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Items: 1 to 20 of 121

1.
An interaction network in the polymerase active site is a prerequisite for Watson-Crick base pairing in Pol γ
Joon Park, Geoffrey K. Herrmann, Arkanil Roy, Christie K. Shumate, G. Andrés Cisneros, Y. Whitney Yin
Sci Adv. 2024 May 24; 10(21): eadl3214. Published online 2024 May 24. doi: 10.1126/sciadv.adl3214
PMCID:
PMC11122685
AbstractArticlePDF–2.6M
2.
Ancestral allele of DNA polymerase gamma modifies antiviral tolerance
Yilin Kang, Jussi Hepojoki, Rocio Sartori Maldonado, Takayuki Mito, Mügen Terzioglu, Tuula Manninen, Ravi Kant, Sachin Singh, Alaa Othman, Rohit Verma, Johanna Uusimaa, Kirmo Wartiovaara, Lauri Kareinen, Nicola Zamboni, Tuula Anneli Nyman, Anders Paetau, Anja Kipar, Olli Vapalahti, Anu Suomalainen
Nature. 2024; 628(8009): 844–853. Published online 2024 Apr 3. doi: 10.1038/s41586-024-07260-z
PMCID:
PMC11041766
AbstractArticlePDF–25M
3.
Polγ coordinates DNA synthesis and proofreading to ensure mitochondrial genome integrity
Joon Park, Geoffrey K. Herrmann, Patrick G. Mitchell, Michael B. Sherman, Y. Whitney Yin
Nat Struct Mol Biol. Author manuscript; available in PMC 2024 Mar 8.
Published in final edited form as: Nat Struct Mol Biol. 2023 Jun; 30(6): 812–823. Published online 2023 May 18. doi: 10.1038/s41594-023-00980-2
PMCID:
PMC10920075
AbstractArticlePDF–2.6M
4.
DNA polymerase gamma variants and hepatotoxicity during maintenance therapy of childhood acute lymphoblastic leukemia: is there a causal relationship?
Tekla Harju, Anri Hurme-Niiranen, Maria Suo-Palosaari, Stine Nygaard Nielsen, Reetta Hinttala, Kjeld Schmiegelow, Johanna Uusimaa, Arja Harila, Riitta Niinimäki
Pharmacogenomics J. 2023; 23(5): 105–111. Published online 2023 May 3. doi: 10.1038/s41397-023-00303-0
PMCID:
PMC10506908
AbstractArticlePDF–845K
5.
Ataxia y neuropatía sensitiva de inicio en la edad adulta como manifestación clínica de mutaciones en el gen POLG
Carmen García-Cabo, Paula Carvajal-García, Iván Fernández-Vega, Jorge Peña-Suárez, Valentín Mateos-Marcos, Patricia Suárez-Santos, Victoria Álvarez-Martínez, Germán Morís-de la Tassa
Rev Neurol. 2023; 76(3): 75–81. Spanish. Published online 2023 Feb 1. doi: 10.33588/rn.7603.2022322
PMCID:
PMC10364044
AbstractArticlePDF–1.0M
6.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
7.
Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell
Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low
Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120
PMCID:
PMC10151615
AbstractArticlePDF–2.9M
8.
Mechanism of strand displacement DNA synthesis by the coordinated activities of human mitochondrial DNA polymerase and SSB
Ismael Plaza-G.A., Kateryna M Lemishko, Rodrigo Crespo, Thinh Q Truong, Laurie S Kaguni, Francisco J Cao-García, Grzegorz L Ciesielski, Borja Ibarra
Nucleic Acids Res. 2023 Feb 28; 51(4): 1750–1765. Published online 2023 Feb 6. doi: 10.1093/nar/gkad037
PMCID:
PMC9976888
AbstractArticlePDF–9.8M
9.
Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease
Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel
Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205
PMCID:
PMC9348576
AbstractArticlePDF–3.0M
10.
Heterozygous p.Y955C mutation in DNA polymerase γ leads to alterations in bioenergetics, complex I subunit expression, and mtDNA replication
Md. Mostafijur Rahman, Carolyn K.J. Young, Steffi Goffart, Jaakko L.O. Pohjoismäki, Matthew J. Young
J Biol Chem. 2022 Aug; 298(8): 102196. Published online 2022 Jun 24. doi: 10.1016/j.jbc.2022.102196
PMCID:
PMC9307957
AbstractArticlePDF–4.8M
11.
