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Items: 1 to 20 of 307

1.
LKB1 gene mutations in Japanese lung cancer patients
Ryoichi Onozato, Takayuki Kosaka, Hiroyuki Achiwa, Hiroyuki Kuwano, Takashi Takahashi, Yasushi Yatabe, Tetsuya Mitsudomi
Cancer Sci. 2007 Nov; 98(11): 1747–1751. Published online 2007 Aug 16. doi: 10.1111/j.1349-7006.2007.00585.x
PMCID:
PMC11158871
AbstractArticlePDF–116K
2.
Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase
John R. Ferrarone, Jerin Thomas, Arun M. Unni, Yuxiang Zheng, Michal J. Nagiec, Eric E. Gardner, Oksana Mashadova, Kate Li, Nikos Koundouros, Antonino Montalbano, Meer Mustafa, Lewis C. Cantley, John Blenis, Neville E. Sanjana, Harold Varmus
Proc Natl Acad Sci U S A. 2024 May 21; 121(21): e2403685121. Published online 2024 May 14. doi: 10.1073/pnas.2403685121
PMCID:
PMC11127050
AbstractArticlePDF–1.4M
3.
Effect of the STK11 mutation on therapeutic efficacy and prognosis in patients with non-small cell lung cancer: a comprehensive study based on meta-analyses and bioinformatics analyses
Ke Xu, Weinan Lu, Airu Yu, Hongwei Wu, Jie He
BMC Cancer. 2024; 24: 491. Published online 2024 Apr 17. doi: 10.1186/s12885-024-12130-y
PMCID:
PMC11025184
AbstractArticlePDF–3.1M
4.
Diminished Efficacy of Programmed Death-(Ligand)1 Inhibition in STK11- and KEAP1-Mutant Lung Adenocarcinoma Is Affected by KRAS Mutation Status
Biagio Ricciuti, Kathryn C. Arbour, Jessica J. Lin, Amir Vajdi, Natalie Vokes, Lingzhi Hong, Jianjun Zhang, Michael Y. Tolstorukov, Yvonne Y. Li, Liam F. Spurr, Andrew D. Cherniack, Gonzalo Recondo, Giuseppe Lamberti, Xinan Wang, Deepti Venkatraman, Joao V. Alessi, Victor R. Vaz, Hira Rizvi, Jacklynn Egger, Andrew J. Plodkowski, Sara Khosrowjerdi, Subba Digumarthy, Hyesun Park, Nuno Vaz, Mizuki Nishino, Lynette M. Sholl, David Barbie, Mehmet Altan, John V. Heymach, Ferdinandos Skoulidis, Justin F. Gainor, Matthew D. Hellmann, Mark M. Awad
J Thorac Oncol. Author manuscript; available in PMC 2024 Mar 29.
Published in final edited form as: J Thorac Oncol. 2022 Mar; 17(3): 399–410. Published online 2021 Nov 2. doi: 10.1016/j.jtho.2021.10.013
PMCID:
PMC10980559
AbstractArticlePDF–1.5M
5.
Impact of LKB1 status on radiation outcome in patients with stage III non-small-cell lung cancer
Piyada Sitthideatphaiboon, Chonnipa Nantavithya, Poonchavist Chantranuwat, Chanida Vinayanuwattikun, Virote Sriuranpong
Sci Rep. 2024; 14: 6146. Published online 2024 Mar 14. doi: 10.1038/s41598-024-55476-w
PMCID:
PMC10938003
AbstractArticlePDF–1.2M
6.
STK11 loss leads to YAP1-mediated transcriptional activation in human KRAS-driven lung adenocarcinoma cell lines
Sean M. Lenahan, Hailey M. Sarausky, Paula Deming, David J. Seward
Cancer Gene Ther. 2024; 31(1): 1–8. Published online 2023 Nov 15. doi: 10.1038/s41417-023-00687-y
PMCID:
PMC10794139
AbstractArticlePDF–4.1M
7.
