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Select item 112244011.

Identification of human host factors required for beta-defensin-2 expression in intestinal epithelial cells upon a bacterial challenge

Weronika Wozniak, Emmanuel Sechet, Yong-Jun Kwon, Nathalie Aulner, Lionel Navarro, Brice Sperandio

Sci Rep. 2024; 14: 15442. Published online 2024 Jul 4. doi: 10.1038/s41598-024-66568-y

PMCID:: PMC11224401

Abstract Article PDF–1.8M

Select item 108003002.

Salivary Th17 cytokine, human β-defensin 1–3, and salivary scavenger and agglutinin levels in Crohn’s disease

Ulvi Kahraman Gürsoy, Mervi Gürsoy, Vuokko Loimaranta, Jaana Rautava

Clin Oral Investig. 2024; 28(1): 108. Published online 2024 Jan 22. doi: 10.1007/s00784-024-05509-5

PMCID:: PMC10800300

Abstract Article PDF–806K

Select item 96065693.

Antimicrobial peptide human β-defensin-2 improves in vitro cellular viability and reduces pro-inflammatory effects induced by enteroinvasive Escherichia coli in Caco-2 cells by inhibiting invasion and virulence factors’ expression

Alessandra Fusco, Vittoria Savio, Brunella Perfetto, Roberto Mattina, Giovanna Donnarumma

Front Cell Infect Microbiol. 2022; 12: 1009415. Published online 2022 Oct 13. doi: 10.3389/fcimb.2022.1009415

PMCID:: PMC9606569

Abstract Article PDF–3.2M

Select item 86390564.

Cervicovaginal levels of human beta defensins during bacterial vaginosis

Nathalia Mayumi Noda-Nicolau, Mariana de Castro Silva, Giovana Fernanda Cosi Bento, Jeniffer Sena Baptista Ferreira, Juliano Novak, Júlia Andrade Pessoa Morales, Júlia Abbade Tronco, Aline Nascimento Bolpetti, Gabriel Vitor Silva Pinto, Jossimara Polettini, Camila Marconi, Márcia Guimarães da Silva

PLoS One. 2021; 16(12): e0260753. Published online 2021 Dec 2. doi: 10.1371/journal.pone.0260753

PMCID:: PMC8639056

Abstract Article PDF–673K

Select item 86164805.

Human β-Defensin 2 and Its Postulated Role in Modulation of the Immune Response

Martyna Cieślik, Natalia Bagińska, Andrzej Górski, Ewa Jończyk-Matysiak

Cells. 2021 Nov; 10(11): 2991. Published online 2021 Nov 3. doi: 10.3390/cells10112991

PMCID:: PMC8616480

Abstract Article PDF–662K

Select item 84502286.

Human beta-defensins 2 and 4 are dysregulated in patients with coronavirus disease 19

Noor T. Al-Bayatee, Ali H. Ad'hiah

Microb Pathog. 2021 Nov; 160: 105205. Published online 2021 Sep 20. doi: 10.1016/j.micpath.2021.105205

PMCID:: PMC8450228

Abstract Article PDF–2.8M

Select item 83465697.

Human beta defensin levels and vaginal microbiome composition in post-menopausal women diagnosed with lichen sclerosus

Alexandra Brunner, Márta Medvecz, Nóra Makra, Miklós Sárdy, Kinga Komka, Máté Gugolya, Dóra Szabó, Márió Gajdács, Eszter Ostorházi

Sci Rep. 2021; 11: 15999. Published online 2021 Aug 6. doi: 10.1038/s41598-021-94880-4

PMCID:: PMC8346569

Abstract Article PDF–3.5M

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79468509.

Human β-Defensin 2 Mutations Are Associated With Asthma and Atopy in Children and Its Application Prevents Atopic Asthma in a Mouse Model

Natascha S. Borchers, Elisangela Santos-Valente, Antoaneta A. Toncheva, Jan Wehkamp, Andre Franke, Vincent D. Gaertner, Peter Nordkild, Jon Genuneit, Benjamin A. H. Jensen, Michael Kabesch

Front Immunol. 2021; 12: 636061. Published online 2021 Feb 25. doi: 10.3389/fimmu.2021.636061

PMCID:: PMC7946850

Abstract Article PDF–1.1M

Select item 711463610.

Human β-defensin 2 is involved in CCR2-mediated Nod2 signal transduction, leading to activation of the innate immune response in macrophages

Ju Kim, Ye Lin Yang, Yong-Suk Jang

Immunobiology. 2019 Jul; 224(4): 502–510. Published online 2019 May 18. doi: 10.1016/j.imbio.2019.05.004

PMCID:: PMC7114636

Abstract Article PDF–1.3M

Select item 647970211.

