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Select item 110103641.

THOC7-AS1/OCT1/FSTL1 axis promotes EMT and serves as a therapeutic target in cutaneous squamous cell carcinoma

Site Yu, Xu Cui, Situo Zhou, Yun Li, Wenjie Feng, Xiangjun Zhang, Yuhui Zhong, Pihong Zhang

J Transl Med. 2024; 22: 347. Published online 2024 Apr 11. doi: 10.1186/s12967-024-05116-8

PMCID:: PMC11010364

Abstract Article PDF–16M

Select item 105677222.

Structural basis of promiscuous substrate transport by Organic Cation Transporter 1

Yi C. Zeng, Meghna Sobti, Ada Quinn, Nicola J. Smith, Simon H. J. Brown, Jamie I. Vandenberg, Renae M. Ryan, Megan L. O’Mara, Alastair G. Stewart

Nat Commun. 2023; 14: 6374. Published online 2023 Oct 11. doi: 10.1038/s41467-023-42086-9

PMCID:: PMC10567722

Abstract Article PDF–3.9M

Select item 91902333.

Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier

Raymond K. Hau, Robert R. Klein, Stephen H. Wright, Nathan J. Cherrington

Drug Metab Dispos. 2022 Jun; 50(6): 770–780. Published online 2022 Jun. doi: 10.1124/dmd.121.000748

PMCID:: PMC9190233

Abstract Article PDF–2.8M

Select item 91305384.

Amino acids in transmembrane helix 1 confer major functional differences between human and mouse orthologs of the polyspecific membrane transporter OCT1

Marleen J. Meyer, Pascale C.F. Schreier, Mert Basaran, Stefaniia Vlasova, Tina Seitz, Jürgen Brockmöller, Barbara Zdrazil, Mladen V. Tzvetkov

J Biol Chem. 2022 Jun; 298(6): 101974. Published online 2022 Apr 22. doi: 10.1016/j.jbc.2022.101974

PMCID:: PMC9130538

Abstract Article PDF–4.4M

Select item 90262895.

The Role of SLC22A1 and Genomic Ancestry on Toxicity during Treatment in Children with Acute Lymphoblastic Leukemia of the Amazon Region

Sweny de S. M. Fernandes, Luciana P. C. Leitão, Amanda de N. Cohen-Paes, Laura P. A. Gellen, Lucas F. Pastana, Darlen C. de Carvalho, Antônio A. C. Modesto, Ana C. A. da Costa, Alayde V. Wanderley, Carlos H. V. de Lima, Esdras E. B. Pereira, Marianne R. Fernandes, Rommel M. R. Burbano, Paulo P. de Assumpção, Sidney E. B. dos Santos, Ney P. C. dos Santos

Genes (Basel) 2022 Apr; 13(4): 610. Published online 2022 Mar 29. doi: 10.3390/genes13040610

PMCID:: PMC9026289

Abstract Article PDF–893K

Select item 90055146.

OCT1-target neural gene PFN2 promotes tumor growth in androgen receptor-negative prostate cancer

Daisuke Obinata, Daigo Funakoshi, Kenichi Takayama, Makoto Hara, Birunthi Niranjan, Linda Teng, Mitchell G. Lawrence, Renea A. Taylor, Gail P. Risbridger, Yutaka Suzuki, Satoru Takahashi, Satoshi Inoue

Sci Rep. 2022; 12: 6094. Published online 2022 Apr 12. doi: 10.1038/s41598-022-10099-x

PMCID:: PMC9005514

Abstract Article PDF–3.5M

Select item 88781597.

Relationships between Inhibition, Transport and Enhanced Transport via the Organic Cation Transporter 1

Ole Jensen, Lukas Gebauer, Jürgen Brockmöller, Christof Dücker

Int J Mol Sci. 2022 Feb; 23(4): 2007. Published online 2022 Feb 11. doi: 10.3390/ijms23042007

PMCID:: PMC8878159

Abstract Article PDF–7.0M

Select item 75969698.

Overexpression of OCT-1 gene is a biomarker of adverse prognosis for diffuse large B-cell lymphoma (DLBCL): data from a retrospective cohort of 77 Brazilian patients

Gisele R. Gouveia, Suzete C. Ferreira, Sheila A. C. Siqueira, Luis Alberto de Pádua Covas Lage, Abrahão E. Hallack Neto, Renata de Oliveira Costa, Juliana Pereira

BMC Cancer. 2020; 20: 1041. Published online 2020 Oct 29. doi: 10.1186/s12885-020-07553-2

PMCID:: PMC7596969

Abstract Article PDF–1.3M

Select item 75598349.

Functional and Pharmacological Comparison of Human, Mouse, and Rat Organic Cation Transporter 1 toward Drug and Pesticide Interaction

Saskia Floerl, Annett Kuehne, Yohannes Hagos

Int J Mol Sci. 2020 Sep; 21(18): 6871. Published online 2020 Sep 19. doi: 10.3390/ijms21186871

PMCID:: PMC7559834

Abstract Article PDF–1.7M

Select item 716998310.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 633509911.