LKB1‐SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition
Sarah Proteau, Imène Krossa, Chrystel Husser, Maxime Guéguinou, Federica Sella, Karine Bille, Marie Irondelle, Mélanie Dalmasso, Thibault Barouillet, Yann Cheli, Céline Pisibon, Nicole Arrighi, Sacha Nahon‐Estève, Arnaud Martel, Lauris Gastaud, Sandra Lassalle, Olivier Mignen, Patrick Brest, Nathalie M Mazure, Frédéric Bost, Stéphanie Baillif, Solange Landreville, Simon Turcotte, Dan Hasson, Saul Carcamo, Christophe Vandier, Emily Bernstein, Laurent Yvan‐Charvet, Mitchell P Levesque, Robert Ballotti, Corine Bertolotto, Thomas Strub
EMBO Mol Med. 2023 Dec; 15(12): e17719. Published online 2023 Nov 15. doi: 10.15252/emmm.202317719
PMCID:
PMC10701601
AbstractArticlePDF–3.7M
8.
DENV-2 NS1 promotes AMPK-LKB1 interaction to activate AMPK/ERK/mTOR signaling pathway to induce autophagy
Ning Wu, Jinzhong Ji, Xiaoqin Gou, Pan Hu, Yao Cheng, Yuhang Liu, Yuanying Wang, Qilong Zhang, Li Zuo
Virol J. 2023; 20: 231. Published online 2023 Oct 11. doi: 10.1186/s12985-023-02166-0
PMCID:
PMC10568820
AbstractArticlePDF–2.1M
9.
STK11 Inactivation Predicts Rapid Recurrence in Inoperable Early-Stage Non–Small-Cell Lung Cancer
Rohan R. Katipally, Liam F. Spurr, Stanley I. Gutiontov, William Tyler Turchan, Philip Connell, Aditya Juloori, Renuka Malik, Michael S. Binkley, Alice L. Jiang, Sherin J. Rouhani, Carolina Soto Chervin, Pankhuri Wanjari, Jeremy P. Segal, Victor Ng, Billy W. Loo, Daniel R. Gomez, Christine M. Bestvina, Everett E. Vokes, Mark K. Ferguson, Jessica S. Donington, Maximilian Diehn, Sean P. Pitroda
JCO Precis Oncol. 2023; 7: e2200273. Published online 2023 Jan 5. doi: 10.1200/PO.22.00273
PMCID:
PMC10530422
AbstractArticlePDF–639K
10.
Alteration of STK11 Expression Associated With Cholangiocarcinoma Progression
PAPITCHAYA SIRITHAWAT, APINYA JUSAKUL, SARINYA KONGPETCH, MALINEE THANEE, PEERADA SRICHANCHARA, SUPARADA PANJAROENSAK, PHONGSARAN KIMAWAHA, SUTTHIWAN JANTHAMALA, CHAIWAT APHIVATANASIRI, ANCHALEE TECHASEN
In Vivo. 2023 Jul-Aug; 37(4): 1638–1648. Published online 2023 Jul 3. doi: 10.21873/invivo.13249
PMCID:
PMC10347919
AbstractArticlePDF–5.4M
11.
STK11 Alterations in the Pan-Cancer Setting: Prognostic and Therapeutic Implications
Nithya Krishnamurthy, Aaron M. Goodman, Donald A. Barkauskas, Razelle Kurzrock
Eur J Cancer. Author manuscript; available in PMC 2023 Jul 13.
Published in final edited form as: Eur J Cancer. 2021 May; 148: 215–229. Published online 2021 Mar 19. doi: 10.1016/j.ejca.2021.01.050
PMCID:
PMC10344467
AbstractArticlePDF–1.0M
12.
Peutz-Jeghers syndrome without STK11 mutation may correlate with less severe clinical manifestations in Chinese patients
Li-Xin Jiang, Yu-Rui Chen, Zu-Xin Xu, Yu-Hui Zhang, Zhi Zhang, Peng-Fei Yu, Zhi-Wei Dong, Hai-Rui Yang, Guo-Li Gu
World J Gastroenterol. 2023 Jun 7; 29(21): 3302–3317. Published online 2023 Jun 7. doi: 10.3748/wjg.v29.i21.3302
PMCID:
PMC10292148
AbstractArticlePDF–1.3M
13.
