Article PDF–5.3M

Select item 81650303.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80208354.

Structural basis of the activation of a metabotropic GABA receptor

Hamidreza Shaye, Andrii Ishchenko, Jordy Homing Lam, Gye Won Han, Li Xue, Philippe Rondard, Jean-Philippe Pin, Vsevolod Katritch, Cornelius Gati, Vadim Cherezov

Nature. Author manuscript; available in PMC 2021 Apr 5.

Published in final edited form as: Nature. 2020 Aug; 584(7820): 298–303. Published online 2020 Jun 17. doi: 10.1038/s41586-020-2408-4

PMCID:: PMC8020835

Abstract Article PDF–2.7M

Select item 77252815.

Structure of human GABA_B receptor in an inactive state

Jinseo Park, Ziao Fu, Aurel Frangaj, Jonathan Liu, Lidia Mosyak, Tong Shen, Vesna N. Slavkovich, Kimberly M. Ray, Jaume Taura, Baohua Cao, Yong Geng, Hao Zuo, Yongjun Kou, Robert Grassucci, Shaoxia Chen, Zheng Liu, Xin Lin, Justin P. Williams, William J. Rice, Edward T. Eng, Rick K. Huang, Rajesh K. Soni, Brian Kloss, Zhiheng Yu, Jonathan A. Javitch, Wayne A. Hendrickson, Paul A. Slesinger, Matthias Quick, Joseph Graziano, Hongtao Yu, Oliver Fiehn, Oliver B. Clarke, Joachim Frank, Qing R. Fan

Nature. Author manuscript; available in PMC 2020 Dec 24.

Published in final edited form as: Nature. 2020 Aug; 584(7820): 304–309. Published online 2020 Jun 24. doi: 10.1038/s41586-020-2452-0

Correction in:: Nature. 2020 Jul; 583(7818): E29.

PMCID:: PMC7725281

Abstract Article PDF–5.3M

Select item 74293646.

Structures of metabotropic GABA_B receptor

Makaía M. Papasergi-Scott, Michael J. Robertson, Alpay B. Seven, Ouliana Panova, Jesper M. Mathiesen, Georgios Skiniotis

Nature. Author manuscript; available in PMC 2020 Dec 24.

Published in final edited form as: Nature. 2020 Aug; 584(7820): 310–314. Published online 2020 Jun 24. doi: 10.1038/s41586-020-2469-4

PMCID:: PMC7429364

Abstract Article PDF–6.1M

Select item 67575807.

Tamalin, a PDZ Domain-Containing Protein, Links a Protein Complex Formation of Group 1 Metabotropic Glutamate Receptors and the Guanine Nucleotide Exchange Factor Cytohesins

Jun Kitano, Kouji Kimura, Yoshimitsu Yamazaki, Takeshi Soda, Ryuichi Shigemoto, Yoshiaki Nakajima, Shigetada Nakanishi

J Neurosci. 2002 Feb 15; 22(4): 1280–1289. doi: 10.1523/JNEUROSCI.22-04-01280.2002

PMCID:: PMC6757580

Abstract Article PDF–529K

Select item 64867838.

Structural basis for auxiliary subunit KCTD16 regulation of the GABA_B receptor

Hao Zuo, Ian Glaaser, Yulin Zhao, Igor Kurinov, Lidia Mosyak, Haonan Wang, Jonathan Liu, Jinseo Park, Aurel Frangaj, Emmanuel Sturchler, Ming Zhou, Patricia McDonald, Yong Geng, Paul A. Slesinger, Qing R. Fan

Proc Natl Acad Sci U S A. 2019 Apr 23; 116(17): 8370–8379. Published online 2019 Apr 10. doi: 10.1073/pnas.1903024116

PMCID:: PMC6486783

Abstract Article PDF–2.6M

Select item 55910299.

Spatial Clustering of de Novo Missense Mutations Identifies Candidate Neurodevelopmental Disorder-Associated Genes

Stefan H. Lelieveld, Laurens Wiel, Hanka Venselaar, Rolph Pfundt, Gerrit Vriend, Joris A. Veltman, Han G. Brunner, Lisenka E.L.M. Vissers, Christian Gilissen

Am J Hum Genet. 2017 Sep 7; 101(3): 478–484. Published online 2017 Aug 31. doi: 10.1016/j.ajhg.2017.08.004

PMCID:: PMC5591029

Abstract Article PDF–785K

Select item 541523510.