Blood-Brain Barrier: From Physiology to Disease and Back

Melanie D. Sweeney, Zhen Zhao, Axel Montagne, Amy R. Nelson, Berislav V. Zlokovic

Physiol Rev. 2019 Jan 1; 99(1): 21–78. Published online 2018 Oct 3. doi: 10.1152/physrev.00050.2017

PMCID:: PMC6335099

Abstract Article

Select item 612345612.

Polymorphisms of SLCO1B1 rs4149056 and SLC22A1 rs2282143 are associated with responsiveness to acitretin in psoriasis patients

Wangqing Chen, Xu Zhang, Wei Zhang, Cong Peng, Wu Zhu, Xiang Chen

Sci Rep. 2018; 8: 13182. Published online 2018 Sep 4. doi: 10.1038/s41598-018-31352-2

PMCID:: PMC6123456

Abstract Article PDF–1.5M

Select item 591969213.

Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content

Xiaomin Liang, Sook Wah Yee, Huan-Chieh Chien, Eugene C. Chen, Qi Luo, Ling Zou, Meiling Piao, Arias Mifune, Ligong Chen, Meredith E. Calvert, Sarah King, Frode Norheim, Janna Abad, Ronald M. Krauss, Kathleen M. Giacomini

PLoS Biol. 2018 Apr; 16(4): e2002907. Published online 2018 Apr 16. doi: 10.1371/journal.pbio.2002907

PMCID:: PMC5919692

Abstract Article PDF–6.4M

Select item 572853414.

Effects of genetic polymorphisms on the OCT1 and OCT2-mediated uptake of ranitidine

Marleen Julia Meyer, Tina Seitz, Jürgen Brockmöller, Mladen Vassilev Tzvetkov

PLoS One. 2017; 12(12): e0189521. Published online 2017 Dec 13. doi: 10.1371/journal.pone.0189521

PMCID:: PMC5728534

Abstract Article PDF–7.0M

Select item 563016215.

Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport

Hye In Kim, Johannes Raffler, Wenyun Lu, Jung-Jin Lee, Deepti Abbey, Danish Saleheen, Joshua D. Rabinowitz, Michael J. Bennett, Nicholas J. Hand, Christopher Brown, Daniel J. Rader

Am J Hum Genet. 2017 Oct 5; 101(4): 489–502. Published online 2017 Sep 21. doi: 10.1016/j.ajhg.2017.08.008

PMCID:: PMC5630162

Abstract Article PDF–1.6M

Select item 547760316.

Increased peroxisome proliferator-activated receptor γ activity reduces imatinib uptake and efficacy in chronic myeloid leukemia mononuclear cells

Jueqiong Wang, Liu Lu, Chung H. Kok, Verity A. Saunders, Jarrad M. Goyne, Phuong Dang, Tamara M. Leclercq, Timothy P. Hughes, Deborah L. White

Haematologica. 2017 May; 102(5): 843–853. doi: 10.3324/haematol.2016.153270

PMCID:: PMC5477603

Abstract Article PDF–1.0M

Select item 537608817.

Organic cation transporter 1 (OCT1) is involved in pentamidine transport at the human and mouse blood-brain barrier (BBB)

Gayathri N. Sekhar, Ana R. Georgian, Lisa Sanderson, Gema Vizcay-Barrena, Rachel C. Brown, Paula Muresan, Roland A. Fleck, Sarah A. Thomas

PLoS One. 2017; 12(3): e0173474. Published online 2017 Mar 31. doi: 10.1371/journal.pone.0173474

PMCID:: PMC5376088

Abstract Article PDF–3.3M

Select item 523356918.

Effects of SLC22A1 Polymorphisms on Metformin-Induced Reductions in Adiposity and Metformin Pharmacokinetics in Obese Children with Insulin Resistance

Wai Johnn Sam, Orsolya Roza, Yuen Yi Hon, Raul M. Alfaro, Karim A Calis, James C Reynolds, Jack A Yanovski

J Clin Pharmacol. Author manuscript; available in PMC 2017 Feb 1.

Published in final edited form as: J Clin Pharmacol. 2017 Feb; 57(2): 219–229. Published online 2016 Aug 23. doi: 10.1002/jcph.796

PMCID:: PMC5233569

Abstract Article PDF–669K

Select item 512244919.

Effect of Serotonin Transporter 5HTTLPR Polymorphism on Gastrointestinal Intolerance to Metformin: A GoDARTS Study

Tanja Dujic, Kaixin Zhou, Roger Tavendale, Prof Colin N.A. Palmer, Prof Ewan R. Pearson

Diabetes Care. Author manuscript; available in PMC 2016 Dec 9.

Published in final edited form as: Diabetes Care. 2016 Nov; 39(11): 1896–1901. Published online 2016 Aug 4. doi: 10.2337/dc16-0706

PMCID:: PMC5122449

Abstract Article PDF–542K

Select item 506464520.

Organic cation transporter 1 variants and gastrointestinal side effects of metformin in patients with Type 2 diabetes

T. Dujic, A. Causevic, T. Bego, M. Malenica, Z. Velija‐Asimi, E. R. Pearson, S. Semiz

Diabet Med. 2016 Apr; 33(4): 511–514. Published online 2015 Dec 24. doi: 10.1111/dme.13040

PMCID:: PMC5064645

Abstract Article PDF–61K

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