Tumor loss-of-function mutations in STK11/LKB1 induce cachexia
Puneeth Iyengar, Aakash Y. Gandhi, Jorge Granados, Tong Guo, Arun Gupta, Jinhai Yu, Ernesto M. Llano, Faya Zhang, Ang Gao, Asha Kandathil, Dorothy Williams, Boning Gao, Luc Girard, Venkat S. Malladi, John M. Shelton, Bret M. Evers, Raquibul Hannan, Chul Ahn, John D. Minna, Rodney E. Infante
JCI Insight. 2023 Apr 24; 8(8): e165419. Published online 2023 Apr 24. doi: 10.1172/jci.insight.165419
PMCID:
PMC10243820
AbstractArticlePDF–6.8M
14.
Clinicopathological and prognostic significance of LKB1 expression in gastric cancer: a systematic review and meta-analysis
Guojiang Tan, Baiying Liu
Sci Rep. 2023; 13: 8937. Published online 2023 Jun 1. doi: 10.1038/s41598-023-36239-5
PMCID:
PMC10235053
AbstractArticlePDF–2.5M
15.
LKB1 Regulates Inflammation of Fibroblast-like Synoviocytes from Patients with Rheumatoid Arthritis via AMPK-Dependent SLC7A11-NOX4-ROS Signaling
Ha-Reum Lee, Su-Jin Yoo, Jinhyun Kim, Seong Wook Kang
Cells. 2023 May; 12(9): 1263. Published online 2023 Apr 26. doi: 10.3390/cells12091263
PMCID:
PMC10177119
AbstractArticlePDF–6.6M
16.
Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex
Liping Xie, Yanmei Yuan, Simiao Xu, Sijia Lu, Jinyang Gu, Yanping Wang, Yibing Wang, Xianjing Zhang, Suzhen Chen, Jian Li, Junxi Lu, Honglin Sun, Ruixiang Hu, Hailong Piao, Wen Wang, Cunchuan Wang, Jing Wang, Na Li, Morris F. White, Liu Han, Weiping Jia, Ji Miao, Junli Liu
Cell Rep. Author manuscript; available in PMC 2023 May 2.
Published in final edited form as: Cell Rep. 2022 Oct 18; 41(3): 111498. doi: 10.1016/j.celrep.2022.111498
PMCID:
PMC10153649
AbstractArticlePDF–1.6M
17.
RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis
Lei Chen, Wenjing Zhang, Dan Chen, Quan Yang, Siwen Sun, Zhenwei Dai, Zhengzheng Li, Xuemei Liang, Chaoqun Chen, Yuexia Jiao, Lili Zhi, Lianmei Zhao, Jinrui Zhang, Xuefeng Liu, Jinyao Zhao, Man Li, Yang Wang, Yangfan Qi
Signal Transduct Target Ther. 2023; 8: 159. Published online 2023 Apr 21. doi: 10.1038/s41392-023-01367-x
PMCID:
PMC10119322
AbstractArticlePDF–7.7M
18.
Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity
Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong
Mol Cell. Author manuscript; available in PMC 2023 Apr 4.
Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015
PMCID:
PMC10072906
AbstractArticlePDF–4.2M
19.
Posttranslational regulation of liver kinase B1 in human cancer
Lanlin Hu, Mingxin Liu, Bo Tang, Qiang Li, Bo-Syong Pan, Chuan Xu, Hui-Kuan Lin
J Biol Chem. 2023 Apr; 299(4): 104570. Published online 2023 Mar 3. doi: 10.1016/j.jbc.2023.104570
PMCID:
PMC10068580
AbstractArticlePDF–2.7M
20.
LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma
Benjamin D. Stein, John R. Ferrarone, Eric E. Gardner, Jae Won Chang, David Wu, Pablo E. Hollstein, Roger J. Liang, Min Yuan, Qiuying Chen, John S. Coukos, Miriam Sindelar, Bryan Ngo, Steven S. Gross, Reuben J. Shaw, Chen Zhang, John M. Asara, Raymond E. Moellering, Harold Varmus, Lewis C. Cantley
Cancer Discov. 2023 Apr 3; 13(4): 1002–1025. Published online 2023 Jan 30. doi: 10.1158/2159-8290.CD-22-0805
PMCID:
PMC10068449
AbstractArticlePDF–13M

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