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Select item 102374221.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 94992382.

SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein

Marius Walter, Irene P. Chen, Albert Vallejo-Gracia, Ik-Jung Kim, Olga Bielska, Victor L. Lam, Jennifer M. Hayashi, Andrew Cruz, Samah Shah, Frank W. Soveg, John D. Gross, Nevan J. Krogan, Keith R. Jerome, Birgit Schilling, Melanie Ott, Eric Verdin

PLoS Pathog. 2022 Sep; 18(9): e1010811. Published online 2022 Sep 12. doi: 10.1371/journal.ppat.1010811

PMCID:: PMC9499238

Abstract Article PDF–3.7M

Select item 85225793.

Short stature and combined immunodeficiency associated with mutations in RGS10

Ivan K. Chinn, Zhihui Xie, Eunice C. Chan, Bianca M. Nagata, Alexey Koval, Wei-Sheng Chen, Fan Zhang, Sundar Ganesan, Diana N. Hong, Motoshi Suzuki, Glenn Nardone, Ian N. Moore, Vladimir L. Katanaev, Andrea E. Balazs, Chengyu Liu, James R. Lupski, Jordan S. Orange, Kirk M. Druey

Sci Signal. Author manuscript; available in PMC 2022 Jan 27.

Published in final edited form as: Sci Signal. 2021 Jul 27; 14(693): eabc1940. Published online 2021 Jul 27. doi: 10.1126/scisignal.abc1940

PMCID:: PMC8522579

Abstract Article PDF–1.6M

Select item 83750804.

Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology

Madelyn C. Houser, W. Michael Caudle, Jianjun Chang, George T. Kannarkat, Yuan Yang, Sean D. Kelly, Danielle Oliver, Valerie Joers, Kathleen M. Shannon, Ali Keshavarzian, Malú Gámez Tansey

Acta Neuropathol Commun. 2021; 9: 139. Published online 2021 Aug 19. doi: 10.1186/s40478-021-01240-4

PMCID:: PMC8375080

Abstract Article PDF–2.6M

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 75797436.

Regulator of G Protein Signaling 10: Structure, Expression and Functions in Cellular Physiology and Diseases

Faris Almutairi, Jae-Kyung Lee, Balázs Rada

Cell Signal. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: Cell Signal. 2020 Nov; 75: 109765. Published online 2020 Aug 31. doi: 10.1016/j.cellsig.2020.109765

PMCID:: PMC7579743

Abstract Article PDF–1.0M

Select item 71699837.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 67292238.

A Retinal-Specific Regulator of G-Protein Signaling Interacts with Gα_o and Accelerates an Expressed Metabotropic Glutamate Receptor 6 Cascade

Anuradha Dhingra, Eva Faurobert, Nathan Dascal, Peter Sterling, Noga Vardi

J Neurosci. 2004 Jun 23; 24(25): 5684–5693. doi: 10.1523/JNEUROSCI.0492-04.2004

PMCID:: PMC6729223

Abstract Article PDF–930K

Select item 61085739.

RGS10 Regulates the Expression of Cyclooxygenase-2 and Tumor Necrosis Factor Alpha through a G Protein–Independent Mechanism

Mohammed Alqinyah, Faris Almutairi, Menbere Y. Wendimu, Shelley B. Hooks

Mol Pharmacol. 2018 Oct; 94(4): 1103–1113. Published online 2018 Oct. doi: 10.1124/mol.118.111674

PMCID:: PMC6108573

Abstract Article PDF–1.3M

Select item 465412110.

Suppression of the GTPase-activating protein RGS10 increases Rheb-GTP and mTOR signaling in ovarian cancer cells

Molly K. Altman, Ali A. Alshamrani, Wei Jia, Ha Nguyen, Jada M. Fambrough, Sterling K. Tran, Mihir Patel, Pooya Hoseinzadeh, Aaron M. Beedle, Mandi M. Murph

Cancer Lett. Author manuscript; available in PMC 2016 Dec 1.

Published in final edited form as: Cancer Lett. 2015 Dec 1; 369(1): 175–183. Published online 2015 Aug 28. doi: 10.1016/j.canlet.2015.08.012

PMCID:: PMC4654121

Abstract Article PDF–638K

Select item 459759311.

Cellular deficiency in the RGS10 protein facilitates chemoresistant ovarian cancer

Shelley B Hooks, Mandi M Murph

Future Med Chem. 2015 Aug; 7(12): 1483–1489. doi: 10.4155/fmc.15.81

PMCID:: PMC4597593

Abstract Article PDF–1.4M

Select item 390367712.