A dual-activity topoisomerase complex regulates mRNA translation and turnover
Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang
Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538
PMCID:
PMC9262614
AbstractArticlePDF–3.6M
12.
POLG mutations lead to abnormal mitochondrial remodeling during neural differentiation of human pluripotent stem cells via SIRT3/AMPK pathway inhibition
Anbin Chen, Cecilie Katrin Kristiansen, Lena Elise Høyland, Mathias Ziegler, Jian Wang, Gareth John Sullivan, Xingang Li, Laurence A. Bindoff, Kristina Xiao Liang
Cell Cycle. 2022; 21(11): 1178–1193. Published online 2022 Mar 17. doi: 10.1080/15384101.2022.2044136
PMCID:
PMC9103491
AbstractArticlePDF–3.0M
13.
Remdesivir triphosphate blocks DNA synthesis and increases exonucleolysis by the replicative mitochondrial DNA polymerase, Pol γ
Elena J. Ciesielska, Shalom Kim, Hyacintha-ghislaine M. Bisimwa, Cody Grier, Md. Mostafijur Rahman, Carolyn K. J. Young, Matthew J. Young, Marcos T. Oliveira, Grzegorz L. Ciesielski
Mitochondrion. Author manuscript; available in PMC 2022 Nov 1.
Published in final edited form as: Mitochondrion. 2021 Nov; 61: 147–158. Published online 2021 Oct 5. doi: 10.1016/j.mito.2021.09.010
PMCID:
PMC8595818
AbstractArticlePDF–1.4M
14.
Urine Cell-Free Mitochondrial DNA as a Marker of Weight Loss and Body Composition in Older Adults with HIV
Carrie D. Johnston, Eugenia L. Siegler, Michelle C. Rice, Heather M. Derry, Katie C. Hootman, Yuan-Shan Zhu, Chelsie O. Burchett, Samir K. Gupta, Mary E. Choi, Marshall J. Glesby
J Acquir Immune Defic Syndr. Author manuscript; available in PMC 2022 Nov 1.
Published in final edited form as: J Acquir Immune Defic Syndr. 2021 Nov 1; 88(3): 229–233. doi: 10.1097/QAI.0000000000002766
PMCID:
PMC8526378
AbstractArticlePDF–365K
15.
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger
Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y
PMCID:
PMC8352964
AbstractArticlePDF–4.5M
16.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
17.
MITOL-dependent ubiquitylation negatively regulates the entry of PolγA into mitochondria
Mansoor Hussain, Aftab Mohammed, Shabnam Saifi, Aamir Khan, Ekjot Kaur, Swati Priya, Himanshi Agarwal, Sagar Sengupta
PLoS Biol. 2021 Mar; 19(3): e3001139. Published online 2021 Mar 3. doi: 10.1371/journal.pbio.3001139
PMCID:
PMC7959396
AbstractArticlePDF–4.1M
18.
Poly(ADP-ribose) polymerase 1 regulates mitochondrial DNA repair in an NAD-dependent manner
Geoffrey K. Herrmann, William K. Russell, Nisha J. Garg, Y. Whitney Yin
J Biol Chem. 2021 Jan-Jun; 296: 100309. Published online 2021 Jan 19. doi: 10.1016/j.jbc.2021.100309
PMCID:
PMC7949115
AbstractArticlePDF–1.7M
19.
De Novo Development of mtDNA Deletion Due to Decreased POLG and SSBP1 Expression in Humans
Yeonmi Lee, Taeho Kim, Miju Lee, Seongjun So, Mustafa Zafer Karagozlu, Go Hun Seo, In Hee Choi, Peter C. W. Lee, Chong-Jai Kim, Eunju Kang, Beom Hee Lee
Genes (Basel) 2021 Feb; 12(2): 284. Published online 2021 Feb 17. doi: 10.3390/genes12020284
PMCID:
PMC7922481
AbstractArticlePDF–3.4M
20.
Progressive External Ophthalmoplegia in Polish Patients—From Clinical Evaluation to Genetic Confirmation
Biruta Kierdaszuk, Magdalena Kaliszewska, Joanna Rusecka, Joanna Kosińska, Ewa Bartnik, Katarzyna Tońska, Anna M. Kamińska, Anna Kostera-Pruszczyk
Genes (Basel) 2021 Jan; 12(1): 54. Published online 2020 Dec 31. doi: 10.3390/genes12010054
PMCID:
PMC7824435
AbstractArticlePDF–4.8M

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