The Identification of Novel Proteins That Interact With the GLP-1 Receptor and Restrain its Activity

X. Huang, F. F. Dai, G. Gaisano, K. Giglou, J. Han, M. Zhang, S. Kittanakom, V. Wong, L. Wei, A. D. Showalter, K. W. Sloop, I. Stagljar, M. B. Wheeler

Mol Endocrinol. September 1, 2013; 27(9): 1550–1563. Published online 2013 Jul 17. doi: 10.1210/me.2013-1047

PMCID:: PMC5415235

Abstract Article

Select item 537173011.

Systematic protein–protein interaction mapping for clinically relevant human GPCRs

Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar

Mol Syst Biol. 2017 Mar; 13(3): 918. Published online 2017 Mar 15. doi: 10.15252/msb.20167430

PMCID:: PMC5371730

Abstract Article PDF–4.1M

Select item 536026712.

Ligand-guided homology modelling of the GABA_B2 subunit of the GABA_B receptor

Thibaud Freyd, Dawid Warszycki, Stefan Mordalski, Andrzej J. Bojarski, Ingebrigt Sylte, Mari Gabrielsen

PLoS One. 2017; 12(3): e0173889. Published online 2017 Mar 21. doi: 10.1371/journal.pone.0173889

PMCID:: PMC5360267

Abstract Article PDF–2.0M

Select item 480729613.

Post-endocytotic Deubiquitination and Degradation of the Metabotropic γ-Aminobutyric Acid Receptor by the Ubiquitin-specific Protease 14

Nicolas Lahaie, Michaela Kralikova, Laurent Prézeau, Jaroslav Blahos, Michel Bouvier

J Biol Chem. 2016 Mar 25; 291(13): 7156–7170. Published online 2016 Jan 27. doi: 10.1074/jbc.M115.686907

PMCID:: PMC4807296

Abstract Article PDF–2.2M

Select item 445245814.

The Contribution of Rare and Common Variants in 30 Genes to Risk Nicotine Dependence

Jiekun Yang, Shaolin Wang, Zhongli Yang, Colin A. Hodgkinson, Polina Iarikova, Jennie Z. Ma, Thomas J. Payne, David Goldman, Ming D. Li

Mol Psychiatry. Author manuscript; available in PMC 2016 May 1.

Published in final edited form as: Mol Psychiatry. 2015 Nov; 20(11): 1467–1478. Published online 2014 Dec 2. doi: 10.1038/mp.2014.156

PMCID:: PMC4452458

Abstract Article PDF–753K

Select item 405568915.

Identification of a Novel Protein Complex Containing ASIC1a and GABA_A Receptors and Their Interregulation

Dongbo Zhao, Nannan Ning, Zhen Lei, Hua Sun, Chuanfei Wei, Dawei Chen, Jingxin Li

PLoS One. 2014; 9(6): e99735. Published online 2014 Jun 12. doi: 10.1371/journal.pone.0099735

PMCID:: PMC4055689

Abstract Article PDF–3.3M

Select item 402489816.

Heterodimeric coiled-coil interactions of human GABA_B receptor

Svetlana Burmakina, Yong Geng, Yan Chen, Qing R. Fan

Proc Natl Acad Sci U S A. 2014 May 13; 111(19): 6958–6963. Published online 2014 Apr 28. doi: 10.1073/pnas.1400081111

PMCID:: PMC4024898

Abstract Article PDF–1.3M

Select item 395328417.

Proteasomal Degradation of γ-Aminobutyric Acid_B Receptors Is Mediated by the Interaction of the GABA_B2 C Terminus with the Proteasomal ATPase Rtp6 and Regulated by Neuronal Activity

Khaled Zemoura, Dietmar Benke

J Biol Chem. 2014 Mar 14; 289(11): 7738–7746. Published online 2014 Jan 30. doi: 10.1074/jbc.M113.541987

PMCID:: PMC3953284

Abstract Article PDF–1.9M

Select item 386506518.

Structural mechanism of ligand activation in human GABA_B receptor

Yong Geng, Martin Bush, Lidia Mosyak, Feng Wang, Qing R. Fan

Nature. Author manuscript; available in PMC 2014 Jun 12.

Published in final edited form as: Nature. 2013 Dec 12; 504(7479): 254–259. Published online 2013 Dec 4. doi: 10.1038/nature12725

PMCID:: PMC3865065

Abstract Article PDF–2.0M

Select item 381014819.

Genome-wide Association Study Identifies New Susceptibility Loci for Posttraumatic Stress Disorder

Pingxing Xie, Henry R. Kranzler, Can Yang, Hongyu Zhao, Lindsay A. Farrer, Joel Gelernter

Biol Psychiatry. Author manuscript; available in PMC 2013 Nov 1.

Published in final edited form as: Biol Psychiatry. 2013 Nov 1; 74(9): 10.1016/j.biopsych.2013.04.013. Published online 2013 May 28. doi: 10.1016/j.biopsych.2013.04.013