Inhibition of HDAC1 and DNMT1 Modulate RGS10 Expression and Decrease Ovarian Cancer Chemoresistance

Ercan Cacan, Mourad W. Ali, Nathaniel H. Boyd, Shelley B. Hooks, Susanna F. Greer

PLoS One. 2014; 9(1): e87455. Published online 2014 Jan 27. doi: 10.1371/journal.pone.0087455

PMCID:: PMC3903677

Abstract Article PDF–1.4M

Select item 358797513.

Specificity of RGS10A as a key component in the RANKL signaling mechanism for osteoclast differentiation

Shuying Yang, Wei Chen, Philip Stashenko, Yi-Ping Li

J Cell Sci. Author manuscript; available in PMC 2013 Mar 5.

Published in final edited form as: J Cell Sci. 2007 Oct 1; 120(Pt 19): 3362–3371. doi: 10.1242/jcs.008300

PMCID:: PMC3587975

Abstract Article PDF–2.5M

Select item 329364814.

A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein–dependent signaling

Peisong Ma, Aleksandra Cierniewska, Rachel Signarvic, Marcin Cieslak, Hong Kong, Andrew J. Sinnamon, Richard R. Neubig, Debra K. Newman, Timothy J. Stalker, Lawrence F. Brass

Blood. 2012 Feb 23; 119(8): 1935–1945. Prepublished online 2011 Dec 30. doi: 10.1182/blood-2011-10-387910

PMCID:: PMC3293648

Abstract Article

Select item 319082615.

Interactions of Pathological Hallmark Proteins: TUBULIN POLYMERIZATION PROMOTING PROTEIN/p25, β-AMYLOID, AND α-SYNUCLEIN

Judit Oláh, Orsolya Vincze, Dezső Virók, Dóra Simon, Zsolt Bozsó, Natália Tőkési, István Horváth, Emma Hlavanda, János Kovács, Anna Magyar, Mária Szűcs, Ferenc Orosz, Botond Penke, Judit Ovádi

J Biol Chem. 2011 Sep 30; 286(39): 34088–34100. Published online 2011 Aug 8. doi: 10.1074/jbc.M111.243907

PMCID:: PMC3190826

Abstract Article PDF–5.7M

Select item 317805916.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 298873117.

Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells

Shelley B Hooks, Phillip Callihan, Molly K Altman, Jillian H Hurst, Mourad W Ali, Mandi M Murph

Mol Cancer. 2010; 9: 289. Published online 2010 Nov 2. doi: 10.1186/1476-4598-9-289

PMCID:: PMC2988731

Abstract Article PDF–1.4M

Select item 296315418.

Association Study of 182 Candidate Genes in Anorexia Nervosa

Andrea Poyastro Pinheiro, Cynthia M. Bulik, Laura M. Thornton, Patrick F. Sullivan, Tammy L. Root, Cinnamon S. Bloss, Wade H. Berrettini, Nicholas J. Schork, Walter H. Kaye, Andrew W. Bergen, Pierre Magistretti, Harry Brandt, Steve Crawford, Scott Crow, Manfred M. Fichter, David Goldman, Katherine A. Halmi, Craig Johnson, Allan S. Kaplan, Pamela K. Keel, Kelly L. Klump, Maria La Via, James E. Mitchell, Michael Strober, Alessandro Rotondo, Janet Treasure, D. Blake Woodside

Am J Med Genet B Neuropsychiatr Genet. Author manuscript; available in PMC 2010 Oct 25.

Published in final edited form as: Am J Med Genet B Neuropsychiatr Genet. 2010 Jul; 153B(5): 1070–1080. doi: 10.1002/ajmg.b.31082

PMCID:: PMC2963154

Abstract Article PDF–315K

Select item 295093319.

Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma

Jianming Wang, Scott M. Lippman, J.Jack Lee, Hushan Yang, Fadlo R. Khuri, Edward Kim, Jie Lin, David W. Chang, Reuben Lotan, Waun K. Hong, Xifeng Wu

Carcinogenesis. 2010 Oct; 31(10): 1755–1761. Published online 2010 Jul 12. doi: 10.1093/carcin/bgq138

PMCID:: PMC2950933

Abstract Article PDF–131K

Select item 235982320.

Structural diversity in the RGS domain and its interaction with heterotrimeric G protein α-subunits

Meera Soundararajan, Francis S. Willard, Adam J. Kimple, Andrew P. Turnbull, Linda J. Ball, Guillaume A. Schoch, Carina Gileadi, Oleg Y. Fedorov, Elizabeth F. Dowler, Victoria A. Higman, Stephanie Q. Hutsell, Michael Sundström, Declan A. Doyle, David P. Siderovski

Proc Natl Acad Sci U S A. 2008 Apr 29; 105(17): 6457–6462. Published online 2008 Apr 23. doi: 10.1073/pnas.0801508105

PMCID:: PMC2359823

Abstract Article PDF–1.2M

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