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Items: 1 to 20 of 369

1.
K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors
Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer
Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740
PMCID:
PMC11109483
AbstractArticlePDF–2.9M
2.
Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2
Wei Dong, Qing Li, Xing Lu, Jianfeng Lan, Zhidong Qiu, Xuehong Wang, Junnan Wang, Xiaojiao Zheng, Sifan Chen, Chong Zhang, Junfei Jin
Exp Mol Med. 2024 Apr; 56(4): 946–958. Published online 2024 Apr 1. doi: 10.1038/s12276-024-01203-4
PMCID:
PMC11059394
AbstractArticlePDF–7.4M
3.
Diminished Efficacy of Programmed Death-(Ligand)1 Inhibition in STK11- and KEAP1-Mutant Lung Adenocarcinoma Is Affected by KRAS Mutation Status
Biagio Ricciuti, Kathryn C. Arbour, Jessica J. Lin, Amir Vajdi, Natalie Vokes, Lingzhi Hong, Jianjun Zhang, Michael Y. Tolstorukov, Yvonne Y. Li, Liam F. Spurr, Andrew D. Cherniack, Gonzalo Recondo, Giuseppe Lamberti, Xinan Wang, Deepti Venkatraman, Joao V. Alessi, Victor R. Vaz, Hira Rizvi, Jacklynn Egger, Andrew J. Plodkowski, Sara Khosrowjerdi, Subba Digumarthy, Hyesun Park, Nuno Vaz, Mizuki Nishino, Lynette M. Sholl, David Barbie, Mehmet Altan, John V. Heymach, Ferdinandos Skoulidis, Justin F. Gainor, Matthew D. Hellmann, Mark M. Awad
J Thorac Oncol. Author manuscript; available in PMC 2024 Mar 29.
Published in final edited form as: J Thorac Oncol. 2022 Mar; 17(3): 399–410. Published online 2021 Nov 2. doi: 10.1016/j.jtho.2021.10.013
PMCID:
PMC10980559
AbstractArticlePDF–1.5M
4.
GSTP alleviates acute lung injury by S-glutathionylation of KEAP1 and subsequent activation of NRF2 pathway
Xiaolin Sun, Chaorui Guo, Chunyan Huang, Ning Lv, Huili Chen, Haoyan Huang, Yulin Zhao, Shanliang Sun, Di Zhao, Jingwei Tian, Xijing Chen, Yongjie Zhang
Redox Biol. 2024 May; 71: 103116. Published online 2024 Mar 6. doi: 10.1016/j.redox.2024.103116
PMCID:
PMC10945259
AbstractArticlePDF–16M
5.
Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma
Suzannah G. Miller, Maria Hoh, Christopher C. Ebmeier, Jian Wei Tay, Natalie G. Ahn
Mol Biol Cell. 2024 Mar 1; 35(3): ar31. Published online 2024 Jan 29. doi: 10.1091/mbc.E23-06-0255
PMCID:
PMC10916866
AbstractArticlePDF–4.7M
6.
A tumor suppressor protein encoded by circKEAP1 inhibits osteosarcoma cell stemness and metastasis by promoting vimentin proteasome degradation and activating anti-tumor immunity
Ying Zhang, Zhaoyong Liu, Zhigang Zhong, Yanchen Ji, Huancheng Guo, Weidong Wang, Chuangzhen Chen
J Exp Clin Cancer Res. 2024; 43: 52. Published online 2024 Feb 21. doi: 10.1186/s13046-024-02971-7
PMCID:
PMC10880370
AbstractArticlePDF–19M
7.
Study of the effect of keap1 on oxidative stress in human umbilical cord mesenchymal stem cells
Hongrong Deng, Yunxia Chen, Huiwen Liu, Li Wang, Hao Xu, Bin Tan, Qin Yi, Rui Wang, Bolin He, Jie Tian, Jing Zhu
Mol Biol Rep. 2024; 51(1): 67. Published online 2024 Jan 3. doi: 10.1007/s11033-023-08997-y
PMCID:
PMC10764455
AbstractArticlePDF–4.1M
8.
KEAP1 mutation in lung adenocarcinoma promotes immune evasion and immunotherapy resistance
Anastasia-Maria Zavitsanou, Ray Pillai, Yuan Hao, Warren L. Wu, Eric Bartnicki, Triantafyllia Karakousi, Sahith Rajalingam, Alberto Herrera, Angeliki Karatza, Ali Rashidfarrokhi, Sabrina Solis, Metamia Ciampricotti, Anna H. Yeaton, Ellie Ivanova, Corrin A. Wohlhieter, Terkild B. Buus, Makiko Hayashi, Burcu Karadal-Ferrena, Harvey I. Pass, John T. Poirier, Charles M. Rudin, Kwok-Kin Wong, Andre L. Moreira, Kamal M. Khanna, Aristotelis Tsirigos, Thales Papagiannakopoulos, Sergei B. Koralov
Cell Rep. Author manuscript; available in PMC 2023 Dec 29.
Published in final edited form as: Cell Rep. 2023 Nov 28; 42(11): 113295. Published online 2023 Oct 26. doi: 10.1016/j.celrep.2023.113295
PMCID:
PMC10755970
AbstractArticlePDF–2.3M
9.
Oxidative stress sensor Keap1 recognizes HBx protein to activate the Nrf2/ARE signaling pathway, thereby inhibiting hepatitis B virus replication
Adi Ariffianto, Lin Deng, Takayuki Abe, Chieko Matsui, Masahiko Ito, Akihide Ryo, Hussein Hassan Aly, Koichi Watashi, Tetsuro Suzuki, Masashi Mizokami, Yoshiharu Matsuura, Ikuo Shoji
J Virol. 2023 Oct; 97(10): e01287-23. Published online 2023 Oct 6. doi: 10.1128/jvi.01287-23
PMCID:
PMC10617466
AbstractArticlePDF–5.0M
10.
Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates
Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert
Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644
PMCID:
PMC10565876
AbstractArticlePDF–3.7M
11.
Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly
Roslin J. Adamson, N Connor Payne, Sergio G. Bartual, Ralph Mazitschek, Alex N. Bullock
Free Radic Biol Med. 2023 Aug 1; 204: 215–225. doi: 10.1016/j.freeradbiomed.2023.04.021
PMCID:
PMC10564622
AbstractArticlePDF–5.7M
12.
FSP1 confers ferroptosis resistance in KEAP1 mutant non-small cell lung carcinoma in NRF2-dependent and -independent manner
Jong Woo Kim, Min-Ju Kim, Tae-Hee Han, Ji-Yoon Lee, Sangok Kim, Hyerin Kim, Kyoung-Jin Oh, Won Kon Kim, Baek-Soo Han, Kwang-Hee Bae, Hyun Seung Ban, Soo Han Bae, Sang Chul Lee, Haeseung Lee, Eun-Woo Lee
Cell Death Dis. 2023 Aug; 14(8): 567. Published online 2023 Aug 26. doi: 10.1038/s41419-023-06070-x
PMCID:
PMC10460413
AbstractArticlePDF–3.8M
13.
Large‐scale phosphomimetic screening identifies phospho‐modulated motif‐based protein interactions
Johanna Kliche, Dimitriya Hristoforova Garvanska, Leandro Simonetti, Dilip Badgujar, Doreen Dobritzsch, Jakob Nilsson, Norman E Davey, Ylva Ivarsson
Mol Syst Biol. 2023 Jul; 19(7): e11164. Published online 2023 May 23. doi: 10.15252/msb.202211164
PMCID:
PMC10333884
AbstractArticlePDF–5.0M
14.
TRIM13 inhibits cell proliferation and induces autophagy in lung adenocarcinoma by regulating KEAP1/NRF2 pathway
Bo Yu, Yu Zhou, Jinxi He
Cell Cycle. 2023; 22(12): 1496–1513. Published online 2023 May 28. doi: 10.1080/15384101.2023.2216504
PMCID:
PMC10281484
AbstractArticlePDF–4.1M
15.
SMURF1 attenuates endoplasmic reticulum stress by promoting the degradation of KEAP1 to activate NRF2 antioxidant pathway
Lei Dong, Mengchuan Xu, Yang Li, Wanting Xu, Chengwei Wu, Hanfei Zheng, Zhenyu Xiao, Guochen Sun, Lei Ding, Xiaobo Li, Wenming Li, Liying Zhou, Qin Xia
Cell Death Dis. 2023 Jun; 14(6): 361. Published online 2023 Jun 14. doi: 10.1038/s41419-023-05873-2
PMCID:
PMC10267134
AbstractArticlePDF–4.4M
16.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
17.
DDRGK1 Enhances Osteosarcoma Chemoresistance via Inhibiting KEAP1‐Mediated NRF2 Ubiquitination
Xin Wang, Tangjun Zhou, Xiao Yang, Xiankun Cao, Gu Jin, Pu Zhang, Jiadong Guo, Kewei Rong, Baixing Li, Yibin Hu, Kexin Liu, Peixiang Ma, An Qin, Jie Zhao
Adv Sci (Weinh) 2023 May; 10(14): 2204438. Published online 2023 Mar 25. doi: 10.1002/advs.202204438
PMCID:
PMC10190621
AbstractArticlePDF–7.3M
18.
The KEAP1-NRF2 pathway: Targets for therapy and role in cancer
Simone Adinolfi, Tommi Patinen, Ashik Jawahar Deen, Sini Pitkänen, Jouni Härkönen, Emilia Kansanen, Jenni Küblbeck, Anna-Liisa Levonen
Redox Biol. 2023 Jul; 63: 102726. Published online 2023 Apr 29. doi: 10.1016/j.redox.2023.102726
PMCID:
PMC10189287
AbstractArticlePDF–3.7M
19.
Optimization of the C2 substituents on the 1,4-bis(arylsulfonamido)naphthalene-N,N’-diacetic acid scaffold for better inhibition of Keap1-Nrf2 protein-protein interaction
Dhulfiqar Ali Abed, Ahmed R. Ali, Sumi Lee, Mai-Uyen Nguyen, Michael P. Verzi, Longqin Hu
Eur J Med Chem. Author manuscript; available in PMC 2024 Apr 5.
Published in final edited form as: Eur J Med Chem. 2023 Apr 5; 252: 115302. Published online 2023 Mar 22. doi: 10.1016/j.ejmech.2023.115302
PMCID:
PMC10101933
AbstractArticlePDF–2.0M
20.
miR-125b-5p in adipose derived stem cells exosome alleviates pulmonary microvascular endothelial cells ferroptosis via Keap1/Nrf2/GPX4 in sepsis lung injury
Kuo Shen, Xujie Wang, Yunwei Wang, Yanhui Jia, Yue Zhang, Kejia Wang, Liang Luo, Weixia Cai, Jin Li, Shaohui Li, Yuting Du, Lixia Zhang, Hao Zhang, Yuxi Chen, Chaolei Xu, Jinxin Zhang, Ruizhi Wang, Xuekang Yang, Yunchuan Wang, Dahai Hu
Redox Biol. 2023 Jun; 62: 102655. Published online 2023 Mar 9. doi: 10.1016/j.redox.2023.102655
PMCID:
PMC10023991
AbstractArticlePDF–16M

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