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Select item 83488341.

Empty spiracles homeobox genes EMX1 and EMX2 regulate WNT pathway activation in sarcomagenesis

Manuel Pedro Jimenez-García, Antonio Lucena-Cacace, Daniel Otero-Albiol, Amancio Carnero

J Exp Clin Cancer Res. 2021; 40: 247. Published online 2021 Aug 7. doi: 10.1186/s13046-021-02048-9

PMCID:: PMC8348834

Abstract Article PDF–10M

Select item 81650302.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 81379393.

Regulation of sarcomagenesis by the empty spiracles homeobox genes EMX1 and EMX2

Manuel Pedro Jimenez-García, Antonio Lucena-Cacace, Daniel Otero-Albiol, Amancio Carnero

Cell Death Dis. 2021 Jun; 12(6): 515. Published online 2021 May 20. doi: 10.1038/s41419-021-03801-w

PMCID:: PMC8137939

Abstract Article PDF–4.1M

Select item 80090484.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 78410845.

Empty Spiracles Homeobox 2 (EMX2) Inhibits the Invasion and Tumorigenesis in Colorectal Cancer Cells

Yan Zhang, Gang Cao, Qing-gong Yuan, Jun-hui Li, Wen-Bin Yang

Oncol Res. 2017; 25(4): 537–544. Published online 2017 Apr 14. doi: 10.3727/096504016X14756640150695

PMCID:: PMC7841084

Abstract Article PDF–2.3M

Select item 71699836.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 68505587.

A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing

Tao Chen, Bin Zhang, Thomas Ziegenhals, Archana B. Prusty, Sebastian Fröhler, Clemens Grimm, Yuhui Hu, Bernhard Schaefke, Liang Fang, Min Zhang, Nadine Kraemer, Angela M. Kaindl, Utz Fischer, Wei Chen

PLoS Genet. 2019 Oct; 15(10): e1008460. Published online 2019 Oct 31. doi: 10.1371/journal.pgen.1008460

PMCID:: PMC6850558

Abstract Article PDF–3.0M

Select item 63030268.

The downregulation of lncRNA EMX2OS might independently predict shorter recurrence-free survival of classical papillary thyroid cancer

Yi Gu, Chao Feng, Tong Liu, Bowei Zhang, Lan Yang

PLoS One. 2018; 13(12): e0209338. Published online 2018 Dec 21. doi: 10.1371/journal.pone.0209338

PMCID:: PMC6303026

Abstract Article PDF–2.5M

Select item 61666829.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 556839310.

EMX2 gene expression predicts liver metastasis and survival in colorectal cancer

Berk Aykut, Markus Ochs, Praveen Radhakrishnan, Adrian Brill, Hermine Höcker, Sandra Schwarz, Daniel Weissinger, Roland Kehm, Yakup Kulu, Alexis Ulrich, Martin Schneider

BMC Cancer. 2017; 17: 555. Published online 2017 Aug 22. doi: 10.1186/s12885-017-3556-2

PMCID:: PMC5568393

Abstract Article PDF–2.8M

Select item 517303811.

Emx2 as a novel tool to suppress glioblastoma

Carmen Falcone, Antonio Daga, Giampiero Leanza, Antonello Mallamaci

Oncotarget. 2016 Jul 5; 7(27): 41005–41016. Published online 2016 May 13. doi: 10.18632/oncotarget.9322

PMCID:: PMC5173038

Abstract Article PDF–9.0M

Select item 448844612.

EMX2 Is a Predictive Marker for Adjuvant Chemotherapy in Lung Squamous Cell Carcinomas

Dongsheng Yue, Hui Li, Juanjuan Che, Yi Zhang, Bhairavi Tolani, Minli Mo, Hua Zhang, Qingfeng Zheng, Yue Yang, Runfen Cheng, Joy Q. Jin, Thomas W. Luh, Cathryn Yang, Hsin-Hui K. Tseng, Etienne Giroux-Leprieur, Gavitt A. Woodard, Xishan Hao, Changli Wang, David M. Jablons, Biao He

PLoS One. 2015; 10(7): e0132134. Published online 2015 Jul 1. doi: 10.1371/journal.pone.0132134

PMCID:: PMC4488446

Abstract Article PDF–8.3M

Select item 410118713.

