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Items: 1 to 20 of 28

1.
Genetic Variants in WNT16 and PKD2L1 Locus Affect Heel Ultrasound Bone Stiffness: Analyses from the General Population and Patients Evaluated for Osteoporosis
Angelique Kragl, Anke Hannemann, Matthias Nauck, Uwe Völker, Heide Siggelkow, Alexander Teumer, Mladen V. Tzvetkov
Calcif Tissue Int. 2023; 113(5): 540–551. Published online 2023 Oct 13. doi: 10.1007/s00223-023-01141-9
PMCID:
PMC10618371
AbstractArticlePDF–1.3M
2.
Polycystic kidney disease 2-like 1 channel contributes to the bitter aftertaste perception of quinine
Takahiro Shimizu, Takuto Fujii, Keisuke Hanita, Ryo Shinozaki, Yusaku Takamura, Yoshiro Suzuki, Teppei Kageyama, Mizuki Kato, Hisao Nishijo, Makoto Tominaga, Hideki Sakai
Sci Rep. 2023; 13: 4271. Published online 2023 Mar 15. doi: 10.1038/s41598-023-31322-3
PMCID:
PMC10017821
AbstractArticlePDF–4.1M
3.
Molecular Mechanism of L-Pyroglutamic Acid Interaction with the Human Sour Receptor
Sanung Eom, Shinhui Lee, Jiwon Lee, Minsu Pyeon, Hye Duck Yeom, Jung Hee Song, Eun Ji Choi, Moeun Lee, Junho H Lee, Ji Yoon Chang
J Microbiol Biotechnol. 2023 Feb 28; 33(2): 203–210. Published online 2022 Dec 30. doi: 10.4014/jmb.2212.12007
PMCID:
PMC9998207
AbstractArticlePDF–3.0M
4.
Adaptive selection drives TRPP3 loss-of-function in an Ethiopian population
Sandra Walsh, Mercè Izquierdo-Serra, Sandra Acosta, Albert Edo, María Lloret, Roser Moret, Elena Bosch, Baldo Oliva, Jaume Bertranpetit, José Manuel Fernández-Fernández
Sci Rep. 2020; 10: 20999. Published online 2020 Dec 2. doi: 10.1038/s41598-020-78081-z
PMCID:
PMC7710729
AbstractArticlePDF–3.4M
5.
Opening TRPP2 (PKD2L1) requires the transfer of gating charges
Leo C. T. Ng, Thuy N. Vien, Vladimir Yarov-Yarovoy, Paul G. DeCaen
Proc Natl Acad Sci U S A. 2019 Jul 30; 116(31): 15540–15549. Published online 2019 Jul 17. doi: 10.1073/pnas.1902917116
PMCID:
PMC6681712
AbstractArticlePDF–2.0M
6.
Cryo-EM structure of the polycystin 2-l1 ion channel
Raymond E Hulse, Zongli Li, Rick K Huang, Jin Zhang, David E Clapham
eLife. 2018; 7: e36931. Published online 2018 Jul 13. doi: 10.7554/eLife.36931
PMCID:
PMC6056229
AbstractArticlePDF–1.9M
7.
Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels
Wang Zheng, Xiaoyong Yang, Ruikun Hu, Ruiqi Cai, Laura Hofmann, Zhifei Wang, Qiaolin Hu, Xiong Liu, David Bulkley, Yong Yu, Jingfeng Tang, Veit Flockerzi, Ying Cao, Erhu Cao, Xing-Zhen Chen
Nat Commun. 2018; 9: 2302. Published online 2018 Jun 13. doi: 10.1038/s41467-018-04586-x
Correction in:
Nat Commun. 2019; 10: 1452.
PMCID:
PMC5998024
AbstractArticlePDF–2.1M
8.
Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1
Qiang Su, Feizhuo Hu, Yuxia Liu, Xiaofei Ge, Changlin Mei, Shengqiang Yu, Aiwen Shen, Qiang Zhou, Chuangye Yan, Jianlin Lei, Yanqing Zhang, Xiaodong Liu, Tingliang Wang
Nat Commun. 2018; 9: 1192. Published online 2018 Mar 22. doi: 10.1038/s41467-018-03606-0
PMCID:
PMC5864754
AbstractArticlePDF–2.5M
9.
Integrative Approach with Electrophysiological and Theoretical Methods Reveals a New Role of S4 Positively Charged Residues in PKD2L1 Channel Voltage-Sensing
Tomohiro Numata, Kunichika Tsumoto, Kazunori Yamada, Tatsuki Kurokawa, Shinichi Hirose, Hideki Nomura, Mitsuhiro Kawano, Yoshihisa Kurachi, Ryuji Inoue, Yasuo Mori
Sci Rep. 2017; 7: 9760. Published online 2017 Aug 29. doi: 10.1038/s41598-017-10357-3
PMCID:
PMC5575081
AbstractArticlePDF–4.7M
10.
