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Items: 1 to 20 of 78

1.
Acid sphingomyelinase as a pathological and therapeutic target in neurological disorders: focus on Alzheimer’s disease
Byung Jo Choi, Min Hee Park, Hee Kyung Jin, Jae-sung Bae
Exp Mol Med. 2024 Feb; 56(2): 301–310. Published online 2024 Feb 9. doi: 10.1038/s12276-024-01176-4
PMCID:
PMC10907607
AbstractArticlePDF–2.1M
2.
Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma
Gregory C. Wilson, Sameer H. Patel, Jiang Wang, Kui Xu, Kevin M. Turner, Katrin Anne Becker, Alexander Carpinteiro, Ildiko Szabo, Syed A. Ahmad, Erich Gulbins
J Mol Med (Berl) 2023; 101(7): 891–903. Published online 2023 May 29. doi: 10.1007/s00109-023-02331-6
PMCID:
PMC10300164
AbstractArticlePDF–4.6M
3.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
4.
SMPD1 gene variants in patients with β-Thalassemia major
Fadime Ersoy Dursun, Filiz Özen
Mol Biol Rep. 2023; 50(4): 3355–3363. Published online 2023 Feb 1. doi: 10.1007/s11033-023-08275-x
PMCID:
PMC10042979
AbstractArticlePDF–1.2M
5.
SMPD1 expression profile and mutation landscape help decipher genotype–phenotype association and precision diagnosis for acid sphingomyelinase deficiency
Ruisong Wang, Ziyi Qin, Long Huang, Huiling Luo, Han Peng, Xinyu Zhou, Zhixiang Zhao, Mingyao Liu, Pinhong Yang, Tieliu Shi
Hereditas. 2023; 160: 11. Published online 2023 Mar 13. doi: 10.1186/s41065-023-00272-1
PMCID:
PMC10009935
AbstractArticlePDF–5.7M
6.
ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1
Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen
Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119
PMCID:
PMC9231623
AbstractArticlePDF–6.0M
7.
Activation of Sphingomyelinase-Ceramide-Pathway in COVID-19 Purposes Its Inhibition for Therapeutic Strategies
Murad Abusukhun, Martin S. Winkler, Stefan Pöhlmann, Onnen Moerer, Konrad Meissner, Björn Tampe, Heike Hofmann-Winkler, Michael Bauer, Markus H. Gräler, Ralf A. Claus
Front Immunol. 2021; 12: 784989. Published online 2021 Dec 20. doi: 10.3389/fimmu.2021.784989
PMCID:
PMC8721106
AbstractArticlePDF–2.5M
8.
Acid Sphingomyelinase, a Lysosomal and Secretory Phospholipase C, Is Key for Cellular Phospholipid Catabolism
Bernadette Breiden, Konrad Sandhoff
Int J Mol Sci. 2021 Aug; 22(16): 9001. Published online 2021 Aug 20. doi: 10.3390/ijms22169001
PMCID:
PMC8396676
AbstractArticlePDF–1.8M
9.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
10.
In Silico Analysis of the Molecular-Level Impact of SMPD1 Variants on Niemann-Pick Disease Severity
François Ancien, Fabrizio Pucci, Marianne Rooman
Int J Mol Sci. 2021 May; 22(9): 4516. Published online 2021 Apr 26. doi: 10.3390/ijms22094516
PMCID:
PMC8123603
AbstractArticlePDF–6.9M
11.
Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells
Alexander Carpinteiro, Barbara Gripp, Markus Hoffmann, Stefan Pöhlmann, Nicolas Hoertel, Michael J. Edwards, Markus Kamler, Johannes Kornhuber, Katrin Anne Becker, Erich Gulbins
J Biol Chem. 2021 Jan-Jun; 296: 100701. Published online 2021 Apr 23. doi: 10.1016/j.jbc.2021.100701
PMCID:
PMC8062550
AbstractArticlePDF–2.1M
12.
Sphingomyelinases and Liver Diseases
Naroa Insausti-Urkia, Estel Solsona-Vilarrasa, Carmen Garcia-Ruiz, Jose C. Fernandez-Checa
Biomolecules. 2020 Nov; 10(11): 1497. Published online 2020 Oct 30. doi: 10.3390/biom10111497
PMCID:
PMC7692672
AbstractArticlePDF–1.4M
13.
Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells
Alexander Carpinteiro, Michael J. Edwards, Markus Hoffmann, Georg Kochs, Barbara Gripp, Sebastian Weigang, Constantin Adams, Elisa Carpinteiro, Anne Gulbins, Simone Keitsch, Carolin Sehl, Matthias Soddemann, Barbara Wilker, Markus Kamler, Thomas Bertsch, Karl S. Lang, Sameer Patel, Gregory C. Wilson, Silke Walter, Hartmut Hengel, Stefan Pöhlmann, Philipp A. Lang, Johannes Kornhuber, Katrin Anne Becker, Syed A. Ahmad, Klaus Fassbender, Erich Gulbins
Cell Rep Med. 2020 Nov 17; 1(8): 100142. Published online 2020 Oct 29. doi: 10.1016/j.xcrm.2020.100142
PMCID:
PMC7598530
AbstractArticlePDF–2.3M
14.