Human β-Defensin 2 Expression in Oral Epithelium: Potential Therapeutic Targets in Oral Lichen Planus

Abdelhakim Salem, Rabeia Almahmoudi, Jaana Hagström, Holger Stark, Dan Nordström, Tuula Salo, Kari K. Eklund

Int J Mol Sci. 2019 Apr; 20(7): 1780. Published online 2019 Apr 10. doi: 10.3390/ijms20071780

PMCID:: PMC6479702

Abstract Article PDF–2.4M

Select item 642888812.

Cervicovaginal microbiota and local immune response modulate the risk of spontaneous preterm delivery

Michal A. Elovitz, Pawel Gajer, Valerie Riis, Amy G. Brown, Michael S. Humphrys, Johanna B. Holm, Jacques Ravel

Nat Commun. 2019; 10: 1305. Published online 2019 Mar 21. doi: 10.1038/s41467-019-09285-9

PMCID:: PMC6428888

Abstract Article PDF–880K

Select item 630998813.

Human β-Defensin 2 and 3 and Their Mouse Orthologs Induce Chemotaxis through Interaction with CCR2

Johann Röhrl, De Yang, Joost J. Oppenheim, Thomas Hehlgans

J Immunol. Author manuscript; available in PMC 2018 Dec 28.

Published in final edited form as: J Immunol. 2010 Jun 15; 184(12): 6688–6694. Published online 2010 May 17. doi: 10.4049/jimmunol.0903984

PMCID:: PMC6309988

Abstract Article PDF–1.0M

Select item 605973114.

Human β-defensin 2 kills Candida albicans through phosphatidylinositol 4,5-bisphosphate–mediated membrane permeabilization

Michael Järvå, Thanh Kha Phan, Fung T. Lay, Sofia Caria, Marc Kvansakul, Mark D. Hulett

Sci Adv. 2018 Jul; 4(7): eaat0979. Published online 2018 Jul 25. doi: 10.1126/sciadv.aat0979

PMCID:: PMC6059731

Abstract Article PDF–1.9M

Select item 583198615.

Human beta defensin (HBD) gene copy number affects HBD2 protein levels: impact on cervical bactericidal immunity in pregnancy

Catherine P. James, Mona Bajaj-Elliott, Razan Abujaber, Frida Forya, Nigel Klein, Anna L. David, Edward J. Hollox, Donald M. Peebles

Eur J Hum Genet. 2018 Mar; 26(3): 434–439. Published online 2018 Jan 24. doi: 10.1038/s41431-017-0061-7

PMCID:: PMC5831986

Abstract Article PDF–1.2M

Select item 581692416.

Beta-Defensin 2 and 3 Promote Bacterial Clearance of Pseudomonas aeruginosa by Inhibiting Macrophage Autophagy through Downregulation of Early Growth Response Gene-1 and c-FOS

Yongjian Wu, Dandan Li, Yi Wang, Xi Liu, Yuanqing Zhang, Wenting Qu, Kang Chen, Ngiambudulu M. Francisco, Lianqiang Feng, Xi Huang, Minhao Wu

Front Immunol. 2018; 9: 211. Published online 2018 Feb 13. doi: 10.3389/fimmu.2018.00211

PMCID:: PMC5816924

Abstract Article PDF–5.0M

Select item 559127317.

Targeting Deficiencies in the TLR5 Mediated Vaginal Response to Treat Female Recurrent Urinary Tract Infection

Ased S. M. Ali, Catherine Mowbray, Marcelo Lanz, Anna Stanton, Samantha Bowen, Claire L. Varley, Paul Hilton, Karen Brown, Wendy Robson, Jennifer Southgate, Phillip D. Aldridge, Alison Tyson-Capper, Soman Abraham, Robert S. Pickard, Judith Hall

Sci Rep. 2017; 7: 11039. Published online 2017 Sep 8. doi: 10.1038/s41598-017-10445-4

PMCID:: PMC5591273

Abstract Article PDF–2.2M

Select item 553161118.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 547356519.

Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease

Anna Manko, Jean-Paul Motta, James A. Cotton, Troy Feener, Ayodele Oyeyemi, Bruce A. Vallance, John L. Wallace, Andre G. Buret

PLoS One. 2017; 12(6): e0178647. Published online 2017 Jun 16. doi: 10.1371/journal.pone.0178647

PMCID:: PMC5473565

Abstract Article PDF–8.2M

Select item 534136120.

Hepatocytes express the antimicrobial peptide HBD-2 after multiple trauma: an experimental study in human and mice

Stefanie Fitschen-Oestern, Matthias Weuster, Sebastian Lippross, Peter Behrendt, Sabine Fuchs, Thomas Pufe, Mersedeh Tohidnezhad, Andreas Bayer, Andreas Seekamp, Deike Varoga, Tim Klüter

BMC Musculoskelet Disord. 2017; 18: 100. Published online 2017 Mar 7. doi: 10.1186/s12891-017-1458-8

PMCID:: PMC5341361

Abstract Article PDF–825K

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