Regulation of TRPP3 Channel Function by N-terminal Domain Palmitoylation and Phosphorylation
Wang Zheng, JungWoo Yang, Erwan Beauchamp, Ruiqi Cai, Shaimaa Hussein, Laura Hofmann, Qiang Li, Veit Flockerzi, Luc G. Berthiaume, Jingfeng Tang, Xing-Zhen Chen
J Biol Chem. 2016 Dec 2; 291(49): 25678–25691. Published online 2016 Oct 17. doi: 10.1074/jbc.M116.756544
PMCID:
PMC5207264
AbstractArticlePDF–2.3M
11.
Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders
Nidhi Sahni, Song Yi, Mikko Taipale, Juan I. Fuxman Bass, Jasmin Coulombe-Huntington, Fan Yang, Jian Peng, Jochen Weile, Georgios I. Karras, Yang Wang, István A. Kovács, Atanas Kamburov, Irina Krykbaeva, Mandy H. Lam, George Tucker, Vikram Khurana, Amitabh Sharma, Yang-Yu Liu, Nozomu Yachie, Quan Zhong, Yun Shen, Alexandre Palagi, Adriana San-Miguel, Changyu Fan, Dawit Balcha, Amelie Dricot, Daniel M. Jordan, Jennifer M. Walsh, Akash A. Shah, Xinping Yang, Ani Stoyanova, Alex Leighton, Michael A. Calderwood, Yves Jacob, Michael E. Cusick, Kourosh Salehi-Ashtiani, Luke J. Whitesell, Shamil Sunyaev, Bonnie Berger, Albert-László Barabási, Benoit Charloteaux, David E. Hill, Tong Hao, Frederick P. Roth, Yu Xia, Albertha J.M. Walhout, Susan Lindquist, Marc Vidal
Cell. Author manuscript; available in PMC 2016 Apr 23.
Published in final edited form as: Cell. 2015 Apr 23; 161(3): 647–660. doi: 10.1016/j.cell.2015.04.013
PMCID:
PMC4441215
AbstractArticlePDF–1.2M
12.
A novel PKD2L1 C-terminal domain critical for trimerization and channel function
Wang Zheng, Shaimaa Hussein, JungWoo Yang, Jun Huang, Fan Zhang, Samuel Hernandez-Anzaldo, Carlos Fernandez-Patron, Ying Cao, Hongbo Zeng, Jingfeng Tang, Xing-Zhen Chen
Sci Rep. 2015; 5: 9460. Published online 2015 Mar 30. doi: 10.1038/srep09460
PMCID:
PMC4377555
AbstractArticlePDF–1.5M
13.
Direct recording and molecular identification of the calcium channel of primary cilia
Paul G. DeCaen, Markus Delling, Thuy N. Vien, David E. Clapham
Nature. Author manuscript; available in PMC 2014 Jun 27.
Published in final edited form as: Nature. 2013 Dec 12; 504(7479): 315–318. doi: 10.1038/nature12832
Correction in:
volume 513 on page 266
PMCID:
PMC4073646
AbstractArticlePDF–2.2M
14.
An atlas of genetic influences on human blood metabolites
So-Youn Shin, Eric B. Fauman, Ann-Kristin Petersen, Jan Krumsiek, Rita Santos, Jie Huang, Matthias Arnold, Idil Erte, Vincenzo Forgetta, Tsun-Po Yang, Klaudia Walter, Cristina Menni, Lu Chen, Louella Vasquez, Ana M. Valdes, Craig L. Hyde, Vicky Wang, Daniel Ziemek, Phoebe Roberts, Li Xi, Elin Grundberg, The Multiple Tissue Human Expression Resource (MuTHER) Consortium, Melanie Waldenberger, J. Brent Richards, Robert P. Mohney, Michael V. Milburn, Sally L. John, Jeff Trimmer, Fabian J. Theis, John P. Overington, Karsten Suhre, M. Julia Brosnan, Christian Gieger, Gabi Kastenmüller, Tim D Spector, Nicole Soranzo
Nat Genet. Author manuscript; available in PMC 2014 Dec 1.
Published in final edited form as: Nat Genet. 2014 Jun; 46(6): 543–550. Published online 2014 May 11. doi: 10.1038/ng.2982
PMCID:
PMC4064254
AbstractArticlePDF–2.4M
15.
Genetic Determinants Influencing Human Serum Metabolome among African Americans
Bing Yu, Yan Zheng, Danny Alexander, Alanna C. Morrison, Josef Coresh, Eric Boerwinkle
PLoS Genet. 2014 Mar; 10(3): e1004212. Published online 2014 Mar 13. doi: 10.1371/journal.pgen.1004212
PMCID:
PMC3952826
AbstractArticlePDF–794K
16.