Heterozygous mutations in SIX3 and SHH are associated with schizencephaly and further expand the clinical spectrum of holoprosencephaly

Ute Hehr, Daniel E. Pineda-Alvarez, Goekhan Uyanik, Ping Hu, Nan Zhou, Andreas Hehr, Chayim Schell-Apacik, Carola Altus, Cornelia Daumer-Haas, Annechristin Meiner, Peter Steuernagel, Erich Roessler, Juergen Winkler, Maximilian Muenke

Hum Genet. Author manuscript; available in PMC 2014 Jul 17.

Published in final edited form as: Hum Genet. 2010 Mar; 127(5): 555–561. Published online 2010 Feb 16. doi: 10.1007/s00439-010-0797-4

PMCID:: PMC4101187

Abstract Article PDF–332K

Select item 381046314.

Genome-Wide Contribution of Genotype by Environment Interaction to Variation of Diabetes-Related Traits

Ju-Sheng Zheng, Donna K. Arnett, Yu-Chi Lee, Jian Shen, Laurence D. Parnell, Caren E. Smith, Kris Richardson, Duo Li, Ingrid B. Borecki, José M. Ordovás, Chao-Qiang Lai

PLoS One. 2013; 8(10): e77442. Published online 2013 Oct 28. doi: 10.1371/journal.pone.0077442

PMCID:: PMC3810463

Abstract Article PDF–716K

Select item 374632715.

Genome-wide association study identifies T_H1 pathway genes associated with lung function in asthmatic patients

Xingnan Li, Gregory A. Hawkins, Elizabeth J. Ampleford, Wendy C. Moore, Huashi Li, Annette T. Hastie, Timothy D. Howard, Homer A. Boushey, William W. Busse, William J. Calhoun, Mario Castro, Serpil C. Erzurum, Elliot Israel, Robert F. Lemanske, Jr, Stanley J. Szefler, Stephen I. Wasserman, Sally E. Wenzel, Stephen P. Peters, Deborah A. Meyers, Eugene R. Bleecker

J Allergy Clin Immunol. Author manuscript; available in PMC 2014 Aug 1.

Published in final edited form as: J Allergy Clin Immunol. 2013 Aug; 132(2): 313–320.e15. Published online 2013 Mar 28. doi: 10.1016/j.jaci.2013.01.051

PMCID:: PMC3746327

Abstract Article PDF–912K

Select item 373228616.

A Possible Mechanism behind Autoimmune Disorders Discovered By Genome-Wide Linkage and Association Analysis in Celiac Disease

Malin Östensson, Caroline Montén, Jonas Bacelis, Audur H. Gudjonsdottir, Svetlana Adamovic, Johan Ek, Henry Ascher, Elisabet Pollak, Henrik Arnell, Lars Browaldh, Daniel Agardh, Jan Wahlström, Staffan Nilsson, Åsa Torinsson-Naluai

PLoS One. 2013; 8(8): e70174. Published online 2013 Aug 2. doi: 10.1371/journal.pone.0070174

PMCID:: PMC3732286

Abstract Article PDF–1.7M

Select item 352258717.

Novel Genetic Loci Identified for the Pathophysiology of Childhood Obesity in the Hispanic Population

Anthony G. Comuzzie, Shelley A. Cole, Sandra L. Laston, V. Saroja Voruganti, Karin Haack, Richard A. Gibbs, Nancy F. Butte

PLoS One. 2012; 7(12): e51954. Published online 2012 Dec 14. doi: 10.1371/journal.pone.0051954

PMCID:: PMC3522587

Abstract Article PDF–130K

Select item 348051718.

