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Select item 110723781.

TSC-insensitive Rheb mutations induce oncogenic transformation through a combination of constitutively active mTORC1 signalling and proteome remodelling

Jianling Xie, Stuart P. De Poi, Sean J. Humphrey, Leanne K. Hein, John B. Bruning, Wenru Pan, Luke A. Selth, Timothy J. Sargeant, Christopher G. Proud

Cell Mol Life Sci. 2021 Apr; 78(8): 4035–4052. Published online 2021 Apr 8. doi: 10.1007/s00018-021-03825-7

PMCID:: PMC11072378

Abstract Article PDF–5.3M

Select item 109457072.

Comparative interactome analysis of α-arrestin families in human and Drosophila

Kyung-Tae Lee, Inez KA Pranoto, Soon-Young Kim, Hee-Joo Choi, Ngoc Bao To, Hansong Chae, Jeong-Yeon Lee, Jung-Eun Kim, Young V Kwon, Jin-Wu Nam

eLife. 2024; 12: RP88328. Published online 2024 Jan 25. doi: 10.7554/eLife.88328

PMCID:: PMC10945707

Abstract Article PDF–2.8M

Select item 106982773.

CBAP regulates the function of Akt-associated TSC protein complexes to modulate mTORC1 signaling

Wei-Ting Liao, Yun-Jung Chiang, Hsin-Fang Yang-Yen, Li-Chung Hsu, Zee-Fen Chang, Jeffrey J.Y. Yen

J Biol Chem. 2023 Dec; 299(12): 105455. Published online 2023 Nov 8. doi: 10.1016/j.jbc.2023.105455

Correction in:: J Biol Chem. 2024 Feb; 300(2): 105686.

PMCID:: PMC10698277

Abstract Article PDF–2.9M

Select item 105501244.

Non-canonical functions of a mutant TSC2 protein in mitotic division

Mary-Bronwen L. Chalkley, Rachel B. Mersfelder, Maria Sundberg, Laura C. Armstrong, Mustafa Sahin, Rebecca A. Ihrie, Kevin C. Ess

PLoS One. 2023; 18(10): e0292086. Published online 2023 Oct 4. doi: 10.1371/journal.pone.0292086

PMCID:: PMC10550124

Abstract Article PDF–1.3M

Select item 103829115.

Design of negative‐regulating proteins of Rheb/mTORC1 with much‐reduced sizes of the tuberous sclerosis protein complex

Wencheng Fu, Geng Wu

Protein Sci. 2023 Aug; 32(8): e4731. Published online 2023 Aug 1. doi: 10.1002/pro.4731

PMCID:: PMC10382911

Abstract Article PDF–6.4M

Select item 103672196.

Association of PI3K/AKT/mTOR pathway autophagy-related gene polymorphisms with pulmonary tuberculosis susceptibility in a Chinese population

Juan He, Shengyuan Liu, Xujun Guo, Fan Zhang, Yuzheng Fan, Lijuan Wu, Howard Eugene Takiff, Yashuang Zhao

Rev Soc Bras Med Trop. 2023; 56: e0104-2023. Published online 2023 Jul 24. doi: 10.1590/0037-8682-0104-2023

PMCID:: PMC10367219

Abstract Article PDF–1.1M

Select item 102374227.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 100774718.

mTOR inhibition overcomes RSK3-mediated resistance to BET inhibitors in small cell lung cancer

Anju Kumari, Lisa Gesumaria, Yan-Jin Liu, V. Keith Hughitt, Xiaohu Zhang, Michele Ceribelli, Kelli M. Wilson, Carleen Klumpp-Thomas, Lu Chen, Crystal McKnight, Zina Itkin, Craig J. Thomas, Beverly A. Mock, David S. Schrump, Haobin Chen

JCI Insight. 2023 Mar 8; 8(5): e156657. Published online 2023 Mar 8. doi: 10.1172/jci.insight.156657

PMCID:: PMC10077471

Abstract Article PDF–7.2M

Select item 100688409.

TSC2 Loss in Lymphangioleiomyomatosis Cells Correlated with Expression of CD44v6, a Molecular Determinant of Metastasis

Gustavo Pacheco-Rodriguez, Wendy K. Steagall, Denise M. Crooks, Linda A. Stevens, Hiroshi Hashimoto, Shaowei Li, Ji-an Wang, Thomas N. Darling, Joel Moss

Cancer Res. Author manuscript; available in PMC 2023 Apr 3.

Published in final edited form as: Cancer Res. 2007 Nov 1; 67(21): 10573–10581. doi: 10.1158/0008-5472.CAN-07-1356

PMCID:: PMC10068840

Abstract Article PDF–2.8M

Select item 997594310.

TSC2 regulates tumor susceptibility to TRAIL‐mediated T‐cell killing by orchestrating mTOR signaling

Chun‐Pu Lin, Joleen J H Traets, David W Vredevoogd, Nils L Visser, Daniel S Peeper

EMBO J. 2023 Mar; 42(5): e111614. Published online 2023 Jan 30. doi: 10.15252/embj.2022111614

PMCID:: PMC9975943

Abstract Article PDF–2.7M

Select item 995018311.