Genome-Wide Association Study Identifies Novel Loci Associated With Concentrations of Four Plasma Phospholipid Fatty Acids in the De Novo Lipogenesis Pathway: Results from the CHARGE Consortium
Jason H.Y. Wu, Rozenn N. Lemaitre, Ani Manichaikul, Weihua Guan, Toshiko Tanaka, Millennia Foy, Edmond K. Kabagambe, Luc Djousse, David Siscovick, Amanda M. Fretts, Catherine Johnson, Irena B. King, Bruce M. Psaty, Barbara McKnight, Stephen S. Rich, Yii-Der I. Chen, Jennifer A. Nettleton, Weihong Tang, Stefania Bandinelli, David R. Jacobs, Jr, Brian L. Browning, Cathy C. Laurie, Xiangjun Gu, Michael Y. Tsai, Lyn M. Steffen, Luigi Ferrucci, Myriam Fornage, Dariush Mozaffarian
Circ Cardiovasc Genet. Author manuscript; available in PMC 2014 Apr 1.
Published in final edited form as: Circ Cardiovasc Genet. 2013 Apr; 6(2): 171–183. Published online 2013 Jan 29. doi: 10.1161/CIRCGENETICS.112.964619
PMCID:
PMC3891054
AbstractArticlePDF–1.9M
17.
Human metabolic individuality in biomedical and pharmaceutical research
Karsten Suhre, So-Youn Shin, Ann-Kristin Petersen, Robert P. Mohney, David Meredith, Brigitte Wägele, Elisabeth Altmaier, CARDIoGRAM, Panos Deloukas, Jeanette Erdmann, Elin Grundberg, Christopher J. Hammond, Martin Hrabé de Angelis, Gabi Kastenmüller, Anna Köttgen, Florian Kronenberg, Massimo Mangino, Christa Meisinger, Thomas Meitinger, Hans-Werner Mewes, Michael V. Milburn, Cornelia Prehn, Johannes Raffler, Janina S. Ried, Werner Römisch-Margl, Nilesh J. Samani, Kerrin S. Small, H.-Erich Wichmann, Guangju Zhai, Thomas Illig, Tim D. Spector, Jerzy Adamski, Nicole Soranzo, Christian Gieger
Nature. Author manuscript; available in PMC 2013 Nov 19.
Published in final edited form as: Nature. 2011 Aug 31; 477(7362): 10.1038/nature10354. Published online 2011 Aug 31. doi: 10.1038/nature10354
PMCID:
PMC3832838
AbstractArticlePDF–839K
18.
Novel Genetic Loci Identified for the Pathophysiology of Childhood Obesity in the Hispanic Population
Anthony G. Comuzzie, Shelley A. Cole, Sandra L. Laston, V. Saroja Voruganti, Karin Haack, Richard A. Gibbs, Nancy F. Butte
PLoS One. 2012; 7(12): e51954. Published online 2012 Dec 14. doi: 10.1371/journal.pone.0051954
PMCID:
PMC3522587
AbstractArticlePDF–130K
19.
Receptor for Activated C Kinase 1 (RACK1) Inhibits Function of Transient Receptor Potential (TRP)-type Channel Pkd2L1 through Physical Interaction
Jungwoo Yang, Qian Wang, Wang Zheng, Jagdeep Tuli, Qiang Li, Yuliang Wu, Shaimaa Hussein, Xiao-Qing Dai, Shiva Shafiei, Xiao-Gai Li, Patrick Y. Shen, Jian-Cheng Tu, Xing-Zhen Chen
J Biol Chem. 2012 Feb 24; 287(9): 6551–6561. Published online 2011 Dec 15. doi: 10.1074/jbc.M111.305854
PMCID:
PMC3307287
AbstractArticlePDF–1.5M
20.
Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations
Ayşe Demirkan, Cornelia M. van Duijn, Peter Ugocsai, Aaron Isaacs, Peter P. Pramstaller, Gerhard Liebisch, James F. Wilson, Åsa Johansson, Igor Rudan, Yurii S. Aulchenko, Anatoly V. Kirichenko, A. Cecile J. W. Janssens, Ritsert C. Jansen, Carsten Gnewuch, Francisco S. Domingues, Cristian Pattaro, Sarah H. Wild, Inger Jonasson, Ozren Polasek, Irina V. Zorkoltseva, Albert Hofman, Lennart C. Karssen, Maksim Struchalin, James Floyd, Wilmar Igl, Zrinka Biloglav, Linda Broer, Arne Pfeufer, Irene Pichler, Susan Campbell, Ghazal Zaboli, Ivana Kolcic, Fernando Rivadeneira, Jennifer Huffman, Nicholas D. Hastie, Andre Uitterlinden, Lude Franke, Christopher S. Franklin, Veronique Vitart, DIAGRAM Consortium, Christopher P. Nelson, Michael Preuss, CARDIoGRAM Consortium, Joshua C. Bis, Christopher J. O'Donnell, Nora Franceschini, CHARGE Consortium, Jacqueline C. M. Witteman, Tatiana Axenovich, Ben A. Oostra, Thomas Meitinger, Andrew A. Hicks, Caroline Hayward, Alan F. Wright, Ulf Gyllensten, Harry Campbell, Gerd Schmitz, on behalf of the EUROSPAN consortium
PLoS Genet. 2012 Feb; 8(2): e1002490. Published online 2012 Feb 16. doi: 10.1371/journal.pgen.1002490
PMCID:
PMC3280968
AbstractArticlePDF–592K

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