Genome-Wide Association Studies Identify CHRNA5/3 and HTR4 in the Development of Airflow Obstruction

Jemma B. Wilk, Nick R. G. Shrine, Laura R. Loehr, Jing Hua Zhao, Ani Manichaikul, Lorna M. Lopez, Albert Vernon Smith, Susan R. Heckbert, Joanna Smolonska, Wenbo Tang, Daan W. Loth, Ivan Curjuric, Jennie Hui, Michael H. Cho, Jeanne C. Latourelle, Amanda P. Henry, Melinda Aldrich, Per Bakke, Terri H. Beaty, Amy R. Bentley, Ingrid B. Borecki, Guy G. Brusselle, Kristin M. Burkart, Ting-hsu Chen, David Couper, James D. Crapo, Gail Davies, Josée Dupuis, Nora Franceschini, Amund Gulsvik, Dana B. Hancock, Tamara B. Harris, Albert Hofman, Medea Imboden, Alan L. James, Kay-Tee Khaw, Lies Lahousse, Lenore J. Launer, Augusto Litonjua, Yongmei Liu, Kurt K. Lohman, David A. Lomas, Thomas Lumley, Kristin D. Marciante, Wendy L. McArdle, Bernd Meibohm, Alanna C. Morrison, Arthur W. Musk, Richard H. Myers, Kari E. North, Dirkje S. Postma, Bruce M. Psaty, Stephen S. Rich, Fernando Rivadeneira, Thierry Rochat, Jerome I. Rotter, María Soler Artigas, John M. Starr, André G. Uitterlinden, Nicholas J. Wareham, Cisca Wijmenga, Pieter Zanen, Michael A. Province, Edwin K. Silverman, Ian J. Deary, Lyle J. Palmer, Patricia A. Cassano, Vilmundur Gudnason, R. Graham Barr, Ruth J. F. Loos, David P. Strachan, Stephanie J. London, H. Marike Boezen, Nicole Probst-Hensch, Sina A. Gharib, Ian P. Hall, George T. O’Connor, Martin D. Tobin, Bruno H. Stricker

Am J Respir Crit Care Med. 2012 Oct 1; 186(7): 622–632. Published online 2012 Oct 1. doi: 10.1164/rccm.201202-0366OC

PMCID:: PMC3480517

Abstract Article PDF–770K

Select item 345926919.

A Meta-Analysis of Genome-Wide Association Studies of the Electrocardiographic Early Repolarization Pattern

Moritz F. Sinner, Kimmo Porthan, Peter A. Noseworthy, Aki S. Havulinna, Jani Tikkanen, Martina Müller-Nurasyid, Gina Peloso, Sheila Ulivi, Britt Maria Beckmann, A. Catharina Brockhaus, Rebecca R. Cooper, Paolo Gasparini, Christian Hengstenberg, Shih-Jen Hwang, Annamaria Iorio, M. Juhani Junttila, Norman Klopp, Mika Kähönen, Maarit A. Laaksonen, Terho Lehtimäki, Peter Lichtner, Leo-Pekka Lyytikäinen, Eimo Martens, Christa Meisinger, Thomas Meitinger, Faisal M. Merchant, Markku S. Nieminen, Annette Peters, Arto Pietilä, Siegfried Perz, Lasse Oikarinen, Olli Raitakari, Wibke Reinhard, Kaisa Silander, Barbara Thorand, H.-Erich Wichmann, Gianfranco Sinagra, Jorma Viikari, Christopher J. O’Donnell, Patrick T. Ellinor, Heikki V. Huikuri, Stefan Kääb, Christopher Newton-Cheh, Veikko Salomaa

Heart Rhythm. Author manuscript; available in PMC 2013 Oct 1.

Published in final edited form as: Heart Rhythm. 2012 Oct; 9(10): 1627–1634. Published online 2012 Jun 6. doi: 10.1016/j.hrthm.2012.06.008

PMCID:: PMC3459269

Abstract Article PDF–826K

Select item 344872620.

Adenoviral Delivery of the EMX2 Gene Suppresses Growth in Human Gastric Cancer

Jie Li, Minli Mo, Zhao Chen, Zhe Chen, Qing Sheng, Hang Mu, Fang Zhang, Yi Zhang, Xiu-Yi Zhi, Hui Li, Biao He, Hai-Meng Zhou

PLoS One. 2012; 7(9): e45970. Published online 2012 Sep 21. doi: 10.1371/journal.pone.0045970

PMCID:: PMC3448726

Abstract Article PDF–2.5M

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