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment

Daphne J. Smits, Jordy Dekker, Rachel Schot, Brahim Tabarki, Amal Alhashem, Jeroen A. A. Demmers, Dick H. W. Dekkers, Antonio Romito, Peter J. van der Spek, Tjakko J. van Ham, Aida M. Bertoli-Avella, Grazia M. S. Mancini

Hum Genet. 2023; 142(3): 379–397. Published online 2022 Dec 20. doi: 10.1007/s00439-022-02511-3

PMCID:: PMC9950183

Abstract Article PDF–2.4M

Select item 989254112.

Refractive Errors, Retinal Findings, and Genotype of Tuberous Sclerosis Complex: A Retrospective Cohort Study

Soyoung Ryu, Hoon-Chul Kang, Sung Chul Lee, Suk Ho Byeon, Sung Soo Kim, Christopher Seungkyu Lee

Yonsei Med J. 2023 Feb; 64(2): 133–138. Published online 2023 Jan 18. doi: 10.3349/ymj.2022.0451

PMCID:: PMC9892541

Abstract Article PDF–622K

Select item 986993313.

Crosstalk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension

Yuanjun Shen, Dmitry A. Goncharov, Andressa Pena, Jeffrey Baust, Andres Chavez Barragan, Arnab Ray, Analise Rode, Timothy N. Bachman, Baojun Chang, Lifeng Jiang, Paul Dieffenbach, Laura E. Fredenburgh, Mauricio Rojas, Horace DeLisser, Ana L. Mora, Tatiana V. Kudryashova, Elena. A. Goncharova

Sci Signal. Author manuscript; available in PMC 2023 Dec 6.

Published in final edited form as: Sci Signal. 2022 Dec 6; 15(763): eabn2743. Published online 2022 Dec 6. doi: 10.1126/scisignal.abn2743

PMCID:: PMC9869933

Abstract Article PDF–3.1M

Select item 984105814.

Knockout of TSC2 in Nav1.8+ neurons predisposes to the onset of normal weight obesity

Jennifer M. Brazill, David Shin, Kristann Magee, Anurag Majumdar, Ivana R. Shen, Valeria Cavalli, Erica L. Scheller

Mol Metab. 2023 Feb; 68: 101664. Published online 2022 Dec 28. doi: 10.1016/j.molmet.2022.101664

PMCID:: PMC9841058

Abstract Article PDF–5.0M

Select item 980667415.

Concurrent Reduced Expression of Contiguous PKD1, TSC2 and NTHL1 Leading to Kidney Diseases and Multiple Diverse Renal Cancers

SATORU MEGURO, TOMOYUKI KOGUCHI, YUSUKE HAKOZAKI, AKIFUMI ONAGI, KANAKO MATSUOKA, SEIJI HOSHI, JUNYA HATA, YUICHI SATO, HIDENORI AKAIHATA, MASAO KATAOKA, SOICHIRO OGAWA, YOSHIYUKI KOJIMA

Cancer Genomics Proteomics. 2023 Jan-Feb; 20(1): 40–50. Published online 2023 Jan 3. doi: 10.21873/cgp.20363

PMCID:: PMC9806674

Abstract Article PDF–5.1M

Select item 948274716.

Gene mutations in sporadic lymphangioleiomyomatosis and genotype–phenotype correlation analysis

Jiannan Huang, Wenshuai Xu, Peng Liu, Yaping Liu, Cheng Shen, Song Liu, Yani Wang, Jun Wang, Tengyue Zhang, Yudi He, Chongsheng Cheng, Luning Yang, Weihong Zhang, Xinlun Tian, Kai-Feng Xu

BMC Pulm Med. 2022; 22: 354. Published online 2022 Sep 18. doi: 10.1186/s12890-022-02154-0

PMCID:: PMC9482747

Abstract Article PDF–1.0M

Select item 948193317.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 934857618.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 934596919.

Targeted inhibition of ubiquitin signaling reverses metabolic reprogramming and suppresses glioblastoma growth

Rossella Delle Donne, Rosa Iannucci, Laura Rinaldi, Luca Roberto, Maria A. Oliva, Emanuela Senatore, Domenica Borzacchiello, Luca Lignitto, Giorgio Giurato, Francesca Rizzo, Assunta Sellitto, Francesco Chiuso, Salvatore Castaldo, Giovanni Scala, Virginia Campani, Valeria Nele, Giuseppe De Rosa, Chiara D’Ambrosio, Corrado Garbi, Andrea Scaloni, Alessandro Weisz, Concetta Ambrosino, Antonella Arcella, Antonio Feliciello

Commun Biol. 2022; 5: 780. Published online 2022 Aug 2. doi: 10.1038/s42003-022-03639-8