Sphingolipid Metabolism in Glioblastoma and Metastatic Brain Tumors: A Review of Sphingomyelinases and Sphingosine-1-Phosphate
Cyntanna C. Hawkins, Tomader Ali, Sasanka Ramanadham, Anita B. Hjelmeland
Biomolecules. 2020 Oct; 10(10): 1357. Published online 2020 Sep 23. doi: 10.3390/biom10101357
PMCID:
PMC7598277
AbstractArticlePDF–1.7M
15.
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism
Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat
Nat Metab. Author manuscript; available in PMC 2020 Dec 1.
Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z
PMCID:
PMC7566881
AbstractArticlePDF–4.8M
16.
Niemann-Pick disease type-B: a unique case report with compound heterozygosity and complicated lipid management
L. Ordieres-Ortega, F. Galeano-Valle, M. Mallén-Pérez, C. Muñoz-Delgado, J. E. Apaza-Chavez, F. J. Menárguez-Palanca, L. A. Alvarez-Sala Walther, P. Demelo-Rodríguez
BMC Med Genet. 2020; 21: 94. Published online 2020 May 6. doi: 10.1186/s12881-020-01027-9
PMCID:
PMC7203852
AbstractArticlePDF–1.0M
17.
Comparative lipidomics of 5-Fluorouracil–sensitive and –resistant colorectal cancer cells reveals altered sphingomyelin and ceramide controlled by acid sphingomyelinase (SMPD1)
Jae Hun Jung, Kohei Taniguchi, Hyeong Min Lee, Min Young Lee, Raju Bandu, Kazumasa Komura, Kil Yeon Lee, Yukihiro Akao, Kwang Pyo Kim
Sci Rep. 2020; 10: 6124. Published online 2020 Apr 9. doi: 10.1038/s41598-020-62823-0
PMCID:
PMC7145850
AbstractArticlePDF–3.0M
18.
Decreased Activity of Blood Acid Sphingomyelinase in the Course of Multiple Myeloma
Marzena Wątek, Ewelina Piktel, Joanna Barankiewicz, Ewa Sierlecka, Sylwia Kościołek-Zgódka, Anna Chabowska, Łukasz Suprewicz, Przemysław Wolak, Bonita Durnaś, Robert Bucki, Ewa Lech-Marańda
Int J Mol Sci. 2019 Dec; 20(23): 6048. Published online 2019 Nov 30. doi: 10.3390/ijms20236048
PMCID:
PMC6929010
AbstractArticlePDF–2.8M
19.
SMPD1 mutations, activity and α-synuclein accumulation in Parkinson’s disease
Roy N. Alcalay, Victoria Mallett, Benoît Vanderperre, Omid Tavassoly, Yves Dauvilliers, Richard Y.J. Wu, Jennifer A. Ruskey, Claire S. Leblond, Amirthagowri Ambalavanan, Sandra B. Laurent, Dan Spiegelman, Alexandre Dionne-Laporte, Christopher Liong, Oren A. Levy, Stanley Fahn, Cheryl Waters, Sheng-Han Kuo, Wendy K. Chung, Blair Ford, Karen S. Marder, Un Jung Kang, Sharon Hassin-Baer, Lior Greenbaum, Jean-Francois Trempe, Pavlina Wolf, Petra Oliva, Xiaokui Kate Zhang, Lorraine N. Clark, Melanie Langlois, Patrick A. Dion, Edward A. Fon, Nicolas Dupre, Guy A. Rouleau, Ziv Gan-Or
Mov Disord. Author manuscript; available in PMC 2020 Apr 1.
Published in final edited form as: Mov Disord. 2019 Apr; 34(4): 526–535. Published online 2019 Feb 20. doi: 10.1002/mds.27642
PMCID:
PMC6469643
AbstractArticlePDF–867K
20.
Nitric Oxide Generated by Tumor-Associated Macrophages Is Responsible for Cancer Resistance to Cisplatin and Correlated With Syntaxin 4 and Acid Sphingomyelinase Inhibition
Cristiana Perrotta, Davide Cervia, Ilaria Di Renzo, Claudia Moscheni, Maria Teresa Bassi, Lara Campana, Cristina Martelli, Elisabetta Catalani, Matteo Giovarelli, Silvia Zecchini, Marco Coazzoli, Annalisa Capobianco, Luisa Ottobrini, Giovanni Lucignani, Patrizia Rosa, Patrizia Rovere-Querini, Clara De Palma, Emilio Clementi
Front Immunol. 2018; 9: 1186. Published online 2018 May 29. doi: 10.3389/fimmu.2018.01186
PMCID:
PMC5987706
AbstractArticlePDF–12M

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